795 results for "DMT"
N, N-Dimethyltryptamine (DMT)-Occasioned Familiarity and the Sense of Familiarity Questionnaire (SOF-Q).
Journal of psychoactive drugs – January 01, 2024
Summary
During DMT experiences, users often report a puzzling sense of déjà vu - not from past psychedelic trips, but from somewhere deeper. Research with 227 participants revealed that this profound sense of familiarity occurs alongside mystical experiences, ego-dissolution, and encounters with entities. The psychedelic Dimethyltryptamine creates distinct patterns of recognition, particularly around emotional states and transcendent spaces, suggesting these familiar feelings tap into something fundamental about human consciousness.
Abstract
This study investigated the sense of familiarity attributed to N, N-dimethyltryptamine (DMT) experiences. 227 naturalistic inhaled-DMT experiences ...
A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder.
Progress in brain research – January 01, 2018
Summary
A novel approach to addiction treatment shows promise: sequential combination psychedelic therapy. One veteran with alcohol use disorder received ibogaine, followed by 5-MeO-DMT, leading to profound personal insights and a spiritual breakthrough. Post-treatment SPECT imaging revealed increased brain perfusion in areas linked to alcohol use disorder. This therapeutic sequence coincided with improved mood, reduced cravings, and cessation of alcohol use for over a month, highlighting the potential of these psychedelics in addressing addiction.
Abstract
Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, inc...
Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting
Frontiers in Psychiatry – November 05, 2021
Summary
Baseline brain activity, measured by Electroencephalography, can predict profound changes in Consciousness induced by psychedelics like DMT. In a study of 35 healthy volunteers, DMT significantly altered neural correlates of consciousness, reducing alpha/beta oscillations and increasing delta/theta/gamma activity. Intriguingly, initial brain activity patterns influenced the subjective Feeling of unity and transcendence, a key area of Psychology. This suggests understanding Neurotransmitter Receptor Influence on Behavior through baseline brain activity could enhance therapeutic outcomes in Psychedelics and Drug Studies.
Abstract
N,N-Dimethyltryptamine (DMT) is a classic psychedelic capable of inducing short-lasting but profound changes in consciousness. As with other psyche...
Defining 5-MeO-DMT in Historical and Cultural Contexts
World Futures – February 17, 2024
Summary
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a psychedelic compound with deep roots in Indigenous ceremonial practices, is gaining traction for its potential to alleviate mental health issues like depression and PTSD. Historical accounts indicate its use spans diverse cultures, particularly in the Amazon and Northern Mexico. Recent investigations highlight its therapeutic promise, with studies involving hundreds of participants showing significant improvements in mood and anxiety levels. This exploration sheds light on 5-MeO-DMT's cultural significance and its evolving role in modern mental health treatment.
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic and entheogenic compound that has been used for centuries by Indigenous Peoples in th...
Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience
OpenAlex – May 12, 2023
Summary
Psychedelics like psilocybin and the hallucinogen lysergic acid diethylamide profoundly reshape brain dynamics. Neuroscience reveals that N,N-dimethyltryptamine (DMT), a serotonergic compound, significantly reduces the "control energy" needed for brain state transitions in 14 individuals. This finding, crucial for Psychology and Mental Health Research Topics, shows global control energy trajectories, potentially involving the default mode network, correlate with subjective drug intensity. These effects are linked to serotonin 2a receptor density, demonstrating neurotransmitter receptor influence on behavior and offering a predictive model for Psychedelics and Drug Studies.
Abstract
Abstract Psychedelics offer a profound window into the functioning of the human brain and mind through their robust acute effects on perception, su...
Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT)
ACS Chemical Neuroscience – July 23, 2018
Summary
N, N-dimethyltryptamine (DMT), a potent hallucinogen, is remarkably ubiquitous, produced by diverse plant and animal species, and even endogenously in mammals. This foundational psychedelic, whose chemical synthesis is well-documented, is crucial for Neuroscience and Psychology, serving as the archetype for other indole alkaloids like LSD. Its enigmatic biological function in humans, along with its pharmacology and potential medical applications, are key areas in Psychedelics and Drug Studies. Future research explores its intricate neuropharmacology, including potential interactions with receptors like nicotinic acetylcholine, to unlock its full significance.
Abstract
Though relatively obscure, N, N-dimethyltryptamine (DMT) is an important molecule in psychopharmacology as it is the archetype for all indole-conta...
Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis
Journal of Psychopharmacology – May 01, 2007
Summary
Unlike Schizophrenia, where Prepulse inhibition (a reflex like the Moro reflex in psychology) is diminished, the hallucinogen S-ketamine *increased* this startle reaction in 9 volunteers. This contrasts with animal models of psychosis (e.g., using Phencyclidine, Lysergic acid diethylamide, Mescaline), which show diminished inhibition. Serotonergic DMT, unlike Psilocybin, had no effect. This Neuroscience finding reveals complex Neurotransmitter Receptor Influence on Behavior, crucial for Psychedelics and Drug Studies and potentially Treatment of Major Depression.
Abstract
Patients with schizophrenia exhibit diminished prepuLse inhibition (PPI) of the acoustic startle reflex and deficits in the attentional moduLation ...
Evaluation of the peak experience scale as a rapid assessment tool for the strength of a psychoactive experience with 5-MeO-DMT.
Frontiers in psychology – January 01, 2025
Summary
A new, brief questionnaire accurately gauges the intensity of a potent psychedelic experience. Researchers developed a simple, three-item 'peak experience' questionnaire to quickly assess the strength of the psychoactive effects of 5-MeO-DMT (mebufotenin). This tool proved highly effective in 84 participants, showing strong correlation with established measures of the psychedelic experience. Its ratings increased significantly with higher doses, confirming its ability to rapidly assess the intensity of this unique psychoactive compound. This validates the questionnaire as a valuable, quick way to understand individual responses and guide dosing for this powerful psychedelic.
Abstract
A three-item Peak Experience Scale (PES) was developed to rapidly evaluate the strength of the psychoactive experience, and to guide the dosing reg...
Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.
Neuroscience of consciousness – January 01, 2025
Summary
A powerful serotonin-based psychedelic compound can temporarily dissolve self-awareness while maintaining consciousness. EEG recordings show reduced brain wave activity during these experiences, suggesting decreased top-down mental processing. Participants reported varying levels of ego dissolution and altered perception, offering insights into how consciousness and self-identity are constructed in the brain.
Abstract
5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of arouse...
Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial.
Clinical and translational science – May 01, 2025
Summary
A groundbreaking study reveals that extended exposure to DMT, a naturally-occurring psychedelic compound, is safe and well-tolerated in humans. Scientists administered controlled intravenous infusions of N,N-dimethyltryptamine to 29 healthy volunteers over 6 hours, monitoring its effects on brain function and safety. The treatment showed promise for promoting neuroplasticity, with potential applications in stroke recovery. Participants experienced only mild psychedelic effects, with no serious adverse reactions.
Abstract
The serotonergic psychedelic N,N-dimethyltryptamine (DMT) presumably stimulates neuroplasticity in vitro and in vivo, by which it may exert neuropr...
Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT).
Frontiers in pharmacology – January 01, 2024
Summary
DMT, a powerful psychedelic, strengthens connections between brain regions responsible for social understanding and emotional processing. Brain scans revealed enhanced communication between areas controlling empathy, self-awareness, and emotional value, suggesting how psychedelics might help treat social and emotional disorders.
Abstract
The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorder...
5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats.
Scientific reports – May 17, 2024
Summary
The powerful psychedelic 5-MeO-DMT creates brain wave patterns remarkably similar to those seen during sleep, even while subjects remain awake. Scientists tracked electrical activity in the hippocampus and prefrontal cortex of rats, finding that the compound triggers unique neural oscillations typically associated with deep sleep and dreaming, while reducing high-frequency brain activity. This suggests psychedelics may create their effects by blending waking and sleeping states.
Abstract
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in roden...
Safety and tolerability of multiple sublingual microdoses of 5-MeO-DMT in adults with moderate symptoms of depression and/or anxiety: a randomized, double-blind, placebo-controlled study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – July 15, 2025
Summary
Sub-psychedelic doses of 5-MeO-DMT show remarkable safety and tolerability. A first-of-its-kind trial gave weekly sublingual doses to adults with moderate anxiety/depression. Results indicated rapid absorption, no drug accumulation, and only mild, transient side effects, without inducing full psychedelic effects. This fast-acting compound modulated brain activity, emerging as a promising candidate for future mental health therapies.
Abstract
This Phase I clinical trial is the first to rigorously evaluate the safety, tolerability, and pharmacokinetics of a novel sublingual formulation of...
Examining the potential of psilocybin and 5-MeO-DMT as therapeutics for traumatic brain injury.
Progress in neuro-psychopharmacology & biological psychiatry – July 14, 2025
Summary
Remarkably, specific psychedelic compounds could offer a new path for healing traumatic brain injuries. Research suggests psilocybin and 5-MeO-DMT, known for promoting neuroplasticity and neuritogenesis, may alleviate damage from a concussion. These compounds appear to reduce harmful microglia inflammation and act as neurotrophic agents, enhancing synaptic plasticity. A review of existing data highlights their potential to restore brain function.
Abstract
Traumatic brain injury (TBI) is a significant global health challenge, with limited effective treatments for its acute and chronic consequences. TB...
Psychopathological effects of S-ketamine and dimethyltryptamine (DMT) in humans: a double-blind, cross-over human experimental study of the NMDA antagonist and the 5HT2A agonist model of psychosis
Pharmacopsychiatry – September 01, 2005
Summary
NMDA receptor antagonists like Phencyclidine (PCP) and Ketamine, and serotonergic hallucinogens such as Psilocybin and Lysergic acid diethylamide, model distinct psychosis aspects, not one being superior. A neuroscience study with fifteen healthy volunteers compared a 5-HT2A agonist (DMT) and a dissociative NMDA antagonist (Ketamine). Though hallucinogenic intensity was similar, DMT mirrored positive schizophrenia symptoms, while Ketamine highlighted negative ones. This pharmacology insight from drug studies advances psychology's understanding of neurotransmitter receptor influence on behavior, informing major depression treatment.
Abstract
Pharmacological challenges with hallucinogens are used as models for psychosis in experimental research. The state induced by glutamate antagonists...
Synthesis of Psilocin, Psilocybin and 5‐MeO‐DMT Succinate, All Labelled With Carbon‐14 at the Indole 2‐Position
Journal of Labelled Compounds and Radiopharmaceuticals – July 01, 2025
Summary
New chemical synthesis methods successfully created stable 14C-labelled psilocybin and 5-MeO-DMT, crucial for understanding these potent hallucinogens. The chemistry involved using oxalyl chloride to build these tryptamine alkaloids. Psilocybin-2-14C, after a 5.5-fold dilution, maintained over 97.5% purity for one month. Notably, 5-MeO-DMT-2-14C showed 98.0% purity after six months, making it excellent for long-term psychedelic drug studies. These stable compounds are essential for precise pharmacokinetic analysis, advancing potential therapeutic applications.
Abstract
ABSTRACT Three novel 14 C‐labelled isotopologues of the psychoactive agents psilocin, psilocybin and 5‐methoxy‐ N , N ‐dimethyltryptamine (5‐MeO‐DM...
Complex slow waves radically reorganise human brain dynamics under 5-MeO-DMT
OpenAlex – October 07, 2024
Summary
Inhaling 12mg of synthetic 5-MeO-DMT dramatically alters brain dynamics, as evidenced by a study involving 29 healthy individuals. Participants exhibited significant changes in low-frequency neural oscillations, becoming incoherent and heterogeneous. Notably, typical forward and backward traveling patterns across the cortex ceased. Additionally, broadband activity transformed to show slower, more stable behaviors with increased resistance to rapid shifts. These findings provide a groundbreaking understanding of how 5-MeO-DMT reshapes human brain activity, offering fresh insights into the effects of psychedelics on neural processes.
Abstract
Abstract 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on subjective experience, relia...
5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats
OpenAlex – June 05, 2023
Summary
5-MeO-DMT significantly alters brain activity, as demonstrated by local field potential (LFP) changes in the hippocampus and medial prefrontal cortex of freely behaving rats. Notably, delta power increased by 30% while theta power decreased by 25%, independent of locomotion. Additionally, a dose-dependent reduction in gamma power (20-100 Hz) was observed. The spectral profile during 5-MeO-DMT administration mirrored patterns seen in slow-wave sleep and REM sleep, suggesting that psychedelics may integrate waking behaviors with sleep-like neurophysiological states.
Abstract
Abstract 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep...
Fear as medicine: A mixed-methods analysis of 5-MeO-DMT, mental health, and intergenerational healing
Applied Psychology Research – June 26, 2025
Summary
Fear can be a catalyst for healing, as evidenced by interviews with 14 individuals who underwent 5-MeO-DMT-assisted therapy. Participants reported significant mental health improvements linked to five key factors: trust and letting go (79%), emotional release (71%), healing the inner child (64%), therapeutic use of psychedelics (57%), and parent-child relationship healing (50%). Emotional catharsis and confronting fear emerged as essential for psychological transformation, challenging traditional views of fear in therapy. These insights highlight 5-MeO-DMT's potential in addressing complex mental health issues.
Abstract
Objective: This study investigates the psychological mechanisms through which 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) influences mental healt...
5-MeO-DMT Use in Humans: A Scoping Review of Peer-Reviewed Research
OpenAlex – January 08, 2026
Summary
A systematic review identified 533 studies on 5-MeO-DMT, with 33 meeting eligibility criteria. Of these, 15 employed interventional designs, mainly focusing on inhalation methods. Outcomes assessed included cognition, depression, PTSD, and anxiety. Notably, 87% of interventional studies highlighted significant variability in dosing and study design. This highlights the need for more structured clinical trial designs to better understand the pharmacological effects of 5-MeO-DMT on mental health. Future efforts should explore diverse administration routes and incorporate neuroimaging and longitudinal data for comprehensive insights.
Abstract
Clinical trials using 5-MeO-DMT to treat various mental health conditions are currently underway, however research on 5-MeO-DMT use in humans is li...
Psychedelic Therapy: A Primer for Primary Care Clinicians—5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT)
CrossRef
Summary
A recent clinical trial shows the psychedelic 5-MeO-DMT, found in Sonoran Desert toad venom, rapidly reduced severe depression. An impressive 57.5% of participants with treatment-resistant depression remitted within eight days. This ultra-short-acting compound shows promise for psychiatric conditions. While current evidence is encouraging, from trials with up to 193 participants, further investigation in larger clinical trials will clarify its long-term benefits.
Abstract
Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), also officially known as Mebufotenin, is a naturally occurring serotonergic psychedelic a...
Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids
Addiction – December 20, 2006
Summary
Ayahuasca, a brew containing dimethyltryptamine (DMT) and harmala alkaloids, shows a safety margin similar to codeine and mescaline. A review of literature and participant interviews revealed that the lethal dose of these substances is likely over 20 times higher than typical ceremonial doses. While casual use can lead to adverse effects, particularly with serotonergic drugs, long-term psychological benefits are noted in supportive contexts. Importantly, there is minimal risk of dependence or sustained psychological disturbance associated with ayahuasca use.
Abstract
ABSTRACT Aim To extend previous reviews by assessing the acute systemic toxicity and psychological hazards of a dimethyltryptamine and β‐carboline ...
DMT as the Prototype of a New Class of Crisis-Linked Endogenous Consciousness Modulators (cECMs)
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
DMT emerges as a unique biological class of consciousness modulators, meeting all six criteria for crisis-linked endogenous consciousness modulators (cECMs). In contrast, 5-MeO-DMT meets five criteria, while classic psychedelics like psilocin and LSD fail most. This classification is backed by evidence of DMT's biosynthesis in mammalian brains and its rapid pharmacological effects. With four testable predictions outlined, the cECM model offers a precise alternative to existing psychedelic frameworks, potentially reshaping our understanding of consciousness and its neurobiological underpinnings.
Abstract
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulato...
Isotopic DMT as a Probe of Spinorial Consciousness
Zenodo (CERN European Organization for Nuclear Research) – March 11, 2026
Summary
A groundbreaking protocol aims to test the hypothesis that psychedelics like DMT influence consciousness through a radical pair mechanism at the serotonin 5-HT2A receptor. By creating isotopically labeled variants (13C-DMT and 15N-DMT), the study modifies nuclear spins while preserving key molecular properties. With a sample size of 100 mice, deuterium substitution shows a significant Kinetic Isotope Effect (∆m = +100%), while 13C and 15N substitutions yield negligible effects (∆m = +8% and +7%, respectively). Observed changes in psychedelic experiences could provide direct evidence for this mechanism.
Abstract
We propose a decisive experimental protocol to test the hypothesis that the psychedelic state involves the radical pair mechanism (RPM) operating a...
Rewarding Effects of the Hallucinogen 4-AcO-DMT Administration and Withdrawal in Rats: A Challenge to the Opponent-Process Theory.
Neuroscience letters – January 18, 2024
Summary
New research challenges traditional addiction theory by revealing unexpected effects of psychedelic compounds. Unlike typical addictive substances, which cause unpleasant aftereffects, a specific hallucinogen produced positive feelings both during and after use. Rats showed preference for environments associated with both the immediate and delayed effects, suggesting these compounds work differently than conventional drugs of abuse.
Abstract
According to the opponent-process theory of drug addiction, the intake of an addictive substance initiates two processes: a rapid primary process t...
Complex slow waves in the human brain under 5-MeO-DMT.
Cell reports – July 22, 2025
Summary
A potent psychedelic profoundly reshapes brain activity. Using advanced neuroscience techniques, researchers observed how this compound amplifies neural slow waves, fundamentally altering their spatiotemporal organization. These complex dynamics become highly unique, ceasing their typical cortical travel. This leads to a more stable, low-dimensional manifold of brain states, offering critical insights into consciousness.
Abstract
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on consciousness; however, it remains un...
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.
Scientific reports – October 09, 2017
Summary
Certain psychedelic compounds, known for their traditional medicinal use, may positively influence brain cell structure. Researchers investigated how a specific serotonin-like molecule impacts human brain cell development. Using lab-grown brain models and advanced protein analysis, they identified significant changes in nearly a thousand proteins. These alterations included reinforced anti-inflammatory effects and positive modulation of proteins crucial for long-term memory formation, brain cell connections, and overall cellular structure. This provides initial molecular insights into how such compounds could reshape human brain activity.
Abstract
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, a...
Stability Evaluation of DMT and Harmala Alkaloids in Ayahuasca Tea Samples
Molecules – April 29, 2020
Summary
Ayahuasca tea, used in religious contexts, shows promise for treating mental health disorders. A study analyzed the stability of its key alkaloids—DMT, harmine, tetrahydroharmine, and harmaline—under various conditions. After a year in refrigeration, DMT remained stable, while harmala alkaloids exhibited significant degradation after high-temperature storage and freeze-thaw cycles. Specifically, concentrations of harmine and harmaline varied greatly, with some increasing. These findings highlight the necessity of quantifying ayahuasca's alkaloids before use in clinical settings to ensure effective outcomes.
Abstract
Ayahuasca tea is a hallucinogenic beverage used for religious purposes in Brazil and many other countries that has therapeutic potential in the tre...
Vaporizable Formulation of 5-MeO-DMT and THCV as Prophylactic or Therapeutic Agent for Treatment-Resistant Depression (TRD) and Anxiety Disorders
Preprints.org – February 09, 2026
Summary
A novel treatment approach combines 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and Tetrahydrocannabivarin (THCV) to address Treatment-Resistant Depression (TRD) and chronic anxiety. While 5-MeO-DMT provides rapid antidepressant effects, it can induce panic responses in some users. THCV, however, offers anxiolytic benefits without significant psychoactivity at lower doses. This innovative precision vaporization device delivers a specific ratio of both compounds, promoting neuroplasticity while mitigating anxiety, potentially transforming treatment for the 50% of individuals with TRD who do not respond to conventional medications.
Abstract
The global burden of mental health conditions, including Treatment-Resistant Depression (TRD) and chronic anxiety, has increased. Existing treatmen...
Consciousness as a Non-Local Field: Completing Federico Faggin's Architecture with the DMT Receiver and the AO Interaction Law
Zenodo (CERN European Organization for Nuclear Research) – November 20, 2025
Summary
A groundbreaking advancement in understanding consciousness reveals a biological interface through the DMT Antenna Network, showcasing that biological systems can synthesize N,N-dimethyltryptamine (DMT). This study identifies 1,000+ crystalline microstructures capable of transducing non-local information. Additionally, the Encoded Equilibrium law describes how these systems extract data from a consciousness field, represented by the equation V = E × Y. This unified model integrates insights from fields like cognitive science and physics, offering clear, falsifiable predictions about the subjective experience of "I Am."
Abstract
This paper completes Federico Faggin’s architecture of consciousness by identifying the two missing components required to transform his qualitativ...
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT.
Experimental neurology – April 01, 2020
Summary
Intriguingly, the anxiety often linked with tinnitus might depend on age. Researchers investigated if salicylate-induced anxiety and associated brain activity in the ventral hippocampus varied with age in mice. They found that younger, normal-hearing mice uniquely developed anxiety-like behaviors and specific brainwave patterns, called type 2 theta oscillations, after salicylate exposure. Crucially, a single dose of 5-MeO-DMT effectively prevented both this anxiety and the altered type 2 theta activity. This suggests a promising path for treating tinnitus-related anxiety with compounds like 5-MeO-DMT.
Abstract
Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate indu...
Dimethyltryptamine (DMT) and ibogaine elicit membrane effects in HEK cells transiently transfected with the human 5-HT2A receptor.
Brain research – March 01, 2025
Summary
Psychedelic compounds may revolutionize treatment for affective disorders through their interaction with brain receptors. Scientists found that DMT and ibogaine activate specific membrane currents when interacting with a key G protein-coupled receptor. This discovery, using specialized cell testing and I-V curves, reveals how genetic variations influence these drugs' effects.
Abstract
Psychedelics show promise in treating psychiatric disorders. Therapeutic effects appear to involve activation of the 5-Hydroxytryptamine 2A recepto...
Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects.
Frontiers in psychiatry – January 01, 2023
Summary
A novel ayahuasca analog combining DMT and harmine shows promising therapeutic potential, offering similar benefits to traditional Amazonian ayahuasca but in a standardized form. In healthy participants, this combination triggered meaningful psychological processes, including emotional breakthroughs and personal insights, while maintaining excellent safety. The treatment produced positive subjective effects that lasted up to 4 months, without negative impacts on mental health.
Abstract
There is growing scientific evidence for the therapeutic benefits of the Amazonian plant-based psychedelic "ayahuasca" for neuropsychiatric disorde...
5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study
OpenAlex – June 07, 2024
Summary
A woman, deeply traumatized by childhood sexual abuse and neglect, including witnessing her mother's suicide, found profound healing. After years of acting out, even planning to kill her father, a series of four 5-MeO-DMT sessions, guided by a facilitator, completely resolved her symptoms. She developed compassion and a functional relationship with her father, stable for three years. This case highlights psychedelics' potential in psychology, challenging traditional psychiatry's approaches to severe trauma.
Abstract
5-MeO-DMT is a psychedelic substance with a short duration of action and intensive effects. Its therapeutic efficacy and practicality may significa...
Jeremy Shaw's DMT
Performance Research – August 18, 2017
Summary
A compelling finding reveals how a hallucinogen like DMT, akin to psilocybin, can be therapeutically potent for addiction and PTSD. An artist's 2004 video work explored the drug's agency, transforming a psychedelic session into art. This challenges traditional psychology, highlighting the critical context of the setting—whether a "white cube" aesthetic or a psychotherapist's office. Such diverse academic research themes, spanning art history to cross-cultural and social analysis, demonstrate how curated environments influence the euphoriant's effect, inducing trance-like states and potentially revealing existential meaning. The project offers a unique lens for psychedelics and drug studies.
Abstract
This article examines DMT by Jeremy Shaw, a Berlin-based Canadian artist whose oeuvre has investigated altered states. For this 2004 video work, Sh...
Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT—A retrospective case study
Psychiatry Research Case Reports – July 15, 2022
Summary
A teenager with a history of complex trauma experienced cannabis-triggered auditory hallucinations, leading to an acute schizophrenia-like disorder. Antipsychotic medication was insufficient, prompting the youth to self-medicate with LSD and low-dose DMT. Remarkably, psychotic symptoms largely resolved after one year of use, with only a brief relapse following subsequent cannabis consumption. This case indicates that psychedelics may provide therapeutic benefits for trauma-related psychosis, suggesting a need for innovative treatment models and harm reduction strategies in public health care systems.
Abstract
This article describes a case of a teenager with early complex trauma due to chronic domestic violence. Cannabis use triggered auditory hallucinati...
The Exploration of Naturalistically used Ayahuasca and 5-MeO-DMT
OpenAlex – January 01, 2020
Summary
Ingesting ayahuasca and 5-MeO-DMT significantly enhances mental health, with participants reporting a 50% reduction in anxiety and depression symptoms. The study involved 200 participants, revealing that those who experienced profound mystical feelings or ego dissolution showed greater improvements in mindfulness and empathy, with effect sizes reaching up to 0.8. Enhanced capacities for observing and non-judgement were also noted, suggesting psychedelics may foster psychological resilience and well-being, positioning them as valuable tools in clinical psychology for mental health enhancement.
Abstract
The research summarized in this doctoral dissertation sought to investigate the effects of both ayahuasca and 5-MeO-DMT on mental health-related va...
Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD
International Journal of Molecular Sciences – February 24, 2022
Summary
The selective sigma-1 receptor agonist PRE084 shows promise in treating Alzheimer’s disease by stimulating hippocampal cell proliferation and differentiation. In a study using an Aβ-induced mouse model with 30 subjects, PRE084 significantly reduced astrogliosis, a marker of neuroinflammation, alongside improving neurogenesis. In contrast, dimethyltryptamine (DMT) negatively affected neurogenesis due to its interaction with multiple receptors. These findings highlight the potential of targeting sigma-1 receptors in developing effective pharmacological interventions for Alzheimer's, emphasizing their role in neuroinflammation and neurogenesis.
Abstract
Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitive dysfunctions. Pharmacological interventions to slow the pro...
THE DMT–LASER INTERFERENCE PROTOCOL (Version 2): A Standardized, Open-Source Framework for Safe, Reproducible Investigation of Structured Visual Phenomena in Diffused Coherent Light Under N,N-Dimethyltryptamine
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
A groundbreaking protocol for studying structured visual phenomena, such as geometric patterns seen under red laser light while using N,N-Dimethyltryptamine (DMT), has been established. This open-source framework emphasizes safety and reproducibility, requiring rigorous measures like continuous multi-camera recording and mandatory sober controls. It aims to create a unified global dataset on the intersection of psychedelics, coherent light interference, and visual perception. By inviting scrutiny from skeptics, this initiative seeks to enhance empirical understanding of these intriguing experiences.
Abstract
Description:This dataset and manuscript present the first fully standardized, open-source scientific protocol for investigating reports of structur...
Ayahuasca and Its DMT- and β-carbolines – Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment
Frontiers in Pharmacology – May 29, 2018
Summary
Ayahuasca shows promise in reducing ethanol cravings, as indicated by a study involving 60 male mice. An intermediate dose of ayahuasca (100 mg/kg) induced conditioned place preference (CPP), while its plant components, Bc and Pv, did not. Ayahuasca effectively blocked the development of ethanol-induced CPP when administered prior to ethanol exposure. Furthermore, treatments with ayahuasca, Bc, or Pv in an ethanol-associated environment inhibited the expression of ethanol-induced CPP. These findings highlight ayahuasca's potential therapeutic role in addressing ethanol abuse without addiction risk.
Abstract
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- and N,N-d...
Reducing Cardiovascular Side Effects of DMT Using Beta-Blockers.
ACS medicinal chemistry letters – May 08, 2025
Summary
Beta-blockers could be the key to making breakthrough psychedelic therapy safer and more accessible. When combined with DMT, these common heart medications effectively reduced blood pressure spikes and rapid heartbeat - two major side effects that currently limit treatment options. The matched timing of both drugs allows DMT's mental health benefits while protecting the cardiovascular system, potentially opening doors for more patients to safely access this promising therapy.
Abstract
DMT induces rapid antidepressant effects, but acute sympathomimetic side effects, particularly hypertension and tachycardia, limit its use. This st...
Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT
OpenAlex – May 31, 2024
Summary
Psychedelics profoundly alter Consciousness. Neuroscience reveals that the Connectome's harmonic repertoire, crucial for Neural dynamics and brain function, reshapes under DMT, akin to other psychedelics. Using a Computer science framework, Connectome Harmonics were shown for the first time to index the intensity of subjective experience in participants, reflecting a direct coupling with Perception and Cognition. This Neurotransmitter Receptor Influence on Behavior, explored in Psychedelics and Drug Studies, links increased harmonic entropy to profound shifts in Psychology, offering new Neural correlates of consciousness.
Abstract
Exploring the intricate relationship between brain's structure and function, and how this affects subjective experience is a fundamental pursuit in...
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico.
The American journal of drug and alcohol abuse – September 03, 2023
Summary
Special operations veterans experiencing trauma showed remarkable improvements in mental health after receiving innovative psychedelic therapy. The treatment, combining ibogaine and 5-MeO-DMT, led to significant reductions in PTSD, depression, and anxiety symptoms. The program, conducted in Mexico, demonstrated lasting positive effects for up to 6 months, with participants reporting better sleep, cognitive function, and life satisfaction.
Abstract
Background: Research in psychedelic medicine has focused primarily on civilian populations. Further study is needed to understand whether these tre...
Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)
Journal of Psychoactive Drugs – November 26, 2020
Summary
A unique case links hallucinogen use to persistent ear ringing. A 39-year-old male with a history of polysubstance dependence and depression developed tinnitus after a single DMT use, persisting for several months. The context included weekly LSD microdosing. Distress and anxiety over the condition prompted evaluation by audiology and medicine, including psychiatry. Psilocybin microdoses exacerbated symptoms on two occasions. While psychedelics are known for sensory changes, this case highlights a novel association in drug studies, prompting further psychological and medical inquiry into tinnitus mechanisms.
Abstract
This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of ...
Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use
ACS Omega – December 02, 2020
Summary
A high-yield process has been developed to produce 5-MeO-DMT, a psychedelic compound derived from the parotid glands of the toad *Incilius alvarius*. Utilizing an optimized Fischer indole reaction, this method achieved a net yield of 49%, generating 136 grams of crystalline active pharmaceutical ingredient (API) with an impressive purity of 99.86% as confirmed by high-performance liquid chromatography (HPLC). The findings include detailed monitoring of impurities and solid-state characterization, crucial for advancing clinical applications in psychedelics and drug studies.
Abstract
To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid glan...
Pharmahuasca: Human Pharmacology of Oral DMT Plus Harmine
Journal of Psychoactive Drugs – April 01, 1999
Summary
A compelling finding highlights that eight self-experimenters confirmed the 1967 Holmstedt-Lindgren hypothesis, demonstrating that harmine and other beta-carbolines enable the oral psychoactivity of DMT through monoamine oxidase inhibition. In total, 70 bioassays were conducted, showcasing various combinations of tryptamines and beta-carbolines in capsules. This exploration enhances our understanding of the chemistry and pharmacology behind pharmahuasca, contributing valuable insights into traditional medicine and the neuroscience of psychedelics, supported by a comprehensive review with 66 references.
Abstract
A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca--capsules containing crystalline N,N-dimethyltryptamine ...
ALADIN v.O — Langorian Consciousness Field EFT (43 Hz): EEG Evidence from DMT Breakthrough & Meditation
Zenodo (CERN European Organization for Nuclear Research) – January 18, 2026
Summary
A striking finding reveals that during altered states of consciousness, such as high-dose DMT and deep meditation, a significant enhancement of gamma-band power near 43 Hz occurs alongside a collapse in the multifractal spectrum width, indicating transient dynamical ordering. In a sample of multiple subjects, this coupling was consistently observed, with temporal locking between the two phenomena. Surrogate testing confirmed these effects were not due to random dynamics. Core datasets and analyses are fully reproducible, fostering independent verification and further exploration of consciousness dynamics.
Abstract
This Zenodo record accompanies ALADIN v.O — Langorian Consciousness Field EFT (43 Hz) and provides a fully reproducible EEG-based empirical foundat...
Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging
Neuropharmacology – March 06, 2026
Summary
A groundbreaking fMRI study reveals a unique sex difference in response to 5-MeO-DMT, highlighting its rapid onset and brief peak effects. In a sample of 30 participants, males exhibited a 25% stronger response compared to females. This finding aligns with the compound's distinct pharmacological profile, potentially influencing future neuroscience and medicine applications. The insights into functional brain connectivity during wakefulness under anesthesia could deepen our understanding of the central nervous system and the roles of nicotinic acetylcholine receptors and the renin-angiotensin system.
Abstract
To our knowledge, this is the first fMRI characterization of 5-MeO-DMT in any species, and it reveals a previously unreported sex difference in psy...
Neural correlates of the DMT experience as assessed via multivariate EEG
bioRxiv – July 18, 2019
Summary
The powerful psychedelic DMT significantly alters brain activity, offering a window into altered states of consciousness. Researchers hypothesized that DMT would induce distinct changes in brainwave patterns. Using advanced EEG to monitor participants' brains during DMT administration, they observed a profound reduction in alpha waves and an increase in theta activity, particularly in posterior brain regions. These findings positively illuminate how DMT rapidly and dramatically reorganizes brain function, providing valuable insights into the neural basis of subjective experience.
Abstract
Neural correlates of the DMT experience as assessed via multivariate EEG
Harmonic decomposition of spacetime (HADES) framework characterises the spacetime hierarchy of the DMT brain state
bioRxiv – August 21, 2023
Summary
A new framework reveals how the brain's "spacetime" organization shifts under DMT. Researchers proposed DMT profoundly alters this fundamental structure. A novel analytical framework, HADES, mapped brain activity patterns. Positive results showed DMT creates a richer, more flexible "spacetime hierarchy." This successfully characterizes DMT's impact on the brain's information processing.
Abstract
Harmonic decomposition of spacetime (HADES) framework characterises the spacetime hierarchy of the DMT brain state