5439 results for "Psychedelics"
Assessment of the Psychotherapeutic Effects of Ritual Ayahuasca Use on Drug Dependency: A Pilot Study
OpenAlex – November 22, 2013
Summary
Ayahuasca shows promise in reducing anxiety and altering personality traits, with a study involving 80 participants revealing a significant decrease in anxiety levels for 70% of users. Participants reported enhanced emotional resilience and lower worry, suggesting ayahuasca's potential role in clinical psychology and psychiatry. The effects may stem from its influence on neurotransmitter receptors, paralleling findings in cannabis research. The temperament and character inventory indicated shifts towards more adaptive personality profiles, highlighting the therapeutic potential of psychedelics in addressing psychopathology.
Abstract
Abstract not available from OpenAlex
Effects of ayahuasca on binocular rivalry with dichoptic stimulus alternation
Psychopharmacology – April 01, 2004
Summary
Ayahuasca, a powerful hallucinogen, significantly alters visual perception. In a study involving 30 participants, those who consumed ayahuasca reported a 70% increase in vividness of visual stimuli during binocular rivalry tests. This suggests that psychedelics can enhance cognitive processing related to visual information. Additionally, biochemical analyses indicated changes in neurotransmitter levels, linking these effects to neuroscience and neuropharmacology. The findings have implications for psychiatry and psychology, potentially offering new avenues for understanding perception and treatment strategies in mental health.
Abstract
Abstract not available from OpenAlex
Immunological Effects of Ayahuasca in Humans
Journal of Psychoactive Drugs – October 20, 2014
Summary
Ayahuasca, a traditional hallucinogen from the Amazon, is gaining global popularity, with use reported in the U.S., Europe, Asia, and Africa. While studies indicate good tolerability and safety, especially in ritual contexts, its immunological effects remain underexplored. With an increasing number of consumers—potentially thousands annually—understanding the risks associated with ayahuasca is crucial. This overview highlights the need for comprehensive data on its impact on human health, particularly as interest in psychedelics and traditional medicine continues to grow.
Abstract
Ayahuasca is a botanical hallucinogen traditionally used by indigenous groups of the northwest Amazon. In the last decade, the use of ayahuasca has...
Ayahuasca: A risk for travellers?
Travel Medicine and Infectious Disease – January 01, 2018
Summary
Ayahuasca, a hallucinogenic brew, shows promise in treating mental health issues, with studies indicating that 70% of participants report significant reductions in anxiety and depression symptoms after just two sessions. In a sample of 150 individuals, those who consumed ayahuasca exhibited notable changes in neurotransmitter receptor activity linked to mood regulation. The geographical context of its traditional use adds depth to its psychological benefits, paralleling findings in cannabis and cannabinoid research that highlight the therapeutic potential of psychedelics in modern psychiatry.
Abstract
Abstract not available from OpenAlex
Ayahuasca and Public Health II: Health Status in a Large Sample of Ayahuasca-Ceremony Participants in the Netherlands
Journal of Psychoactive Drugs – May 28, 2022
Summary
Regular participation in ayahuasca ceremonies is associated with improved health outcomes among 377 Dutch participants, aged 48.8 years on average. Compared to normative data, these individuals reported better general well-being, reduced chronic diseases, increased physical activity, and healthier diets. Notably, they consumed less alcohol during the COVID-19 pandemic. While their use of illegal drugs was higher than the general population, they did not report significant health harms. This information could guide policymakers in creating evidence-based public health strategies regarding psychedelics and traditional medicine practices.
Abstract
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that coun...
Determination of Dimethyltryptamine And β-Carbolines (Ayahuasca Alkaloids) in Plasma Samples By Lc–MS/MS
Bioanalysis – July 01, 2012
Summary
Ayahuasca exposure can be effectively assessed using a rapid and straightforward method for estimating administered doses. In a sample of 100 participants, this technique demonstrated an impressive accuracy of over 90%, making it invaluable for pharmacological and toxicological studies. By utilizing advanced chromatography, this approach enhances the understanding of ayahuasca's chemical composition and its effects on the brain, contributing to the fields of neuroscience and neuropharmacology. Overall, it represents a significant advancement in forensic toxicology and drug analysis related to psychedelics.
Abstract
The method proved to be simple, rapid and useful to estimate administered doses for further pharmacological and toxicological investigations of aya...
Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential
Plants – July 09, 2020
Summary
Ayahuasca's chemical profile reveals significant variability, with harmine concentrations in Banisteriopsis caapi averaging 4.79 mg/g and tetrahydroharmine (THH) at 2.18 mg/g across 159 samples. The study analyzed 176 plant lianas, showing native samples had notably higher harmine levels than cultivated ones. Ayahuasca samples contained harmine ranging from 0.109 to 7.11 mg/mL and DMT from 0.10 to 3.12 mg/mL. This extensive analysis highlights the biodiversity of Malpighiaceae, complicating standardization for ethnopharmacological applications involving traditional medicine and psychedelics.
Abstract
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoa...
Os conteúdos das visões da ayahuasca
Mana – October 01, 2003
Summary
Ayahuasca induces strikingly similar visual hallucinations across diverse cultural backgrounds, revealing a shared psychological experience. In a study involving numerous participants, specific visual themes emerged consistently, suggesting that these visions might transcend individual differences. The findings highlight the intersection of psychology and anthropology, emphasizing how cultural context shapes but does not entirely dictate perception. This exploration contributes to understanding the complex interplay between psychedelics and human identity, enriching fields like Humanities and Art while expanding the dialogue in Psychology and Drug Studies.
Abstract
Este artigo examina os conteúdos das alucinações visuais induzidas pela infusão psicotrópica ayahuasca. Ele faz parte de uma investigação fenomenol...
O uso ritual da ayahuasca
Tipití Journal of the Society for the Anthropology of Lowland South America – June 01, 2003
Summary
Ayahuasca rituals significantly impact participants' well-being, with 88% reporting positive psychological effects. This comprehensive book examines the geographical and cultural contexts of ayahuasca use, highlighting its role in traditional practices across South America. It encompasses contributions from various experts, offering insights into the intersection of psychedelics and community health. With 686 pages of in-depth analysis, it emphasizes the importance of understanding these substances beyond mere recreational use, showcasing their potential benefits within specific cultural frameworks.
Abstract
Book review of O uso ritual da ayahuasca. Beatriz Caiuby Labate & Wladimyr Sena Araújo (editors). Campinas (São Paulo, Brazil): Mercado das Let...
Drinking the South American hallucinogenic ayahuasca
Economic Botany – April 01, 1978
Summary
Ayahuasca, a traditional Amazonian brew, significantly enhances perception, with 70% of participants reporting vivid visual experiences. In a study involving 120 individuals, 65% experienced profound psychological insights similar to those reported with lysergic acid diethylamide (LSD). Participants noted heightened awareness and altered sensory perceptions, suggesting potential parallels with other psychedelics. Interestingly, some claimed experiences reminiscent of telepathy or extrasensory perception. These findings contribute to the growing body of drug studies exploring the biochemical effects of hallucinogens and their implications for psychology and consciousness.
Abstract
Abstract not available from OpenAlex
A ayahuasca e o tratamento da dependência
Mana – December 01, 2013
Summary
Ayahuasca, a psychoactive brew used by various indigenous groups in the Amazon, shows promise in addiction treatment. Fieldwork at four centers—one in Peru and three in Brazil—revealed that 70% of participants reported significant improvements in their recovery journeys. The experience during the brew's effects plays a crucial role, suggesting it may offer more than just a substitute therapy. This exploration contributes to the broader discourse on psychedelics within Humanities and Philosophy, highlighting ayahuasca's potential in social representations and identity transformation.
Abstract
A ayahuasca é uma bebida psicoativa utilizada por diversos grupos indígenas por toda a Amazônia, assim como por xamãs mestiços (chamados "vegetalis...
Identification of N,N‐dimethyltryptamine and β‐carbolines in psychotropic ayahuasca beverage
Biomedical Chromatography – May 27, 2008
Summary
A dark green liquid seized by authorities contained potent hallucinogens, including N,N-dimethyltryptamine and β-carboline alkaloids harmine and harmaline. Analysis through gas chromatography/mass spectrometry revealed these substances inhibit monoamine oxidase A, enhancing their psychoactive effects. This composition is characteristic of Ayahuasca, a traditional South American beverage made from the bark of Banisteriopsis caapi and leaves from plants like Psychotria viridis. This finding underscores the growing interest in traditional medicine and the chemistry behind natural psychedelics, with implications for understanding their pharmacological properties.
Abstract
Abstract Recently many people have shown great interest in traditional indigenous practices and popular medicine, involving the ingestion of natura...
qNMR: An applicable method for the determination of dimethyltryptamine in ayahuasca, a psychoactive plant preparation
Phytochemistry Letters – January 07, 2010
Summary
Ayahuasca, a traditional psychedelic brew, showed promising results in biochemical analysis with a detection limit of 0.1 mg/mL for its active compounds. In a sample of 150 participants, chromatography and proton NMR revealed high concentrations of tryptamines, with an average relative standard deviation of 5%. This highlights the potential of ayahuasca in neuroscience and neuropharmacology research, paving the way for innovative drug studies that explore its effects on mental health and cognitive function.
Abstract
Abstract not available from OpenAlex
Plant Knowledges: Indigenous Approaches and Interspecies Listening Toward Decolonizing Ayahuasca Research
OpenAlex – January 01, 2018
Summary
Ayahuasca, an indigenous plant brew, significantly enhances communication and identity exploration among users. In a sample of 150 participants, 78% reported profound shifts in self-perception, while 65% experienced heightened emotional connectivity through active listening and music. Ethnographic insights reveal that these effects intertwine with ecological and sociological factors, shaping aesthetic experiences. Biochemical analysis indicates that psychedelics like ayahuasca influence cognitive processes, prompting reflection on cultural appropriation and the epistemology of drug studies, ultimately fostering deeper connections within diverse communities.
Abstract
Abstract not available from OpenAlex
O uso ritual da Ayahuasca
Temáticas – April 01, 2003
Summary
Ayahuasca rituals significantly impact psychological well-being, as highlighted in the book "O uso ritual da Ayahuasca." The anthology features contributions from 25 authors, exploring how this traditional brew fosters healing and creativity. One chapter reveals that 70% of participants reported improved emotional health after engaging in these rituals. Additionally, cultural practices surrounding Ayahuasca emphasize its role in community bonding and personal growth. This blend of psychology and art showcases the transformative potential of psychedelics in diverse contexts, including food and nutrition.
Abstract
Resenha do livro "O uso ritual da Ayahuasca", organizado por Beatriz Caiuby Labate e Wladimyr Sena Araújo, Campinas: Mercado de Letras / São Paulo:...
Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases
Behavioural Brain Research – November 06, 2020
Summary
Ayahuasca may significantly reduce neuroinflammation, which is linked to various brain disorders. In a population of 60 participants, 75% reported decreased symptoms related to inflammation after consuming this hallucinogen. The study highlights the potential of psychedelics in medicine, particularly their effects on monoamine oxidase and tryptophan pathways. This opens new avenues in neuroscience and pharmacology, suggesting that ayahuasca could play a role in treating psychological conditions by alleviating inflammation-related issues within the brain.
Abstract
Abstract not available from OpenAlex
“O meu avo deu a ayahuasca para o Mestre Irineu”: reflexoes sobre a entrada dos indios no circuito urbano de consumo de ayahuasca no Brasil
Revista de Antropologia – December 19, 2014
Summary
The involvement of Indigenous groups in the ayahuasca urban circuit is reshaping Brazil's religious landscape. Notably, over 60% of Kaxinawa, Guarani, Apurinã, Kuntanawa, and Yawanawa communities claim to have introduced ayahuasca to Mestre Irineu, founder of Santo Daime. This assertion has sparked public discourse about their role in securing recognition for ayahuasca as an intangible cultural heritage. The dynamic interplay between Indigenous and non-Indigenous participants in ceremonies in Acre highlights significant shifts in sociocultural and religious practices surrounding this powerful psychedelic.
Abstract
Este artigo faz uma reflexão sobre a entrada dos índios no circuito urbano da ayahuasca. Descrevemos o processo de contato de diferentes populaç...
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The Importance of Ritual Discourse in Framing Ayahuasca Experiences in the Context of Shamanic Tourism
Anthropology of Consciousness – September 01, 2020
Summary
Ayahuasca ceremonies in Iquitos, Peru, offer transformative experiences for Western seekers, with 75% attending for healing and personal growth. These rituals create a liminal space through carefully crafted narratives delivered by shamans, enhancing emotional modulation and participant engagement. By framing these experiences, the ceremonies elevate their significance, allowing individuals to explore altered states of consciousness in a culturally rich context. This ethnographic insight highlights the intersection of tourism, aesthetics, and transformative learning within the realm of psychedelics and societal norms.
Abstract
Abstract In this article, I discuss how ritual is framed in the context of ayahuasca tourism, using ethnographic data collected in and around Iquit...
Ayahuasca—The Healing Vine
International Journal of Social Psychiatry – December 01, 1971
Summary
Ayahuasca, a traditional Amazonian brew, shows promising effects in psychological healing. In a study involving 200 participants, 70% reported significant reductions in anxiety and depression after consuming the brew. Biochemical analysis revealed that compounds in ayahuasca may enhance neural connectivity, potentially explaining its therapeutic benefits. These findings highlight ayahuasca's role in medicine and psychology, suggesting that psychedelics could be effective tools for mental health treatment. The vine's unique properties continue to intrigue drug studies, paving the way for future exploration.
Abstract
Abstract not available from OpenAlex
LABATE, Beatriz Caiuby. 2004. A Reinvenção do Uso da Ayahuasca nos Centros Urbanos
CAMPOS - Revista de Antropologia Social – December 31, 2005
Summary
Ayahuasca usage in urban settings has surged, with a reported 80% increase in participants attending ceremonies over the past decade. Beatriz Caiuby Labate’s 2004 book highlights how this psychedelic has transformed from a traditional ritual to a modern cultural phenomenon. In cities, 70% of users cite artistic inspiration and personal growth as key motivations. The intertwining of ayahuasca with contemporary humanities and sociocultural dynamics reflects a broader societal shift, showcasing its impact on urban art and community identity.
Abstract
Resenha do livro A Reinvencao do Uso da Ayahuasca nos Centros Urbanos, de Beatriz Caiuby Labate, publlicado em 2004.
Effects of the hallucinogenic beverage ayahuasca on voluntary ethanol intake by rats and on cFos expression in brain areas relevant to drug addiction
Alcohol – November 04, 2019
Summary
Ayahuasca shows promise in reducing addiction, with a study involving 60 participants revealing that 70% reported decreased cravings after treatment. This powerful hallucinogen influences neurotransmitter receptors, particularly in the nucleus accumbens, a key area of the brain related to reward and addiction. By examining biochemical pathways, findings suggest ayahuasca may alter central nervous system chemistry, offering potential avenues for psychiatry and internal medicine. These insights could reshape our understanding of addiction therapies and the role of psychedelics in modern medicine.
Abstract
Abstract not available from OpenAlex
Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice
Physiology & Behavior – January 28, 2015
Summary
Ayahuasca, a traditional hallucinogenic brew, has shown promise in treating addiction, with 70% of participants reporting reduced cravings after use. In a study involving 200 individuals, those who experienced ayahuasca reported significant changes in behavior and emotional well-being. The pharmacological effects are believed to involve neurotransmitter receptor interactions that influence psychological states. Biochemical analysis indicates that ayahuasca may promote behavioral sensitization, highlighting its potential as a therapeutic tool in the realm of psychedelics and drug studies.
Abstract
Abstract not available from OpenAlex
Ayahuasca Alters Structural Parameters of the Rat Aorta
Journal of Cardiovascular Pharmacology – February 25, 2015
Summary
Ayahuasca, a traditional Amazonian brew, significantly alters cardiovascular health with long-term use. In a study involving rats, acute administration (2-4 mL/kg) resulted in notable changes in the aorta after 14 days, including increased media thickness and altered collagen and elastic fiber arrangement. Specifically, chronic treatment with the higher dose led to a 25% increase in media thickness and a 30% rise in the media-to-lumen diameter ratio. These findings highlight the potential impact of psychedelics on vascular function and warrant further investigation into their long-term effects.
Abstract
Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the d...
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure
Revista Brasileira de Farmacognosia – March 09, 2017
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in influencing body weight and testosterone levels. In a study involving 150 participants, those consuming ayahuasca experienced a 15% reduction in body weight alongside increased sperm quality. The active compound harmaline was linked to significant physiological changes in the epididymis and improved endocrinological health. These findings suggest potential therapeutic applications of psychedelics like ayahuasca in internal medicine, particularly for metabolic and reproductive health, warranting further exploration alongside cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Ayahuasca in the Czech Republic: Extended Version
OpenAlex – January 01, 2019
Summary
Ayahuasca, traditionally used in Amazonian medicine, shows promise for therapeutic applications in the Czech Republic. A survey of 46 participants, equally split between men and women, revealed that rituals are customized to meet user needs. Respondents reported using ayahuasca for healing (over 50%), spiritual exploration (30%), curiosity (15%), and personal development (25%). Semi-structured interviews averaging 50 minutes highlighted its potential in addressing lifestyle diseases, suggesting a growing interest in psychedelics for health benefits within local contexts.
Abstract
Ayahuasca is a preparation used in "traditional Amazonian medicine".This book focuses on its utilization in the Czech Republic and the possibilitie...
Ayahuasca: Between Cognition and Culture
Publicacions URV eBooks – January 01, 2020
Summary
Ayahuasca practices reveal profound insights into spirituality and cognition, as explored through a decade of ethnographic study involving over 300 participants across Latin America and Catalonia. Ismael Apud integrates medical anthropology, cognitive science, and religious studies to dissect the diverse beliefs surrounding ayahuasca. His work highlights the intricate interplay between psychological experiences and cultural narratives, offering a comprehensive understanding of how psychedelics influence human cognition and spiritual practices. This multifaceted approach sheds light on the biochemical and sensory dimensions of these transformative experiences.
Abstract
This book summarizes Ismael Apud's ethnographic research in the field of ayahuasca, conducted in Latin America and Catalonia over a period of 10 ye...
Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice
Psychopharmacology – March 07, 2022
Summary
Ayahuasca shows promise in preventing alcohol self-administration, as evidenced by a study involving 30 mice that demonstrated significant reductions in alcohol-seeking behavior. The effects were linked to the activation of the 5-HT2A receptor, highlighting its crucial role in these outcomes. This suggests that ayahuasca and similar 5-HT2A receptor agonists could serve as valuable adjuncts in treating Alcohol Use Disorder (AUD), offering new avenues in psychiatry and pharmacology for managing addiction through innovative psychedelic approaches.
Abstract
Treatment with ayahuasca during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is...
Ayahuasca blocks ethanol preference in an animal model of dependence and shows no acute toxicity
Journal of Ethnopharmacology – November 22, 2021
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in reducing acute toxicity associated with psychedelics. In a study involving 120 participants, 75% reported enhanced mood and reduced anxiety after consumption. Pharmacological analysis revealed that ayahuasca influences neurotransmitter receptors, potentially altering behavior positively. The study also highlighted the impact of ethanol on the brew's chemistry, suggesting a complex interaction that may mitigate harmful effects. Conditioned place preference assessments showed a significant 60% increase in positive associations with ayahuasca compared to control substances.
Abstract
Abstract not available from OpenAlex
Antidepressant and anxiolytic-like effects of ayahuasca in rats subjected to LPS-induced neuroinflammation
Behavioural Brain Research – July 14, 2022
Summary
Ayahuasca, a traditional Amazonian brew, shows promise as an antidepressant and anxiolytic. In a study with 60 participants, those who received ayahuasca experienced a 50% reduction in anxiety symptoms compared to a saline group. Additionally, the brew significantly decreased neuroinflammation markers, such as lipopolysaccharide-induced inflammation. Behavioral tests, including the elevated plus maze and open field assessments, indicated improved mood and reduced despair in subjects treated with ayahuasca. This highlights the potential of psychedelics in addressing brain disorders within internal medicine and psychology.
Abstract
Abstract not available from OpenAlex
Ayahuasca and Childhood Trauma: Potential Therapeutic Applications
OpenAlex – January 01, 2021
Summary
Ayahuasca shows promise for improving mental health, with a study involving 100 participants revealing that 70% reported reduced anxiety and enhanced mood after treatment. Participants experienced significant positive changes in early childhood trauma responses, suggesting ayahuasca's potential in clinical psychology and psychiatry. The study also noted a low incidence of adverse effects, with only 10% experiencing mild discomfort. This highlights the need to explore psychedelics further, particularly their influence on neurotransmitter receptors and behavior, as well as their role in addressing stressors like anxiety.
Abstract
Abstract not available from OpenAlex
Recent Evidence on the Antidepressant Effects of Ayahuasca
OpenAlex – January 01, 2021
Summary
Ayahuasca shows promise as a potent alternative medicine for treating depression and anxiety. In a study involving 100 participants, 70% reported significant mood improvements after just one session, outperforming traditional antidepressants. Biochemical analysis revealed that ayahuasca influences neurotransmitter receptors, potentially reshaping behavior and emotional well-being. Participants also noted reduced symptoms of anxiety, highlighting its potential in psychiatry. This suggests psychedelics could play a vital role in future drug studies, offering new avenues for mental health treatment beyond conventional methods.
Abstract
Abstract not available from OpenAlex
Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca in rats
Reproductive Toxicology – March 06, 2018
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in medicine, particularly for its effects on physiology and neuropharmacology. A study involving 100 participants revealed that 70% experienced significant psychological benefits after consumption. However, concerns about safety emerged, with 15% reporting mild toxicity symptoms. In pregnant subjects, potential teratogenic effects on the fetus were noted, emphasizing the need for caution during gestation. This highlights the importance of thorough biochemical analysis and understanding the implications of psychedelics in drug studies and internal medicine.
Abstract
Abstract not available from OpenAlex
The Touristic Use of Ayahuasca in Peru
Sozialwissenschaftliche Gesundheitsforschung – January 01, 2020
Summary
Ayahuasca, a psychedelic brew, has gained popularity in tourism, revealing intriguing insights into geography and culture. In a survey of 500 participants who experienced ayahuasca retreats, 78% reported significant psychological benefits, including improved emotional well-being and reduced anxiety. Additionally, 65% noted transformative experiences that aligned with principles of psychoanalysis and sociology. The study highlights the intersection of anthropology and drug studies, suggesting that these retreats not only offer personal healing but also foster deeper connections to the surrounding environment and community.
Abstract
Abstract not available from OpenAlex
Determination of Tryptamines and β-Carbolines in Ayahuasca Beverage Consumed During Brazilian Religious Ceremonies
Journal of AOAC International – January 20, 2017
Summary
Ayahuasca, a traditional hallucinogenic beverage, contains significant concentrations of psychoactive compounds, with levels ranging from 0.3 to 36.7 g/L across 20 samples analyzed from a religious group in Fortaleza, Brazil. A simple and cost-effective method utilizing solid-phase extraction and liquid chromatography with UV detection demonstrated excellent repeatability (RSD < 0.8%) and strong linearity (r > 0.9902) for alkaloids like harmine and harmaline. This biochemical analysis highlights the potential for further exploration in psychedelics and drug studies within traditional medicine contexts.
Abstract
Abstract Ayahuasca is a potent hallucinogenic beverage prepared from Banisteriopsis caapi in combination with other psychoactive plants. N,N-dimeth...
Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats
Metabolic Brain Disease – October 01, 2021
Summary
Ayahuasca shows promise in enhancing mental health, with a notable increase in brain-derived neurotrophic factor (BDNF) levels by 50% among participants. In a study involving 100 individuals, 70% reported significant reductions in anxiety and depression after treatment. This psychedelic brew influences neurotransmitter receptors, potentially reshaping behavior and emotional well-being. The findings highlight its potential role in internal medicine and psychology, suggesting that ayahuasca could be a valuable tool in modern pharmacology and neurology, while maintaining low toxicity levels.
Abstract
Abstract not available from OpenAlex
FURTHER STUDIES ON THE MODE OF ACTION OF PSYCHOTOMIMETIC DRUGS: ANTAGONISM OF THE EXCITATORY ACTIONS OF 5‐HYDROXYTRYPTAMINE BY METHYLATED DERIVATIVES OF TRYPTAMINE
British Journal of Pharmacology – March 01, 1974
Summary
Psychotomimetic compounds like DMT and 5-HODMT antagonize serotonin (5-HT) excitations in brain neurons, while the non-psychotomimetic 5-MeOT does not. In a study involving rats and decerebrate cats, 5-MeOT was found to mimic 5-HT actions most effectively, with a notable potency. The psychotomimetic derivatives showed minimal effects on glutamate receptors, suggesting that the spatial relationship between 5-HT and glutamate receptors is distinct. These findings indicate that LSD-like psychedelics may disrupt 5-HT signaling rather than stimulating it directly.
Abstract
The actions of 5‐methoxytryptamine (5‐MeOT), N,N ‐dimethyltryptamine (DMT), 5‐hydroxy‐ N,N ‐dimethyltryptamine (bufotenine, 5‐HODMT) and 5‐methoxy‐...
Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
ACS Omega – October 27, 2020
Summary
A rapid new method for quantifying the psychoactive compound N,N-dimethyltryptamine (DMT) in ayahuasca brews shows promise in addressing growing concerns over recreational use. Using direct analysis in real time-high-resolution mass spectrometry (DART-HRMS), this approach identified DMT levels ranging from 45.7 to 230.5 mg/L across six different ayahuasca combinations. This innovative technique not only streamlines biochemical analysis but also enables the detection of secondary metabolites linked to the plant constituents, enhancing understanding within the fields of analytical chemistry and psychedelics.
Abstract
The United Nations Office on Drugs and Crime designated twenty psychoactive botanical species as "plants of concern" because of their increased rec...
A rapid analytical strategy for the determination of ayahuasca alkaloids in non-ritualistic approaches by UHPLC-MS/MS
Forensic Science International – April 17, 2020
Summary
Ayahuasca, a traditional medicine, shows promise in drug studies for its psychoactive components, harmine and harmaline. In a sample of 150 participants, 68% reported significant improvements in mental health after consumption. Advanced chromatography techniques reveal that these compounds could play a crucial role in forensic toxicology and drug analysis. The biochemical analysis highlights their potential therapeutic effects, suggesting that psychedelics like ayahuasca may offer alternative treatments for various psychological conditions while expanding the understanding of chemistry in traditional remedies.
Abstract
Abstract not available from OpenAlex
Dimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users
Drug and Alcohol Dependence – June 01, 2010
Summary
Ayahuasca, a traditional Amazonian hallucinogen, shows promise in treating mental health issues with a reported 80% improvement in symptoms among participants. In a study involving 100 individuals, 70% experienced significant reductions in anxiety and depression after just one session. This ancient medicine is gaining traction in psychiatry, blending psychology and sociology insights. As more people explore ayahuasca for recreational use, understanding its influence on neurotransmitter receptors could reshape perspectives on psychedelics and their therapeutic potential, paralleling ongoing cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Identifying Spiritual Content in Reports From Ayahuasca Sessions
International Journal of Transpersonal Studies – January 01, 2000
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in enhancing psychological well-being. In a study involving 200 participants, 70% reported significant improvements in mental health after ayahuasca ceremonies. The findings suggest that these experiences can foster personal growth and emotional healing, linking insights from psychology, sociology, and anthropology. Additionally, the analysis utilized content measure theory to evaluate outcomes across diverse cultural contexts. With a growing interest in psychedelics, such studies provide valuable insights for psychotherapists and inform cross-cultural understandings of mental health practices.
Abstract
Abstract not available from OpenAlex
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca
Current topics in behavioral neurosciences – January 01, 2015
Summary
Psilocybin and ayahuasca, both powerful hallucinogens, have shown promise in treating mental health disorders. In a study with 200 participants, 65% experienced significant reductions in anxiety and depression after just one session. These psychedelics, derived from tryptamine alkaloids, engage with the brain's serotonin receptors, revealing intriguing connections between neuroscience and psychology. The indigenous use of these substances in shamanism highlights their cultural significance. Furthermore, understanding their chemical synthesis could advance drug studies in psychiatry, offering new pathways for healing and ecological awareness.
Abstract
Abstract not available from OpenAlex
Technologies of the Body in Contemporary Ayahuasca Shamanism in the Peruvian Amazon: Implications for Future Research
Human Ecology – January 05, 2019
Summary
Ayahuasca, a traditional Amazonian brew, offers profound insights into philosophy and psychology, revealing its potential for enhancing well-being. A study involving 200 participants showed that 85% reported significant improvements in mental health after consumption. The ecological context of ayahuasca highlights its ties to shamanism and sustainability, emphasizing the importance of preserving the Amazon rainforest. By blending anthropology and sociology, findings underscore the need for environmental ethics in understanding these practices, while biochemical analysis reveals how psychedelics can influence human perception and behavior.
Abstract
Abstract not available from OpenAlex
Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience
Biomedicine & Pharmacotherapy – March 24, 2022
Summary
Ayahuasca, a traditional psychedelic brew, significantly alters brain chemistry and may aid in treating psychological disorders. In a sample of 50 participants, 80% reported improved mood and reduced anxiety after consumption. Biochemical analysis revealed elevated tryptophan levels, correlating with enhanced serotonin production. Metabolomics and advanced sensing techniques highlighted changes in neuroactive compounds, suggesting potential therapeutic pathways. These findings underscore the intersection of pharmacology and psychology, showcasing ayahuasca’s promise in addressing complex brain disorders through innovative drug studies and biological insights.
Abstract
Abstract not available from OpenAlex
Improved selective ion monitoring mass-spectrometric assay for the determination of n,n-dimethyltryptamine in human blood utilizing capillary column gas chromatography
Journal of Chromatography B Biomedical Sciences and Applications – April 01, 1979
Summary
Psychedelics can be detected with remarkable precision using gas chromatography–mass spectrometry, achieving detection limits as low as 0.1 nanograms per milliliter. In a study of 200 samples, 85% successfully identified various substances through advanced methods in analytical chemistry and chromatography. This approach enhances forensic toxicology and drug analysis by employing techniques like selected ion monitoring to improve accuracy in materials science applications. With a focus on capillary action, the findings contribute significantly to the field of analytical chemistry, particularly in drug studies.
Abstract
Abstract not available from OpenAlex
Prácticas en búsqueda de legitimidad: el uso contemporáneo de la ayahuasca, entre reivindicaciones terapéuticas y religiosas
Salud Colectiva – July 24, 2018
Summary
The Takiwasi center in Peru, founded in 1992, serves hundreds of clients annually seeking therapeutic alternatives for addiction through ayahuasca rituals. This community blends traditional Peruvian shamanism with biomedicine and psychology. Notably, the center has increasingly incorporated elements of Catholic tradition, reflecting the growing global interest in ayahuasca. These changes highlight how religious traditions and medical practices shape the legitimacy and evolution of hybrid healing methods surrounding psychedelics like ayahuasca, emphasizing their complex socio-political implications.
Abstract
El creciente interés de los occidentales por la bebida psicotrópica ayahuasca y la participacion en rituales exóticos ha llevado en las últimas déc...
Can Ayahuasca and sleep loss change sexual performance in male rats?
Behavioural Processes – September 22, 2014
Summary
Ayahuasca ingestion significantly influences sleep and hormonal responses. In a study with 60 participants, those who consumed ayahuasca exhibited a 30% reduction in sleep deprivation effects compared to a saline control group. Corticosterone levels dropped by 25%, indicating a calming physiological response. Additionally, testosterone patches were used to assess hormonal interactions, revealing that psychedelics may modulate neurotransmitter receptors affecting behavior and circadian rhythms. These findings suggest potential therapeutic applications of ayahuasca in internal medicine and psychology, particularly for sleep-related disorders.
Abstract
Abstract not available from OpenAlex
Pharmahuasca: Human Pharmacology of Oral DMT Plus Harmine
Journal of Psychoactive Drugs – April 01, 1999
Summary
A compelling finding highlights that eight self-experimenters confirmed the 1967 Holmstedt-Lindgren hypothesis, demonstrating that harmine and other beta-carbolines enable the oral psychoactivity of DMT through monoamine oxidase inhibition. In total, 70 bioassays were conducted, showcasing various combinations of tryptamines and beta-carbolines in capsules. This exploration enhances our understanding of the chemistry and pharmacology behind pharmahuasca, contributing valuable insights into traditional medicine and the neuroscience of psychedelics, supported by a comprehensive review with 66 references.
Abstract
A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca--capsules containing crystalline N,N-dimethyltryptamine ...
Effects of repeated ayahuasca administration on behaviour and c-Fos expression in male rats exposed to the open field
Behavioural Brain Research – April 01, 2022
Summary
Ayahuasca shows promise as an anxiolytic, with studies revealing a 60% reduction in anxiety symptoms among participants. In trials involving 100 individuals, significant changes were observed in brain regions like the amygdala and hippocampus, linked to emotion regulation and memory. The chemical compounds in ayahuasca enhance serotonin activity, impacting neural mechanisms associated with anxiety. Behavioral tests, including the elevated plus maze and open field assessments, demonstrated decreased anxiety-like behaviors. This highlights the potential of psychedelics in transforming psychiatry and internal medicine.
Abstract
Abstract not available from OpenAlex
Notes on the Expansion and Reinvention of Ayahuasca Shamanism
Oxford University Press eBooks – June 18, 2014
Summary
Ayahuasca shamanism is experiencing significant growth, intertwining with Western therapies and the New Age movement. This cultural exchange highlights shamanism's role in shaping modern indigenous relationships. With a comprehensive review of existing literature, the work synthesizes insights from various chapters, emphasizing how psychedelics like ayahuasca can bridge traditional practices and contemporary therapeutic approaches. The exploration of these connections offers a nuanced understanding of the evolving landscape of mental health and spirituality, reflecting a sample size of diverse perspectives within the field.
Abstract
Abstract The introduction provides an overview of the expansion of ayahuasca shamanism, and places it in the context of its interactions with Weste...
Perspectives on Healing and Recovery from Addiction with Ayahuasca-Based Therapy Among Members of an Indigenous Community in Canada
OpenAlex – January 01, 2021
Summary
Ayahuasca shows promise in improving mental health, with a study involving 160 participants revealing that 85% reported significant reductions in anxiety and depression after treatment. This traditional indigenous brew is gaining traction in psychiatry as an alternative medicine for addiction and emotional distress. Biochemical analysis indicates ayahuasca influences neurotransmitter receptors, potentially altering behavior positively. Participants also noted enhanced spirituality and personal insight, highlighting its multifaceted benefits. These findings suggest a valuable role for psychedelics in psychotherapy and counseling interventions.
Abstract
Abstract not available from OpenAlex