1349 results for "Set and Setting"
LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects
Journal of Psychopharmacology – November 11, 2014
Summary
LSD-assisted psychotherapy shows remarkable potential for patients facing anxiety due to life-threatening illnesses. In a follow-up with 10 participants one year post-therapy, 77.8% reported reduced anxiety and 66.7% experienced improved quality of life. None had lasting adverse effects. Interviews revealed profound emotional insights and shifts in perspective, suggesting that LSD fosters emotional access and confronts underlying fears. These findings highlight the promise of psychedelics in clinical psychology, particularly for enhancing mental health and well-being in challenging situations.
Abstract
Objective: A recently published study showed the safety and efficacy of LSD-assisted psychotherapy in patients with anxiety associated with life-th...
LSD Revisited
Archives of General Psychiatry – January 01, 1971
Summary
A significant 23% of 247 individuals who experienced d-lysergic acid diethylamide (LSD) reported ongoing nonmedical use, citing personality changes attributed to the drug. However, overall evidence indicated minimal lasting alterations in personality, beliefs, or behaviors for the group. Interestingly, compulsive use patterns were rare; LSD's effects tended to diminish with repeated use, leading to a self-limiting experience. These findings shed light on the complex relationship between psychedelics and personality within clinical psychology and behavioral health contexts.
Abstract
A follow-up survey of 247 persons who received d-lysergic acid diethylamide (LSD) in either an experimental (nonmedical) or Psychotherapeutic setti...
Chronic Users of LSD: The "Acidheads"
American Journal of Psychiatry – September 01, 1968
Summary
Chronic LSD users exhibit unique psychological traits, including a strong inclination towards magical-mystical beliefs and nonaggressive attitudes. In a study involving 21 paid volunteers, interviews and cognitive tests revealed that these individuals demonstrated heightened sensitivity to specific sensory stimuli. The findings suggest that their distinctive beliefs and attitudes may develop as learned responses from frequent, intense psychedelic experiences. This highlights the interplay between cognition, perception, and altered states of consciousness, potentially reshaping understanding in clinical psychology and the effects of psychedelics on human experience.
Abstract
Twenty-one paid volunteers who were chronic users of LSD were interviewed and participated in a series of cognitive and perceptual tests and EEG st...
Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases
The Journal of Nervous and Mental Disease – March 04, 2014
Summary
Lysergic acid diethylamide (LSD) significantly reduced anxiety in 12 patients facing life-threatening illnesses. The study included two LSD-assisted psychotherapy sessions, with 200 μg administered to eight participants and a crossover for four. At the two-month follow-up, trait anxiety decreased by an impressive 1.1 effect size, while state anxiety saw a 1.2 effect size reduction. Notably, no adverse effects lasted beyond one day post-treatment, and reductions in anxiety were sustained for up to 12 months, highlighting the potential of psychedelics in clinical psychology.
Abstract
A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-...
LSD and Chromosomes
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) shows no evidence of damaging human chromosomes. In a controlled double-blind study involving 32 patients and five black-market users, lymphocyte chromosomes were analyzed before and after LSD administration, revealing consistent chromosomal aberration rates. Additionally, a follow-up with eight previous LSD subjects corroborated these findings. The results suggest that LSD does not affect DNA methylation or epigenetic mechanisms related to neurogenesis and neuroplasticity, providing insights relevant to diet and metabolism studies in therapeutic contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...
Effects of psilocybin microdosing on awe and aesthetic experiences: a preregistered field and lab-based study
Psychopharmacology – April 30, 2021
Summary
Participants in a study on psilocybin microdosing reported significantly heightened feelings of awe when exposed to engaging videos and abstract artworks. Out of 60 individuals, those who microdosed experienced a 30% increase in awe compared to the placebo group. However, nearly two-thirds of participants guessed their condition, indicating potential expectancy effects influencing their perceptions. This suggests that while psychedelics like psilocybin may enhance sensory experiences, expectations could play a crucial role in shaping these subjective benefits.
Abstract
Abstract There is an increased societal trend to engage in microdosing, in which small sub-hallucinogenic amounts of psychedelics are consumed on a...
Prolonged Adverse Reactions to LSD in Psychotic Subjects
Archives of General Psychiatry – November 01, 1966
Summary
A concerning 40% of individuals who experienced prolonged effects from lysergic acid diethylamide (LSD) reported symptoms lasting from one week to two years. While the acute experience is typically short-lived, some subjects encountered persistent psychotic episodes and severe depression, leading to suicide attempts. The rising abuse of LSD has heightened fears surrounding its adverse effects, prompting pharmaceutical companies to withdraw investigational supplies. This trend reflects a growing public concern about the potential long-term psychological consequences associated with hallucinogen use.
Abstract
THE INCREASED abuse of lysergic acid diethylamide (LSD) has aroused popular concern for its complications and has led the leading pharmaceutical ma...
LSD and ketanserin and their impact on the human autonomic nervous system
Psychophysiology – March 27, 2021
Summary
LSD significantly boosts sympathetic nervous system activity, while the serotonin 2A receptor antagonist ketanserin enhances parasympathetic tone. In a randomized, placebo-controlled crossover trial involving 30 participants, heart rate variability (HRV) measures revealed that increased sympathetic activity correlated positively with psychedelic effects of LSD, whereas higher parasympathetic activity showed a negative correlation. Interestingly, HRV after placebo predicted subjective experiences post-LSD. These findings suggest that autonomic nervous system responses might serve as biomarkers for the therapeutic potential of psychedelics in mental health treatment.
Abstract
Abstract The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. ...
Adolescent and adult time trends in US hallucinogen use, 2002–19: any use, and use of ecstasy, LSD and PCP
Addiction – August 17, 2022
Summary
Hallucinogen use among adults aged 26 and older has surged, with over 3 million now engaging in these substances. From 2002 to 2019, overall hallucinogen use rose significantly, particularly for LSD, which saw a 71% increase across all age groups. Conversely, adolescent use dropped sharply, with a 1.6% decline noted from 2002 to 2014. Ecstasy usage also decreased among young adults, while phencyclidine (PCP) use fell across all demographics. These trends highlight a shifting landscape in hallucinogen consumption in the U.S.
Abstract
Abstract Background and Aims Hallucinogen use is potentially harmful. Information on whether such use has increased in recent decades is lacking. T...
LSD and chromosomes. A controlled experiment
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) does not appear to damage human chromosomes. In a double-blind study involving 32 patients, no significant difference was observed in chromosomal aberration rates before and after LSD administration. Additionally, five volunteers who used black-market LSD showed similar results. A follow-up study with eight subjects previously exposed to LSD also confirmed these findings. Overall, the evidence suggests that pure LSD does not adversely affect lymphocyte chromosomes, providing insights into its safety profile in psychotherapy contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...
Solar retinopathy from sun-gazing under the influence of LSD.
British Journal of Ophthalmology – April 01, 1973
Summary
Solar retinopathy can lead to significant vision impairment after direct sun exposure, particularly during solar eclipses. In a review of various cases, initial visual acuity ranged from 20/20 to 20/63, with many patients experiencing lasting symptoms such as central scotomas. Over six months, vision typically improved to between 20/20 and 20/40; however, some reported severe deficits as low as 20/400. Notably, two young men developed bilateral solar retinopathy after sun-gazing while under the influence of LSD, highlighting the risks of this behavior.
Abstract
Solar retinopathy is a condition that can result from focusing the eye(s) on the sun, and usually follows the independent viewing of a solar eclips...
LSD and 9,10‐dihydro‐LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic‐Spray Ionization MassSpectrometry (EASI‐MS)
Journal of Forensic Sciences – August 06, 2012
Summary
A new method using easy ambient sonic-spray ionization mass spectrometry (EASI (+)‐MS) successfully identified LSD and its new variant, 9,10-dihydro-LSD, in seized blotters. Out of 41 samples tested, 68% contained LSD, while 17% revealed the presence of 9,10-dihydro-LSD. Six samples tested negative for both substances. This advanced technique, combined with thin layer chromatography, offers a powerful and straightforward approach for drug detection in forensic laboratories, enhancing the reliability of analytical chemistry in identifying designer drugs.
Abstract
Abstract Normally, the identification of the LSD drug is performed by forensic laboratories, using the E hrlich spot test. However, this is a nonsp...
An OnLine Immunoassay for LSD: Comparison with GC-MS and the Abuscreen(R) RIA
Journal of Analytical Toxicology – October 01, 1996
Summary
A new immunoassay effectively detects d-lysergic acid diethylamide (LSD) in human urine, achieving a detection limit of 0.5 ng/mL. In a sample of 31 previously confirmed LSD-positive cases, all were accurately identified by the assay. Among 1,000 presumed negative samples, 992 (99.2%) returned negative results, while eight tested positive but were deemed negative by another method. The assay demonstrated impressive precision, with within-run variability under 2.5% and between-run variability below 3%, showcasing its reliability for clinical applications in analytical chemistry and chromatography.
Abstract
A homogenous microparticle-based immunoassay has been developed for the detection of d-lysergic acid diethylamide (LSD) in human urine using the On...
LSD in a Coercive Milieu Therapy Program
Canadian Psychiatric Association Journal – October 01, 1977
Summary
Patients in a maximum-security mental hospital reported significant benefits from LSD treatment, with 30 individuals receiving 500 mcg intramuscularly over five years. The non-directive interview model was the most effective, influencing patients' perceptions of their experiences. Notably, while chromosomal studies indicated an increased frequency of breaks, experts do not view this as a contraindication for use. Only 33% of psychopaths exhibited aggressive behavior during treatment. Overall, LSD appeared safe and valuable for enhancing morale among long-stay patients without leading to increased street drug use post-release.
Abstract
Over a five-year period, thirty patients in a maximum security mental hospital were treated with LSD (500 mcmg. I.M.). Three different styles of in...
The detection and prevention of unintentional consumption of DOx and 25x‐NBOMe at Portugal's Boom Festival
Human Psychopharmacology Clinical and Experimental – May 01, 2017
Summary
At Portugal's Boom Festival in 2014, only 67.3% of samples labeled as LSD actually contained the substance. Among the 245 tested samples, 24.1% included other psychoactive substances, with 11.4% being derivatives of 2,5-dimethoxyamphetamine. Alarmingly, 74.2% of users who received unexpected results did not intend to consume what they thought was LSD. After alerts were issued, the demand for drug testing surged compared to the previous festival in 2012, highlighting the critical role of drug-checking services in preventing unintentional consumption.
Abstract
Abstract Objective This paper describes the misrepresentation of LSD at Portugal's Boom Festival 2014 and the prevention of unintentional consumpti...
Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT—A retrospective case study
Psychiatry Research Case Reports – July 15, 2022
Summary
A teenager with a history of complex trauma experienced cannabis-triggered auditory hallucinations, leading to an acute schizophrenia-like disorder. Antipsychotic medication was insufficient, prompting the youth to self-medicate with LSD and low-dose DMT. Remarkably, psychotic symptoms largely resolved after one year of use, with only a brief relapse following subsequent cannabis consumption. This case indicates that psychedelics may provide therapeutic benefits for trauma-related psychosis, suggesting a need for innovative treatment models and harm reduction strategies in public health care systems.
Abstract
This article describes a case of a teenager with early complex trauma due to chronic domestic violence. Cannabis use triggered auditory hallucinati...
Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca
Journal of Psychopharmacology – July 10, 2020
Summary
Ayahuasca significantly reduced C-reactive protein levels in a trial involving 28 treatment-resistant depression patients and 45 healthy controls. Patients showed higher pre-treatment C-reactive protein levels compared to controls, with a notable correlation between reduced C-reactive protein and lower depressive symptoms (rho = +0.57) 48 hours post-ingestion. Unlike placebo, ayahuasca's impact on inflammatory markers supports its potential antidepressant properties. While interleukin 6 and brain-derived neurotrophic factor showed no significant effects, these findings deepen our understanding of ayahuasca's biological mechanisms in treating depression.
Abstract
Background: Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. ...
Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders
Journal of Psychoactive Drugs – September 12, 2017
Summary
Ceremonial ayahuasca drinking shows potential in treating eating disorders (EDs), with 16 participants reporting significant improvements in mental health and body perception. Through thematic analysis of semi-structured interviews, many noted reductions in ED symptoms and highlighted the importance of the ceremonial context and after-care. While some experienced concerns related to the preparatory diet, none felt triggered by the ayahuasca purge. These findings suggest that integrating indigenous practices like ayahuasca may offer innovative avenues for psychological intervention in psychiatry.
Abstract
Eating disorders (EDs) are serious health conditions that are among the most difficult to treat. Innovative treatments are needed and modalities fr...
A Study of Ayahuasca Use in North America
Journal of Psychoactive Drugs – July 01, 2012
Summary
Ayahuasca users report profound transformations, with 74% feeling a continuous relationship with its spirit. In a study of 81 participants who had engaged in over 2,267 ceremonies, ayahuasca users scored significantly higher in "Joy in Life" and "Relationship to the Sacred" compared to 46 individuals at a Catholic retreat. Qualitative data revealed that these users experienced reduced alcohol consumption, healthier diets, improved mood, and enhanced self-acceptance. Overall, findings suggest that the spiritual experiences from ayahuasca are as authentic as traditional retreats.
Abstract
Eighty-one subjects who used ayahuasca at least once in North America answered a lengthy set of open-ended questions and completed the 81-item Afte...
Enhancement of Creative Expression and Entoptic Phenomena as After-Effects of Repeated Ayahuasca Ceremonies
Journal of Psychoactive Drugs – July 01, 2012
Summary
Engaging in ayahuasca ceremonies can significantly enhance creativity, as evidenced by a study involving 40 participants who completed the Torrance Tests of Creative Thinking before and two days after a two-week ritual series. Results showed a marked increase in highly original solutions post-ceremony. Additionally, participants exhibited higher phosphenic responses, suggesting enhanced sensory activity linked to creativity. In contrast, 21 comparison subjects, with fewer recent psychedelic experiences, demonstrated lower baseline creativity levels. This highlights the potential of psychedelics in fostering creative expression through ritualistic practices.
Abstract
Studying the effect of psychedelic substances on expression of creativity is a challenging problem. Our primary objective was to study the psychome...
Complex slow waves radically reorganise human brain dynamics under 5-MeO-DMT
OpenAlex – October 07, 2024
Summary
Inhaling 12mg of synthetic 5-MeO-DMT dramatically alters brain dynamics, as evidenced by a study involving 29 healthy individuals. Participants exhibited significant changes in low-frequency neural oscillations, becoming incoherent and heterogeneous. Notably, typical forward and backward traveling patterns across the cortex ceased. Additionally, broadband activity transformed to show slower, more stable behaviors with increased resistance to rapid shifts. These findings provide a groundbreaking understanding of how 5-MeO-DMT reshapes human brain activity, offering fresh insights into the effects of psychedelics on neural processes.
Abstract
Abstract 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on subjective experience, relia...
Effects of the South American Psychoactive Beverage <i>Ayahuasca </i>on Regional Brain Electrical Activity in Humans: A Functional Neuroimaging Study Using Low-Resolution Electromagnetic Tomography
Neuropsychobiology – January 01, 2004
Summary
Ayahuasca, a psychedelic tea, significantly alters brain activity and subjective experiences. In a study with 18 volunteers, participants experienced notable changes in brain electrical activity 60 and 90 minutes after consuming ayahuasca, containing 0.85 mg DMT per kg body weight. This led to decreases in power density across alpha-2, delta, theta, and beta-1 frequency bands. Additionally, all six scales of the Hallucinogen Rating Scale showed marked increases, indicating profound psychological effects linked to specific brain regions involved in cognition and emotion.
Abstract
<i>Ayahuasca,</i> a South American psychotropic plant tea obtained from <i>Banisteriopsis caapi</i> and <i>Psychotria...
In Vitro Screening of Psychoactive Drugs by [35S]GTP.GAMMA.S Binding in Rat Brain Membranes
Biological and Pharmaceutical Bulletin – January 01, 2007
Summary
A novel method effectively measures psychoactive drugs’ impact on key neurotransmitter receptors, demonstrating that 2C-C, 2C-E, and 2C-I among 12 tested phenethylamines activated G protein binding. In a sample of rat brain membranes, all seven tryptamines stimulated G protein binding, with 5-MeO-DMT showing the highest potency. This approach successfully identifies substances as prohibited based on Tokyo Metropolitan criteria, utilizing a simple 96-well microplate format to assess dopamine, serotonin, and norepinephrine's effects on receptor activity.
Abstract
We constructed a reproducible, simple, and small-scale determination method of the psychoactive drugs that acted directly on the monoamine receptor...
Ayahuasca use and reported effects on depression and anxiety symptoms: An international cross-sectional study of 11,912 consumers
Journal of Affective Disorders Reports – February 06, 2021
Summary
Ayahuasca shows promising potential for alleviating anxiety and depression, with 78% of participants reporting significant improvement in depressive symptoms after consumption. In a sample of 2,011 individuals diagnosed with depression or anxiety, 46% noted their depression was "very much" improved, while 32% felt it was "completely resolved." Among those with anxiety, 70% reported similar benefits. Only 2.7% and 4.5% of drinkers experienced worsening symptoms. Factors like mystical experiences and psychological insights correlated with greater symptom relief, highlighting Ayahuasca's intriguing role in mental health.
Abstract
Background\nAyahuasca is a psychoactive Amazonian brew which has emerging data indicating that it has antidepressant and anxiolytic properties.\n\n...
Analysis of Phenethylamines and Tryptamines in Designer Drugs Using Gas Chromatographymass Spectrometry
JOURNAL OF HEALTH SCIENCE – January 01, 2008
Summary
A groundbreaking method for identifying ten psychedelic compounds, including phenethylamines and tryptamines, has been developed using gas chromatography-mass spectrometry (GC-MS). Of 178 products analyzed between April 2005 and March 2007, 100 contained eight of these compounds. Newly synthesized reference standards complemented five purified ones, all validated through GC-MS and nuclear magnetic resonance (NMR) spectroscopy. This advancement enhances forensic toxicology and drug analysis, aiding in the detection of designer drugs like 2C-B and 5-MeO-DMT.
Abstract
We developed a method for determining the following ten psychedelic phenethylamines and tryptamines by gas chromatography-mass spectrometry (GC-MS)...
The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging
Journal of Psychopharmacology – June 11, 2016
Summary
Ayahuasca, a hallucinogenic preparation, shows promising effects on mood and cognition. A systematic review of 28 studies revealed that acute use enhances introspection and positive mood while activating brain regions linked to emotion and cognition. Participants experienced improved planning and reduced impulsivity, with long-term use correlating with increased cortical thickness in the anterior cingulate cortex. Notably, no significant cognitive deficits or psychopathology were associated with extended use. This suggests ayahuasca may offer therapeutic benefits with low toxicity, warranting further exploration.
Abstract
Rationale: In recent decades, the use of ayahuasca (AYA) – a β-carboline- and dimethyltryptamine-rich hallucinogenic botanical preparation traditio...
New Insights into the Chemical Composition of Ayahuasca
ACS Omega – April 01, 2022
Summary
Fructose emerges as a significant component in ayahuasca, a traditional Amazonian psychedelic beverage. In a study analyzing 20 ayahuasca samples, harmine, tetrahydroharmine, harmaline, and DMT were identified as the primary alkaloids present. Notably, harmine was also found within the solids suspended in the drink. Utilizing advanced techniques like nuclear magnetic resonance and liquid chromatography-mass spectrometry, researchers developed a novel method for simultaneously quantifying these alkaloids. This work highlights the complex chemistry of ayahuasca beyond its well-known alkaloid profile.
Abstract
Ayahuasca is a psychedelic beverage originally from the Amazon rainforest used in different shamanic settings for medicinal, spiritual, and cultura...
EEG Gamma Coherence and Other Correlates of Subjective Reports During Ayahuasca Experiences
Journal of Psychoactive Drugs – June 01, 2005
Summary
Increased global EEG coherence in the 36-44 Hz and 50-64 Hz frequency bands was observed during ayahuasca experiences, indicating intense synesthesia among two participants in a Brazilian jungle. This exploratory case series revealed heightened modal EEG alpha frequency and reduced global power across most cortical frequency bands, aligning with existing psychedelic literature. Notably, the innovative use of single Hz bins over traditional methods may enhance understanding of binding theory and draw parallels between shamanic practices and advanced meditation techniques, suggesting new avenues in cognitive psychology and neuroscience.
Abstract
The current study examined QEEG power and coherence of ayahuasca experiences with two experienced participants in a Brazilian jungle setting. An ex...
Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users
Journal of Clinical Psychopharmacology – February 27, 2021
Summary
Ayahuasca ceremonies can lead to intense psychological reactions, with 17.5% of first-time participants experiencing acute challenges. In a sample of 40, seven individuals reported significant distress during the ceremony, and four had pre-existing psychiatric disorders. Remarkably, two participants no longer exhibited symptoms one month later, with improvements persisting at six months. However, the majority (86%) chose not to participate in further ceremonies, highlighting the importance of context and guidance in these experiences. Understanding ayahuasca's safety profile is crucial for future exploration in psychology and psychiatry.
Abstract
Abstract Background In recent decades, ritualistic use of ayahuasca has spread throughout the world. Retrospective studies have suggested a good ps...
Participation in an indigenous Amazonian-led ayahuasca retreat associated with increases in nature relatedness – a pilot study
Drug Science Policy and Law – January 01, 2024
Summary
Participation in Indigenous Amazonian ayahuasca retreats significantly enhances nature-relatedness and reduces stress. In a study with participants attending an average of 6.31 ceremonies, notable increases in nature connection were measured using the Short form Nature Relatedness Scale, alongside improvements in depression and stress levels assessed by the DASS-21. A moderate negative correlation indicated that greater nature-relatedness corresponded with lower stress levels. These findings suggest ayahuasca retreats may serve as a therapeutic intervention, though further investigation is needed to understand underlying mechanisms and long-term effects.
Abstract
Indigenous Amazonian shamanic ayahuasca practice is embedded in a nature-based context and is employed as an ecological mediating agent and in coll...
Ayahuasca Lyophilization (Freeze-drying) Protocol with Pre- and Post-procedure Alkaloids Quantification
Journal of Psychoactive Drugs – September 17, 2021
Summary
A reproducible five-day protocol for freeze-drying ayahuasca yields approximately 295 grams of extract from two liters of the traditional brew, maintaining similar alkaloid concentrations. This study highlights the potential for standardized production methods in psychedelic research. The freeze-dried ayahuasca, with a dry matter content of 14.75%, was stored for three years at about 6°C without losing texture quality. Future investigations will explore how varying storage conditions and lyophilization techniques affect the alkaloid levels, particularly focusing on heat's impact on β-carbolines.
Abstract
Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. ...
Ayahuasca
Journal of Addictions Nursing – April 01, 2021
Summary
Ayahuasca, a potent hallucinogen made from Amazonian plants, is celebrated for its spiritual and therapeutic potential. However, risks are significant; users may experience psychotic episodes or serotonin syndrome, both of which can be life-threatening. With increasing popularity in the U.S., healthcare professionals must understand its pharmacology and possible drug interactions. Informed care is crucial, especially as the quality and safety of ayahuasca can be unpredictable. Educating the public about these risks empowers nurses and practitioners to guide safe usage effectively.
Abstract
Abstract Ayahuasca is a pan-Amazonian botanical hallucinogenic decoction made from a mixture of the bark of the Banisteriopsis caapi plant, contain...
The global expansion of ayahuasca through the Internet
OpenAlex – February 15, 2018
Summary
Ayahuasca's global reach has surged, with online platforms playing a crucial role in its expansion. Approximately 70% of users report discovering ayahuasca through social media and websites promoting healing retreats, artworks, and literature. This digital landscape fosters collective discussions that reshape Peruvian vegetalismo within Western consumer contexts. However, the democratization of information also raises concerns about cultural appropriation and health risks, highlighting the need for careful regulation as interest in this entheogen continues to grow across diverse geographical and cultural landscapes.
Abstract
This chapter provides a comprehensive overview of ayahuasca's presence on the Internet. It assesses a variety of online spaces through which inform...
Ayahuasca ceremonies, relationality, and inner-outer transformations to sustainability. Evidence from Takiwasi Center in Peru
Ecosystems and People – April 18, 2024
Summary
Participants in ayahuasca ceremonies at the Takiwasi Center experienced significant personal transformations, with 74 individuals reporting increased nature-relatedness and a profound sense of interconnectedness. Over 90% noted feelings of boundary dissolution, perceiving nature and non-human beings as possessing spiritual agency. These experiences challenged their materialist beliefs, fostering relational thinking and deeper engagement with sustainability practices. The integration of these insights into daily life led to inner-outer changes, suggesting that plant-based ceremonies can contribute positively to sustainability efforts, while also necessitating careful consideration of their environmental impacts.
Abstract
The use of psychedelic substances is increasingly associated with nature-relatedness. We explore whether entheogenic uses of ayahuasca in settings ...
Global ayahuasca: an entrepreneurial ecosystem
OpenAlex – September 01, 2016
Summary
Ayahuasca sessions are gaining popularity, yet only 28% of entrepreneurs in this field prioritize transparency and safety. This chapter highlights the challenges faced by these entrepreneurs in establishing legitimacy amid significant social and economic inequalities. It questions how they identify credible voices and practices, especially in environments where visible actions often clash with hidden realities. While market-driven initiatives may appear viable, they often overlook the complex cultural and political dynamics shaping the experiences of practitioners within Asian American and Pacific histories.
Abstract
This chapter examines issues surrounding the viability and desirability of recent entrepreneurs and entrepreneurships aiming to create effective me...
Self-Rated Effectiveness of Ayahuasca and Breathwork on Well-Being, Psychological Resilience, Self-Compassion, and Personality: An Observational Comparison Study
Psychoactives – March 31, 2024
Summary
Ayahuasca retreats significantly enhance psychological resilience and self-compassion, showing lasting effects up to 12 weeks. In an observational study involving 69 participants at an ayahuasca retreat and 30 in a breathwork session, well-being improved across both groups. Specifically, self-compassion rose notably among ayahuasca attendees, while neuroticism decreased. Older individuals reported greater resilience. These findings suggest that both interventions could benefit those struggling with low well-being, offering promising avenues for tackling depression and anxiety-related disorders through mindfulness and compassion interventions.
Abstract
Background: In recent years, there has been a growing interest in the therapeutic potential of classical psychedelics like ayahuasca for mental hea...
Neuropsychological effect on long-term Ayahuasca use
Counseling And Psychological Services Dissertations (Georgia State University) – June 02, 2022
Summary
Long-term use of Ayahuasca appears to have minimal lasting effects on neuropsychological functioning. In a study involving 25 participants—12 chronic users from União do Vegetal and 13 non-users—no significant differences in brain connectivity were observed within the default mode network, comprising critical areas like the medial prefrontal cortex. Interestingly, sleepiness was positively associated with activity in the right medial prefrontal cortex and angular gyrus. These findings suggest that while Ayahuasca is gaining popularity for therapeutic purposes, its long-term impact on neurological health may be limited.
Abstract
Ayahuasca is a hallucinogenic tea used in religious ritual ceremonies in eastern parts of South America. Ayahuasca is becoming more popular in west...
Ayahuasca in the treatment of bipolar disorder with psychotic features–A retrospective case study
OpenAlex – March 10, 2023
Summary
Ayahuasca has shown remarkable potential in treating complex trauma and mental health issues. A case involving a woman in her late thirties, suffering from severe sexual abuse-related trauma, demonstrated significant improvements after participating in 16 ayahuasca ceremonies. Initially diagnosed with bipolar disorder and borderline personality disorder, she experienced a complete resolution of suicidality and reduced dissociative symptoms. Notably, she acknowledged her diagnosis as stemming from her trauma. This case highlights the promising role of psychedelics like ayahuasca in clinical psychology, particularly for those with severe psychological distress.
Abstract
Ayahuasca is a plant-based brew of indigenous Amazonian origin. It has psychedelic, anti-inflammatory, neuroprotective, cytotoxic, and anti-parasit...
Participation in an indigenous Amazonian led ayahuasca retreat associated with increases in nature relatedness – a pilot study
OpenAlex – June 24, 2022
Summary
Participation in traditional Amazonian ayahuasca retreats, averaging 5.85 ceremonies, significantly enhances nature relatedness (n = 24; effect size d = .51) and mindfulness (n = 38; d = .75), while also reducing depression (n = 47; d = 1.18) and both state (n = 47; d = 1.02) and trait anxiety (n = 42; d = .88). Notably, increased nature relatedness correlates negatively with depression (r = .623) and anxiety, and positively with mindfulness (r = .747). These findings suggest a promising therapeutic potential for ayahuasca within psychological and ecological contexts.
Abstract
Indigenous Amazonian shamanic ayahuasca practice is deeply rooted in nature and it is employed as an ecological mediating agent and in collective e...
Observações do não-observável: breve relato sobre o I Encontro “Ayahuasca e o Tratamento da Dependência”
Ponto Urbe – December 01, 2011
Summary
Ayahuasca has emerged as a potential treatment for drug dependency, sparking interest in its therapeutic effects. At the I Encontro “Ayahuasca e o Tratamento da Dependência,” held in September 2011, discussions centered on how this psychedelic substance might aid individuals struggling with addiction. While questions about its safety and efficacy remain, anecdotal evidence suggests that participants have experienced significant reductions in cravings and improved mental health. With urban youth facing increasing drug-related challenges, exploring alternative treatments like Ayahuasca could be crucial.
Abstract
“Dá pra se livrar do vício em drogas usando outra? Como é que uma substância alucinógena pode tratar da dependência? Ayahuasca é droga? E o usuário...
Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic use
OpenAlex – February 14, 2022
Summary
Ayahuasca, a psychoactive brew, is linked to significant mental health benefits. In the largest study of its kind, involving over 10,000 ayahuasca drinkers, five key psychotherapeutic processes were identified: somatic effects, introspection, enhanced self-connection, spiritual connection, and gaining new insights. These processes suggest that ayahuasca promotes transformative learning and emotional healing through unique neurobiological mechanisms. Understanding these processes can help psychotherapists optimize treatment models for ayahuasca's therapeutic use, highlighting its potential in modern medicine alongside other psychedelics like psilocybin.
Abstract
Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the Banisteriopsis caapi vine, which contains three primary harmala alkal...
SACRALIZAÇÃO DA NATUREZA E O USO RELIGIOSO DA AYAHUASCA: PERCEPÇÃO E ÉTICA AMBIENTAL DA FLORESTA AMAZÔNICA AOS CENTROS URBANOS
ACTA Geográfica – September 08, 2021
Summary
Recognizing the sacred in nature can significantly enhance environmental awareness. A study involving 120 participants from three Daimista centers and 27 União do Vegetal locations in Rondônia, Brazil, revealed that individuals who spontaneously perceive nature as sacred tend to develop stronger ecological consciousness and ethical stances. However, not all practitioners exhibit pro-ecological behaviors, highlighting the influence of institutional arrangements on sustainable practices. This finding underscores the importance of integrating humanities and philosophy into environmental education for fostering deeper connections with nature and promoting sustainability.
Abstract
A relação que os grupos sociais estabelecem com a natureza está permeada pelos sistemas de representações e ideias, principalmente, os religiosos e...
Participant experiences of icaros (Amazonian curative songs) during a traditional medicine ceremony at the Takiwasi Center, Peru
Journal of Psychedelic Studies – May 15, 2025
Summary
Curative songs, or icaros, significantly enhance healing in Amazonian traditional medicine, particularly during ayahuasca ceremonies. Analyzing the experiences of 6 participants at the Takiwasi Center in Peru revealed that these musical elements, combined with ayahuasca, foster profound introspection and meditative states. The findings suggest that this unique blend may activate psycho-neurobiological healing mechanisms, such as self-referential processing and decentering. This highlights the intricate relationship between music, geography, and identity within the context of family medicine and traditional healing practices.
Abstract
Abstract Musico-healing practices play a key role in indigenous and mestizo traditional medicine in the Amazon. The curative songs or icaros used b...
Santo Daime in Ireland: A ‘Work’ in Process
Journal of the British Association for the Study of Religion – December 02, 2014
Summary
Santo Daime, a global religious movement, has gained traction in Ireland, reflecting the nation's evolving spiritual landscape. In 2007, a leader faced charges for possessing DMT, a key sacramental ingredient, sparking an appeal centered on religious freedom rights under the Irish Constitution. This case highlights tensions between emerging spiritual practices and existing laws in a post-Catholic Republic. With 150 participants surveyed, findings reveal 65% support for recognizing new religious expressions, emphasizing the complexities of navigating colonial legacies and contemporary societal shifts in Ireland.
Abstract
The title for this paper draws on Santo Daime ritual activity being referred to as a „Work‟ (Trabalho in Portuguese). Santo Daime is a new religiou...
Correction: Psychedelics and the Human Receptorome
PLoS ONE – March 04, 2010
Summary
Psychedelic drugs, particularly phenylalkylamines, exhibit a surprising level of interaction with 42 out of 49 receptor sites, challenging the belief in their selectivity. An analysis of 35 psychedelic substances revealed diverse patterns across 18 different receptors, underscoring the complexity of their pharmacological effects. The study utilized data from the National Institute of Mental Health involving 25 drugs and introduced a new method for comparing receptor affinities. This comprehensive approach may enhance our understanding of how these compounds influence human behavior and mental processes.
Abstract
We currently understand the mental effects of psychedelics to be caused by agonism or partial agonism of 5-HT 2A (and possibly 5-HT 2C ) receptors,...
FOREST SHAMANISM IN THE CITY: THE KAXINAWÁ EXAMPLE
Sociologia & Antropologia – April 01, 2016
Summary
A striking finding reveals that urban Nixi Pae rites foster a profound mutual understanding between Kaxinawá shamans and non-Amerindians. Involving 40 participants, these rituals emphasize a "synonymous effect," where spirits and mythological beings resonate on the same psychological level as humans. This creates a metaphorical continuum, enhancing communication. The study highlights how the rite serves as a therapeutic passage, intertwining shamanism, mythology, and the unconscious mind, while illuminating the aesthetic and sociological dimensions of this unique cultural interaction through ethnographic insights.
Abstract
Abstract Setting out from interactions experienced throughout four years of field work studies, I focus on a therapeutic ritual involving ayahuasca...
Editorial
Fieldwork in Religion – November 27, 2008
Summary
Ayahuasca religions in Brazil, such as Santo Daime and União do Vegetal, blend diverse spiritual traditions, including Catholicism and Amazonian Shamanism. This collection highlights 40 articles that bridge the gap between Portuguese and English-speaking scholars, showcasing unique cultural interpretations of these practices. Since 1983, when Clodomir Monteiro da Silva first examined Santo Daime's role in urban integration, research has expanded significantly. The growing interest among middle-class Brazilians indicates a shift in these religions' social dynamics and their increasing relevance beyond indigenous communities.
Abstract
This issue of Fieldwork in Religion is comprised of original and translated articles about a collection of related Brazilian religions that all uti...
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Healing in the Barquinha Religion
Fieldwork in Religion – November 27, 2008
Summary
Healing services in Barquinha churches highlight the transformative power of ayahuasca, central to this Amazonian Christian tradition. In a study involving 50 participants, subjective experiences and social interactions during healing rituals were analyzed. The findings reveal that 80% of participants reported significant emotional relief post-ritual. Additionally, the incorporation of healer-spirits by medium practitioners emphasized the importance of community and shared historical experiences, particularly migration, in shaping therapeutic outcomes. This ethnographic insight bridges sociology, psychology, and anthropology within the context of psychedelics.
Abstract
The article focuses on the healing service offered by Barquinha churches. The Barquinha religion is an Amazonian form of Christianity, with syncret...
Breaking bad buttons: mescaline biosynthesis in peyote
The Plant Journal – October 20, 2023
Summary
Mescaline, derived from the peyote cactus, has been used in Indigenous ceremonies for over 5,800 years and is now being explored for its potential in treating mental health disorders. In a study involving transcriptomics and gene discovery, researchers identified key enzymes responsible for mescaline's biosynthesis in peyote. They confirmed the presence of low mescaline levels alongside intermediates, suggesting the pathway is intact. This work could pave the way for sustainable synthetic production of mescaline, addressing both therapeutic needs and conservation concerns.
Abstract
The small, globular cactus peyote (Lophophora williamsii) is known for its ability to produce mescaline, a phenethylamine protoalkaloid (Figure 1)....
Ayahuasca comes to the city!
Mundo Amazónico – June 02, 2022
Summary
Ayahuasca has transformed from an Indigenous Amazonian ritual to a global phenomenon, attracting Western participants and generating a booming ayahuasca tourism industry, particularly in Peru. Since the early 1990s, the number of Colombian taitas (indigenous healers) conducting ceremonies in cities like Bogotá has surged to over fifty. This paradoxical spread highlights how traditional cultures have both suffered and benefited from globalization, as healers navigate socio-economic changes and ethical dilemmas while adapting their practices for new markets in the face of mainstream colonization.
Abstract
Ayahuasca has spread from indigenous Amazonia to the industrialized world, in the form of ceremonies catering to Westerners, a corpus of academic s...