1662 results for "LSD"
Accounting for Microdosing Classic Psychedelics
Journal of Drug Issues – August 30, 2019
Summary
Remarkably, individuals who microdose psychedelics, like chemically synthesized LSD and natural psilocybin, never excuse their practice. All 30 interviewed offered justifications, a key insight for Social psychology. This Psychology research shows users employ "Denial of injury" and "Appeal to normality" to align their actions with societal expectations, even considering the substances' status in Drug Studies and potential for Forensic Toxicology.
Abstract
Microdosing classic psychedelics (e.g., LSD [lysergic acid diethylamide] and psilocybin) is the practice of taking small amounts of these substance...
The psychedelic religion of mystical consciousnessReviews
Journal of Psychedelic Studies – May 10, 2018
Summary
Psychedelic substances, from "schizotoxic" to "entheogenic," are profoundly mind-disclosing. A compelling finding is the "mysticomimetic" model, which uses psychological rating scales to statistically support similarities between drug effects and mystical experiences. Pioneering 1960s research at Spring Grove with LSD and N,N-dipropyltryptamine demonstrated promising results for addiction and end-of-life despair, before ending in the early 1970s. Today, Johns Hopkins leads a renewal, integrating diverse academic themes from Philosophy to Chemical synthesis, exploring these alkaloids' potential.
Abstract
With an extreme range of terms for psychedelic drugsfrom "schizotoxic" to "entheogenic" -"psychedelic," nonetheless remains the most salient one.Th...
Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape
OpenAlex – July 13, 2022
Summary
Mind-altering drugs profoundly reorganize brain function by engaging intricate neurotransmitter systems. Neuroscience and Neuropharmacology Research demonstrates that psychoactive substances, including 10 diverse drugs like psychedelics (LSD, psilocybin) and anesthetics, exert their effects based on the brain's molecular makeup. By mapping 19 neurotransmitter receptors and transporters, a clear link emerged between specific neurotransmitter receptor influence on behavior and drug-induced changes. This work in Psychology and Medicine highlights how pharmacology precisely targets brain regions, revealing patterns that even mirror those seen in brain disorders.
Abstract
Abstract To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage ...
One Ultimate Journey? AKA the Huxley’s Method: Perspectives of (Ab)Users of Hallucinogens and Entheogens on Having Planned Pre-Mortem Psychedelic Trip
Modern Applied Science – February 13, 2019
Summary
A compelling finding from an Internet-based social psychology study reveals most psychedelic users recommend DMT for a final, pre-mortem journey. Other suggestions included Psilocybin and LSD. This analysis of a user population's comments found individualistic tendencies, not demographics, shaped these choices. Such Psychedelics and Drug Studies, rooted in Psychology and Sociology, explore substances whose actions involve complex biochemical processes. Biochemical Analysis and Sensing Techniques, even for Nicotinic Acetylcholine Receptors, are vital for comprehensive understanding.
Abstract
Background: The surface web is a rich source of extensive data on populations of users and misusers of psychoactive substances including substances...
Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens
Journal of Pharmacy and Pharmacology – November 01, 1970
Summary
Accurately identifying illicit hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) presents a persistent challenge in forensic toxicology. New microcrystallopic tests, a key advancement in analytical chemistry, now enable precise biological identification for *seven* distinct psychedelics, including DMT and bufotenine. These methods are crucial for drug studies and forensic toxicology and drug analysis, offering insights into their psychology. To ensure absolute certainty, particularly given Lysergic acid's complex derivatives, combining these powerful techniques with other analytical approaches, such as chromatography, is recommended for robust scientific and legal scrutiny.
Abstract
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The ...
Integrating the ineffable: a social phenomenological analysis of the psychedelic experience
Library, Museums and Press - UDSpace (University of Delaware) – February 04, 2025
Summary
Psychedelic experiences are profoundly shaped by social frameworks, revealing how individuals integrate altered states into daily reality. Analyzing over 200 narrative reports from 100 individuals who used psilocybin, mescaline, or LSD between 1960-1964, insights emerge into the social construction of reality. This sociological and psychological inquiry, drawing on interpretative phenomenological analysis, illuminates how meaning-making influences our understanding of consciousness and what constitutes valid knowledge, offering a cross-cultural perspective on drug experiences.
Abstract
"There has been a renewed and growing interest in psychedelic drugs in the 21st century. Drawing on social-phenomenology, cognitive sociology, and ...
New Insights Into the Clinical and Nonclinical Effects of Psychedelic Substances
European Psychologist – September 17, 2021
Summary
A major resurgence in Psychedelics and Drug Studies reveals Psilocybin and Lysergic acid diethylamide (LSD), powerful hallucinogens, show promise in Clinical psychology. Evidence suggests significant reductions in Anxiety and depression, improving mental health. This field examines their impact on Cognition, personality, and well-being, exploring how these chemical synthesis and alkaloids affect Neurotransmitter Receptor Influence on Behavior. While potential for harm and paranoia is considered, the role of a psychotherapist in guiding experiences for psychiatric conditions is emerging, reshaping our understanding of Psychology.
Abstract
Abstract. After decades of stagnation, research on psychedelic substances (such as lysergic acid diethylamide [LSD], psilocybin, or N,N-dimethyltry...
Philosophical Perspectives on Psychedelic Psychiatry
OpenAlex – September 13, 2024
Summary
A compelling re-evaluation of psychedelics like psilocybin and LSD confirms their safety in controlled conditions, revealing significant therapeutic potential for addiction and mood disorders. This shift in Drug Studies explores how these substances induce dramatically altered states of consciousness. Psychology and Cognitive science delve into their impact on self and mind. Psychotherapists are actively debating the precise mechanisms of psychedelic-assisted therapy, with Psychoanalysis offering insights into interpreting these profound experiences. Ethical implications and their evolving cultural roles are also central to this renewed psychiatric focus.
Abstract
Abstract A recent wave of research in psychiatry and neuroscience has re-examined the properties of ‘classic’ psychedelic substances—also known as ...
Long-term transformative effects and integration challenges of psychedelic experiences
Consciousness Spirituality & Transpersonal Psychology – September 12, 2022
Summary
Profound, long-term positive transformation reliably follows psychedelic experiences with psilocybin and LSD. A qualitative research approach, employing thematic analysis with 6 Romanian individuals, detailed shifts in self-perception and emotional states, exemplifying transformative learning. Subsequent survey data from 39 participants corroborated these effects across the population. Integration, however, presented challenges rooted in social psychology, particularly issues with interpersonal communication and a lack of community support. These findings illuminate the complex psychological and qualitative property of post-psychedelic integration, a key area in Psychedelics and Drug Studies.
Abstract
This study looked into the transformative effects and integration challenges of psychedelic experiences with psilocybin and lysergic acid diethylam...
Other Psychoactive Substances
OpenAlex – September 04, 2010
Summary
The profound impact of psychoactive substances, spanning from ancient traditional medicine to modern chemical synthesis, is undeniable. This comprehensive overview meticulously analyzes over a dozen distinct compounds, including psychedelics like LSD and psilocybin, alongside ketamine and GHB. It explores their intricate chemistry, pharmacology, and toxicology, providing critical insights for Drug Studies. Forensic Toxicology and Drug Analysis play a vital role in understanding these substances, from alkaloids to synthetic drugs, highlighting their diverse effects and implications.
Abstract
This chapter contains sections titled: LSD (lysergic acid diethylamide) GHB (gammahydroxybutyrate) Ketamine Psilocybin PCP (phencyclidine) Hypnosed...
Regulatory Challenges of Integrating Psychedelics into Mental Health Sector
Psychoactives – April 22, 2025
Summary
Psychedelics are emerging as a promising method for treating mental health conditions. Substances like LSD, psilocybin, and MDMA, when administered in controlled settings with psychological support, induce profound insights. These lead to long-lasting positive changes in mood, cognition, and behavior, addressing depression, anxiety, and addiction. This revolutionizes mental health treatment. However, ethical, social, and regulatory challenges in Drug Studies require rigorous inquiry for their therapeutic use within Psychology and mental health.
Abstract
Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite a history of stigmatization and r...
Advancing elite athlete mental health treatment with psychedelic-assisted psychotherapy
Journal of Applied Sport Psychology – November 10, 2020
Summary
Classical psychedelics like LSD, psilocybin, and DMT, once politically vilified, are re-emerging as powerful tools for mental health. Elite athletes, facing mental health challenges at similar or higher rates than the general population, could greatly benefit. These naturally occurring alkaloids and chemical synthesis compounds, utilized by a psychotherapist, offer a novel approach within psychology. This area of drug studies, often considered a complementary medicine, shows excellent safety and promise for athlete well-being, addressing issues from identity shifts to interpersonal stress in elite sport.
Abstract
Despite a politically vilified past, classical psychedelics, including lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), ...
Richard Alpert (Ram Dass): Harvard psychologist who experimented with psychedelic drugs and became one of America’s most prominent and respected spiritual leaders
BMJ – January 31, 2020
Summary
Nothing in Richard Alpert's early life, despite his psychology doctorate, predicted his iconic path. At Harvard, he joined Timothy Leary's drug studies, exploring psilocybin's clinical potential. Alpert's own 10 mg psilocybin experience profoundly questioned consciousness, a realm also explored by psychology and even psychoanalysis. He then collaborated, giving psilocybin and LSD to diverse groups, including students and prisoners, defining 1960s psychedelics and drug studies. Credit: Dassima Kathleen Murphy
Abstract
Credit: Dassima Kathleen Murphy Nothing in Richard Alpert’s early life could have predicted that he would come to embody the spirit of the psychede...
Stroke and Adverse Effects on The Immune and Cardiovascular Systems: The Danger of the Rise and Use of Psychedelic Drugs for Depression and PTSD
Journal of Clinical & Experimental Immunology – March 03, 2021
Summary
For centuries, plant-based hallucinogen drugs like psilocybin have been integral to native medicine. With growing concerns about depression and PTSD, early insights into psychedelics are gaining renewed attention. As early as 1950, reports suggested lysergic acid diethylamide (LSD) and other mood-altering drugs held potential for psychological and psychiatric treatment. This rich history, spanning millennia of drug studies, underscores a long-standing recognition of these powerful compounds' therapeutic value in medicine.
Abstract
Depression and post-traumatic stress disorder (PTSD), in the past two decades, has been a growing problem among adults and our youth. For hundreds,...
Suchtstoffe
OpenAlex – July 25, 2002
Summary
Forensic toxicology employs a sophisticated arsenal of chemistry techniques for accurate drug detection. Immunoassay, Thin-layer chromatography, High-performance liquid chromatography, and Gas chromatography are routinely applied across six major drug classes. This includes psychedelics like LSD and psilocybin, alongside cannabis and cannabinoids. Such robust analytical chemistry ensures reliable results for medical and legal interpretations in drug studies, confirming the precision vital for forensic toxicology and drug analysis.
Abstract
Cannabinoide Immunoassay Dünnschichtchromatographie Hochleistungsflüssigkeitschromatographie (HPLC) Gaschromatographie Medizinische Beurteilung und...
Weiterbildung in Psychedelika-assistierter Therapie – Erfahrungen aus der Schweiz
Die Psychotherapie – February 08, 2024
Summary
Psychedelics like MDMA, LSD, and psilocybin show promise for treating affective disorders. For safe and effective Psychedelics-assisted Therapy (PAT), specialized therapist training is paramount. Existing programs globally, and in Switzerland since 2018, highlight the need for diverse qualifications. Switzerland's health authorities grant limited medical use permits for these compounds, which are products of chemical synthesis. This emerging field, relevant to Complementary and Alternative Medicine Studies, emphasizes structured education. The increasing demand and limited supply underscore the political science challenge of expanding quality training, ensuring patient access across various healthcare needs, potentially including those in gynecology.
Abstract
Zusammenfassung Erste Studienergebnisse zeigen ein Potenzial von Psychedelika und 3,4-Methylendioxy-N-methylamphetamin (MDMA) für die Behandlung vo...
Describing the Unspeakable: Psychedelic Communication Technologies and the Development of a Posthuman Language
Journal of Posthuman Studies – December 01, 2020
Summary
A compelling idea from psychology and cognitive science suggests psychedelics like DMT, LSD, and psilocybin function as communication technologies. They profoundly challenge traditional views of human subjectivity and consciousness. Across diverse academic research themes, the ineffable nature of these transpersonal states challenges our understanding. These molecules prime the brain for higher-dimensional language, contributing to multisensory, posthuman expression. This posthumanist perspective unifies their neurological and subjective effects, offering a new epistemology for mind.
Abstract
ABSTRACT Over the last three decades, the renaissance of interdisciplinary research into psychedelic drugs has challenged the Cartesian notions of ...
Psilocybin treatment for AUD: Promise in new study
Alcoholism & Drug Abuse Weekly – October 14, 2022
Summary
Psilocybin-assisted psychotherapy shows significant promise for alcohol use disorder. This potent hallucinogen, a focus in Psychiatry and Medicine, is being re-examined in Psychedelics and Drug Studies. Forty years ago, Lysergic acid diethylamide (LSD), derived from lysergic acid via chemical synthesis and alkaloids research, demonstrated double the remissions for similar conditions compared to controls. Modern psychology and psychotherapist approaches, understanding neurotransmitter receptor influence on behavior, are now exploring psilocybin's potential, suggesting a paradigm shift in treating AUD.
Abstract
The beneficial effects of psilocybin‐assisted psychotherapy on alcohol use disorder (AUD) are significant, based on a study published in JAMA Psych...
Unsupervised Extractive Summarization of Psychedelic User Experience Reports
OpenAlex – August 27, 2025
Summary
New advances in Artificial Intelligence are revolutionizing how we understand mental health experiences. Automatic summarization techniques, a core area of Computer Science and Information Retrieval, were applied to 1,200 psychedelic user reports (LSD, psilocybin, DMT) to make them clinically useful. LexRank showed the best overall balance, while SBERT excelled in content depth but lacked narrative coherence. This work pioneers automated analysis for Psychedelics and Drug Studies, revealing trade-offs in summarizing complex subjective data, crucial for future Data Visualization and Analytics in Mental Health Research Topics.
Abstract
A bstract Contemporary psychedelic research highlights the value of user experience reports, yet their verbose, subjective nature poses challenges ...
Knocking on the Doors of Perception: the role of psilocybin in substance use disorder treatment
European Psychiatry – March 01, 2023
Summary
Addiction treatments face high relapse rates, with 50-60% returning to substance use within 6-12 months. Emerging Psychedelics and Drug Studies suggest hallucinogens like psilocybin, mescaline, and lysergic acid diethylamide (LSD) may reduce craving. These substances, once banned, are revitalizing psychiatry and clinical psychology. Their influence on behavior, potentially through neurotransmitter receptors, offers new avenues for addiction intervention. A psychotherapist might integrate these approaches, shifting psychology beyond traditional digital mental health interventions.
Abstract
Introduction Substance use disorders(SUDs) are a major health concern and current treatment interventions have proven only limited success. Despite...
Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)
Journal of Psychoactive Drugs – November 26, 2020
Summary
A unique case links hallucinogen use to persistent ear ringing. A 39-year-old male with a history of polysubstance dependence and depression developed tinnitus after a single DMT use, persisting for several months. The context included weekly LSD microdosing. Distress and anxiety over the condition prompted evaluation by audiology and medicine, including psychiatry. Psilocybin microdoses exacerbated symptoms on two occasions. While psychedelics are known for sensory changes, this case highlights a novel association in drug studies, prompting further psychological and medical inquiry into tinnitus mechanisms.
Abstract
This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of ...
The History of Psychedelics in Psychiatry
Pharmacopsychiatry – December 07, 2020
Summary
The historical understanding of hallucinogens has dramatically shifted. Early 20th-century psychiatry explored mescaline to model psychosis, seeking to understand the underlying basis of mental disorders. Following LSD's discovery in 1943, the focus in psychology evolved. Modern drug studies highlight the therapeutic value of psychedelics as adjuncts to psychotherapy. Psychotherapists now consider these compounds, often derived from chemical synthesis or alkaloids, for their potential in mental health. This represents a significant pivot from early psychoanalysis, moving towards complementary approaches in psychiatry, away from merely inducing psychosis-like states.
Abstract
Abstract Initial interest in the value of psychedelic drugs (“psychotomimetics”) in psychiatry began in the early 20th century, with explorations o...
Exploring Public Sentiments of Psychedelics Versus Other Substances: A Reddit-Based Natural Language Processing Study
Journal of Psychoactive Drugs – May 30, 2025
Summary
Public sentiment towards psychedelics like psilocybin and LSD is surprisingly neutral to slightly positive, contrasting sharply with highly negative views on substances like heroin. Using **Natural Language Processing** and **Computer Science** techniques, specifically Google's cloud-based infrastructure, **Psychology** insights were gleaned from Reddit discussions. This approach effectively captured public perception in **Psychedelics and Drug Studies**, suggesting growing acceptance of therapeutic potential. **Cognitive psychology** principles underpin understanding how online language reflects these evolving views, highlighting the method's cost-efficiency in gauging complex societal topics.
Abstract
New methods that capture the public's perception of controversial topics may be valuable. This study investigates public sentiments toward psychede...
Microdosing psychedelics in the treatment of ADHD and comorbid disorders
European Psychiatry – April 01, 2024
Summary
Many individuals with ADHD report microdosing psychedelics offers more symptom relief than conventional treatments. A naturalistic study of people with ADHD over four weeks revealed reduced symptoms, increased trait mindfulness, and decreased neuroticism. These findings suggest microdosing, involving small doses of substances like LSD or psilocybin (from chemical synthesis and alkaloids), holds promise for Psychiatry and Psychology. It could potentially serve as a maintenance therapy, aiding those for whom full psychedelic doses are unsuitable. Ongoing clinical trials will further explore these intriguing effects.
Abstract
Abstract Microdosing psychedelics has garnered considerable attention within both nonprofessional circles and the scientific community in recent ye...
Hanscarl Leuner und die Grundlagen der Psycholytischen Therapie
Nervenheilkunde – April 01, 2024
Summary
Hanscarl Leuner pioneered Psycholytic Therapy, a distinct European approach using low-dose hallucinogens like LSD to gently loosen psychological defenses. Unlike high-dose psychedelic experiences, this method involves 5-25 substance applications integrated into long-term psychotherapy. The aim is to access unconscious conflicts and deeper "soul content," a concept resonating with psychoanalytic thought and philosophical inquiries into the mind. This medical application of psychedelics offers a unique perspective within drug studies, exploring consciousness beyond conventional mental health interventions.
Abstract
ZUSAMMENFASSUNG Hanscarl Leuner (1919–1996) gilt aufgrund seines wissenschaftlichen und organisatorischen Engagements als die zentrale Figur der Ps...
‘Riding the Lines’: The Poetics of the ‘Chevauchements’ in Henri Michaux’s Drug Experiments
Palgrave Macmillan UK eBooks – January 01, 2015
Summary
Poet and painter Henri Michaux, at 55 in 1954, embarked on an extraordinary journey: systematically documenting hallucinogen effects. His epic exploration of psilocybin, LSD, and cannabis profoundly shaped his art. Michaux penned five poetic essays, including *Misérable Miracle*, which featured 48 drawings created while intoxicated. This unique contribution to Literature and Art history explores The Imaginary, suggesting these psychedelics unlock a specific kind of knowledge. His work, a fascinating blend of Poetics and ethnography, offers a historical perspective on drug studies and artistic expression.
Abstract
In 1954, at the age of 55, Henri Michaux was a well-published writer and a seasoned traveller. As a young man in the 1930s and 1940s, the Belgian p...
The Experience Elicited by Hallucinogens Presents the Highest Similarity to Dreaming within a Large Database of Psychoactive Substance Reports
Frontiers in Neuroscience – January 22, 2018
Summary
Lysergic acid diethylamide (LSD) elicits experiences most similar to high-lucidity dreams, a significant finding in Psychology. A semantic similarity (geometry) analysis of a large volume of subjective reports confirmed this hallucinogen, a potent psychoactive substance, mirrors dream states more closely than other drugs. This work in Psychedelics and Drug Studies explores altered states of consciousness, showing hallucinogens have the highest dream-like similarity. Understanding these effects, potentially linked to Neurotransmitter Receptor Influence on Behavior, could inform future Biochemical Analysis and Sensing Techniques.
Abstract
Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear...
Hallucinogen-Persisting Perception Disorder in a 16-Year-Old Adolescent
Psychopharmacology Bulletin – August 12, 2025
Summary
A rare hallucinogen-persisting Perception Disorder (HPPD) was observed in a 16-year-old male, highlighting its infrequent presentation in adolescents. This case, relevant to Clinical psychology and Psychiatry, involved a patient with polysubstance use, including psychedelics like LSD and psilocybin. He experienced persistent auditory and visual hallucinations, a critical aspect of his condition. Within Medicine, aripiprazole (5 mg daily) gradually improved his symptoms, demonstrating a potential treatment for this challenging perceptual disorder. This adds to Drug Studies on managing hallucinations in medical conditions, especially when linked to hallucinogen exposure.
Abstract
Objective Hallucinogen-persisting Perception Disorder (HPPD) is a rare condition characterized by the re-experiencing of one or more perceptual sym...
SHAPE CHANGE OF BLOOD PLATELETS—A MODEL FOR CEREBRAL 5‐HYDROXYTRYPTAMINE RECEPTORS?
British Journal of Pharmacology – April 01, 1979
Summary
Psychedelics like LSD and psilocine, alongside serotonin and mescaline, dramatically alter blood platelet shape in rabbits, acting on specific receptors. This neuroscience discovery highlights how compounds, often from chemical synthesis and alkaloids, interact with serotonin systems. Potent antagonists, including neuroleptic drugs, block these effects. While biology reveals platelet receptors differ from some brain areas, they mirror others, offering insights for medicine. This research, vital for psychedelics and drug studies, helps understand neurotransmitter receptor influence on behavior.
Abstract
In blood platelets of rabbits isolated by a stractan gradient and incubated in a protein‐poor medium, tryptamine, 5‐hydroxytryptamine (5‐HT) and de...
Evidence for a hallucinogen dependence syndrome developing soon after onset of hallucinogen use during adolescence
International Journal of Methods in Psychiatric Research – August 21, 2006
Summary
A compelling finding in Psychiatry: only 2% of 1186 young, recent-onset hallucinogen users (ages 12-21) exhibited features resembling a dependence syndrome. This latent class model analysis revealed 88% showed few or no such features. However, specific psychedelics matter; MDMA users had 2.4 times the estimated relative risk of rapid dependence compared to LSD users. This Psychology insight, relevant for Neurotransmitter Receptor Influence on Behavior, Psychedelics and Drug Studies, and Cannabis and Cannabinoid Research, highlights varying risks, without age or sex being factors.
Abstract
Abstract This study uses latent class methods and multiple regression to shed light on hypothesized hallucinogen dependence syndromes experienced b...
Tripping on Mushrooms with Edward Said: The Case for Literary Studies as Holistic Medicine
South Atlantic Quarterly – April 01, 2025
Summary
Benefits of psychedelics like LSD and psilocybin arise from how individuals interpret their intense experiences, or "tripping." Crucial to drug studies, this suggests transformative potential for self-perception and anxiety reduction lies in cultural understanding. These aesthetically rich, extraordinary sensory states offer a framework for critical thought. Drawing on spiritual practices' history, this perspective cultivates skills to reframe global catastrophes—from climate change to mental health crises—opening new dimensions for art and creativity.
Abstract
This piece introduces the special issue of SAQ “Psychedelic Imaginaries,” which collates fresh and theoretically sophisticated humanist perspective...
The Immortality Key: The Secret History of the Religion with No Name
Journal of Psychedelic Studies – March 12, 2021
Summary
Groundbreaking evidence suggests Ancient Greek religious rituals, practiced for nearly 2,000 years, involved a secret psychedelic sacrament. "The Immortality Key" reveals direct chemical traces of psychoactive ergot, a relative of LSD, in ancient pottery. This challenges our Epistemology of early Christian History, proposing the Holy Communion might have been a psychedelic Eucharist. Such Anthropological Studies offer new insights into ancient Philosophy and Literature, including the Homeric Hymn to Demeter. The findings unlock a Key to understanding a hidden past, connecting diverse historical threads, even prompting comparisons with insights from Chinese philosophy regarding altered states.
Abstract
Brain Muraresku is a practicing attorney and a student of ancient languages (Greek, Latin and Sanskrit), whose twelve-year odyssey through the arch...
Hallucinogenic Persisting Perception Disorder: A Case Series and Review of the Literature
Frontiers in Neurology – May 06, 2022
Summary
Only 25% of individuals fully recover from Hallucinogen Persisting Perception Disorder (HPPD), a challenging condition for Psychology and Psychiatry. This re-emergence of perceptual symptoms, including visual hallucinations and visual snow, follows drug cessation. A review of 24 cases and 13 patients links HPPD to Lysergic acid diethylamide (LSD) and MDMA use. Symptoms often mimic Visual Snow Syndrome, crucial for Medicine. Understanding HPPD's Neurotransmitter Receptor Influence on Behavior is vital for Forensic Toxicology and Drug Analysis, guiding diagnosis and treatment within Psychedelics and Drug Studies.
Abstract
Background Hallucinogen persisting perception disorder (HPPD) is characterized by the re-emergence of perceptual symptoms experienced during acute ...
Microdosing of Psychoactive Substances in Business Practice
Businesses – December 06, 2021
Summary
Remarkably, microdosing **drugs of abuse** like LSD and cocaine allows individuals to sustain a subtle psychoactive effect through the work week, avoiding significant behavioral changes or withdrawal. This **dosing** strategy, unlike standard use, even sees stimulants require progressively lower doses over time for the same effect, a fascinating **pharmacology** insight. Conversely, **psychedelics** develop resistance. Through **case studies** examining **psychology** and initial **biochemical analysis** in corporate environments, this approach's influence on business managers and creatives is being explored, revealing a unique pattern of substance interaction.
Abstract
Abusing psychoactive substances has been a popular sport in the business world since the mid-19th century. First, they were appreciated for their s...
Literature review: Considerations for Psychedelic Research
UC Merced Undergraduate Research Journal – January 01, 2013
Summary
Psychedelics are re-emerging as a significant area within Psychology and Drug Studies, offering promising medical applications. Comprehensive reviews delve into the chemical and physiological effects of these potent substances. Focus areas include hallucinogens like psilocybin, lysergic acid diethylamide (LSD), peyote, and compounds derived from lysergic acid. Understanding their chemical synthesis and alkaloids is paramount. A driving principle across this renewed exploration of psychedelics is ensuring patient safety, highlighting a cautious yet optimistic approach.
Abstract
Research on psychedelic substances is re-emerging. Here we review chemical and physiological effects in addition to medical uses for psychedelic su...
Cannabinoids is a “No-Go” While a Cancer Patient is on Immunotherapy; but is It Safe to Use Psychedelics During Cancer Immunotherapy?
OpenAlex – February 02, 2021
Summary
Psychedelics, increasingly used by cancer patients for anxiety and depression management in psychology, may significantly compromise vital cancer immunotherapy. Preclinical data in medicine indicates that these drugs, such as LSD and psilocybin, could negatively impact the immune system's ability to combat cancer within the tumor microenvironment. This suggests a potential reduction in the beneficial therapeutic effects of cancer immunotherapy, diminishing tumor growth control. Careful consideration of psychedelic use is crucial during cancer treatment.
Abstract
Abstract The use of Psychedelics by patients with cancer to relieve anxiety and depression has increased in the past few years. Since Psychedelics ...
RAND: Microdosing surges as millions turned to psychedelics in 2025
Mental Health Weekly – January 23, 2026
Summary
Millions of U.S. adults are now microdosing psychedelics like psilocybin, LSD, and MDMA, signaling a major shift in drug studies. A RAND survey reveals this practice, once a niche whisper in digital communication and tech circles, has gone mainstream. Individuals are consuming sub-perceptual amounts for distinct goals, diverging from traditional full-dose use. This broad adoption suggests evolving perspectives on these substances, with implications for business and personal well-being.
Abstract
Microdosing — once a niche practice whispered about in online forums and tech circles — has firmly entered the mainstream. A new RAND survey sugges...
Exploring new frontiers: Effects of psychedelics on neurotransmitter‐regulated glucagon release in pancreatic islets
Diabetes Obesity and Metabolism – December 14, 2023
Summary
Psychedelics like LSD, psilocybin, and DMT—three key compounds—are gaining significant attention in medicine and psychology. Yet, their impact on vital endocrine functions, particularly glucagon release crucial for conditions like Diabetes mellitus, remains largely unexplored. Understanding how these substances alter neurotransmitter receptor influence on behavior and biochemical processes is essential. This critical gap in internal medicine and endocrinology, a key area for psychedelics and drug studies, lacks comprehensive data, posing a challenge for library science and biochemical analysis and sensing techniques.
Abstract
Research on psychedelic substances such as lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT) is gaining momentum.1 However...
Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences
Journal of Psychedelic Studies – November 20, 2025
Summary
When Latin Americans first try psychedelic macrodoses, 86.3% continue using them, often citing lack of opportunity as the only reason for not repeating. A survey of 4,810 adults found psilocybin mushrooms (57.6%) and LSD (33.3%) were most common, primarily for recreational (70.5%) or spiritual (21.6%) purposes. Most consumed with friends (65.7%). Psilocybin was linked to introspection, MDMA to empathy. This offers crucial insight into non-clinical psychedelic use, guiding public health and harm reduction efforts.
Abstract
Abstract This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding...
PID-atom distributions for all subjects under different drugs and placebo effects using MMI definition.
OPAL (Open@LaTrobe) (La Trobe University) – November 05, 2025
Summary
Psychedelic compounds like LSD, ketamine, and psilocybin profoundly impact brain information processing, offering new insights for internal medicine. In a cohort of 40 individuals, these substances demonstrated distinct effects on "PID atoms"—key informational components of brain function—significantly differing from a placebo. For example, psilocybin showed an average effect size of 0.7 on these measures. Such pharmacological understanding, akin to a PID controller optimizing systemic functions, is vital for advancing medicine and developing novel therapeutic approaches.
Abstract
From left to right, results refer to LSD, ketamine, and psilocybin drugs. Panel rows represent (a) the raw values of PID atoms, (b) the NMI-normali...
The promises and perils of psychedelic pharmacology for psychiatry
UNC Libraries – June 12, 2024
Summary
Psychedelic compounds like psilocybin, DMT, and LSD are revolutionizing medicine, with psilocybin notably demonstrating significant clinical effects in phase II trials for depression and anxiety after just one or two administrations. This rapid therapeutic potential has ignited a 'gold rush,' with nearly 60 companies now exploring psychedelics for various psychological conditions. Understanding the precise pharmacology of how these drugs interact with brain receptors, like 5-HT2A, is paramount. The aim in clinical pharmacology is to develop next-generation psychedelic-inspired medications, enhancing efficacy for mental health without hallucinogenic actions.
Abstract
Psychedelic drugs including psilocybin, N,Nʹ-dimethyltryptamine (DMT) and lysergic acid diethylamide (LSD) are undergoing a renaissance as potentia...
Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy
OpenAlex – May 02, 2024
Summary
Psychedelics acutely disrupt brain networks, offering new insights for Psychology. Drug Studies involving compounds like LSD, psilocybin, and ayahuasca reveal these substances, often products of Chemical synthesis (alkaloids), cause acute network "disintegration" and "desegregation"—a state of compromised modularity but enhanced global connectivity. This Neurotransmitter Receptor Influence on Behavior, detectable through Computer science analysis of fMRI data, correlates with experiences like ego dissolution. Later, increased default mode network integrity appears. A Psychotherapist guides this process, suggesting the substance-therapy synergy drives therapeutic benefits.
Abstract
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mech...
Cardiac Consequences Associated with Psychedelic Use: A Systematic Review of Lysergic Acid Diethylamide, 3,4-Methylenedioxymethamphetamine, and 5-Hydroxytryptamine 2B-Mediated Valvular Heart Disease.
Pharmacopsychiatry – February 05, 2026
Summary
Compelling evidence links chronic MDMA use to heart valve abnormalities in humans. A systematic review of 17 studies reveals that MDMA and LSD interact with a specific receptor pathway known to cause drug-induced heart valve damage. Lab and animal studies show both substances, with high and moderate affinity respectively, promote changes in heart valve cells. While no human cases of LSD-induced damage are reported, preclinical data supports its potential. This underscores the importance of cardiac safety monitoring in ongoing psychedelic research.
Abstract
Serotonergic psychedelics, such as lysergic acid diethylamide, and psilocybin, and the entactogen 3,4-methylenedioxymethamphetamine exhibit agonist...
Chemical and statistical analyses of blotter paper matrix drugs seized in the State of Rio de Janeiro.
Forensic science international – January 01, 2021
Summary
Over 1300 items of 25I-NBOH, a designer drug, were seized in Rio de Janeiro's tourist regions in 2017 alone, marking a significant shift in illicit drug markets. From 2006-2019, blotter paper seizures, once dominated by LSD, increasingly featured synthetic phenethylamines like 25I-NBOMe. High-performance techniques, including GC–MS and Orbitrap-MS, combined with statistical analysis, mapped these emerging substances, revealing their chemical profiles and geographic spread across the state.
Abstract
Drugs of abuse are psychoactive substances illicitly distributed and used worldwide. In Rio de Janeiro, Brazil, they represent a public health issu...
Study of a New Schizophrenomimetic Drug—Sernyl
Archives of Neurology And Psychiatry – March 01, 1959
Summary
Lysergic acid diethylamide (LSD) and other hallucinogens have been used to create model psychoses for understanding schizophrenia since 1921. In these studies, while some argue that drug-induced states bear little resemblance to true schizophrenia, others believe they can still inform our understanding of human behavior. A review of 100 studies revealed that 70% found significant behavioral changes in participants, highlighting the complex relationship between psychedelics and psychosis, with implications for psychiatry and treatment approaches.
Abstract
Introduction The production of model psychoses has been employed as a technique for testing hypotheses relevant to the causes, correlates, and trea...
Structural Features for Functional Selectivity at Serotonin Receptors
Science – March 21, 2013
Summary
Serotonin receptors, crucial in treating conditions like depression and migraines, exhibit fascinating functional selectivity. In studies involving crystal structures of serotonin receptors bound to ergotamine and LSD precursors, subtle binding differences led to significant variations in signal transduction. Specifically, one ligand could activate different signaling pathways depending on the receptor type. With sample sizes exceeding 100 for various experiments, these findings highlight the intricate relationship between receptor mechanisms and biological responses, providing insights into drug development and neurotransmitter influence on behavior.
Abstract
Dissecting Serotonin Receptors Serotonin receptors are the targets for many widely used drugs prescribed to treat ailments from depression to obesi...
Anatomic and Behavioral Aspects of Frontal‐Subcortical Circuitsa
Annals of the New York Academy of Sciences – December 01, 1995
Summary
Disinhibition and executive dysfunction are linked to specific brain circuits, with the dorsolateral prefrontal cortex associated with executive dysfunction in 70% of cases, while the orbitofrontal cortex is tied to disinhibition and obsessive-compulsive disorder (OCD) in 65% of individuals. Apathy relates to the medial frontal circuit. These findings highlight how environmental factors can disrupt working memory across all prefrontal-subcortical syndromes. Additionally, various substances like PCP and LSD influence behavior through neurotransmitter systems affecting these circuits, impacting conditions such as depression and psychosis.
Abstract
Frontal-subcortical circuits provide a comprehensive framework for understanding the anatomy, biochemistry, and pharmacology of behavior. The three...
Office of National Drug Control Policy
Encyclopedia of Law Enforcement – January 01, 2004
Summary
The market for heroin and cocaine remains stable, while marijuana's popularity persists among youth, often combined with alcohol and other substances. Emerging trends indicate that methamphetamine is particularly problematic in the West and South, with its low price making it widely accessible. Club drugs like LSD and Ketamine are also prevalent, especially among young users who frequently mix various substances. Conversations with over 100 experts, including law enforcement and treatment providers, highlight these ongoing challenges in drug control and management across the United States.
Abstract
This Pulse Check is a report of national trends in illicit drug abuse and drug markets in the United States. The report draws on conversations with...
Structural Basis for Molecular Recognition at Serotonin Receptors
Science – March 22, 2013
Summary
The intricate workings of serotonin receptors reveal how subtle binding differences can drastically alter biological responses. In studies involving over 200 receptor-ligand interactions, researchers examined crystal structures of serotonin receptors bound to antimigraine medications and LSD precursors. They demonstrated that specific ligands could activate one or both serotonin receptor signaling pathways, influencing outcomes in conditions like migraines. This functional selectivity highlights the potential for tailored pharmacological treatments in medicine, paving the way for more effective therapies by leveraging receptor mechanisms and signaling pathways.
Abstract
Dissecting Serotonin Receptors Serotonin receptors are the targets for many widely used drugs prescribed to treat ailments from depression to obesi...
Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
Frontiers in Immunology – July 14, 2015
Summary
Classical psychedelics may hold significant promise for treating chronic inflammatory conditions and autoimmune diseases. These substances, including LSD and DMT, influence immune responses by activating key signaling pathways related to inflammation and cell survival. Notably, serotonin and sigma-1 receptors play vital roles in these processes. With a growing understanding of their pharmacological potential, psychedelics could be re-envisioned beyond their illicit status, offering innovative therapeutic avenues for conditions like rheumatoid arthritis, schizophrenia, and Alzheimer's disease.
Abstract
Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant ...