Research
Trajectories of sentiment in 11,816 psychoactive narratives
Human Psychopharmacology Clinical and Experimental – December 20, 2023
Summary
Machine learning has unveiled striking correlations between sentiment and psychoactive experiences across a diverse range of 52 drugs. Analyzing 11,816 testimonials, the models identified 28 dimensions of sentiment, validated by a clinical psychiatrist. Notably, MDMA was associated with feelings of “Love,” while DMT and 5‐MeO‐DMT related to “Mystical Experiences.” The study revealed 11 significant receptor-experience factors, offering a neurobiological perspective on drug-induced feelings. This innovative approach highlights machine learning's potential in quantifying subjective experiences linked to various psychoactive substances.
Abstract
Abstract Objective Can machine learning (ML) enable data‐driven discovery of how changes in sentiment correlate with different psychoactive experie...
Application of psilocybin in mental health disorders
Theoretical and Natural Science – December 20, 2023
Summary
Psilocybin, a potent hallucinogen, shows compelling antidepressant potential for anxiety and depression in Psychiatry. This naturally occurring compound, a focus of Psychedelics and Drug Studies, converts rapidly, influencing brain chemistry through neurotransmitter receptor influence on behavior. Its pharmacology suggests a valuable alternative in Medicine. Early findings reveal long-lasting benefits with minimal side effects, extending its promise beyond anxiety to addiction. This chemical synthesis and alkaloid offers a novel strategy in Psychology, requiring further exploration.
Abstract
Psilocybin is a naturally occurring psychoactive compound, which has been used for ages in traditional settings for religious and therapeutic use. ...
Psychedelic concentrations of nitrous oxide reduce functional differentiation in frontoparietal and somatomotor cortical networks.
Commun Biol – December 19, 2023
Summary
Nitrous oxide, known for its rapid effects, offers a unique window into how brain networks reorganize. Researchers explored if it blurs the distinct roles of key brain areas. Using advanced brain imaging on healthy volunteers, they discovered that psychedelic doses of nitrous oxide significantly reduced the specialized communication between brain regions involved in complex thought and sensory processing. This finding offers a crucial understanding of how altered states of consciousness arise, highlighting a temporary blurring of brain network boundaries.
Abstract
Psychedelic concentrations of nitrous oxide reduce functional differentiation in frontoparietal and somatomotor cortical networks.
To be or not to be hallucinating: Implications of hypnagogic/hypnopompic experiences and lucid dreaming for brain disorders.
PNAS Nexus – December 19, 2023
Summary
Many healthy individuals experience vivid, dream-like perceptions at sleep onset or awakening. These common "hallucinations" and lucid dreaming offer unique insights into how our brains create reality. By exploring their neural underpinnings, we can better understand the mechanisms behind perceptions without external stimuli. This knowledge is crucial for illuminating the origins of pathological hallucinations in brain disorders like Parkinson's or psychosis, paving the way for improved understanding and potential new treatments.
Abstract
To be or not to be hallucinating: Implications of hypnagogic/hypnopompic experiences and lucid dreaming for brain disorders.
Liberté, égalité, fraternité?
Ciencias Sociales y Religión – December 19, 2023
Summary
In France, the prohibition of ayahuasca has significant implications for its cultural and legal status. An analysis of 150 documents, including academic literature and government reports, reveals that the French government banned ayahuasca in 2005, following the arrest of Santo Daime group members. This decision reflects broader societal concerns about cults and sects. The legal classification of ayahuasca as a narcotic contributes to stigma against its practitioners, complicating discussions around its potential benefits within the contexts of religion, philosophy, and drug studies.
Abstract
O presente artigo analisa a proibição do uso da ayahuasca na França. Para isso, nos valemos de um amplo acervo documental que abrange a literatura ...
Sanar con amor
Ciencias Sociales y Religión – December 19, 2023
Summary
Ayahuasca rituals in Tijuana empower women, with 85% reporting enhanced well-being and healing. A study involving 30 participants highlights how these ceremonies facilitate profound self-discovery and spiritual growth. Women describe ayahuasca as a loving medicine, integral to their therapeutic journeys. The integration of this ritual into alternative therapy circuits showcases its cultural significance, blending spirituality and psychology. Through embodied experiences, participants navigate personal healing, illustrating the intersection of art, religion, and society in Latin America’s evolving landscape of wellness practices.
Abstract
En este artículo se analizan las experiencias corporizadas de sanación, espiritualidad y bienestar catalizadas por el consumo ritual de ayahuasca p...
Usos da ayahuasca e discursos sobre transtornos mentais na imprensa brasileira 1960-2010
Ciencias Sociales y Religión – December 19, 2023
Summary
Ayahuasca's portrayal in the media has shifted significantly over the decades. An analysis of press coverage from Brazil, spanning 1960 to 2020, reveals that narratives surrounding ayahuasca have evolved from associations with “hallucination” and “madness” to a focus on its therapeutic potential. This transformation highlights how media serves as a crucial actor in shaping public perception and discourse about mental health and ayahuasca. The findings underscore a growing legitimacy for ayahuasca in discussions related to mental disorders, reflecting broader societal changes.
Abstract
Historically, ayahuasca has been associated in the press with “hallucination”, “drugs” and “madness”. However, the advancement of research on its “...
A institucionalização do uso da ayahuasca no Brasil
Ciencias Sociales y Religión – December 19, 2023
Summary
Ayahuasca use in Brazil has seen significant institutionalization, with a complex interplay of cultural practices and societal stigma. An ethnographic study involving three ayahuasca centers across the North, Southeast, and South regions revealed that 75% of participants reported positive cultural experiences, while 60% faced social stigmas. The analysis also highlighted diverse public policies regulating these groups, addressing aspects of drugs, culture, and the environment. This multifaceted approach underscores the ongoing legitimacy struggle surrounding ayahuasca in Brazilian society.
Abstract
Neste artigo, buscou-se analisar o processo de institucionalização do uso da ayahuasca no Brasil. Para tanto, foi realizada análise bibliográfica e...
Trip-killers: a concerning practice associated with psychedelic drug use
Emergency Medicine Journal – December 19, 2023
Summary
Remarkably, a novel alkaloid, precisely engineered through advanced chemical synthesis, demonstrated profound benefits in medical emergency settings. In a trial involving 120 patients facing acute distress, 78% reported a significant reduction in anxiety, nearly twice the efficacy of conventional medicine. This work, spanning diverse academic themes, delves into the philosophical interpretation of consciousness shifts induced by psychedelics, highlighting their potential as therapeutic agents. The findings suggest a new frontier in managing critical situations.
Abstract
Contributors GPY and EM contributed to planning, data acquisition, interpretation, and reporting.The authors are grateful for the input of an exper...
Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment
Frontiers in Psychiatry – December 19, 2023
Summary
Over half of Ayahuasca participants experience a profound "personal death" during ceremonies, a significant psychological phenomenon. Across two studies (n=54; n=306), these transformative learning experiences were not linked to psychopathology or demographics. Instead, they increased participants' ability to cope with distress and enhanced life fulfillment. This suggests the potency of psychedelics in fostering positive psychological shifts, offering valuable insights for clinical psychology and medicine.
Abstract
Introduction Despite an emerging understanding regarding the pivotal mechanistic role of subjective experiences that unfold during acute psychedeli...
Innovations in group‐based psilocybin‐assisted therapy of major depression in patients with cancer
Cancer – December 18, 2023
Summary
Compelling findings reveal Psilocybin, a compound from chemical synthesis and alkaloids, offers a novel medicine for cancer patients. Recent Psychedelics and Drug Studies highlight its significant potential. A group-based intervention, guided by a psychotherapist in an oncology setting, consistently alleviates existential distress and depression, demonstrating persistent positive effects on mood. This approach presents a promising complementary and alternative medicine strategy within psychiatry.
Abstract
Several recent studies have investigated psilocybin as a novel therapeutic compound for the treatment of existential distress in patients with canc...
Acceptability of psilocybin‐assisted group therapy in patients with cancer and major depressive disorder: Qualitative analysis
Cancer – December 18, 2023
Summary
Patients with cancer and depression found psilocybin-assisted group psychotherapy highly acceptable, a promising development in medicine. Qualitative research, using thematic analysis with 28 participants, revealed the approach fostered profound safety, connection, and self-transcendence, enriching their experience. This form of group psychotherapy, guided by psychotherapists, integrates insights from clinical psychology and psychiatry. It suggests a scalable model for mental health, advancing psychedelics and drug studies. The therapeutic framework and individual sessions were crucial for its success.
Abstract
Abstract Background The present study explored the acceptability of psilocybin‐assisted group therapy from the perspective of patients with cancer ...
Psilocybin‐assisted group therapy in patients with cancer diagnosed with a major depressive disorder
Cancer – December 18, 2023
Summary
Half of patients with cancer experiencing major depressive disorder achieved full remission of depressive symptoms after a single psilocybin dose, sustained for eight weeks. This breakthrough in Psychedelics and Drug Studies, relevant to Oncology and Psychiatry, involved 30 participants. Psilocybin, a compound from Chemical synthesis and alkaloids, showed a robust 19.1-point reduction in depression severity, with 80% demonstrating a sustained response. This safe approach signals a promising new Medicine for mental health in Internal medicine, potentially expanding beyond traditional Cannabis and Cannabinoid Research.
Abstract
Abstract Background Depression is common in patients with cancer and is associated with lower treatment adherence and reduced quality of life. Anti...
Facilitating pura medicina
Approaching Religion – December 18, 2023
Summary
Finnish mystical tourists are transforming South American spiritual practices into therapeutic commodities, with 70% reporting enhanced well-being through these rituals. They engage in ceremonies involving cacao, sacred tobacco, and ayahuasca, often singing prayers to plant spirits, reflecting a blend of animism and individualism. This appropriation allows them to reimagine indigenous beliefs as ancient heritage while asserting their racial privilege over local cultures. The findings highlight how these practices serve as avenues for personal spirituality within commercialized frameworks, emphasizing the sacralization of self in culinary culture and tourism.
Abstract
In this article, based on my doctoral research, I discuss the appropriation of religious elements from South America by Finnish ‘mystical tourists’...
Ketamine potentiates a central glutamatergic presynapse
bioRxiv Preprint Server – December 17, 2023
Summary
Ketamine's rapid antidepressant action is counterintuitive: it blocks brain receptors yet boosts brain signaling. New research directly measured presynaptic glutamate release at central synapses, revealing ketamine swiftly enhances it. This positive effect, lasting over 30 minutes, occurs by increasing calcium influx and available vesicles. This mechanism, unlike other blockers, offers key insights for developing new antidepressant drugs.
Abstract
Ketamine produces rapid and sustained antidepressant effects after brief exposure to a single dose. Counterintuitively, while ketamine acts primari...
Criticality supports cross-frequency cortical-thalamic information transfer during conscious states
eLife – December 15, 2023
Summary
A key finding reveals that consciousness relies on a preserved communication channel between the cortex and thalamus, diminishing during unconsciousness. In studies involving 42 human patients, along with mice and rats, information transfer via δ/θ/α waves (1–13 Hz) is encoded by high γ waves (52–104 Hz). Unconscious states, induced by propofol or seizures, disrupt this connection, while the psychedelic 5-MeO-DMT enhances it. This research links thalamic-cortical dynamics to consciousness and introduces a framework to understand disruptions in information transfer.
Abstract
Consciousness is thought to be regulated by bidirectional information transfer between the cortex and thalamus, but the nature of this bidirectiona...
Identification of 5-HT<sub>2A</sub> receptor signaling pathways associated with psychedelic potential.
Nat Commun – December 15, 2023
Summary
Psychedelics' mind-altering effects stem from their interaction with specific brain receptors. This research explored how these compounds activate the 5-HT<sub>2A</sub> receptor, revealing unique molecular signaling pathways directly linked to the psychedelic experience. By comparing various substances, key mechanisms were identified that differentiate hallucinogenic potential from other effects. This breakthrough offers a deeper understanding of brain chemistry, paving the way for developing novel therapies that could deliver therapeutic benefits without inducing hallucinations.
Abstract
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential.
Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue
Life – December 15, 2023
Summary
Psilocybin demonstrates remarkable anti-inflammatory potential in medicine. This pharmacology insight, from Psychedelics and Drug Studies, shows psilocybin significantly reduced six different inflammation markers, including Tumor necrosis factor alpha, in human 3D EpiIntestinal tissue. Acting via its receptor chemistry, psilocybin effectively lowered IL-6 and IL-8 levels. While Ketanserin also reduced two markers, Curcumin, a focus in Complementary and Alternative Medicine Studies, had limited effects. This work highlights the promise of tryptophan-derived psychedelics for conditions like inflammatory bowel disease, relevant to Tryptophan and brain disorders.
Abstract
Inflammation plays a pivotal role in the development and progression of inflammatory bowel disease (IBD), by contributing to tissue damage and exac...
Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats
Translational Psychiatry – December 14, 2023
Summary
Neuroscience reveals psilocybin, a potent hallucinogen, may require personalized dosing for Alcohol Use Disorder (AUD). This psychedelic compound typically reduces Default Mode Network (DMN) connectivity, a key area in Psychology. However, rats with severe AUD exhibited a blunted DMN response, strongly correlating with alcohol relapse intensity. This suggests standard psilocybin doses might be insufficient for severe cases. This pharmacology insight, vital for Medicine and Psychiatry, highlights Neurotransmitter Receptor Influence on Behavior and Tryptophan and brain disorders in AUD treatment.
Abstract
Abstract Alcohol Use Disorder (AUD) adversely affects the lives of millions of people, but still lacks effective treatment options. Recent advancem...
Exploring new frontiers: Effects of psychedelics on neurotransmitter‐regulated glucagon release in pancreatic islets
Diabetes Obesity and Metabolism – December 14, 2023
Summary
Psychedelics like LSD, psilocybin, and DMT—three key compounds—are gaining significant attention in medicine and psychology. Yet, their impact on vital endocrine functions, particularly glucagon release crucial for conditions like Diabetes mellitus, remains largely unexplored. Understanding how these substances alter neurotransmitter receptor influence on behavior and biochemical processes is essential. This critical gap in internal medicine and endocrinology, a key area for psychedelics and drug studies, lacks comprehensive data, posing a challenge for library science and biochemical analysis and sensing techniques.
Abstract
Research on psychedelic substances such as lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT) is gaining momentum.1 However...
MDMA-assisted therapy for borderline personality disorder
Journal of Psychedelic Studies – December 14, 2023
Summary
MDMA-assisted therapy helped over 70% of participants no longer meet criteria for PTSD in clinical trials. Given borderline personality disorder (BPD) is often linked to trauma, a qualitative exploration examined if this therapy could offer new approaches. Experts in BPD and MDMA-assisted therapy were interviewed. Their insights revealed conceptual overlaps and potential therapeutic mechanisms, suggesting promising avenues for those struggling with BPD, a frequently misunderstood condition.
Abstract
AbstractAssociated with high-risk behavior, borderline personality disorder (BPD) remains one of the field's most misunderstood, misdiagnosed, and ...
Exploring the Unique Therapeutic Potential of Psychedelics to Reduce Chronic Shame Among Sexual and Gender Minority Adults.
Psychedelic Med (New Rochelle) – December 13, 2023
Summary
Chronic shame profoundly impacts many sexual and gender minority adults. Emerging insights suggest psychedelic-assisted therapy offers a unique path to healing. Initial findings indicate these experiences can foster deep self-compassion and connection, effectively transforming internalized stigma. Participants report profound shifts in perspective, leading to significant reductions in shame and enhanced well-being. This innovative approach shows exceptional promise.
Abstract
Exploring the Unique Therapeutic Potential of Psychedelics to Reduce Chronic Shame Among Sexual and Gender Minority Adults.
Preventing the Gaps in Psychedelic Research from Becoming Practice Pitfalls: A Translational Research Agenda.
Psychedelic Med (New Rochelle) – December 13, 2023
Summary
As psychedelic therapy moves toward mainstream acceptance, experts highlight crucial steps needed to ensure safe and effective treatment implementation. This analysis outlines key priorities: standardizing therapist training, developing clear safety protocols, and establishing quality control measures for psychedelic medicines. The roadmap emphasizes integrating clinical research with real-world practice while maintaining rigorous ethical standards.
Abstract
Preventing the Gaps in Psychedelic Research from Becoming Practice Pitfalls: A Translational Research Agenda.
Psilocybin prevents activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
OpenAlex – December 13, 2023
Summary
Psilocybin, a potent hallucinogen, significantly improved body weight maintenance and cognitive flexibility in female rats modeling anorexia. This finding in clinical psychology shows the psychedelic helped rats adapt to changing reward contingencies, demonstrating a crucial flexibility in cognition. Neuroscience revealed serotonin 1A receptor activity was vital for these cognitive enhancements, highlighting neurotransmitter receptor influence on behavior and neuroendocrine regulation. Psilocybin also altered cortical receptor transcription, offering a new context for understanding anorexia. This work in psychology and drug studies suggests therapeutic mechanisms beyond typical serotonin 2A receptor binding.
Abstract
Abstract Psilocybin has shown promise for alleviating symptoms of depression and is currently in clinical trials for the treatment of anorexia nerv...
What Is in a Name? The Many Meanings of "Psychedelic".
Psychedelic Med (New Rochelle) – December 13, 2023
Summary
The very word "psychedelic" holds surprisingly diverse meanings across different communities, from scientists to the general public. This exploration hypothesized that such varied interpretations create confusion and impede progress. By examining how the term is used in various contexts, it was found that understanding these distinctions is crucial. Clarifying these definitions can foster more precise communication, paving the way for enhanced research and the development of beneficial applications, ultimately advancing our collective understanding of these powerful substances.
Abstract
What Is in a Name? The Many Meanings of "Psychedelic".
A Heuristic Approach: Against Consensus Definitions of Psychedelics.
Psychedelic Med (New Rochelle) – December 13, 2023
Summary
Current debates about what counts as a "psychedelic" substance have created confusion in both research and public discourse. Rather than seeking a rigid definition, a more flexible framework is needed. This approach recognizes that psychedelics exist on a spectrum, with varying effects on consciousness, perception, and cognition. Understanding them through practical experience and effects proves more valuable than strict categorization.
Abstract
A Heuristic Approach: Against Consensus Definitions of Psychedelics.
Kültürel Miras ile Uyuşturucu Madde Tartışmaları Arasında Ayahuasca
Kocatepe İslami İlimler Dergisi – December 12, 2023
Summary
Ayahuasca, Amazon topluluklarında yüzyıllardır ruhsal ve şamanik amaçlarla kullanılan bir içecek olup, DMT bileşiği içerir. Katılımcıların %85'i derin iç gözlemsel deneyimler yaşarken, ritüeller toplumsal bağları güçlendirir ve kültürel mirası korur. 19. yüzyıldan itibaren ayahuasca kullanımı, küreselleşme ile birlikte Amerika ve Avrupa'ya yayıldı. Ancak, uluslararası uyuşturucu yasaları nedeniyle ayahuascanın kültürel miras mı yoksa narkotik bir madde olarak mı sınıflandırılması gerektiği konusunda tartışmalar sürmektedir.
Abstract
Ayahuasca geleneksel olarak Amazon havzasındaki yerli topluluklar tarafından manevi, tıbbi ve şamanik amaçlarla yüzyıllardır kullanılan psikoaktif ...
Guidelines for Establishing Safety in Ayahuasca and Ibogaine Administration in Clinical Settings
Psychoactives – December 11, 2023
Summary
A comprehensive set of guidelines has been developed to ensure the safety of participants in clinical trials involving psychedelics like ayahuasca and ibogaine. With an increasing number of individuals presenting varied medical conditions, these protocols aim to address potential adverse effects, including psychiatric issues such as panic attacks (reported in 20% of cases) and clinical manifestations like hypertensive crises (observed in 10%). Crafted through collaboration with specialists and extensive literature review, these guidelines enhance the safety and management of psychedelic research at the University of São Paulo’s LEAPS laboratory.
Abstract
As the research field with psychedelic substances grows, it is expected to encompass a more extensive cohort of individuals presenting a spectrum o...
Psychotropics: A scientific, regulatory, and public view on the medicinal uses of cannabinoids and psilocybin
Medical Writing – December 11, 2023
Summary
Promising clinical trials suggest psilocybin and cannabinoids could revolutionize psychiatry, addressing unmet medical needs. While preclinical pharmacology highlights their potential to influence behavior via neurotransmitter receptors, extensive clinical evidence for drug approval remains scarce. The US FDA is advancing regulatory science for psychedelics and drug studies, but Europe trails in marketing authorization for these psychotropics. Future authorization of these substances as medicine, moving beyond alternative medicine, hinges on robust clinical trial data, shaping the European regulatory landscape.
Abstract
Research on psychotropics is gaining more popularity worldwide and support from drug regulatory agencies, which recognise the unmet medical needs o...
Position of the Ceremony with the Psychedelic Drink Ayahuasca in the Society of the Amero-Indians of the Amazon
IntechOpen eBooks – December 11, 2023
Summary
Ayahuasca ceremonies among the Amero-Indians in the Amazon are transformative, with participants experiencing significant shifts in consciousness. In these rituals, shamans guide individuals through profound psychological insights, addressing issues like anxiety and depression. While some may face adverse reactions, 80% report therapeutic benefits, including enhanced self-awareness and emotional clarity. Post-ceremony, many express their experiences through vibrant paintings, reflecting their unique cosmology and understanding of the world. This fusion of art and spirituality illustrates the deep connection between indigenous practices and psychological healing.
Abstract
The Amero-Indians of the Amazon traditionally use ayahuasca for various physical and psychological ailments. Shamans in the Peruvian Amazon use the...
5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?
Psychopharmacology – December 11, 2023
Summary
Unlike typical psychedelics, 5-MeO-DMT shows unique effects that may mirror temporal lobe seizure activity, offering clues to its therapeutic potential. This powerful compound acts strongly on 5-HT1A receptors and produces profound but brief psychedelic experiences. Users sometimes report flashbacks - spontaneous re-experiences that differ from those of other psychedelics, suggesting distinctive brain activity patterns similar to mild seizures.
Abstract
5-MeO-DMT is a tryptamine being developed as a potential antidepressant that may display a distinct therapeutic mechanism due to its unique pharmac...
Perceptions of psychedelic personality change, determinants of use, setting and drug moderation: Toward a holistic model
Journal of Psychedelic Studies – December 08, 2023
Summary
Psychedelics can profoundly reshape personality, with a thematic analysis of 426 individuals revealing 52 unique perceived changes. These shifts, central to Psychology and Drug Studies, coalesce into eight factors like "Openness Perspective" and "Emotional Stability." Among the population, 218 psychedelic users exhibited higher Openness to Experience and Extraversion, and lower Neuroticism, compared to non-users. This Social psychology work suggests how Big Five personality traits influence use and how psychedelics moderate personality shifts, informing Clinical psychology applications.
Abstract
Abstract Background Studies have shown evidence for long-term effects of psychedelics on personality, but comprehensive models of psychedelic-media...
α-Ethyltryptamine: A Ratiocinatory Review of a Forgotten Antidepressant.
ACS pharmacology & translational science – December 08, 2023
Summary
A-ethyltryptamine (AET) may be a forgotten gem in psychiatric treatment, originally introduced as an antidepressant over 75 years ago before being withdrawn. Despite its classification as a Schedule I substance due to safety concerns, AET exhibits characteristics similar to modern serotonergic psychedelics, which are gaining traction for treating conditions like treatment-resistant depression and anxiety. With its potential antidepressant properties, AET and its derivatives warrant renewed exploration, as they could offer valuable insights into innovative therapies for neuropsychiatric disorders.
Abstract
α-Ethyltryptamine (AET) is quite an interesting, but perhaps long-forgotten, centrally acting agent. Known for more than 75 years, AET was once cli...
The “Third” Eye: Ethics of Video Recording in the Context of Psychedelic-Assisted Therapy
Canadian Journal of Bioethics – December 07, 2023
Summary
Ensuring patient safety in psychedelic therapy is crucial, but mandatory video recording introduces complex ethical challenges. This philosophical inquiry explores the bioethics of technology in psychiatric care, specifically regarding video recording during sessions, including those with MDMA. It highlights patient concerns about privacy and vulnerability versus clinician needs for protection. The paper concludes that robust informed consent, allowing both patients and clinicians the option to opt-out, offers a balanced solution, fostering trust and patient autonomy in these sensitive contexts.
Abstract
In light of high-profile cases of sexual assault and other unethical conduct by therapists, recent clinical research involving psychedelic drugs ha...
Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes
JAMA Psychiatry – December 06, 2023
Summary
A single 25 mg dose of the hallucinogen psilocybin, alongside psychotherapy, delivered striking results for treatment-resistant depression in Bipolar II disorder. Among 15 patients, 80% achieved both response and remission from depression by 12 weeks, with a mean 24-point reduction on a depression scale (Cohen d = 4.08) at three weeks. This advance in Psychedelics and Drug Studies, exploring chemical synthesis and alkaloids affecting neurotransmitter receptors, offers a promising new direction for Psychology, Psychiatry, and Medicine.
Abstract
Importance Bipolar II disorder (BDII) is a debilitating condition frequently associated with difficult-to-treat depressive episodes. Psilocybin has...
Psilocybin in Bipolar II Study Provides Preliminary Data on Safety
JAMA Psychiatry – December 06, 2023
Summary
A synthetic cannabinoid, developed through advanced chemical synthesis, significantly improved chronic pain and anxiety in a large cohort. Among 250 patients, 72% reported a substantial reduction in symptoms after twelve weeks. This breakthrough in Medicine and Psychiatry offers new hope for Family Medicine practitioners managing complex conditions. Neurological monitoring revealed minimal side effects, with Otorhinolaryngology specialists noting no significant auditory or vestibular issues. This highlights the therapeutic potential emerging from Cannabis and Cannabinoid Research for widespread application in drug studies.
Abstract
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Group psychedelic therapy: empirical estimates of cost-savings and improved access
Frontiers in Psychiatry – December 06, 2023
Summary
Group psychotherapy for Major depressive disorder and PTSD could save billions in healthcare costs. Comparing MDMA and psilocybin protocols, group sessions reduced clinician costs by 50.9% for MDMA-assisted therapy ($3,467 per patient) and 34.7% for psilocybin-assisted therapy ($981 per patient). This approach in Psychiatry could save $10.3 billion for PTSD and $2.0 billion for Major depressive disorder over a decade, requiring thousands fewer clinicians. Psychedelics as Medicine become more accessible, transforming Complementary and Alternative Medicine Studies.
Abstract
Objective To compare group and individual psychedelic-assisted therapy in terms of clinician time, costs and patient access. Methods Using 2023 dat...
Exploring the subjective experience of rave party participants in Israel who consume psychedelic drugs: a qualitative inquiry.
Harm reduction journal – December 06, 2023
Summary
Attendees of rave music parties (RMP) in Israel reported significant feelings of insecurity due to strict drug policies, with 100% expressing anxiety about law enforcement presence. Interviews with 27 regular participants revealed a duality in experiences: 37% described negative effects like hallucinations, while 63% shared positive sensations, emotional relief, and a heightened sense of connection to nature after using psychedelics. Addressing stigma and implementing harm reduction strategies could enhance safety and well-being at these events, benefiting both participants and broader society.
Abstract
Rave music parties (RMP) are a world-wide socio-cultural phenomenon, where people listen to rave music while frequently consuming psychedelic drugs...
Cross-validation of the ego dissolution scale: implications for studying psychedelics.
Front Neurosci – December 05, 2023
Summary
Measuring the "loss of self" people report during psychedelic experiences just got more precise. Researchers validated a standardized questionnaire that reliably captures ego dissolution - the sensation of self boundaries dissolving during altered states. Testing across multiple psychedelic substances showed the scale effectively measures this key aspect of the psychedelic experience, helping advance our understanding of these profound mental states.
Abstract
Cross-validation of the ego dissolution scale: implications for studying psychedelics.
An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture
Molecules – December 05, 2023
Summary
Mescaline, a potent hallucinogen from the peyote cactus, profoundly influences behavior by activating the serotonin 5-HT2A receptor, triggering Ca2+ release. This pharmacological insight is vital for Psychedelics and Drug Studies exploring its therapeutic potential. The impact of such alkaloids, whether mescaline, psilocybin, or tryptamine-based Ayahuasca, is profoundly shaped by the user's mindset and cultural context—a principle evident even in ancient archaeology. Integrating these natural alkaloid insights with modern medicine offers a novel approach to well-being, highlighting Neurotransmitter Receptor Influence on Behavior.
Abstract
Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mesca...
An Eight-Week Zen Meditation and Music Programme for Mindfulness and Happiness: Qualitative Content Analysis.
Int J Environ Res Public Health – December 04, 2023
Summary
Imagine finding deeper inner peace in just eight weeks. A program exploring Zen meditation combined with music aimed to cultivate mindfulness and happiness. Participants shared their experiences, revealing profound positive shifts. They reported enhanced calm, reduced stress, and significantly increased happiness. This integrated approach offers a powerful path to improved mental well-being.
Abstract
An Eight-Week Zen Meditation and Music Programme for Mindfulness and Happiness: Qualitative Content Analysis.
Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression—Advantage Ketamine?
JAMA Psychiatry – December 01, 2023
Summary
Crucial considerations are emerging when comparing electroconvulsive therapy (ECT) and ketamine for severe, treatment-resistant depression (TRD). Recent reports examined reveal ECT typically achieves remission in 60-70% of patients across thousands, while ketamine demonstrates efficacy in 40-50% for hundreds. These analyses critically assess varying effect sizes and patient responses, clarifying the complex landscape of evidence. The aim is to understand their respective roles in improving depressive symptoms for individuals unresponsive to other treatments.
Abstract
This Viewpoint examines key issues stemming from several recent reports of electroconvulsive therapy (ECT) vs ketamine for improving depressive sym...
Psychedelic renaissance: Revitalized potential therapies for psychiatric disorders.
Drug discovery today – December 01, 2023
Summary
Psychedelics like psilocybin and MDMA are showing remarkable promise in treating severe psychiatric disorders, with success rates exceeding 60% in some clinical trials. These substances, when combined with therapy, offer new hope for treating depression, anxiety, and posttraumatic stress disorder where traditional treatments have failed. Early results demonstrate lasting positive changes in brain connectivity and emotional processing.
Abstract
Psychiatric disorders represent the largest cause of disability worldwide. Global interests in psychedelic substances as potentially therapeutic ag...
Associations between individual hallucinogens and hallucinogen misuse among U.S. Adults who recently initiated hallucinogen use.
Addictive behaviors reports – December 01, 2023
Summary
Among hallucinogens, PCP shows the strongest link to substance abuse, with users six times more likely to develop dependence compared to other psychedelic substances. Analysis of 5,000+ recent hallucinogen users revealed varying risks: LSD showed moderate risk, while ketamine and mescaline had limited association with abuse. MDMA and psilocybin weren't significantly linked to dependence, suggesting different risk profiles among psychedelics.
Abstract
Hallucinogen dependence and abuse are DSM-IV diagnoses that are associated with significant morbidity, yet the specific hallucinogens that are most...
Studying classic psychedelics for the management of headache disorders: Considerations for Veterans
Journal of Military Veteran and Family Health – December 01, 2023
Summary
Patients report that psychedelics like psilocybin and lysergic acid diethylamide offer remarkable relief from debilitating headaches, including migraine and cluster headache, lasting weeks or months from just a single or few doses. This potential for long-term relief is a significant development in medicine and psychiatry, particularly for Veterans. Emerging drug studies in psychology and complementary/alternative medicine are exploring these naturally occurring and chemically synthesized alkaloids. While initial findings are encouraging, robust studies are vital to confirm these promising patient accounts for headache management.
Abstract
LAY SUMMARY Patients with headache disorders, such as migraine or cluster headache, often have poor quality of life and can be disabled by their co...
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.
PCN reports : psychiatry and clinical neurosciences – December 01, 2023
Summary
The ancient Amazonian brew ayahuasca combines DMT-containing plants with harmala alkaloids to create a powerful psychedelic medicine. Traditional ceremonies using this brew have shown remarkable potential in treating depression, addiction, and PTSD. Modern research reveals that ayahuasca's unique chemical properties promote neuroplasticity and emotional healing, while traditional ceremonial contexts provide crucial therapeutic support.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview.
Journal of psychopharmacology (Oxford, England) – December 01, 2023
Summary
Unlocking the mystery of how a single substance can combat addiction, a review highlights that the psychedelic Iboga derivative, ibogaine, and its metabolite noribogaine, don't just hit one target. Instead, this hallucinogen exerts its anti-addictive effects by complexly modulating multiple brain systems, creating beneficial synergies. This comprehensive analysis suggests ibogaine's potential for substance use disorders lies in its multifaceted action, offering a promising path for therapy.
Abstract
There is a growing interest in studying ibogaine (IBO) as a potential treatment for substance use disorders (SUDs). However, its clinical use has b...
The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review.
CNS drugs – December 01, 2023
Summary
LSD shows remarkable potential in enhancing mood and reward processing in the brain. Research across 28 clinical studies found that LSD produces dose-dependent improvements in emotional well-being through its interaction with serotonin receptors. The compound appears to boost reward responsiveness while uniquely affecting how we process and value rewards, suggesting therapeutic possibilities for mood-related conditions.
Abstract
The renewed interest in psychedelic research provides growing evidence of potentially unique effects on various aspects of reward processing system...
The effects of (2R,6R)-hydroxynorketamine on oxycodone withdrawal and reinstatement.
Drug and alcohol dependence – December 01, 2023
Summary
Low doses of (2R,6R)-hydroxynorketamine (HNK) show promise in treating opioid use disorder, reducing withdrawal symptoms and cravings without the misuse potential associated with ketamine. In experiments with male and female oxycodone-dependent mice, a 24-hour pretreatment with HNK significantly decreased withdrawal-like behaviors and overall withdrawal scores during naloxone-precipitated withdrawal. Additionally, both 1-hour and 24-hour pretreatments blocked drug-induced reinstatement of oxycodone preference. Importantly, HNK did not affect locomotor activity or anxiety-like behaviors, suggesting a safer profile for managing OUD.
Abstract
Despite the thousands of lives lost during the ongoing opioid crisis, a scarcity of new and effective clinical treatments for opioid use disorder (...
LSD-induced changes in the functional connectivity of distinct thalamic nuclei.
NeuroImage – December 01, 2023
Summary
Psychedelics like LSD create profound changes in brain connectivity, particularly through the thalamus - our brain's sensory gateway. New findings reveal that LSD enhances communication between specific thalamic regions and sensory areas of the brain, while reducing connectivity with the striatum. These changes help explain the altered sensory experiences and consciousness shifts associated with psychedelic states.
Abstract
The role of the thalamus in mediating the effects of lysergic acid diethylamide (LSD) was recently proposed in a model of communication and corrobo...