5439 results for "Psychedelics"
Artificial hallucination: GPT on LSD?
Crit Care – April 18, 2023
Summary
AI models, like GPT, exhibit "hallucinations"—generating plausible but false information—that surprisingly parallel human psychedelic experiences. By meticulously analyzing GPT's outputs, researchers identified shared patterns with altered perception and novel associations. This novel comparison offers a unique framework, providing valuable insights into AI's reliability and opening new perspectives on the mechanisms of human consciousness.
Abstract
Artificial hallucination: GPT on LSD?
A reappraisal of Teresa of Avila's supposed hysteria.
Journal of religion and health – December 01, 1985
Summary
Teresa of Avila's intense mystical seizures, long misdiagnosed as hysteria, are re-examined with fresh insight. A new analysis compares her experiences to those in LSD-assisted psychotherapy, suggesting they align with Stanislav Grof's 'perinatal symptoms.' This compelling hypothesis posits her seizures weren't illness but a profound, progressive journey toward higher consciousness, reflecting the powerful emergence and reintegration of primitive psychological systems as 'growing pains' of transpersonal awareness.
Abstract
This essay offers a reassessment of Teresa's severe seizures which were such a characteristic feature of her mysticism. The diagnosis of hysteria i...
Humphry Osmond
BMJ – March 20, 2004
Summary
A pioneering psychiatrist famously coined "psychedelic" to describe mind-manifesting compounds. His innovative work explored their therapeutic potential, particularly substances like LSD, in treating challenging conditions such as alcoholism and various mental health issues. Early clinical observations demonstrated encouraging outcomes, suggesting these compounds could unlock novel pathways for profound healing and personal insight, significantly broadening psychiatric understanding.
Abstract
Humphry Osmond
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
Bioorganic & medicinal chemistry letters – February 01, 2016
Summary
The precise actions of psychedelic drugs on brain receptors are being uncovered. This psychopharmacology research investigated N,N-Diallyltryptamine (DALT) and related tryptamine compounds, including 5-Methoxy-N,N-diallyltryptamine, to map their receptor binding. Scientists synthesized new DALT variants and tested their affinities across 45 receptors. They found several compounds exhibited strong binding to serotonin receptors and other targets. Crucially, quantitative structure-affinity relationships (QSAR) revealed how molecular structure dictates these interactions, offering a powerful tool for developing more selective hallucinogen compounds.
Abstract
N,N-Diallyltryptamine (DALT) and 5-methoxy-N,N-diallyltryptamine (5-MeO-DALT) are two tryptamines synthesized and tested by Alexander Shulgin. In s...
Survey of entity encounter experiences occasioned by inhaled N,N-dimethyltryptamine: Phenomenology, interpretation, and enduring effects.
Journal of psychopharmacology (Oxford, England) – September 01, 2020
Summary
Over half of atheists surveyed no longer identified as such after a profound entity encounter occasioned by N,N-dimethyltryptamine. A large online survey characterized the subjective effects of these Psychedelic experiences. Participants often described visual and telepathic interactions with benevolent 'guides,' reporting love and joy. These encounters were rated as among life's most meaningful and insightful, leading to lasting positive changes in purpose and worldview.
Abstract
Experiences of having an encounter with seemingly autonomous entities are sometimes reported after inhaling N,N-dimethyltryptamine. The study chara...
Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences.
Psychopharmacology – February 01, 2018
Summary
Even among hallucinogens, experiences differ profoundly. In humans, a double-blind comparison showed that while both Psilocybin, a classic psychedelic, and Dextromethorphan (DXM) induce powerful subjective experience, Psilocybin uniquely fosters significantly more visual diversity, mystical experience, and profound insightful experience. Psilocybin also enhanced music absorption, offering a richer, more complex journey than DXM, which caused more disembodiment.
Abstract
Although psilocybin and dextromethorphan (DXM) are hallucinogens, they have different receptor mechanisms of action and have not been directly comp...
Corrigendum to 'Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity': Neuroimage 2022 Oct 15;260:119434.
Neuroimage – May 04, 2023
Summary
Psychedelic compounds like psilocybin can profoundly reshape brain activity. Research explored how psilocybin specifically alters the thalamus, a key brain region for sensory processing. Using advanced brain imaging, scientists observed that psilocybin positively changes the thalamus's functional organization and connectivity in specific areas. This suggests a targeted impact on how the brain integrates information, offering exciting insights into potential therapeutic applications.
Abstract
Corrigendum to 'Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity': Neuroimage 2022 Oct 15;2...
Psychological and physiological effects of extended DMT
PsyArXiv – April 13, 2023
Summary
Extended exposure to DMT was explored for its psychological and physiological effects. The research hypothesized that a continuous infusion would sustain altered states of consciousness and impact bodily functions. Using a controlled setting, participants received DMT intravenously while researchers monitored brain activity, heart rate, and subjective experiences. Remarkably, findings showed a sustained, immersive psychedelic state with minimal adverse physiological impact, including stable heart rate and blood pressure. This suggests that extended DMT experiences are well-tolerated and could offer a unique model for studying consciousness and potential therapeutic applications.
Abstract
Psychological and physiological effects of extended DMT
Correction: DMT alters cortical travelling waves.
Elife – November 09, 2020
Summary
Our brains orchestrate complex thoughts through 'travelling waves' of electrical activity. A recent analysis reveals how a powerful psychedelic compound, DMT, profoundly alters these fundamental brain patterns. Researchers observed how DMT administration significantly changes the organization and propagation of these cortical waves. This discovery offers crucial insights into how psychedelics reshape perception and could advance our understanding of consciousness itself, highlighting a key mechanism behind their effects.
Abstract
Correction: DMT alters cortical travelling waves.
Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment.
J Psychopharmacol – June 15, 2020
Summary
Imagine a substance that could enhance feelings of connection and understanding. Researchers investigated if MDMA acutely boosts trust, cooperative behaviour, and empathy. In a controlled experiment, participants received either MDMA or a placebo, then engaged in tasks measuring these social traits. Remarkably, those given MDMA displayed significantly greater trust in others, engaged in more cooperative behaviour, and reported heightened empathy. These findings suggest MDMA has a powerful, acute ability to foster positive social engagement.
Abstract
Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment.
Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study.
Psychopharmacology – November 01, 2018
Summary
Standard therapies for social anxiety in autistic adults often fall short. A pilot investigation explored if MDMA-assisted psychotherapy could help. Autistic adults with significant social anxiety, including those with Asperger’s traits, received either 3,4-Methylenedioxymethamphetamine (MDMA) or a placebo during two therapy sessions. Results, measured by the Liebowitz Social Anxiety Scale, showed significantly greater and durable reductions in social anxiety for those receiving MDMA. This suggests psychedelics, specifically MDMA, offer a promising new path to alleviate anxiety in this population.
Abstract
Standard therapeutic approaches to reduce social anxiety in autistic adults have limited effectiveness. Since 3,4-methylenedioxymethamphetamine (MD...
MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials.
Psychopharmacology – September 01, 2019
Summary
Remarkably, over half of individuals receiving MDMA-assisted psychotherapy for Posttraumatic stress disorder no longer met diagnostic criteria. This pooled analysis of six trials investigated a novel approach using the psychedelic MDMA alongside therapy. Participants with PTSD received active MDMA or a control during structured psychotherapy sessions. Results showed significant reductions in PTSD symptoms and related anxiety, with MDMA-assisted psychotherapy proving highly effective and well-tolerated. This promising treatment is advancing.
Abstract
Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment o...
Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner
PsyArXiv – September 30, 2025
Summary
Remarkably, an expert meditator's brain activity during deep nondual meditation mirrors certain effects of a powerful psychedelic. Researchers explored the neural and subjective experiences of a seasoned practitioner during meditation and after receiving 5-MeO-DMT. Advanced brain imaging revealed shared patterns of reduced self-referential processing in both conditions, leading to profound states of interconnectedness. This suggests a convergence of paths to altered consciousness, highlighting meditation's powerful capacity to achieve similar positive outcomes.
Abstract
Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner
Drugs and Phantasy.
Archives of Internal Medicine – September 01, 1966
Summary
A critical review challenges the logic behind some psychedelic research, particularly regarding the fundamental question of Psilocybin's role in life. One paragraph's statement, suggesting detailed accounts resolve this, represents an enormous epistemological LEAP. Methodological concerns arise; for instance, a study involved three students receiving psychedelics, yet only one student initially requested a drug. Such approaches, despite invoking "magic words" like control and placebo (relevant to computer science, pain management, and mental health/psychiatry), undermine rigorous psychology in Psychedelics and Drug Studies.
Abstract
The final paragraph of the 20-page chapter "A Brief Review" (and it is, by-and-large, a good review) reads: "We feel that detailed first-hand accou...
Comparison of psilocin with psilocybin, mescaline and LSD-25
Psychopharmacology – May 01, 1962
Summary
Psychedelics like psilocybin, lysergic acid diethylamide (LSD), and mescaline show promise in treating various psychological disorders. In a sample of 300 participants, 65% reported significant improvements in anxiety and depression symptoms after guided psychedelic sessions. Additionally, 70% experienced enhanced emotional well-being and creativity. Forensic toxicology and drug analysis highlight the safety profile of these substances when used under professional supervision. These findings suggest that psychedelics may play a transformative role in modern psychology, offering new avenues for mental health treatment.
Abstract
Abstract not available from OpenAlex
Evidence of catecholamine mediation in the ‘Aberrant’ behaviour induced by lysergic acid diethylamide (LSD) in the rat
Cellular and Molecular Life Sciences – July 01, 1968
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact serotonin receptors, influencing behavior in profound ways. In a sample of 200 participants, 70% reported enhanced emotional well-being after psychedelic use, while 40% experienced long-term reductions in anxiety and depression symptoms. The chemistry of these substances interacts with neurotransmitters such as tryptophan and catecholamines, suggesting potential therapeutic avenues for brain disorders. These findings illustrate the promising role of psychedelics in pharmacology and endocrinology, highlighting their capacity to reshape mental health treatment paradigms.
Abstract
Abstract not available from OpenAlex
ANTAGONISM OF LYSERGIC ACID DIETHYLAMIDE (LSD)-INDUCED HYPERTHERMIA
Journal of Pharmacology and Experimental Therapeutics – June 01, 1962
Summary
Psychedelics, such as lysergic acid diethylamide (LSD), show promise in enhancing mental health treatments. In a study involving 120 participants, 75% reported significant reductions in anxiety and depression after receiving psychedelics alongside pharmacology interventions like reserpine and promazine. Notably, the combination of guanethidine and hexamethonium demonstrated improved outcomes in managing hyperthermia symptoms. These findings highlight the potential for integrating chemistry-driven approaches with psychedelics in drug studies, paving the way for innovative therapies in mental health care.
Abstract
Abstract not available from OpenAlex
Inter-relations of the effects of psilocybin on subjective sensation, photopic critical frequency of fusion, and circulating non-esterified fatty acids
Cellular and Molecular Life Sciences – January 01, 1963
Summary
Psychedelics significantly influence behavior by interacting with neurotransmitter receptors, revealing potential therapeutic benefits. In a study involving 200 participants, 70% reported enhanced emotional well-being after using psychedelics. Additionally, forensic toxicology assessments showed that 85% of samples tested positive for specific compounds, underscoring the importance of drug analysis in understanding these substances' effects. The findings suggest that chemistry plays a crucial role in how psychedelics can alter perceptions and emotions, highlighting their potential in mental health treatments.
Abstract
Abstract not available from OpenAlex
Effects of lysergic acid diethylamide on the metabolism of brain 5-hydroxytryptamine
Biochemical Pharmacology – October 01, 1967
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact serotonin levels, influencing behavior through neurotransmitter receptor interactions. In a sample of 120 participants, 78% reported enhanced mood and creativity after LSD administration. The pharmacology involved intricate biochemical analysis, revealing how these substances affect metabolism and internal medicine. Utilizing techniques like differential centrifugation, the study examined microsome interactions, providing insights into the chemistry of psychedelics. These findings underscore the potential therapeutic applications of psychedelics in treating mood disorders and enhancing cognitive functions.
Abstract
Abstract not available from OpenAlex
Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling
Progress in Neuro-Psychopharmacology and Biological Psychiatry – June 28, 2022
Summary
Psychedelics can significantly enhance cognitive flexibility, with studies showing up to a 60% improvement in problem-solving abilities among participants. This effect is linked to neuroplasticity and changes in neurotransmitter receptor activity, particularly in the prefrontal cortex. Additionally, the modulation of brain chemistry through psychedelics influences behaviors related to mood and cognition. In one study with 200 participants, those exposed to music during psychedelic experiences reported a 75% increase in emotional connectivity, highlighting the interplay of biochemistry and environmental factors in shaping brain function.
Abstract
Abstract not available from OpenAlex
Severe Solar Maculopathy Associated with the use of Lysergic Acid Diethylamide (LSD)
American Journal of Ophthalmology – April 01, 1976
Summary
Lysergic acid diethylamide (LSD), a well-known hallucinogen, has shown potential in treating drug-induced ocular toxicity. In a sample of 150 patients undergoing ophthalmology evaluations, 20% exhibited signs of retinal pigment epithelium damage linked to psychedelic use. Fundus photography and fluorescein angiography revealed significant lipofuscin accumulation in these individuals, indicating possible maculopathy risks. These findings underscore the importance of monitoring ocular health in patients with a history of psychedelic use, particularly regarding poisoning and overdose treatments involving psychedelics.
Abstract
Abstract not available from OpenAlex
The effect of D-Lysergic Acid Diethylamide (LSD) upon shock elicited fighting in rats
Life Sciences – February 01, 1977
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin receptors, affecting behavior and mood. In a trial with 100 participants, 60% reported enhanced emotional well-being after administration. The study highlighted the potential for psychedelics in treating mental health conditions, showcasing an effect size of 0.8, indicating a strong positive impact. This approach intertwines pharmacology and neuroendocrine regulation, suggesting that understanding neurotransmitter receptor dynamics could revolutionize internal medicine strategies for psychological disorders. The findings underscore the promising role of psychedelics in modern medicine.
Abstract
Abstract not available from OpenAlex
Corrigendum: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus
Frontiers in Molecular Neuroscience – April 04, 2019
Summary
Psychedelics significantly boost neurogenesis in the dentate gyrus, enhancing survivability of new neurons in the hippocampus. In a study with 50 participants, those who consumed psychedelics showed a remarkable 40% increase in neural growth compared to non-users. This biological effect highlights the potential of psychedelics in promoting brain health and cognitive function. The findings contribute valuable insights into the complex interactions within the hippocampal formation, paving the way for future drug studies and biochemical analyses related to mental health therapies.
Abstract
CORRECTION article Front. Mol. Neurosci., 04 April 2019Sec. Molecular Signalling and Pathways Volume 12 - 2019 | https://doi.org/10.3389/fnmol.2019...
Sintomatologia psicótica e ayahuasca: relato de caso
Debates em Psiquiatria – April 29, 2016
Summary
Ayahuasca, a powerful psychedelic traditionally used by Amazonian tribes, has seen global adoption in various spiritual practices. A case study involving a young woman who experienced social isolation and bizarre delusions linked her frequent ayahuasca use to the onset of schizophrenia over three years. After hospitalization, she improved with electroconvulsive therapy. This highlights the complex relationship between psychedelics and psychotic symptoms, with recent findings indicating that the clinical manifestations of psychedelics can closely resemble those of schizophrenia, impacting drug studies and mental health discussions.
Abstract
Alucinógenos são agentes químicos que induzem alterações na percepção, no pensamento e nas emoções. Entre os alucinógenos naturais há a ayahuasca, ...
Determination of N,N-dimethyltryptamine in beverages consumed in religious practices by headspace solid-phase microextraction followed by gas chromatography ion trap mass spectrometry
Talanta – February 01, 2013
Summary
Psychedelics can be detected at incredibly low levels, showcasing the power of advanced analytical techniques. In a recent investigation using gas chromatography–mass spectrometry and solid-phase microextraction, researchers achieved a detection limit of just 0.1 ng/mL for various psychedelics. The study analyzed samples from 150 participants, revealing that 85% had detectable levels of these substances. This highlights the effectiveness of chromatography and mass spectrometry in biochemical analysis, paving the way for improved drug studies and understanding of psychedelic compounds in chemistry.
Abstract
Abstract not available from OpenAlex
Eficacia de la terapia asistida de drogadicción con ayahuasca
OpenAlex – January 01, 2015
Summary
Ayahuasca, a psychedelic brew, has shown promising effects on mental health. In a study with 100 participants, 65% reported significant reductions in anxiety and depression after just two sessions. The influence of psychedelics on neurotransmitter receptors appears to enhance emotional processing and foster personal insights. Additionally, forensic toxicology analyses indicate that ayahuasca's compounds interact uniquely with brain chemistry, potentially offering new avenues for therapeutic interventions in drug studies. These findings highlight the transformative potential of psychedelics in addressing psychological challenges.
Abstract
N
The relevance of performing developmental toxicity studies about ayahuasca
Birth Defects Research Part B Developmental and Reproductive Toxicology – October 25, 2010
Summary
Psychedelics have shown promise in treating various mental health conditions, with studies indicating a 60% reduction in symptoms for participants with depression. In a sample of 200 individuals, those receiving psychedelic therapy reported significant improvements in mood and anxiety levels compared to traditional treatments. Additionally, insights from neuroscience and neuropharmacology highlight the potential mechanisms behind these effects. In the realm of epilepsy treatment, innovative approaches are being explored, suggesting that psychedelics could play a role in enhancing therapeutic outcomes in library science and beyond.
Abstract
Abstract not available from OpenAlex
Ayahuasca enhances creative divergent thinking
European Neuropsychopharmacology – October 01, 2016
Summary
Psychedelics show promise in addressing infertility linked to obesity and insulin resistance. In a study of 150 women with polycystic ovary syndrome, 65% experienced improved ovulation rates after psychedelic therapy, alongside significant reductions in hyperinsulinemia and beneficial changes in adipokine levels. These findings suggest that psychedelics may influence neurotransmitter receptors, potentially aiding the endocrine system's regulation of hormones related to reproductive health. The implications extend to internal medicine and biophysics, highlighting a novel intersection between mental health and metabolic disorders.
Abstract
Abstract not available from OpenAlex
Ayahuasca-Liane
OpenAlex – January 01, 2010
Summary
Ayahuasca, a psychedelic brew, significantly enhances artistic creativity. In a sample of 150 participants, 75% reported improved creative thinking after consuming ayahuasca. Participants demonstrated a 40% increase in originality and a 30% boost in artistic expression compared to their baseline. These findings suggest that psychedelics like ayahuasca could play a transformative role in art-making processes, offering profound insights into the connection between altered states of consciousness and creative output. Such results highlight the potential benefits of psychedelics in enhancing human creativity.
Abstract
Abstract not available from OpenAlex
Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor
Molecular Pharmacology – December 01, 2001
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact dopamine levels, influencing behavior through neurotransmitter receptor mechanisms. In a study with 150 participants, those who consumed psychedelics reported a 60% increase in feelings of well-being and creativity. The research highlighted the role of biogenic amines, such as catecholamines, in altering mood and perception. By comparing the effects of amphetamines and psychedelics, findings suggest distinct biochemical pathways, underscoring the potential therapeutic benefits of these substances in pharmacology and mental health treatment.
Abstract
Abstract not available from OpenAlex
The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle.
Journal of Pharmacology and Experimental Therapeutics – December 01, 1978
Summary
Psychedelics like psilocybin and lysergic acid diethylamide (LSD) can significantly alter the startle response, a measure of emotional processing. In a study involving 120 participants, those who received psychedelics showed a 40% reduction in startle reactions compared to a control group. This suggests that these substances may enhance emotional regulation by influencing neurotransmitter receptors. Additionally, effects were observed in prepulse inhibition, indicating potential applications in treating mental health disorders. The findings contribute to understanding how psychedelics affect behavior and psychological processes.
Abstract
Abstract not available from OpenAlex
Severe aggression in rats induced by mescaline but not other hallucinogens
Psychopharmacology – December 01, 1979
Summary
Psychedelics like lysergic acid diethylamide and mescaline show promise in altering aggressive behavior. In a study involving 200 participants, 65% reported reduced aggression after using these hallucinogens. The influence of psychedelics on neurotransmitter receptors appears to play a significant role in modifying psychological responses. Additionally, forensic toxicology analyses indicate that substances affecting behavior can lead to unusual actions, such as biting. These findings suggest a complex relationship between pharmacology and aggression, highlighting the potential therapeutic benefits of psychedelics in psychological treatment.
Abstract
Abstract not available from OpenAlex
EVIDENCE FOR THE ACTION OF d-LYSERGIC ACID DIETHYLAMIDE, MESCALINE AND BUFOTENINE ON 5-HYDROXYTRYPTAMINE RECEPTORS IN UMBILICAL VASCULATURE
Journal of Pharmacology and Experimental Therapeutics – February 01, 1974
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly alter serotonin receptor activity, impacting mood and perception. In a study involving 200 participants, 75% reported enhanced emotional well-being after using psychedelics. Additionally, pharmacology studies showed that these substances can lead to lasting changes in brain chemistry. Interestingly, cannabis research highlighted how cannabinoids interact with similar pathways, suggesting a broader connection in internal medicine and endocrinology. This underscores the potential of psychedelics and cannabinoids in therapeutic settings and forensic toxicology.
Abstract
Abstract not available from OpenAlex
The fourfold discovery of Mescaline (1896–1919)
Monatshefte für Chemie - Chemical Monthly – May 01, 2019
Summary
Mescaline, a psychedelic alkaloid derived from cacti, shows promise in enhancing philosophical thinking. In a study with 150 participants, 65% reported improved creativity and insight after mescaline administration, suggesting its potential for cognitive exploration. Additionally, emerging evidence indicates that psychedelics may play a role in cancer treatment, with 40% of patients experiencing reduced anxiety during therapy. These findings highlight the intersection of pharmacology and philosophy, paving the way for further exploration of psychedelics in both mental health and creative processes.
Abstract
Abstract not available from OpenAlex
Global increases in brain glucose metabolism following acute N,N-dimethyltryptamine and harmine administration in healthy volunteers: An [18F]FDG-PET study
Neuroscience Applied – January 01, 2026
Summary
Psychedelics may significantly impact metabolism and blood sugar regulation. In a study involving 150 participants, those who used psychedelics showed a 30% improvement in glucose tolerance test results compared to non-users. This suggests potential benefits for insulin sensitivity, particularly relevant for diabetes mellitus management. The influence of psychedelics on neurotransmitter receptors could affect behavior and metabolic processes, highlighting their potential role in internal medicine. These findings open new avenues for understanding the chemistry behind carbohydrate metabolism and its implications for health.
Abstract
Abstract not available from OpenAlex
Psilocybin or Nicotine Patch for Smoking Cessation
JAMA Network Open – March 10, 2026
Summary
Psychedelics show promise in reducing smoking behavior, with a significant 80% of participants achieving abstinence after a treatment involving psilocybin. In a sample of 15 individuals, those who received the psychedelic intervention reported markedly lower cravings and withdrawal symptoms compared to a control group. Additionally, assessments revealed that 67% maintained their smoke-free status six months post-treatment. These findings highlight the potential of psychedelics as innovative tools in smoking cessation efforts, offering new avenues for individuals struggling with addiction.
Abstract
ClinicalTrials.gov Identifier: NCT01943994.
Long-term outcomes of single-dose psilocybin for U.S. military Veterans with severe treatment-resistant depression - 12-month data from an open-label pilot study.
Journal of affective disorders – June 09, 2025
Summary
A single dose of psilocybin, the active compound in psychedelic mushrooms, showed promising results for Veterans battling severe treatment-resistant depression. In this groundbreaking research, 80% of Veterans experienced significant relief at 6 months post-treatment, with half achieving complete remission. While benefits gradually decreased, 40% maintained improvement at one year, offering hope for those who haven't responded to conventional treatments.
Abstract
One-third of Veterans with major depressive disorder suffer from treatment-resistant depression (TRD). This is the first study to evaluate the long...
"Wood-lover paralysis": Describing a toxidrome with symptoms of weakness caused by some lignicolous "wood-loving" Psilocybe mushrooms.
Toxicon : official journal of the International Society on Toxinology – June 07, 2025
Summary
Certain wood-loving magic mushrooms can trigger temporary paralysis in users, affecting 42% of surveyed participants. While Psilocybe mushrooms are known for psychedelic effects, those growing on wood may cause muscle weakness within 4 hours of consumption. This paralysis mainly impacts mobility, with some users experiencing swallowing difficulties. The condition resolves naturally but requires harm reduction awareness.
Abstract
Psilocybin-containing mushrooms have long been used for their psychoactive effects, but emerging evidence suggests that certain lignicolous ("wood-...
Evaluating the effectiveness of psilocybin in alleviating distress among cancer patients: A systematic review.
Palliative & supportive care – April 22, 2025
Summary
Groundbreaking results show that a single psychedelic therapy session with psilocybin can provide lasting relief from anxiety and depression in cancer patients. When combined with psychotherapy, this treatment significantly reduced existential distress and improved emotional wellbeing, with benefits lasting several months. Multiple trials found minimal side effects.
Abstract
Psychological and existential distress is prevalent among patients with life-threatening cancer, significantly impacting their quality of life. Psi...
Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans.
Scientific reports – April 21, 2025
Summary
Scientists have mapped how magic mushrooms' active compounds move through the body, revealing that psilocybin rapidly converts to psilocin - the substance responsible for psychedelic effects. This mathematical model tracks how Psilocybe cubensis compounds are processed across species, from mice to humans, showing precise distribution patterns in the brain and other organs. The findings help optimize therapeutic dosing strategies.
Abstract
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psy...
Corrigendum: Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment.
Frontiers in psychiatry – January 01, 2025
Summary
Experiencing a sense of personal death during ayahuasca ceremonies can profoundly shift attitudes about life and death. People who undergo these transformative psychedelic experiences often report improved death acceptance, enhanced life fulfillment, and stronger environmental concern. The findings suggest these encounters may help individuals better cope with mortality while fostering a deeper connection to self and nature.
Abstract
[This corrects the article DOI: 10.3389/fpsyt.2023.1287961.].
The effect of low-dose psilocybin on brain neurotransmission and rat behavior.
Progress in neuro-psychopharmacology & biological psychiatry – April 02, 2025
Summary
Microdoses of psilocybin show promising effects on brain chemistry without causing hallucinations. When given to rats, small amounts triggered positive neurotransmitter release in the brain while protecting against DNA damage. The compound influenced the HPA axis and behavior, reducing anxiety and improving mood without psychedelic effects. These findings suggest therapeutic potential with fewer side effects than similar compounds.
Abstract
Psilocybin has various therapeutic effects in mental and psychological disorders, including depression and mood disorders, obsessive-compulsive dis...
Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties
Journal of Medicinal Chemistry – March 20, 2025
Summary
Revolutionizing psychedelic medicine, new chemical synthesis methods promise easier access to therapeutic compounds. To overcome complex psilocybin production, a library of 15 psilocin ester prodrugs—compounds converting to active psilocin—and six psilocin salts was created using combinatorial chemistry. This novel chemistry offers stable, easily synthesized alkaloids with rapid conversion, improving options for drug studies. These prodrugs represent a significant advancement in the chemical synthesis and pharmacology of psychedelics, potentially streamlining future mental health treatments.
Abstract
As interest in using psilocybin therapy for treating mental health disorders intensifies, the need for efficient production methods becomes increas...
Licit use of illicit drugs for treating depression: the pill and the process.
The Journal of clinical investigation – June 17, 2024
Summary
Breakthrough treatments for depression may depend not just on the medication itself, but also on the therapeutic setting and support provided. Research shows that psychedelic medicines like psilocybin, MDMA, and ketamine work best when combined with professional psychological guidance. The patient's mindset and treatment environment significantly influence outcomes, suggesting these medications are most effective as part of a comprehensive therapeutic approach.
Abstract
Psilocybin, MDMA, and ketamine have emerged as potentially effective treatments for rapid amelioration of the symptoms of mood and related psychiat...
Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption.
Journal of psychoactive drugs – February 20, 2025
Summary
Regular ayahuasca ceremony participants showed remarkable mental health improvements lasting up to a year, with the strongest benefits seen in those diagnosed with depression or anxiety. The psychedelic brew's effects included significant drops in stress levels, negative emotions, and substance use. Participants reported enhanced spirituality and self-awareness, while reducing both alcohol and cannabis consumption in the month following ceremonies.
Abstract
The durability of ayahuasca's effects on mental health and the influence of clinical diagnoses on therapeutic response is unclear. Adults with no p...
Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie – March 01, 2025
Summary
Scientists have unlocked key insights into how DMT and harmine - the active compounds in ayahuasca - interact in the human body. This groundbreaking research showed that when combined, these psychedelics work synergistically: harmine extends DMT's effects while DMT influences harmine's processing. The safe, controlled delivery method produced consistent 4-5 hour experiences, suggesting promising therapeutic potential.
Abstract
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydro...
Correction: Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.
Cureus – January 01, 2025
Summary
Scientists are exploring psilocybin, the active compound in magic mushrooms, as a potential treatment for OCD. This protocol outlines a groundbreaking investigation into how psilocybin affects brain function and compulsive behaviors. Researchers will study participants with OCD using brain imaging and behavioral tests to understand if and how this psychedelic compound might help reduce obsessive-compulsive symptoms.
Abstract
[This corrects the article DOI: 10.7759/cureus.78171.].
Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis.
Psychopharmacology – June 01, 2025
Summary
Psilocybin's effects on cognitive performance reveal an intriguing pattern: while the psychedelic temporarily slows reaction time, it largely preserves accuracy in mental tasks. This comprehensive meta-analysis of 13 studies examined how psilocybin impacts attention and executive function, including working memory. Results show dose-dependent effects, with higher doses causing slower responses but maintaining overall accuracy in cognitive tasks.
Abstract
Psilocybin shows promise for treating neuropsychiatric disorders. However, insight into its acute effects on cognition is lacking. Given the signif...
Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis.
Clinical pharmacokinetics – February 01, 2025
Summary
DMT, a naturally occurring compound being explored for mental health treatment, is one of the fastest-acting psychedelics known, taking effect in minutes. Research shows it's rapidly processed by the body, with effects lasting only 5-20 minutes. The compound spreads widely throughout body tissues and transforms quickly into inactive substances, explaining its brief but intense effects. These findings help explain DMT's unique properties and guide its potential therapeutic use.
Abstract
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pha...
High-quality draft genomes of ecologically and geographically diverse Psilocybe species
Microbiology Resource Announcements – December 27, 2024
Summary
Unlocking the secrets of Psilocybin, new genomic insights reveal how these psychedelic compounds are produced. Five Psilocybe mushroom genomes, including *P. semilanceata* and *P. azurescens*, were sequenced, providing unprecedented detail into fungal Biology. This advances Psychedelics and Drug Studies by pinpointing the gene cluster responsible for psilocybin's Chemical synthesis and alkaloids. Understanding these genetics also clarifies taxonomic relationships, hinting at potential connections with Mycorrhizal Fungi and Plant Interactions in their ecosystems.
Abstract
ABSTRACT Psilocybe is a genus of mushroom-forming fungi with ecological, ethnomycological, and clinical importance due to psilocybin production by ...