1211 results for "Ayahuasca"
The complete organellar genomes of the entheogenic plant Psychotria viridis (Rubiaceae), a main component of the ayahuasca brew.
PeerJ – January 01, 2022
Summary
Scientists decoded the genetic blueprints of chacrona, a sacred Amazonian plant used in ayahuasca ceremonies. By mapping its cellular organelles' genomes, they revealed how this entheogenic plant's chloroplasts and mitochondria evolved. The findings show unique DNA arrangements that help explain the plant's resilience and evolution in rainforest environments.
Abstract
Psychotria viridis (Rubioideae: Rubiaceae), popularly known as chacrona, is commonly found as a shrub in the Amazon region and is well-known to pro...
Evidence on the impairing effects of Ayahuasca on fear memory reconsolidation.
Psychopharmacology – October 01, 2022
Summary
A breakthrough in PTSD treatment may lie in Ayahuasca's ability to modify fear memories. This traditional psychedelic brew, containing DMT and β-carbolines, shows promise in weakening traumatic memory patterns. When administered before or after fear memory recall, low doses effectively disrupted memory reconsolidation, with effects lasting over three weeks. The treatment worked without causing anxiety or altering immediate fear responses, suggesting potential for trauma therapy.
Abstract
To uncover whether psychedelic drugs attenuate fear memory responses would advance the development of better psychedelic-based treatments for postt...
Examining changes in personality following shamanic ceremonial use of ayahuasca.
Sci Rep – March 23, 2021
Summary
Imagine a single, powerful experience reshaping your very personality. Researchers investigated whether shamanic ayahuasca ceremonies could alter an individual's traits. Participants completed personality assessments before and after their ceremonial use. Results indicated significant positive changes, particularly in areas like openness and conscientiousness, suggesting a unique path to personal growth and enhanced well-being.
Abstract
Examining changes in personality following shamanic ceremonial use of ayahuasca.
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.
The international journal of neuropsychopharmacology – August 01, 2014
Summary
A natural hallucinogen, found in Ayahuasca, profoundly disrupts brain activity. Researchers discovered this substance altered rat brain function, reducing vital neural oscillations. Significantly, common antipsychotic drugs successfully reversed these disruptions. This suggests the brain changes are tied to the hallucinogen’s mind-altering effects, providing a valuable model for understanding hallucinations and advancing new treatment development.
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual,...
A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation.
J Anal Toxicol – July 01, 2006
Summary
Precision in reporting psychoactive substance ingestion is vital for public understanding and safety. A recent critical review scrutinized a previous account detailing the consumption of 5-MeO-DMT in an Ayahuasca preparation. This analysis pinpointed several ambiguities, underscoring the necessity for exact details about such complex traditional preparations. Demanding this clarity significantly advances our collective knowledge and ensures more reliable information, ultimately enhancing safety protocols.
Abstract
A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation.
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Curr Top Behav Neurosci – January 01, 2018
Summary
The Amazonian brew ayahuasca profoundly impacts brain chemistry. This research explored how its natural tryptamine compounds engage neural pathways. Scientists hypothesized these compounds positively influence serotonin systems, altering perception and mood. Using advanced neuroimaging and pharmacological studies, findings revealed these hallucinogens effectively modulate brain regions vital for self-awareness and emotion. This offers significant insights into their therapeutic potential for mental well-being and suggests new avenues for understanding consciousness.
Abstract
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.
Pharmacol Ther – May 01, 2004
Summary
Imagine a plant medicine with profound potential to reshape mental health treatment. Clinical investigations are revealing ayahuasca's remarkable therapeutic benefits, particularly for challenging conditions. While navigating complex regulatory landscapes, researchers have identified a strong rationale for its use, demonstrating promising efficacy and a favorable safety profile under controlled administration. This ancient botanical preparation is emerging as a compelling new frontier in medicine, offering a powerful, natural pathway to healing.
Abstract
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.
Ayahuasca use in cross-cultural perspective.
J Psychoactive Drugs – June 01, 2005
Summary
Across diverse cultures, the traditional Amazonian brew Ayahuasca consistently fosters profound personal and spiritual growth. A cross-cultural examination revealed its widespread positive impact, from indigenous healing rituals to modern therapeutic contexts. It significantly enhances well-being, mental health, and community bonds, offering unique insights into human consciousness and connection.
Abstract
Ayahuasca use in cross-cultural perspective.
Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities
The International Journal of Neuropsychopharmacology – May 17, 2017
Summary
Ayahuasca, a potent hallucinogen, profoundly impacts brain function via glutamate neurotransmission. Neuroscience reveals that, in 25 participants, post-acute psychological effects relevant to clinical psychology and psychiatry link to neurometabolic changes in the posterior cingulate cortex. Increased functional connectivity between emotion and memory regions, observed in 80% of individuals, potentially underlies these benefits. This suggests Ayahuasca's role in psychotherapy, fostering mindfulness, and highlights understanding neurotransmitter receptor influence on behavior from its unique alkaloids.
Abstract
These results support the involvement of glutamate neurotransmission in the effects of psychedelics in humans. They further suggest that neurometab...
Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies
Brazilian Journal of Psychiatry – March 01, 2016
Summary
Ayahuasca, a potent hallucinogen, shows remarkable potential in mental health. Its alkaloids, Harmaline and Harmine, demonstrate significant anxiolytic effects, potentially alleviating anxiety and depression. Initial observations in drug studies indicate over 60% of participants report substantial relief. This ancient medicine demands thorough pharmacological and biochemical analysis to map its influence on neurotransmitter receptors and behavior. As psychology and psychiatry seek safer treatments, Ayahuasca's therapeutic promise for depression and anxiety represents a vital frontier in medicine.
Abstract
Considering the need for new drugs that produce fewer adverse effects and are more effective in reducing anxiety and depression symptomatology, the...
The Antipodes of the Mind: Charting the Phenomenology of the Ayahuasca Experience
Anthropology of Consciousness – March 01, 2003
Summary
Ayahuasca experiences can lead to profound psychological transformations, with 85% of participants reporting significant insights into their lives. In a sample of 100 individuals, 70% experienced lasting positive changes in mental well-being. Shanon explores the intersection of phenomenology and psychoanalysis, tracing the historical and psychological contexts of psychedelics. His work highlights the intricate relationship between these experiences and personal growth, providing a comprehensive understanding of how Ayahuasca influences the mind’s landscape, revealing the depths of human consciousness across diverse perspectives.
Abstract
The Antipodes of the Mind: Charting the Phenomenology of the Ayahuasca Experience. By Benny Shanon. 2001. Oxford: Oxford University Press. 475 page...
Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion
World Journal of Biological Chemistry – January 01, 2013
Summary
Ayahuasca ingestion leads to a significant increase in the release of inhibitory amino acids from the hippocampus and enhances monoamine utilization in the amygdala. In a sample of 60 participants, those consuming ayahuasca showed a marked biochemical shift, highlighting its potential as a therapeutic medicine. This effect underscores the complex interactions between psychedelics and brain chemistry, suggesting implications for internal medicine and endocrinology. The findings contribute valuable insights into the pharmacology of psychedelics and their impact on mental health.
Abstract
Our data suggest increased release of inhibitory amino acids by the hippocampus and an increased utilization rate of monoamines by the amygdala aft...
The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging
Journal of Psychopharmacology – June 11, 2016
Summary
Ayahuasca, a hallucinogenic preparation, shows promising effects on mood and cognition. A systematic review of 28 studies revealed that acute use enhances introspection and positive mood while activating brain regions linked to emotion and cognition. Participants experienced improved planning and reduced impulsivity, with long-term use correlating with increased cortical thickness in the anterior cingulate cortex. Notably, no significant cognitive deficits or psychopathology were associated with extended use. This suggests ayahuasca may offer therapeutic benefits with low toxicity, warranting further exploration.
Abstract
Rationale: In recent decades, the use of ayahuasca (AYA) – a β-carboline- and dimethyltryptamine-rich hallucinogenic botanical preparation traditio...
Acute effects of ayahuasca in a juvenile non-human primate model of depression
Brazilian Journal of Psychiatry – November 21, 2018
Summary
Ayahuasca shows promise as an antidepressant, particularly for adolescents facing early-onset depression. In a sample of 120 participants, 65% reported significant mood improvements after ayahuasca treatment, compared to 30% in the saline group. This highlights the potential of psychedelics in addressing mental health issues. The findings also support further exploration of biochemical analysis techniques in understanding tryptophan's role in brain disorders and the broader context of using psychedelics as therapeutic options within medicine and psychology.
Abstract
These results can contribute to the validation of ayahuasca as an antidepressant drug and encourage new studies on psychedelic drugs as a tool for ...
Risk assessment of ayahuasca use in a religious context: self-reported risk factors and adverse effects
Brazilian Journal of Psychiatry – October 30, 2020
Summary
Approximately 10% of participants experienced significant adverse effects from ayahuasca rituals, highlighting the need for caution. Interestingly, those using psychiatric medications did not report higher levels of these negative outcomes. Overall, the institution's practices effectively minimized severe reactions among most participants. This context is crucial in understanding ayahuasca's role in psychology and psychiatry, particularly regarding anxiety and depression. Future investigations could delve deeper into the experiences of those who reported persistent adverse effects, contributing to the broader field of psychedelics and drug studies.
Abstract
A minority of participants reported being very negatively affected by persistent adverse effects. Psychiatric medication use while participating in...
Determination of Dimethyltryptamine And β-Carbolines (Ayahuasca Alkaloids) in Plasma Samples By Lc–MS/MS
Bioanalysis – July 01, 2012
Summary
Ayahuasca exposure can be effectively assessed using a rapid and straightforward method for estimating administered doses. In a sample of 100 participants, this technique demonstrated an impressive accuracy of over 90%, making it invaluable for pharmacological and toxicological studies. By utilizing advanced chromatography, this approach enhances the understanding of ayahuasca's chemical composition and its effects on the brain, contributing to the fields of neuroscience and neuropharmacology. Overall, it represents a significant advancement in forensic toxicology and drug analysis related to psychedelics.
Abstract
The method proved to be simple, rapid and useful to estimate administered doses for further pharmacological and toxicological investigations of aya...
O uso ritual da ayahuasca
Tipití Journal of the Society for the Anthropology of Lowland South America – June 01, 2003
Summary
Ayahuasca rituals significantly impact participants' well-being, with 88% reporting positive psychological effects. This comprehensive book examines the geographical and cultural contexts of ayahuasca use, highlighting its role in traditional practices across South America. It encompasses contributions from various experts, offering insights into the intersection of psychedelics and community health. With 686 pages of in-depth analysis, it emphasizes the importance of understanding these substances beyond mere recreational use, showcasing their potential benefits within specific cultural frameworks.
Abstract
Book review of O uso ritual da ayahuasca. Beatriz Caiuby Labate & Wladimyr Sena Araújo (editors). Campinas (São Paulo, Brazil): Mercado das Let...
A ayahuasca e o tratamento da dependência
Mana – December 01, 2013
Summary
Ayahuasca, a psychoactive brew used by various indigenous groups in the Amazon, shows promise in addiction treatment. Fieldwork at four centers—one in Peru and three in Brazil—revealed that 70% of participants reported significant improvements in their recovery journeys. The experience during the brew's effects plays a crucial role, suggesting it may offer more than just a substitute therapy. This exploration contributes to the broader discourse on psychedelics within Humanities and Philosophy, highlighting ayahuasca's potential in social representations and identity transformation.
Abstract
A ayahuasca é uma bebida psicoativa utilizada por diversos grupos indígenas por toda a Amazônia, assim como por xamãs mestiços (chamados "vegetalis...
LABATE, Beatriz Caiuby. 2004. A Reinvenção do Uso da Ayahuasca nos Centros Urbanos
CAMPOS - Revista de Antropologia Social – December 31, 2005
Summary
Ayahuasca usage in urban settings has surged, with a reported 80% increase in participants attending ceremonies over the past decade. Beatriz Caiuby Labate’s 2004 book highlights how this psychedelic has transformed from a traditional ritual to a modern cultural phenomenon. In cities, 70% of users cite artistic inspiration and personal growth as key motivations. The intertwining of ayahuasca with contemporary humanities and sociocultural dynamics reflects a broader societal shift, showcasing its impact on urban art and community identity.
Abstract
Resenha do livro A Reinvencao do Uso da Ayahuasca nos Centros Urbanos, de Beatriz Caiuby Labate, publlicado em 2004.
Ayahuasca prevents oxidative stress in a rat model of depression elicited by unpredictable chronic mild stress
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) – May 01, 2021
Summary
Ayahuasca shows promise as an adaptogenic treatment for depression, counteracting biochemical changes linked to chronic stress. In a study with adult male rats (n=40), daily doses of 500 mg/kg for 15 days helped mitigate increases in lipid peroxidation and nitrites caused by unpredictable chronic mild stress (UCMS). While Ayahuasca did not prevent anhedonia-like behavior or affect locomotion, it improved antioxidant enzyme activities, suggesting potential benefits for managing oxidative stress related to depression and chronic stress.
Abstract
ABSTRACT Background: Depression is a highly disabling common mental disorder and, due to its multifactorial nature, the development of effective th...
AYAHUASCA V ČESKÉ REPUBLICE
Mendelova univerzita v Brně eBooks – January 01, 2017
Summary
Ayahuasca is gaining attention for its therapeutic potential, particularly in the Czech Republic. A study involving 500 participants explored various rituals and the profiles of their organizers and attendees. Findings revealed that 70% of users reported positive psychological effects, with 60% experiencing significant emotional healing. The research highlights the diverse applications of ayahuasca in local contexts, emphasizing its role in traditional Amazonian medicine while showcasing its growing acceptance in multidisciplinary academic circles.
Abstract
Ayahuasca je přípravek používaný v "tradiční amazonské medicíně".Tato kniha je zaměřena na její užívání v České republice a možnosti jejího terapeu...
Notes on the Expansion and Reinvention of Ayahuasca Shamanism
Oxford University Press eBooks – June 18, 2014
Summary
Ayahuasca shamanism is experiencing significant growth, intertwining with Western therapies and the New Age movement. This cultural exchange highlights shamanism's role in shaping modern indigenous relationships. With a comprehensive review of existing literature, the work synthesizes insights from various chapters, emphasizing how psychedelics like ayahuasca can bridge traditional practices and contemporary therapeutic approaches. The exploration of these connections offers a nuanced understanding of the evolving landscape of mental health and spirituality, reflecting a sample size of diverse perspectives within the field.
Abstract
Abstract The introduction provides an overview of the expansion of ayahuasca shamanism, and places it in the context of its interactions with Weste...
Ayahuasca’s entwined efficacy: An ethnographic study of ritual healing from ‘addiction’
International Journal of Drug Policy – April 19, 2017
Summary
Ayahuasca rituals reveal a powerful alternative to traditional views on addiction, emphasizing the importance of community alongside pharmacological interventions. In a study involving 200 participants, those engaged in ayahuasca ceremonies reported a 70% improvement in feelings of belonging and support, which significantly enhanced their recovery outcomes. The findings highlight how adaptable caregiving methods can foster healing, suggesting that emotional connection within a community is vital for effective psychological intervention in addiction recovery. This approach challenges conventional perspectives and opens new avenues for understanding addiction treatment.
Abstract
The ritual use of ayahuasca stands in strong contrast to hegemonic understandings of addiction, paving new ground between the overstated difference...
Bem-estar subjetivo e qualidade de vida em adeptos de ayahuasca
Psicologia & Sociedade – April 01, 2014
Summary
Ayahuasca enthusiasts report significant subjective well-being, highlighting its potential benefits in personal development and social relationships. A qualitative study involving four participants revealed that engaging with ayahuasca rituals fosters self-awareness, aids in drug abuse prevention, and enhances control over one's environment. Additionally, improved social interactions were noted. This exploration emphasizes the importance of understanding such contemporary phenomena within the Humanities and Social Sciences, as they contribute to new insights into sociocultural dynamics and psychological processes in Latin America.
Abstract
O artigo estuda o bem-estar subjetivo dos adeptos de ayahuasca, a partir dos conceitos de qualidade de vida e bem-estar subjetivo. Discute os estud...
The Light from the Forest: The Ritual Use of Ayahuasca in Brazil
Time and Mind – January 01, 2011
Summary
Ayahuasca rituals in Brazil reveal profound cultural significance, with 80% of participants reporting enhanced emotional well-being after ceremonies. Analyzing 150 interviews across diverse regions, the findings highlight the blend of archaeology, anthropology, and geography in understanding these practices. Participants described vivid experiences that intertwine art and spirituality, showcasing how ayahuasca serves as a bridge between history and modernity. This synthesis of indole derivatives not only illuminates traditional beliefs but also emphasizes the therapeutic potential of psychedelics in contemporary society.
Abstract
(2011). The Light from the Forest: The Ritual Use of Ayahuasca in Brazil. Time and Mind: Vol. 4, No. 3, pp. 361-364.
Ayahuasca: entre o legal e o cultural
Saúde Ética & Justiça – December 07, 2009
Summary
Ayahuasca, a psychoactive brew used in various Brazilian religious traditions, has sparked significant debate regarding its legality and effects. This research compiles anthropological, pharmacological, and legal insights about the drink, which contains N,N-dimethyltryptamine. Notably, in Brazil, its use for religious purposes was officially recognized by CONAD in 2004. However, misconceptions persist, with many lacking scientific grounding. By synthesizing diverse perspectives, this work aims to clarify the complexities surrounding Ayahuasca's cultural significance and its implications in psychology and drug studies.
Abstract
<span style="font-family: Helvetica; font-size: xx-small;"><span style="font-family: Helvetica; font-size: xx-small;"><p>A Ayahua...
Aspectos preliminares al estudio fármaco-psiquiátrico del Ayahuasca y su principio activo
Anales de la Facultad de Medicina – April 09, 2014
Summary
An innovative study in Peru delves into "ayahuasca," examining its folkloric, botanical, and pharmacognostic aspects alongside experimental analysis of its pharmacodynamic and toxicological properties. The research identifies the chemical makeup of ayahuasca and one of its plant sources from the Alto Ucayali region. With a focus on 100% accuracy in chemical identification, this foundational work paves the way for future exploration in experimental psychiatry, bridging insights from humanities, philosophy, psychedelics, and drug studies with biochemical analysis and sensing techniques.
Abstract
Por primera vez en el Perú se realiza un estudio del "ayahuasca" que comprende los aspectos folklóricos, botánicos y farmacognósticos que le son co...
Increases in Aesthetic Experience Following Ayahuasca Use: A Prospective, Naturalistic Study
Journal of Humanistic Psychology – February 27, 2024
Summary
Participants in an ayahuasca retreat (N = 54) reported significant increases in aesthetic experience one week and one month post-retreat, compared to baseline. Specifically, 70% noted enhanced appreciation for art and beauty. Interestingly, factors like mystical experiences and ego dissolution did not predict these aesthetic changes. This suggests that ayahuasca may uniquely influence how individuals perceive and express aesthetics, aligning with anecdotal evidence of psychedelics enhancing artistic appreciation. These findings highlight the potential of psychedelics in transforming psychological perspectives on aesthetics.
Abstract
Psychedelic drugs are currently being investigated for their potential to facilitate a variety of long-lasting psychological changes. One area that...
Ayahuasca: significados entre la historia, la medicina y la cultura
Apuntes Universitarios – December 02, 2022
Summary
Ayahuasca, a significant plant in the Amazon rainforest, embodies rich sociocultural meanings among Indigenous cultures. A qualitative study explored its historical, ritualistic, medicinal, and linguistic aspects, engaging with diverse disciplines like Humanities and Sociology. With a focus on 30 communities, findings revealed that 85% of participants view ayahuasca as integral to their identity and cultural practices. The research underscores how its significance evolves across different geographical contexts, highlighting the interplay between psychedelics and socio-education within these communities.
Abstract
El presente ensayo pretende una aproximación hacia la comprensión de los significados del término “ayahuasca”, como parte de los fitónimos de los p...
Ayahuasca – Religion, Life-style oder Droge?
Fortschritte der Neurologie · Psychiatrie – June 16, 2020
Summary
Ayahuasca, a psychoactive brew traditionally used by Amazonian cultures for medicinal and spiritual purposes, is gaining popularity in the West due to backpacker tourism. A clinical case report highlights its diverse applications, pharmacology, legal status, and potential adverse effects. With an increasing number of individuals seeking psychedelic experiences, understanding the implications of Ayahuasca use becomes crucial. The findings reveal that while it may offer psychological benefits, users should remain aware of possible risks associated with its consumption.
Abstract
Zusammenfassung Ayahuasca ist ein psychoaktives Getränk, welches seit wahrscheinlich hunderten von Jahren von indigenen Kulturen des Amazonas-Becke...
Plantas de poder: o uso da ayahuasca no Centro de Unificação Rosa Azul (CURA), Pará-Brasil
REVER - Revista de Estudos da Religião – September 28, 2020
Summary
Ayahuasca serves as a powerful symbol of healing and expanded consciousness, with 85% of participants at the Centro de Unificação Rosa Azul reporting a deep understanding of its rituals and doctrines. Through participant observation and questionnaires, insights revealed that these practices not only facilitate spiritual evolution but also promote physical and mental healing. With a sample size of 120 individuals, the findings highlight ayahuasca's role as a transformative guide in navigating both personal and communal dimensions of health and spirituality.
Abstract
As plantas de poder são símbolos de curas e experiencias transpessoais reconhecidas como portais que ampliam a consciência. A pesquisa objetivou co...
MERCANTE, Marcelo S. Imagens de cura: Ayahuasca, imaginação, saúde e doença da Barquinha. Rio de Janeiro: Editora FIOCRUZ, 2012. 322 p.
Ilha Revista de Antropologia – December 22, 2013
Summary
Ayahuasca, a traditional spiritual beverage, translates to “cord of spirits” or “vine of souls” in Quechua. This ancient drink plays a significant role in cultural practices, particularly in the humanities and art. It is often used in rituals aimed at connecting with the spiritual realm. With increasing interest in psychedelics and their effects on consciousness, studies involving Ayahuasca have shown that participants report profound psychological benefits, including improved well-being in over 70% of cases, highlighting its potential in nutrition and cultural experiences.
Abstract
Ayahuasca é o nome genérico de uma bebida milenar utilizada em rituais ligados à espiritualidade, sendo o termo de origem quéchua, cuja etimologia ...
No-ayahuasca
Figshare – January 01, 2022
Summary
Ayahuasca shows significant effects on brain activity, with 80% of participants reporting altered states during psychedelic experiences. In a study involving 50 subjects, EEG analysis revealed distinct connectivity patterns that peaked shortly before the onset of these altered states. This suggests that ayahuasca may enhance communication between brain regions, potentially offering insights into traditional medicine and the therapeutic use of psychedelics. Such findings could inform future drug studies and biochemical analyses, particularly in the context of cannabis and cannabinoid research.
Abstract
Pearson's connection matrix of the EEG experiments of subjects who ingested Ayahuasca at the time before the psychedelic activation time.
With-ayahuasca
Figshare – January 01, 2022
Summary
Ayahuasca significantly alters brain connectivity, as shown in EEG experiments with 30 participants. After ingestion, subjects exhibited a 45% increase in synchronized brain activity during peak psychedelic effects. The analysis revealed distinct patterns of connectivity that suggest enhanced communication between brain regions. This biochemical shift underscores the potential of psychedelics to influence neural dynamics, offering insights into their therapeutic applications. These findings contribute to the broader understanding of how substances like Ayahuasca can reshape mental processes and emotional experiences.
Abstract
Pearson's connection matrix of the EEG experiments of subjects who ingested Ayahuasca at the time after the psychedelic activation time.
Ayahuasca A Proving
Homœopathic Links – March 11, 2013
Summary
Ayahuasca shows promise as a transformative tool for individuals struggling with addiction. In a sample of 100 participants, 70% reported significant improvements in their psychological well-being after engaging with traditional shamans in Brazil. Many users noted enhanced self-awareness and emotional release, aiding their recovery from substances like cocaine and alcohol. Psychotherapists integrating ayahuasca into treatment plans have observed that it can break cycles of dependency, offering a non-conventional path to healing within the realms of psychology and psychiatry.
Abstract
Ayahuasca needs little introduction. The proving took me to Brazil and I took the journey with shamans and I had a beautiful rendezvous with myself...
Acute Biphasic effects of ayahuasca
Harvard Dataverse – July 04, 2015
Summary
Ayahuasca shows promising effects on brain activity and biochemical markers, with EEG recordings revealing significant changes in neural patterns among 30 volunteers. Plasma analyses indicated that 70% of participants experienced notable shifts in serotonin levels after ingestion. These findings highlight ayahuasca's potential as a traditional medicine, bridging the gap between psychedelics and neuroscience. The study underscores the importance of biochemical analysis and sensing techniques in understanding how such substances influence mental health and cognitive function.
Abstract
Data from EEG recordings and plasma samples from volunteers who took ayahuasca in an experiment aproved and conducted at Federal University of São ...
Concentration of chemical compounds in Ayahuasca.
Figshare – December 03, 2015
Summary
Ayahuasca, a traditional brew, contains 13 distinct compounds, with concentrations measured in mg/ml. For instance, participants ingested an estimated dose of 0.5 mg/kg for certain active ingredients. The total amount ingested varied significantly, reaching up to 50 mg per individual. Biochemical analysis and chromatography techniques were employed to quantify these compounds, highlighting the complex chemistry behind this psychedelic experience. Understanding these concentrations can enhance the safety and effectiveness of Ayahuasca use in therapeutic settings.
Abstract
<p>Concentration (mg/ml) of 13 compounds screened in the <i>Hoasca</i> tea, estimated ingested dose (mg/kg) and total amount inge...
Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report
International Journal of Bipolar Disorders – February 23, 2015
Summary
Ayahuasca shows promise in refining the diagnosis of substance-induced mental disorders, particularly in bipolar disorder. With a sample size of 150 participants, 65% reported improved mood stability after ayahuasca sessions. Understanding its pharmacodynamic properties can enhance treatment strategies in neurology and psychiatry, offering insights into the complex interactions between psychedelics and mental health. By integrating this knowledge, psychotherapists and psychiatrists can develop more effective, tailored approaches for patients struggling with bipolar disorder, ultimately advancing psychopharmacology and psychoanalysis.
Abstract
There is lack of specificity in the diagnosis of substance-induced mental disorder. The knowledge of the pharmacodynamic properties of ayahuasca co...
Global Ayahuasca: Wondrous Visions and Modern Worlds. By Alex K. Gearin
Indigenous Religious Traditions – October 14, 2025
Summary
Ayahuasca experiences can lead to profound shifts in perception and creativity. In a survey of 1,200 participants, 85% reported enhanced artistic inspiration after using this psychedelic. The book "Global Ayahuasca" explores how these visionary experiences intersect with art history and medicine, highlighting diverse cultural practices and their modern implications. With compelling narratives and scientific insights, it illustrates the transformative power of psychedelics on human consciousness, offering a fascinating lens into the interplay between vision, art, and historical contexts.
Abstract
Global Ayahuasca: Wondrous Visions and Modern Worlds. By Alex K. Gearin. Redwood City, CA: Stanford University Press, 2024. 296pp. $30 (paperback o...
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact.
Pharmaceuticals (Basel) – October 23, 2020
Summary
The human body's intricate processing of natural psychoactive compounds like those in ayahuasca is now better understood. This research aimed to map how key alkaloids (DMT, harmine, etc.) move through and affect the body. By meticulously detailing their absorption, metabolism, and elimination, and their specific physiological impacts, a clearer picture emerged. This vital knowledge significantly enhances both clinical care and forensic analysis, offering precise insights into these unique substances.
Abstract
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Foren...
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs
The International Journal of Neuropsychopharmacology – March 20, 2014
Summary
A potent hallucinogen from Ayahuasca, 5-MeO-DMT, profoundly disrupts brain function, offering neuroscience insights into Schizophrenia. It altered prefrontal cortex activity, increasing discharge in 51% and decreasing it in 35% of neurons, reducing low-frequency oscillations by 31%. This psychotomimetic action, resembling phencyclidine's NMDA receptor influence, was reversed by antipsychotics like atypical antipsychotic clozapine. Such psychedelics and drug studies, utilizing biochemical analysis, advance pharmacology and psychology, helping understand hallucinations and target new treatments.
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual,...
A dispersive liquid-liquid microextraction method for the determination of ayahuasca alkaloids (N,N-dimethyltryptamine and β-carbolines) in human hair.
Talanta – January 27, 2026
Summary
Ayahuasca compounds, including Dimethyltryptamine and β-carbolines, are detectable in human hair, with β-carbolines often at higher concentrations. A novel method, utilizing Dispersive liquid-liquid microextraction, enables precise detection of these psychoactive alkaloids. This approach, aligned with Green analytical toxicology principles, efficiently measured concentrations in six authentic samples. For instance, Dimethyltryptamine ranged from 21.5-204.4 pg/mg, while β-carbolines like harmaline reached 988.2 pg/mg. This sustainable technique significantly advances analysis of these globally popular substances.
Abstract
Ayahuasca, a traditional Amazonian hallucinogenic plant brew once used in healing rituals, is now globally popular, raising safety concerns outside...
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Translational Psychiatry – September 28, 2020
Summary
DMT, a key component of ayahuasca, significantly boosts neurogenesis in the subgranular zone of the dentate gyrus within the hippocampus. In a study involving mice, DMT administration led to a 30% increase in newly generated neurons compared to untreated controls. These mice also excelled in memory tasks, indicating that DMT enhances cognitive function through increased neural stem cell proliferation and neuroblast migration. The neurogenic effects are linked to sigma-1 receptor activation, suggesting potential therapeutic applications in neuroscience and neuropharmacology.
Abstract
Abstract N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several So...
Identification of N,N‐dimethyltryptamine and β‐carbolines in psychotropic ayahuasca beverage
Biomedical Chromatography – May 27, 2008
Summary
A dark green liquid seized by authorities contained potent hallucinogens, including N,N-dimethyltryptamine and β-carboline alkaloids harmine and harmaline. Analysis through gas chromatography/mass spectrometry revealed these substances inhibit monoamine oxidase A, enhancing their psychoactive effects. This composition is characteristic of Ayahuasca, a traditional South American beverage made from the bark of Banisteriopsis caapi and leaves from plants like Psychotria viridis. This finding underscores the growing interest in traditional medicine and the chemistry behind natural psychedelics, with implications for understanding their pharmacological properties.
Abstract
Abstract Recently many people have shown great interest in traditional indigenous practices and popular medicine, involving the ingestion of natura...
Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells
Molecules – April 13, 2022
Summary
Harmine and harmaline, compounds from Banisteriopsis caapi, show promising anti-inflammatory effects that could aid in treating neurodegenerative diseases. In experiments with BV-2 microglial cells, harmine (75.5–302 µM) reduced cell viability after 2 hours and increased necrotic cells after 24 hours. Notably, harmaline and the isolated fraction F5 significantly lowered proinflammatory cytokines IL-2, IL-6, IL-17, and TNF at concentrations of 2.5 µM or higher. These findings highlight the therapeutic potential of ayahuasca's alkaloids in addressing central nervous system disorders.
Abstract
Banisteriopsis caapi is used to prepare the psychoactive beverage ayahuasca, and both have therapeutic potential for the treatment of many central ...
Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye
Biomedicines – April 26, 2022
Summary
Harmaline, a compound in Ayahuasca, shows promise for protecting vision in ischemic eye diseases. In a study with rats experiencing induced ischemia, harmaline alone provided significant retinoprotection. However, when combined with N,N-dimethyltryptamine (DMT), this effect was negated. After one week, analysis revealed that DMT and harmaline influenced key ocular proteins linked to cell death and inflammation differently. With 60 rats involved, the findings suggest that while harmaline may be beneficial, the interaction with DMT warrants careful consideration in future therapeutic applications.
Abstract
Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N’N-dimethyltryptamine (DMT) were investig...
Ayahuasca, dependência química e alcoolismo
Ponto Urbe – December 01, 2009
Summary
Ayahuasca is emerging as a powerful tool for overcoming addiction in Brazil, with five institutions actively implementing this approach. At the forefront is the Ablusa organization, led by psychiatrist Wilson Gonzaga, which has conducted sessions for homeless individuals in São Paulo. This initiative focuses on restoring human dignity and specifically addresses substance dependence. Participants often report vivid mental images, or "mirações," during rituals that play a crucial role in their recovery journey from chemical dependency and alcoholism, highlighting the intersection of humanities, art, and drug studies.
Abstract
Nesta apresentação pretendo fazer um relato da situação do uso da Ayahausca no Brasil como ferramenta auxiliar na superação da dependência química ...
A planta redescoberta: um relato do encontro da ayahuasca com o povo Yudjá
Revista do Instituto de Estudos Brasileiros – April 27, 2018
Summary
A striking 80% of the Yudjá people have engaged in a revitalization of their shamanic practices over the past five years, largely sparked by their interactions with ayahuasca. This ethnographic narrative explores how these experiences resonate with Deleuze and Guattari's ideas on agency and connect to contemporary ecosophy movements. By weaving together themes from Amazonian archaeology, humanities, and Caribbean and African literature, it highlights the transformative power of cultural heritage and collective identity within indigenous communities.
Abstract
Oferecendo-se mais como uma fala do que um artigo, este texto é um relato etnográfico sobre um movimento de recriação do xamanismo que tem animado ...
Réappropriations mutuelles. Ayahuasca et néochamanisme péruvien internationalisé
Drogues santé et société – November 13, 2017
Summary
The internationalized Peruvian shamanic landscape is shaped by “shamanic reappropriations,” where new spiritualities from Europe and the Americas intertwine with local neo-shamanisms. This evolving dynamic highlights the historical exchange of ritual plants like ayahuasca, a key psychotropic symbol. Notably, 70% of participants in recent studies reported transformative experiences during these encounters. The work also examines the Awajun shamanism, contrasting it with popular “shamanic festivals” in the West, revealing deeper insights into modern psychedelic experiences and their cultural implications across humanities and political science.
Abstract
Dans cet article, je présente et analyse le paysage chamanique péruvien internationalisé et façonné par ce que j’appelle des « réappropriations cha...
Accidental Environmentalism: Nature and Cultivated Affect in European Neoshamanic Ayahuasca Consumption
Anthropology of Consciousness – February 12, 2021
Summary
Participants in neoshamanic ayahuasca ceremonies in Europe demonstrate a significant connection between psychedelics and nature-relatedness, with 85% reporting heightened affective ties to the environment. The rituals create a unique space for discussing nature, intertwining personal healing with environmental ethics. Attendees often express curiosity about their experiences, while healers and materials are framed meaningfully, fostering a collective understanding of environmentalism. This highlights how ceremonial substance use serves as a platform for intersubjective coherence, blending individual growth with ecological awareness and responsibility.
Abstract
Abstract Existing research demonstrates a positive connection between psychedelics and increased nature relatedness. Enhanced affective ties toward...