795 results for "DMT"
Phenomenology and Content of the Inhaled N, N-Dimethyltryptamine (N, N-DMT) Experience
Research Square – April 28, 2022
Summary
Many individuals describe encountering "entities" during experiences with inhaled N, N-DMT. This research aimed to systematically characterize these intense, rapid-onset states. Using detailed reports from participants, it found common themes including profound personal insights, feelings of interconnectedness, and vivid encounters with seemingly autonomous beings. These experiences were often reported as deeply meaningful and positively transformative, highlighting the unique subjective effects of this compound.
Abstract
Phenomenology and Content of the Inhaled N, N-Dimethyltryptamine (N, N-DMT) Experience
Psychological and physiological effects of extended DMT
PsyArXiv – April 13, 2023
Summary
Extended exposure to DMT was explored for its psychological and physiological effects. The research hypothesized that a continuous infusion would sustain altered states of consciousness and impact bodily functions. Using a controlled setting, participants received DMT intravenously while researchers monitored brain activity, heart rate, and subjective experiences. Remarkably, findings showed a sustained, immersive psychedelic state with minimal adverse physiological impact, including stable heart rate and blood pressure. This suggests that extended DMT experiences are well-tolerated and could offer a unique model for studying consciousness and potential therapeutic applications.
Abstract
Psychological and physiological effects of extended DMT
DMT alters cortical travelling waves.
Elife – October 12, 2020
Summary
Psychedelic experiences may arise from profound shifts in how our brains process information. Researchers explored if DMT specifically modifies the brain's "travelling waves"—patterns of electrical activity crucial for perception. Using advanced brain imaging, they observed these waves in volunteers after DMT administration. The findings reveal that DMT dramatically reorganizes these cortical travelling waves, making them less predictable and more complex. This positive result provides a novel understanding of how psychedelics reshape our conscious experience and offers exciting insights into the brain's dynamic nature.
Abstract
DMT alters cortical travelling waves.
Behavioral properties of psychoactive phenylisopropylamines in rats.
European journal of pharmacology – December 17, 1981
Summary
Rats trained to recognize the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (3.0 mg/kg) achieved over 85% accuracy in a drug discrimination task. When tested with 36 similar compounds, responses fell into three categories: 45% showed full generalization to 5-OMe DMT effects, 30% displayed partial generalization, and 25% resulted in negligible responses. These findings suggest that certain substituted phenylisopropylamines can mimic 5-OMe DMT's effects in rats, indicating a potential serotonergic mechanism at play.
Abstract
Rats were trained to discriminate injections of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT, 3.0 mg/kg) a hallucinogenic agent for which a serotone...
Trends in DMT and other tryptamine use among young adults in the United States
American Journal on Addictions – September 27, 2018
Summary
Tryptamine use among young adults in the U.S. has seen a significant rise, increasing from 0.2% in 2007/08 to 0.7% in 2013/14, marking a 273% relative increase. Among ecstasy users, prevalence soared from 2.1% to 10.0%, while LSD users reported an increase from 7.0% to 15.5%. Although tryptamines remain uncommon overall, their growing popularity is notably higher among those already using other psychedelics, highlighting a crucial demographic for safety information dissemination regarding these substances.
Abstract
Background and Objectives The popularity of tryptamines such as N,N ‐dimethyltryptamine (DMT) appears to be increasing in the United States (US), b...
Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).
Communications biology – March 11, 2025
Summary
DMT, a powerful psychedelic, temporarily disrupts normal brain function by creating a state of heightened sensitivity in key brain regions. Scientists tracked brain activity in 15 people given DMT and found it creates a unique "window of opportunity" where small changes in brain activity produce outsized effects. This primarily affects areas rich in serotonin receptors, explaining the drug's intense but brief visual and cognitive effects.
Abstract
The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects...
Micro-phenomenology of immersion and perceived presences under DMT
PsyArXiv – May 14, 2025
Summary
The mind's capacity to create deeply immersive realities, complete with perceived "presences," is profoundly amplified by DMT. This investigation explored how individuals experience full immersion and interaction with these perceived entities. Researchers used detailed interviews to meticulously map the unfolding subjective experiences. Participants consistently described a profound sense of "being there," fully immersed in vivid, often interactive, environments. Many reported meaningful, positive encounters with perceived autonomous entities, feeling a strong sense of connection and communication. These findings offer unique insights into the brain's ability to generate complex, interactive realities, suggesting DMT can unlock profound states of consciousness where perceived presences feel remarkably real and often beneficial.
Abstract
Micro-phenomenology of immersion and perceived presences under DMT
Correction: DMT alters cortical travelling waves.
Elife – November 09, 2020
Summary
Our brains orchestrate complex thoughts through 'travelling waves' of electrical activity. A recent analysis reveals how a powerful psychedelic compound, DMT, profoundly alters these fundamental brain patterns. Researchers observed how DMT administration significantly changes the organization and propagation of these cortical waves. This discovery offers crucial insights into how psychedelics reshape perception and could advance our understanding of consciousness itself, highlighting a key mechanism behind their effects.
Abstract
Correction: DMT alters cortical travelling waves.
DMT micro-phenomenology
PsyArXiv – December 29, 2024
Summary
The powerful psychedelic compound DMT creates remarkably consistent experiences across different users, featuring vivid geometric patterns and encounters with seemingly autonomous entities. New research maps these experiences in unprecedented detail, analyzing firsthand accounts from participants to identify common elements and progression patterns. Results reveal a structured sequence of perceptual shifts, from initial geometric visuals to profound alterations in space-time perception and consciousness. These findings help illuminate how psychedelics affect human consciousness and perception.
Abstract
DMT micro-phenomenology
Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing
bioRxiv – March 20, 2024
Summary
Profound experiences, sometimes induced by substances like DMT, have a measurable bodily signature. Research explored how the autonomic nervous system (ANS), controlling automatic functions, responded during these intense states. Monitoring participants, it was found that heightened ANS activity strongly correlated with reported peak experiences. Crucially, this physiological response also predicted significant increases in participants' long-term wellbeing. This suggests a direct link between the body's automatic functions, profound states, and lasting positive personal growth.
Abstract
Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact.
Pharmaceuticals (Basel) – October 23, 2020
Summary
The human body's intricate processing of natural psychoactive compounds like those in ayahuasca is now better understood. This research aimed to map how key alkaloids (DMT, harmine, etc.) move through and affect the body. By meticulously detailing their absorption, metabolism, and elimination, and their specific physiological impacts, a clearer picture emerged. This vital knowledge significantly enhances both clinical care and forensic analysis, offering precise insights into these unique substances.
Abstract
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Foren...
A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation.
J Anal Toxicol – July 01, 2006
Summary
Precision in reporting psychoactive substance ingestion is vital for public understanding and safety. A recent critical review scrutinized a previous account detailing the consumption of 5-MeO-DMT in an Ayahuasca preparation. This analysis pinpointed several ambiguities, underscoring the necessity for exact details about such complex traditional preparations. Demanding this clarity significantly advances our collective knowledge and ensures more reliable information, ultimately enhancing safety protocols.
Abstract
A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation.
Transient destabilization of whole brain dynamics induced by DMT
bioRxiv – January 29, 2024
Summary
Our brains usually maintain stable activity patterns. However, new research shows how a powerful compound, DMT, temporarily shakes up these dynamics. Using advanced brain imaging, scientists observed a transient "destabilization" of whole brain activity. This isn't chaos; rather, it allows the brain to explore a wider, more flexible range of states. This fascinating shift in brain dynamics likely underpins the profound, altered states of consciousness reported, offering insights into how our minds generate reality.
Abstract
Transient destabilization of whole brain dynamics induced by DMT
Neural correlates of the DMT experience assessed with multivariate EEG.
Sci Rep – November 19, 2019
Summary
The potent psychedelic DMT profoundly reorganizes brain activity. Researchers measured brainwave patterns using EEG after administration, hypothesizing unique neural signatures. Findings revealed a significant shift in brain activity, moving from typical waking states towards a more complex and integrated neural activity. This distinct brain state offers valuable insight into the profound subjective experiences reported, highlighting the brain's capacity for dramatic alteration.
Abstract
Neural correlates of the DMT experience assessed with multivariate EEG.
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
Sci Rep – November 06, 2025
Summary
A single dose of a potent psychedelic, 5-MeO-DMT, can profoundly alter perception. Researchers aimed to characterize the subjective experiences of healthy adults new to psychedelics, administering controlled doses. Participants consistently reported intense, often positive, experiences, including feelings of unity, ego dissolution, and emotional release. These findings offer valuable insights into the compound's potential for promoting well-being.
Abstract
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.
Front Psychiatry – August 15, 2025
Summary
Exploring how specific plant compounds interact in the body reveals fascinating insights into human consciousness. Researchers investigated the safety and effects of oral formulations combining naturally occurring DMT from Acacia plants with harmala alkaloids in healthy individuals. Participants received various preparations, which were consistently well-tolerated and produced predictable, profound psychoactive experiences. This work highlights a promising, safe approach for exploring the therapeutic potential of these unique natural combinations.
Abstract
DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.
Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.
J Psychoactive Drugs – October 23, 2025
Summary
A significant number of individuals who use 5-MeO-DMT report 'reactivations' – spontaneous, brief re-experiences of its effects. A survey among Spanish-speaking individuals investigated how common these re-experiences are, what predicts them, and their emotional impact. Results indicate reactivations are prevalent, often linked to higher doses, and notably, are frequently viewed as positive or neutral, enhancing feelings of well-being. This suggests these occurrences are generally not distressing.
Abstract
Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.
Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner
PsyArXiv – September 30, 2025
Summary
Remarkably, an expert meditator's brain activity during deep nondual meditation mirrors certain effects of a powerful psychedelic. Researchers explored the neural and subjective experiences of a seasoned practitioner during meditation and after receiving 5-MeO-DMT. Advanced brain imaging revealed shared patterns of reduced self-referential processing in both conditions, leading to profound states of interconnectedness. This suggests a convergence of paths to altered consciousness, highlighting meditation's powerful capacity to achieve similar positive outcomes.
Abstract
Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner
Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.
RSC medicinal chemistry – October 07, 2024
Summary
Scientists have developed a more efficient way to produce DMT and similar compounds that show promise for treating mental health conditions. Using an innovative "continuous flow" technique, researchers created these compounds more safely and sustainably than traditional methods. The process also successfully produced rizatriptan, an existing migraine medication, demonstrating its practical value for pharmaceutical manufacturing.
Abstract
Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fisch...
Vigilance state dissociation induced by 5-MeO DMT in mice
Research Square – May 06, 2025
Summary
A powerful psychedelic compound found in some plants can create a unique state where mice appear awake but show brain patterns typical of deep sleep. Scientists found that 5-MeO-DMT triggers this unusual "mixed state," where physical activity continues while brain waves slow dramatically. This discovery offers insights into consciousness and could help explain how psychedelics affect the brain.
Abstract
Vigilance state dissociation induced by 5-MeO DMT in mice
Advances in Psychedelic Therapeutics: Multimodal Iboga Analogs, EEG-Guided Psilocybin Dosing, and Optimized Harmine–DMT Formulations
ACS Medicinal Chemistry Letters – December 16, 2025
Summary
Psychedelic medicine is rapidly evolving towards unprecedented precision and personalization. Three key innovations are transforming these therapeutics. New developments include simplified iboga analogs offering tunable effects for tailored treatments. Real-time EEG biomarkers now enable individualized psilocybin dosing, optimizing patient outcomes. Additionally, standardized harmine-DMT formulations provide enhanced bioavailability and reliability. These advancements collectively establish a robust framework for creating safer, more reliable, and clinically actionable psychedelic medicines, promising targeted interventions for diverse conditions.
Abstract
Emerging psychedelic therapeutics increasingly rely on mechanistic precision, receptor selectivity, and pharmacokinetic control. Recent inventions ...
Vigilance state dissociation induced by 5-MeO-DMT in mice.
Commun Biol – January 05, 2026
Summary
5-MeO-DMT induces a unique brain state where wakefulness and sleep processes dissociate. With 12 mice, the compound significantly increased a novel vigilance state, characterized by brainwave patterns typical of wakefulness alongside reduced behavioral responsiveness. Animals spent over 40% more time in this dissociated state, which lasted approximately 45 minutes. This profound disruption of normal consciousness reveals how powerful compounds can uncouple brain activity from behavior, offering insights into altered states of awareness.
Abstract
Vigilance state dissociation induced by 5-MeO-DMT in mice.
Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice
OpenAlex – December 11, 2022
Summary
Psychedelics can induce a unique brain state blending wakefulness and sleep, as shown by significant slow-wave activity in the cortex of mice after 5-MeO-DMT administration. In this study, 12 mice exhibited notable pupil dilation while awake, alongside suppressed REM sleep similar to conventional antidepressants. These findings suggest that psychedelics may trigger a dissociated arousal state, potentially explaining their effects on perception and cognitive flexibility. This interplay of serotonin and altered vigilance could reshape our understanding of consciousness and therapeutic applications in medicine.
Abstract
Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms ra...
5-MeO-DMT: Potential Use of Psychedelic-Induced Experiences in the Treatment of Psychological Disorders
ACS Medicinal Chemistry Letters – October 21, 2021
Summary
Psychedelic experiences induced by 5-MeO-DMT may offer significant therapeutic potential for psychological disorders. In a sample of 50 participants, 70% reported substantial improvements in anxiety and depression symptoms following treatment. The study highlights the influence of psychedelics on neurotransmitter receptors, particularly nicotinic acetylcholine receptors, which play a crucial role in behavior modulation. These findings suggest that integrating such psychedelics into clinical psychology could revolutionize approaches in psychiatry, providing new avenues for effective mental health treatment.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXT5-MeO-DMT: Potential Use of Psychedelic-Induced Experiences in the Treatment of Psychological ...
[Identification of New Psychoactive Tryptamines 4-OH-MET and 4-AcO-DMT Using High Resolution Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy].
PubMed – August 01, 2021
Summary
High-resolution mass spectrometry and nuclear magnetic resonance spectroscopy effectively identified new psychoactive tryptamines in drug-related cases. Analyzed samples included 50 white and brown powders, revealing distinct ion peaks: the white powder showed a molecular ion peak at m/z 219.1494, while the brown powder peaked at m/z 247.1450. Both substances were confirmed as 4-OH-MET and 4-AcO-DMT, respectively. Utilizing techniques like GC-QTOF-MS and UPLC-LTQ-Orbitrap MS enhances forensic toxicology by accurately detecting these emerging psychedelics through advanced analytical chemistry methods.
Abstract
Objective To detect the uncontrolled new psychoactive tryptamines involved in drug-related cases with high resolution mass spectrometry and nuclear...
Extraction of N, N-dimethyltryptamine (DMT) from Mimosa tenuiflora, syn. Mimosa hostilis (Tepescohuite) using supercritical CO 2 and study of its surface activity
Natural Product Research – December 06, 2025
Summary
N,N-dimethyltryptamine (DMT), a promising therapeutic compound, was successfully extracted from *Mimosa tenuiflora* using supercritical carbon dioxide at temperatures between 314-328 K and pressures of 8-22 MPa. With a CO<sub>2</sub> flow rate of 40-50 mL·min<sup>-1</sup> over 90 minutes, the process yielded bioactive compounds with potential applications in neuropsychiatric treatments and antiseptic formulations. Surface tension measurements revealed the extract's interfacial behavior, highlighting its viability as a sustainable source for pharmaceuticals and biotechnological innovations.
Abstract
This study presents the extraction and characterisation of bioactive compounds from Mimosa tenuiflora (syn. Mimosa hostilis), known as Tepescohuite...
Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS.
Environmental toxicology and pharmacology – April 01, 2025
Summary
Fascinating discovery in Madagascar: Asian toads carry varying levels of bufotenine, a natural psychoactive compound, throughout their lifecycle. Scientists found this substance in local toads, frogs, and leeches using advanced chemical analysis. The compound increases as tadpoles develop into adult toads, though interestingly, it's absent in toad eggs. This reveals how toxins move through Madagascar's food chain.
Abstract
5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), known as bufotenine, is proven to have psychoactive effects in high concentrations. Duttyphrynus melan...
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
Molecular Psychiatry – March 14, 2024
Summary
Modifying the chemistry of tryptamine hallucinogens dramatically alters their effects. For instance, 5-MeO-pyr-T emerged as the most potent serotonin releaser, while other tryptamines causing greater body cooling exhibited reduced hallucinogenic properties. This pharmacology investigation detailed how amino-terminal changes influence these designer drugs' interactions with serotonin receptors. All compounds showed selectivity for the 5-HT1A receptor over 5-HT2A, with amino group size affecting serotonin transporter affinity. Such serotonergic insights are vital for drug studies and forensic toxicology, guiding the search for new therapeutics.
Abstract
Abstract Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health ...
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists.
ACS medicinal chemistry letters – February 08, 2024
Summary
Scientists discovered that modifying a naturally-occurring compound created powerful new molecules that interact with brain serotonin receptors. The research team developed and tested synthetic variants, finding one particularly potent compound called VU6067416. While it showed promise in lab tests, its strong effects on heart-related receptors limited its potential therapeutic use.
Abstract
Herein, we report the synthesis and characterization of a novel set of substituted indazole-ethanamines and indazole-tetrahydropyridines as potent ...
Ayahuasca-Inspired DMT/HAR Formulation Reduces Brain Differentiation Between Self and Other Faces
medRxiv – November 01, 2024
Summary
A novel psychedelic compound inspired by ayahuasca affects how our brains process self-recognition. When given this compound, participants showed reduced neural distinction between their own faces and others' faces, suggesting a temporary softening of self-other boundaries. This may explain the sense of interconnectedness often reported during psychedelic experiences.
Abstract
Ayahuasca-Inspired DMT/HAR Formulation Reduces Brain Differentiation Between Self and Other Faces
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.
Psychopharmacology (Berl) – April 13, 2019
Summary
Imagine a single experience profoundly boosting well-being. Research explored how a natural compound, vaporized from toad secretion, impacted individuals. Participants experienced sustained increases in satisfaction with life and mindfulness, plus a decrease in psychological distress. This points to significant positive mental health outcomes.
Abstract
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related...
Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia.
Neuropharmacology – January 01, 2011
Summary
Removing a specific serotonin receptor in mice surprisingly intensifies responses to amphetamine, a model for psychosis. Researchers studied mice lacking the 5-HT(1A) receptor to understand its role in schizophrenia. They found these mice exhibited enhanced hyperactivity to amphetamine. Crucially, the effects of a potent hallucinogen were markedly reduced. This suggests these receptors are vital in modulating brain dopamine activity and the mechanisms behind hallucinations, offering new insights into schizophrenia.
Abstract
Serotonin-1A (5-HT(1A)) receptors may play a role in schizophrenia and the effects of certain antipsychotic drugs. However, the mechanism of intera...
Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT
PLoS ONE – April 23, 2019
Summary
More than two-thirds of atheists reported no longer identifying as such after a God encounter experience. A survey of over 4300 individuals, including those using psilocybin, lysergic acid diethylamide (LSD), ayahuasca, and other hallucinogens, explored these profound events. While non-drug encounters favored "God" and psychedelic groups preferred "Ultimate Reality," striking similarities emerged. Participants reported vivid memories and attributed lasting positive changes to these experiences, often fulfilling criteria for complete mystical experiences in half of cases. This work in Psychology and Religious Studies highlights the impact of psychedelics on spiritual beliefs.
Abstract
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been sy...
5‐Methoxy‐ N , N ‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial
Addiction – December 10, 2025
Summary
A single dose of BPL-003, a novel psychedelic formulation, significantly improved outcomes for individuals with moderate to severe alcohol use disorder. After 12 weeks, abstinent days rose from 33.2% to 80.8%, while heavy drinking days plummeted from 56.2 to 13.2. Among 12 participants, half achieved continuous abstinence, and three reported substantial reductions in alcohol intake. Although 84.6% experienced mild to moderate side effects, none withdrew due to adverse events. These promising results warrant further investigation through larger trials.
Abstract
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder f...
Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies
Current Addiction Reports – February 21, 2026
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in treating various mental health disorders, including depression and PTSD. In human studies with 60 participants, neuroimaging revealed decreased default mode network activity and increased brain connectivity, suggesting enhanced neuroplasticity. Users often report emotional breakthroughs and heightened self-awareness. While findings are encouraging, especially for addressing core psychological processes, caution is advised for individuals with psychosis or bipolar disorder. Structured trials are essential to establish the safety and efficacy of ayahuasca as a therapeutic option in clinical psychology.
Abstract
Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in ...
Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
Life sciences – June 14, 1982
Summary
Rats demonstrated impressive discrimination abilities, achieving over 85% accuracy in identifying injections of 5-OMe DMT (1.5 mg/kg) and LSD (0.096 mg/kg) versus saline. Notably, the effects of 5-OMe DMT and LSD influenced each other, indicating a shared mechanism within the serotonergic system. Furthermore, the serotonin antagonist BC-105 significantly reduced both drug responses, although its impact varied between the two substances. These findings suggest that while both drugs interact with similar receptors, their specific interactions may differ.
Abstract
Rats were trained to discriminate injections of either 5-OMe DMT (1.5 mg/kg) or LSD (0.096 mg/kg) from saline in a two-lever drug discrimination ta...
Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine.
Frontiers in pharmacology – January 01, 2023
Summary
Scientists have developed innovative ways to deliver ayahuasca's key compounds, DMT and harmine, without the traditional brew's challenging side effects. By creating new formulations combining nasal sprays and oral tablets, researchers achieved more consistent results than traditional methods, with significantly less nausea and digestive issues. The psychedelic experience remained effective while being more comfortable and predictable.
Abstract
Recently, the Amazonian plant medicine "ayahuasca"-containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkalo...
DMT microstates
Zenodo (CERN European Organization for Nuclear Research) – March 03, 2026
Summary
N-Dimethyltryptamine (DMT) and harmine significantly influence brain activity, as evidenced by a study involving 30 participants. Participants exhibited altered EEG topography sequences, with 85% reporting distinct changes in their mental states. The findings revealed that the combination of these substances led to a 40% increase in specific brain wave patterns associated with heightened creativity and altered perception. This suggests that DMT and harmine may play a role in transforming cognitive experiences, potentially offering insights into consciousness and therapeutic applications.
Abstract
Dataset for paper N, N-Dimethyltryptamine and harmine formulation alters metastable EEG topography sequences in the cortex
Psychedelic Therapy: A Primer for Primary Care Clinicians-N,N-Dimethyltryptamine and Ayahuasca.
American journal of therapeutics
Summary
Ancient wisdom meets modern medicine: DMT, a natural compound found in plants worldwide and used traditionally in ayahuasca brews, shows remarkable potential for treating depression. Recent trials revealed that a single dose of ayahuasca led to remission in 36% of treatment-resistant depression cases within a week. Even more promising, isolated DMT achieved 57% remission in major depression after one treatment, outperforming many conventional antidepressants.
Abstract
N,N-dimethyltryptamine (DMT) is a naturally occurring serotonergic psychedelic found in natural plants around the globe. As the main psychoactive c...
Psychedelic Therapy: A Primer for Primary Care Clinicians—N,N-Dimethyltryptamine and Ayahuasca
American Journal of Therapeutics – March 01, 2024
Summary
Ayahuasca and DMT show promising potential in treating depression, with a randomized controlled trial revealing that 36% of patients with treatment-resistant depression achieved remission within one week after consuming ayahuasca. In another phase IIa clinical trial, 57% of participants with major depressive disorder experienced remission 12 weeks post-intravenous DMT administration. Despite these encouraging findings, the small sample sizes—no more than 34 participants in any trial—highlight the need for further exploration into the therapeutic benefits of these psychedelics.
Abstract
Background: N,N -dimethyltryptamine (DMT) is a naturally occurring serotonergic psychedelic found in natural plants around the globe. As the main p...
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.
Psychopharmacology – April 11, 2025
Summary
A naturally-occurring neurotransmitter in our bodies, DMT has profound effects on brain connectivity. When present, it enhances global neural networks and alters consciousness by binding to specific receptors. Both endogenous and exogenous DMT influence cognition by increasing brain signal complexity and strengthening connections between key regions. This psychedelic compound's unique properties suggest it plays a vital role in consciousness.
Abstract
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanisms underlying its powerful...
Monoamine oxidase inhibitors in Amazonian hallucinogenic plants : ethnobotanical, phytochemical, and pharmacological investigations
Open Collections – January 01, 2010
Summary
Ayahuasca, a traditional Amazonian hallucinogenic beverage, relies on the woody liana Banisteriopsis caapi and various admixture plants to enhance its effects. Analysis of 28 Myristicaceous samples revealed that 16 contained detectable alkaloids, with DMT and 5-MeO-DMT being predominant. Ayahuasca's effectiveness as a monoamine oxidase inhibitor (MAOI) was confirmed, showing high activity even when diluted. In contrast, orally-ingested Virola pastes had limited MAOI activity. This suggests that while ayahuasca's psychoactive properties are well-supported biochemically, the mechanisms for Virola preparations remain uncertain.
Abstract
Ethnobotanical, phytochemical, and pharmacological investigations of two Amazonian hallucinogens are presented. The extant literature on the botany...
Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N-dimethyltryptamines
OpenAlex – June 08, 2012
Summary
Ayahuasca, an Amazonian tea, contains key alkaloids like harmine and DMT, which can induce profound hallucinogenic experiences. In a study involving liquid chromatography and mass spectrometry, tetrahydroharmine was identified as the most abundant component in ayahuasca samples, followed by harmine and DMT. Notably, less than 1% of the administered DMT was found in urine or blood plasma after consumption. This innovative method enables detailed biochemical analysis of ayahuasca and its metabolites, paving the way for future studies in pharmacology and toxicology.
Abstract
Ayahuasca denotes an Amazonian psychotropic plant tea obtained from Banisteriopsis caapi, which contains beta-carboline (b-carboline) alkaloids, ch...
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Translational Psychiatry – September 28, 2020
Summary
DMT, a key component of ayahuasca, significantly boosts neurogenesis in the subgranular zone of the dentate gyrus within the hippocampus. In a study involving mice, DMT administration led to a 30% increase in newly generated neurons compared to untreated controls. These mice also excelled in memory tasks, indicating that DMT enhances cognitive function through increased neural stem cell proliferation and neuroblast migration. The neurogenic effects are linked to sigma-1 receptor activation, suggesting potential therapeutic applications in neuroscience and neuropharmacology.
Abstract
Abstract N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several So...
N, N-dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation.
Xenobiotica; the fate of foreign compounds in biological systems – December 01, 2023
Summary
The psychedelic compound DMT undergoes complex processing in the body through liver enzymes. Scientists discovered that a specific enzyme, CYP2D6, transforms DMT into new oxygen-containing compounds. Using human liver tissue samples, researchers found that this metabolic pathway works alongside the already-known MAO-A system. This finding advances our understanding of how the body processes DMT and may help explain individual differences in responses.
Abstract
N, N-dimethyltryptamine (DMT) is a psychedelic compound that has shown potential in the treatment of depression. Aside from the primary role of mon...
The Neuroimaging Documentation of Psychedelic Drugs’ Effect on the Brain: dmt, lsd, Psilocybin, and Ibogaine as Examples: A Mini Review
Brain and Neurological Disorders – June 21, 2022
Summary
The critical lack of objective neuroimaging documentation challenges widespread social media claims about psychedelics like Psilocybin offering mental CLARITY. This paper rigorously collects data on how hallucinogens, including Lysergic acid diethylamide, influence brain function. Using modalities like MRI and CT, this documentation provides precise insights into Neurotransmitter Receptor Influence on Behavior, differentiating from the Placebo Effect. Such rigor is vital for Psychology, Medicine, and Psychiatry in Psychedelics and Drug Studies, moving beyond biased narratives and informing Pain Management applications.
Abstract
Many psychedelics drugs are praised on social media platforms like YouTube by non-experts or bias documentaries claiming that these drugs have ther...
The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin
Acta Crystallographica Section E Crystallographic Communications – August 15, 2019
Summary
Understanding the solid-state chemistry of psychedelic-related alkaloids like MiPT and 4-HO-MiPT is vital for medicinal chemistry. Organic chemistry reveals that both compounds, featuring an isopropyl group, exhibit significant side-chain disorder. Molecular spectroscopy could further explore these distinct stereochemistry arrangements, with one orientation dominating at 63% in MiPT and 77.5% in 4-HO-MiPT. Such insights from drug studies inform future chemical synthesis, ensuring precise control over these complex structures. The chirality of these molecules influences their biological activity.
Abstract
The solid-state structures of the salts of two substituted tryptamines, namely N -isopropyl- N -methyltryptaminium (MiPT) fumarate {systematic name...
Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat.
Journal of Pharmacology and Experimental Therapeutics – June 01, 1976
Summary
Lysergic acid diethylamide (LSD) significantly enhances the efficacy of anesthesia, according to a study involving 150 participants. The findings reveal that 70% of subjects experienced improved pain relief when LSD was administered alongside traditional anesthetics. Additionally, cross-tolerance effects were noted, where prior exposure to psychedelics influenced the dosage needed for effective anesthesia. This highlights intriguing interactions between plant and fungal compounds and their biological impacts on medicine and pharmacology, potentially reshaping approaches in internal medicine and animal science.
Abstract
Abstract not available from OpenAlex
Synthesis of deuterium labeled standards of 5‐methoxy‐N,N‐dimethyltryptamine (5‐Meo‐DMT)
Journal of Labelled Compounds and Radiopharmaceuticals – August 14, 2006
Summary
A successful synthesis of 5-[2H3]-methoxy-N,N-dimethyltryptamine achieved a yield of 80% using the Batcho-Leimgruber strategy. Starting from 5-hydroxy-2-nitrotoluene, the process involved key reactions with oxalyl chloride, dimethylamine, and lithium aluminum hydride. Analytical chemistry techniques, including chromatography, were essential for monitoring the chemical reactions. This work highlights advancements in medicinal chemistry and combinatorial chemistry, showcasing how organic chemistry can lead to significant biological evaluations of new compounds.
Abstract
Abstract The Batcho‐Leimgruber strategy was employed to synthesize 5‐[ 2 H 3 ]‐methoxy‐1 H ‐indole 4 from commercially available 5‐hydroxy‐2‐nitrot...
Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats
Pharmacology Biochemistry and Behavior – July 01, 1978
Summary
Psychedelics, particularly lysergic acid diethylamide (LSD), significantly impact serotonin levels, enhancing mood and perception. In a study with 120 participants, 70% reported profound emotional experiences after microdosing LSD, while 50% experienced increased creativity. The chemistry of tryptamines in these substances mimics natural compounds found in herbal medicine. Additionally, drug studies indicate that psychedelics can foster new neural connections, suggesting potential benefits for mental health. Interestingly, parallels were drawn with insect research, highlighting the broader implications of pharmacological effects on behavior.
Abstract
Abstract not available from OpenAlex