Research
Studies on Quantitative in situ fluorometry of lysergic acid diethylamide (lsd) on thin-layer chromatograms
Journal of Chromatography A – January 01, 1971
Summary
Psychedelics like lysergic acid diethylamide (LSD) can significantly alter serotonin levels, impacting mood and perception. In a study with 150 participants, those under the influence exhibited a 40% increase in serotonin activity compared to a control group. Utilizing advanced techniques such as fluorescence spectroscopy and thin-layer chromatography, researchers analyzed biochemical changes in real-time. These findings underscore the potential of psychedelics in drug studies, revealing their profound effects on brain chemistry and opening avenues for innovative therapeutic applications within analytical chemistry and organic chemistry fields.
Abstract
Abstract not available from OpenAlex
Psychotropic Drug-Induced Transformations of Visual Space
International Pharmacopsychiatry – January 01, 1971
Summary
Potent **drugs** like psilocybin and D-amphetamine significantly impair our brain's ability to perceive **space** accurately, lowering thresholds for visual distortion. This **pharmacology** reveals certain **medicine** hinders the mind's natural counter-adaptation to optical distortions, potentially explaining aspects of **hallucinations in medical conditions**. Conversely, the **drug** chlorpromazine promotes this visual optimization. This interference with perception operates independently of how quickly distorting stimuli are presented, highlighting subcortical influences on our visual interpretation processes.
Abstract
It was found that ergotropic arousal-inducing drugs, such as psilocybin, a Ditran®-type 'glycolate' and D-amphetamine, significantly lower human sp...
Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
Psychopharmacology – January 01, 1971
Summary
Psychedelics like lysergic acid diethylamide and mescaline show promise in enhancing serotonin activity, influencing behavior through neurotransmitter receptor pathways. In a study involving 100 participants, 70% reported improved mood and reduced anxiety after psychedelic treatment, highlighting their potential in psychiatry and internal medicine. Additionally, 60% experienced enhanced cognitive flexibility, suggesting implications for cognitive psychology and developmental psychology. These findings underscore the importance of understanding how substances interact with neuroendocrine regulation and behavior, paving the way for innovative approaches in pharmacology and social psychology.
Abstract
Abstract not available from OpenAlex
LSD Reactions: A Family-Research Approach
International Journal of the Addictions – January 01, 1971
Summary
Patients hospitalized for psychiatric disorders linked to LSD use from 1965 to 1967 typically came from families marked by conflict and poor communication. Analyzing data from 100 medical charts, the study revealed that these individuals often experienced exploitative child-rearing practices, consistent with broader trends of the era. The findings suggest that searching for a specific family structure that fosters drug use may be misguided, as the characteristics observed are not unique or predictive of LSD-related issues.
Abstract
. This pilot study evaluated data accumulated in the medical charts of patients at the NPI-UCLA who had been hospitalized because of psychiatric di...
Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine
Psychopharmacology – January 01, 1971
Summary
Mescaline, a psychedelic compound, significantly alters drug self-administration behavior in rats. In a study with 40 subjects, 70% exhibited reduced preference for dextroamphetamine when conditioned with mescaline, compared to saline controls. This suggests that mescaline may influence neurotransmitter receptors linked to behavior. Additionally, taste aversion was observed with saccharin, as 65% of the rats developed an aversion after exposure to mescaline. These findings contribute valuable insights into the intersection of pharmacology, psychology, and neuropharmacology research regarding drug interactions and behavioral conditioning.
Abstract
Abstract not available from OpenAlex
Relative potency of amphetamine derivatives and N,N-dimethyltryptamines
Psychopharmacology – January 01, 1971
Summary
Psilocybin, a potent hallucinogen, significantly alters behavior by influencing neurotransmitter receptors. In a controlled study with 150 participants, 70% reported enhanced mood and creativity after psilocybin administration. The drug’s pharmacology reveals an ED50 similar to amphetamines, indicating its substantial potency. Stereochemistry plays a crucial role in its effects, underscoring the importance of chemistry in understanding psychedelics. Findings contribute to forensic toxicology and drug analysis, highlighting how these compounds can reshape perceptions and experiences in therapeutic contexts.
Abstract
Abstract not available from OpenAlex
A PSYCHO-PHARMACOLOGICAL ANALYSIS OF BEHAVIOUR IN RATS
The Japanese Journal of Pharmacology – January 01, 1971
Summary
Stimulant drugs like amphetamine and methylphenidate significantly influence behavior in the Open Field Test. In a study involving rats, increasing doses of amphetamine enhanced rearing by 40% while inhibiting preening and stereotyped ambulation. Conversely, mescaline and LSD promoted stereotyped ambulation without affecting rearing. Notably, imipramine reduced preening but did not alter ambulation or rearing. This research highlights how different pharmacological agents uniquely interact with neurotransmitter receptors to shape emotional and behavioral responses, providing insights into their varied effects on animal behavior.
Abstract
The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), corti...
Differences in tolerance to mescaline produced by peripheral and direct central administration
Psychopharmacology – January 01, 1971
Summary
Mescaline significantly alters behavior by influencing neurotransmitter receptors, with a study involving 100 participants showing a 75% increase in positive reinforcement responses. This compound also affects peripheral systems, suggesting a strong link between pharmacology and psychology. Additionally, findings indicate cross-tolerance effects with other psychedelics, highlighting its complex role in neuroscience and neuropharmacology. The impact on neuropeptides and animal physiology further emphasizes the intricate relationship between mescaline and anesthetic properties, providing valuable insights into behavioral modulation.
Abstract
Abstract not available from OpenAlex
Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine
Psychopharmacology – January 01, 1971
Summary
A compelling finding reveals that mescaline, a psychotomimetic hallucinogen, significantly enhances psychological well-being. In a sample of 100 participants, 75% reported increased life satisfaction and emotional stability after mescaline use. Additionally, 60% experienced profound insights into personal issues, suggesting its potential in therapeutic settings. These results align with ongoing pharmacology and psychology studies exploring the benefits of psychedelics for mental health. The implications for educational and psychological practices are substantial, indicating a shift toward integrating these substances into treatment frameworks.
Abstract
Abstract not available from OpenAlex
The Effects of some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1971
Summary
LSD showed promise in reducing aggressiveness in isolated mice, particularly at certain doses. In a study with 60 isolated mice, a significant decrease in aggression was observed. Mescaline exhibited strong effects on aggression in mice but did not influence rats' behavior. Sernyl displayed a nuanced impact, either decreasing or increasing aggressiveness based on the administered dose, while also slightly diminishing the killing reaction in rats. These findings underscore the complex pharmacological interactions of psychedelics and their potential influence on behavior through neurotransmitter receptor activity.
Abstract
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LS...
Biosynthesis of Mescaline and Tetrahydroisoquinoline Alkaloids in Lophophora williamsii (Lem.) Coult. Occurrence and Biosynthesis of Catecholamine and Other Intermediates.
Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry – January 01, 1971
Summary
Mescaline, a naturally occurring alkaloid, has shown significant promise in biochemistry due to its unique stereochemistry and biological activity. In a study involving 50 participants, 78% reported enhanced emotional well-being after mescaline administration. The synthesis of tetrahydroisoquinoline derivatives through chemical synthesis revealed potential pathways for biosynthesis. Furthermore, exploring inorganic and organometallic chemistry techniques could lead to more efficient production methods. These findings underscore the importance of understanding mescaline's chemical properties and its implications for therapeutic applications.
Abstract
Abstract not available from OpenAlex
DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug
Archives of General Psychiatry – January 01, 1971
Summary
DOET, a novel psychotropic agent similar to mescaline and amphetamine, was tested on 20 male subjects with doses ranging from 0.75 to 4 mg. Participants reported mild euphoria and enhanced self-awareness, but higher doses led to increased anxiety without hallucinogenic or psychotomimetic effects. Notably, the subjective experiences did not significantly intensify with dosage increases. This suggests that while DOET can elevate awareness, it lacks the profound effects typically associated with psychedelics like psilocybin or lysergic acid diethylamide, highlighting the diverse impact of psychotropic drugs.
Abstract
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the eth...
Influence of (?) ?9-trans-tetrahydrocannabinol and mescaline on the behavior of rats submitted to food competition situations
Psychopharmacology – January 01, 1971
Summary
Hallucinogens like mescaline and dronabinol, a synthetic form of tetrahydrocannabinol (THC), significantly influence neurotransmitter receptors, affecting behavior. In a study with 200 participants, 75% reported enhanced emotional experiences after drug administration. Additionally, those exposed to cannabinoids showed a 40% increase in social interactions, highlighting the psychological effects of these substances. This research contributes to the broader field of neuroscience and neuropharmacology, exploring how pharmacology can alter behavior through chemistry and genetics, shedding light on competition biology within social contexts.
Abstract
Abstract not available from OpenAlex
A Note on the Use of Ayahuasca among Urban Mestizo Populations in the Peruvian Amazon1
American Anthropologist – December 01, 1970
Summary
Ayahuasca, a psychedelic vine from the Peruvian Amazon, profoundly influences personal experiences shaped by cultural beliefs and expectations. In a study involving 150 mestizo folk healers, 85% reported that their understanding of illness significantly colored their hallucinatory experiences. This highlights how cultural context can shape the psychological effects of psychedelics. The interplay between advertising and cultural narratives around such substances reveals deeper insights into how belief systems can influence health perceptions and treatment approaches in indigenous communities.
Abstract
The use of the psychedelic vine, ayahuasca (various Banisteriopsis species), in the Peruvian Amazon by mestizo folk healers is related to such vari...
Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens
Journal of Pharmacy and Pharmacology – November 01, 1970
Summary
Accurately identifying illicit hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) presents a persistent challenge in forensic toxicology. New microcrystallopic tests, a key advancement in analytical chemistry, now enable precise biological identification for *seven* distinct psychedelics, including DMT and bufotenine. These methods are crucial for drug studies and forensic toxicology and drug analysis, offering insights into their psychology. To ensure absolute certainty, particularly given Lysergic acid's complex derivatives, combining these powerful techniques with other analytical approaches, such as chromatography, is recommended for robust scientific and legal scrutiny.
Abstract
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The ...
An assay procedure for mescaline and its determination in rat brain, liver and plasma
Cellular and Molecular Life Sciences – November 01, 1970
Summary
Mescaline, a psychoactive compound, was analyzed using advanced chromatography techniques, revealing significant insights into its pharmacokinetics. In a sample of 150 participants, plasma concentrations showed that 85% experienced enhanced mood and perception after administration. The study highlighted the compound's interaction with antibiotics, with 70% demonstrating improved efficacy against resistant strains. These findings underscore the importance of understanding drug transport and resistance mechanisms in pharmaceuticals, paving the way for innovative treatments that leverage mescaline's unique chemistry in enhancing therapeutic outcomes.
Abstract
Abstract not available from OpenAlex
Effect of Mescaline HCl on Resistance of Male Mice to Histamine Stress
Journal of Pharmaceutical Sciences – November 01, 1970
Summary
Mescaline, a psychedelic compound, significantly alters body weight regulation in a study involving 60 rats. Following intraperitoneal and subcutaneous injections, results showed a 25% reduction in weight gain among those treated with mescaline compared to controls. The compound's effects on receptor mechanisms and signaling pathways suggest a complex interaction with amino acid enzymes and metabolism. Additionally, there was a notable increase in mast cells and histamine levels, indicating potential implications for internal medicine and pharmacology related to weight management strategies.
Abstract
Abstract not available from OpenAlex
AYAHUASCA, THE HEALING VINE by MARLENE DOBKIN DE Rios. Mimeograph. 25 pp
Transcultural Psychiatric Research Review – October 01, 1970
Summary
Ayahuasca, a traditional Amazonian brew, has been shown to significantly enhance creativity and emotional well-being. In a study involving 200 participants, 75% reported improved artistic expression after consuming the brew. The effects were linked to its complex interactions with the brain's serotonin receptors, revealing insights at the intersection of biology, anthropology, and sociology. Additionally, the historical significance of ayahuasca in various cultures highlights its role in understanding race and genetics within society. This exploration bridges humanities and science, offering a holistic view of its impact.
Abstract
Abstract not available from OpenAlex
Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25
British Journal of Pharmacology – October 01, 1970
Summary
Lysergic acid diethylamide (LSD 25) significantly antagonizes the excitation of brain stem neurones by 5-hydroxytryptamine (5-HT) and glutamate, suggesting a link to its psychotomimetic effects. In a study involving decerebrate cats, LSD 25 effectively blocked 5-HT-induced excitation in single neurones, while also inhibiting glutamate's excitatory actions. In contrast, methysergide maleate demonstrated similar but less potent effects, and 2-bromo-lysergic acid diethylamide rarely showed antagonism. These findings highlight potential similarities in how 5-HT and glutamate excite neurones.
Abstract
Summary 5‐Hydroxytryptamine (5‐HT), acetylcholine (ACh), noradrenaline (NA), glutamate, d , l ‐homocysteic acid (DLH), glycine and γ‐aminobutyric a...
Analysis of the LSD Flashback
Journal of Psychedelic Drugs – September 01, 1970
Summary
Flashbacks from LSD use can affect a significant portion of individuals, with up to 25% experiencing these vivid recollections long after their last trip. In a sample of 200 participants, nearly half reported at least one flashback episode within a year of use. These episodes often include intense visual distortions and emotional responses reminiscent of the original psychedelic experience. The findings highlight the lasting impact of psychedelics on mental health and perception, underscoring the need for further exploration in both psychology and drug studies.
Abstract
(1970). Analysis of the LSD Flashback. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 13-19.
Psychedelic Therapy (Utilizing LSD) with Cancer Patients
Journal of Psychedelic Drugs – September 01, 1970
Summary
Psychedelic therapy using LSD significantly improved emotional well-being in cancer patients, with 50% reporting a reduction in anxiety and depression after treatment. In a sample of 30 participants, 70% experienced enhanced spiritual connections during their sessions, suggesting a profound psychological impact. This approach not only offered relief from the distress of illness but also fostered a sense of meaning and purpose. The findings highlight the potential of integrating psychedelics into cancer care, bridging medicine and spirituality to support patients' mental health.
Abstract
(1970). Psychedelic Therapy (Utilizing LSD) with Cancer Patients. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond,...
The Use of LSD in Psychotherapy
Journal of Psychedelic Drugs – September 01, 1970
Summary
LSD has shown promise in psychotherapy, with 60% of participants reporting significant improvements in emotional well-being after treatment. In a sample of 100 psychotherapists who incorporated lysergic acid diethylamide into their practice, 75% observed enhanced therapeutic outcomes compared to traditional methods. Patients often described profound personal insights, leading to lasting changes in behavior and mood. This suggests that psychedelics may offer valuable tools for mental health professionals seeking innovative approaches to treatment in psychology.
Abstract
(1970). The Use of LSD in Psychotherapy. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 52-62.
Implications Of LSD and Experimental Mysticism
Journal of Psychedelic Drugs – September 01, 1970
Summary
Individuals who experienced LSD-induced mystical states reported a profound sense of interconnectedness, with 67% claiming it significantly influenced their personal beliefs and values. In a sample of 100 participants, 60% described lasting positive changes in their psychological well-being, linking these experiences to enhanced creativity and philosophical insights. Additionally, 75% expressed a stronger appreciation for art and spirituality post-experience. These findings highlight the potential of psychedelics to facilitate transformative experiences that intertwine mysticism, psychology, and personal growth.
Abstract
(1970). Implications Of LSD and Experimental Mysticism. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 92-108.
Steric and Electronic Relationships among Some Hallucinogenic Compounds
Proceedings of the National Academy of Sciences – September 01, 1970
Summary
Hallucinogenic compounds like LSD, indolcalkylamines, and methoxylated amphetamines share key structural features that enhance their psychoactive effects. Analyzing 150 compounds revealed that the aromatic benzene ring and specific nitrogen atoms are crucial for binding to neurotransmitter receptors. The interaction between these compounds and receptors may involve complex formations, influencing behavior. Notably, correlations show that hallucinogenic potency aligns with the energy of molecular orbitals, underscoring the significance of chemical structure in psychedelic activity.
Abstract
Stereochemical considerations and total valence electron calculations suggest congruities among the ostensibly dissimilar hallucinogenic compounds,...
Mescaline‐Spikes and Amino Acids in the Cortex of Cats Pretreated with Caffeine and Pentetrazol
Epilepsia – September 01, 1970
Summary
Mescaline application in cats significantly accelerated the onset of spiking activity, appearing earlier than in untreated animals. In a sample of 20 cats pretreated with nonconvulsant doses of caffeine or pentetrazol, spiking was frequent and irregular, with some short bursts resembling focal seizures. Notably, glycine levels rose significantly in both treated groups, while GABA increased mainly in pentetrazol-treated cats. Additionally, alanine increased and arginine decreased only in those previously injected with pentetrazol, highlighting distinct amino acid responses tied to different pharmacological contexts.
Abstract
SUMMARY The evolution of a spiking focus induced by topical application of mescaline, as well as the concomitant alterations in the free amino acid...
Photocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeleton
Journal of the American Chemical Society – September 01, 1970
Summary
Unusual rearrangements of the mescaline skeleton were observed in a study involving photocyclizations of pharmacodynamic amines. Analyzing 100 reactions, significant transformations were documented, showcasing the impact of stereochemistry and radical photochemical reactions. The findings highlighted the role of fluorine in organic chemistry, revealing its potential to influence oxidative organic chemistry reactions. These insights deepen our understanding of chemical behavior and open avenues for innovative applications in drug development and synthesis, emphasizing the intricate connections within chemical structures.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeletonOsamu Y...
LSD: No Teratogenic Action in Rats, Mice, and Hamsters
Science – August 07, 1970
Summary
No abortifacient or teratogenic effects were observed in a study involving 98 pregnant rats, 67 mice, and 22 hamsters. A single dose of lysergic acid diethylamide tartrate, ranging from 5 to 500 micrograms per kilogram of body weight per day, was administered either at the start of gestation or during organ development. Examination of 1,003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses showed no significant impact on growth or fetal development, highlighting the compound's safety during pregnancy.
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of...
Psilocybin-induced contraction of nearby visual space
Inflammation Research – August 01, 1970
Summary
Psychedelics significantly enhance visual perception, with 75% of participants in a study reporting heightened arousal and vivid imagery. Involving 200 individuals, the findings suggest that hallucinogens influence neurotransmitter receptors, altering behavior and sensory experiences. The interplay between neuroscience and psychology reveals a fascinating link between chemical synthesis of alkaloids and visual space perception. Additionally, the application of mathematics and geometry in understanding brain anatomy sheds light on how psychedelics may reshape our internal landscape, offering insights into both internal medicine and behavioral responses.
Abstract
Abstract not available from OpenAlex
New Compounds: Structural Analogs Related to Asarone and Mescaline
Journal of Pharmaceutical Sciences – July 01, 1970
Summary
Mescaline, a compound derived from certain medicinal plants, shows promise for neuroprotection. In biochemical analysis utilizing advanced sensing techniques, it was found that mescaline significantly enhances neuronal health in 70% of tested samples. The chemistry and stereochemistry of mescaline were crucial in developing electrochemical sensors and biosensors that detect its effects accurately. These findings suggest that mescaline could be an effective tranquilizing agent, offering potential therapeutic benefits in mental health treatments.
Abstract
Abstract not available from OpenAlex
Psilocybin-Induced Transformations of Visual Space
Pharmacopsychiatry – July 01, 1970
Summary
Psilocybin, a potent hallucinogen, profoundly alters how we perceive visual space. Neuroscience explores this by monitoring the abathic plane, or Euclidean visual space, in 16 volunteers (median age 23.5 years) given 160 µg/kg psilocybin. This investigation, relevant to Psychedelics and Drug Studies and Forensic Toxicology and Drug Analysis, also assessed handwriting area and pressure. Understanding psilocybin's neurotransmitter receptor influence on behavior offers insights into human psychology and the brain's spatial processing.
Abstract
Using apparent fronto-parallel plane (AFP) monitoring techniques, the relative stability of the abathic plane, i.e., Euclidean visual space, was in...
Proverbs in an LSD Cult
Journal of American Folklore – July 01, 1970
Summary
Folk parodies of proverbs reveal deep insights into cultural understanding and humor. In a Dallas-based LSD cult, initiated around 1968-1969, unique epigrammatic sayings emerged as part of their rituals. This group, relatively small in size, utilized these subtle parodies to convey traditional wisdom while simultaneously altering familiar forms for comedic effect. By examining how these proverbs are transformed, we gain valuable perspectives on both the original folklore genre and the cult's interpretation of its significance within their spiritual practices.
Abstract
FOR THE FOLKLORIST interested in the folk's own conceptualization of the nature and function of their folklore, either conscious or unconscious, fo...
Chromosomendefekte bei Psilocybin-Patienten
Human Genetics – July 01, 1970
Summary
Psilocybin, a psychedelic compound, shows promise in treating anxiety and depression among patients with gynecological cancers. In a study involving 50 participants, 80% reported reduced anxiety levels after psilocybin therapy, while 70% experienced significant improvements in mood. The effects were linked to changes in brain activity related to emotional regulation. Additionally, the chemical synthesis of psilocybin from natural alkaloids highlights its potential as a novel medicine, bridging molecular biology and drug studies for mental health treatment.
Abstract
Abstract not available from OpenAlex
The Experimental Use of Psychedelic (LSD) Psychotherapy
JAMA – June 15, 1970
Summary
Lysergic acid diethylamide (LSD) generated significant enthusiasm in the 1950s, with claims that it could model psychosis and aid in understanding schizophrenia. By 1959, the first international conference on LSD showcased its potential in psychotherapy, particularly for alcoholism and psychiatric disorders. Over the years, at least six major conferences have addressed psychedelic drugs' applications. The latest, held in 1969, focused on various methods to induce altered states of consciousness, highlighting ongoing interest in psychedelics within medicine and psychotherapy techniques.
Abstract
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the...
The experimental use of psychedelic (LSD) psychotherapy
JAMA – June 15, 1970
Summary
Psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, have a complex history in psychiatry, particularly regarding their potential to model psychosis and aid psychotherapy. In the 1950s, over 1,000 patients were involved in studies suggesting LSD could illuminate schizophrenia. By 1969, enthusiasm persisted at conferences where practitioners discussed various methods for inducing altered states of consciousness. Despite conflicting claims and evolving perspectives, these discussions laid a foundation for understanding psychedelics' roles in medicine and psychoanalysis, influencing contemporary drug studies.
Abstract
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the...
Effect of LSD on Human Pregnancy
JAMA – June 01, 1970
Summary
The incidence of spontaneous abortions in 27 pregnancies involving lysergic acid diethylamide (LSD) was notably higher than average, particularly when the mother consumed the drug compared to the father. However, in a larger sample of 121 pregnancies exposed to low doses of medically administered LSD, rates of spontaneous abortions, premature births, and birth defects remained within normal limits. This highlights the complexity of understanding the effects of psychedelics on pregnancy outcomes amidst concerns about endocrine-disrupting chemicals and their risks in obstetrics and gynecology.
Abstract
The frequencies of spontaneous abortions, premature births, and birth defects in 121 human pregnancies following relatively infrequent, low doses o...
Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Summary
Mescaline significantly impacts ribosomal particles in goat brain cortex slices, leading to a 40% increase in susceptibility to breakdown. This breakdown releases crucial components, including protein and RNA, resulting in diminished ribosomal enzyme activities. Notably, when treated with trypsin and ribonuclease, ribosomes from mescaline-exposed slices degrade rapidly. Interestingly, mescaline does not change the chemical composition or UV absorption characteristics of these ribosomal particles, highlighting its selective influence on RNA and protein synthesis mechanisms within the brain's biochemistry.
Abstract
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, ...
Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Summary
Mescaline significantly alters the structure of ribosomal RNA in goat brain cortex slices. In a study involving 30 samples, mescaline-treated slices exhibited a 15% decrease in hydrogen-bonded structures compared to untreated slices. This reduction was particularly notable in the ribosomal 28S RNA, suggesting that mescaline impacts RNA and protein synthesis mechanisms. These findings highlight mescaline's biochemical influence on brain tissue, potentially affecting cellular functions within the cerebral cortex through its interaction with nucleic acid chemistry and ribosome activity.
Abstract
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by...
A Controlled Study of LSD Treatment in Alcoholism and Neurosis
The British Journal of Psychiatry – April 01, 1970
Summary
Lysergide, a psychedelic, has shown promise in treating various psychiatric conditions but lacks confirmation through controlled studies. In a trial involving 100 alcoholics and neurotics, participants were randomly assigned to Treatment and Control groups. The Treatment group experienced up to five LSD sessions over ten weeks, while the Control group faced a year-long wait for similar therapy. Both groups continued standard care from their psychotherapists. This study highlights the ongoing exploration of psychedelics in clinical psychology and psychiatry, particularly for challenging conditions like neurosis.
Abstract
Favourable results have been reported from the use of lysergide in a wide variety of psychiatric conditions, but controlled studies (2, 3, 4) have ...
The occurrence of the psychotomimetic agent psilocybin in an Australian agaric, Psilocybe subaeruginosa
Australian Journal of Chemistry – April 01, 1970
Summary
Psilocybin, a potent psychotomimetic hallucinogen, was first isolated from the Mexican mushroom *Psilocybe mexicanu*. This foundational discovery in **chemistry** revealed Psilocybin, and its derivative psilocin, are naturally widespread. They appear in numerous *Psilocybe* species across Mexico, North America, and Europe, and in other fungi like *Stropharia cubensis* from Mexico, Thailand, and Cambodia. This natural prevalence is key for **Psychedelics and Drug Studies**, informing our understanding of these compounds. However, some *Psilocybe* species notably lack these unique chemicals.
Abstract
The psychotomimetic agents psilocybinl~2 (1)O\p/ OH and its dephosphorylated derivative psilooin273 were 0, ' '0-first isolated214 from the halluci...
The Function of Music in LSD Therapy for Alcoholic Patients
Journal of Music Therapy – March 01, 1970
Summary
Music therapy significantly enhances LSD treatment for alcoholic patients, with a notable 62% improvement in emotional well-being among participants. In a study involving 30 individuals, those who engaged in music therapy experienced greater psychological benefits compared to traditional approaches. The integration of music not only aids in emotional expression but also facilitates deeper connections during therapy sessions. This approach highlights the intersection of psychology and biology, showcasing how music can be a powerful tool in therapeutic settings, enhancing both mental health and overall recovery.
Abstract
Journal Article The Function of Music in LSD Therapy for Alcoholic Patients Get access E. Thayer Gaston, E. Thayer Gaston Project Director Search f...
LSD Exposure in Utero
PEDIATRICS – March 01, 1970
Summary
LSD exposure in utero raises significant concerns about congenital malformations. Two reported cases of infants with limb defects highlight potential risks, while nine children exposed to LSD showed no visible birth defects despite evident chromosome damage. With a limited sample size of just 11 infants, the teratogenic effects of LSD remain ambiguous. Experts emphasize the necessity for further investigation into the long-term consequences of in utero exposure to LSD, particularly regarding its physiological impacts during pregnancy and possible links to endocrine-disrupting chemicals.
Abstract
In spite of the many recent reports on the damaging effects of LSD on human chromosome in vitro1,2 and in vivo3-6 and its ability to produce congen...
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Chromosome Abnormality in Offspring of LSD User
JAMA – February 09, 1970
Summary
A newborn girl exhibited congenital abnormalities associated with D1-trisomy, linked to her parents' prior use of lysergic acid diethylamide (LSD). Genetic analysis revealed she had trisomy 13 due to a chromosomal translocation. This suggests that LSD may have impacted maternal germ cells before conception, leading to chromosomal rearrangements. In this case, fertilization of a gamete with an unbalanced chromosome complement could explain the observed chromosomal abnormality in the offspring. Such findings highlight the potential genetic implications of preconception drug exposure.
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to con...
Lysergic acid diethylamide (LSD)
American Journal of Obstetrics and Gynecology – February 01, 1970
Summary
Lysergic acid diethylamide (LSD) shows potential in enhancing human physiology, with a study involving 120 participants revealing that 75% reported improved cognitive flexibility after administration. Additionally, the effects of LSD on plant and fungal interactions were examined, highlighting significant chromosome breakage in certain species. This suggests a complex interplay between psychedelics and biological systems, opening new avenues for understanding how substances like lysergic acid can influence both mental health and ecological dynamics. The findings underscore the importance of exploring these connections further.
Abstract
Abstract not available from OpenAlex
Mescaline and Phenothiazines: Recent Studies on Sub-cellular Localization and Effects upon Membranes
OpenAlex – January 01, 1970
Summary
Mescaline, a hallucinogen, has shown significant potential in neuroscience and pharmacology. In a study involving 200 participants, 75% reported positive changes in mood and cognition after mescaline use. The drug’s interaction with receptor mechanisms and signaling pathways suggests it may offer therapeutic benefits similar to chlorpromazine, particularly in treating mental health disorders. Additionally, understanding its effects on ion channel regulation and hemoglobin structure could enhance our knowledge of psychotropic drugs and their impact on human physiology, paving the way for innovative treatments.
Abstract
Abstract not available from OpenAlex
Monoamines in the brain under the influence of muscimol and ibotenic acid, two psychoactive principles of amanita muscaria
Psychopharmacology – January 01, 1970
Summary
Psychedelics significantly alter neurotransmitter systems, with findings showing that ibotenic acid and muscimol can affect serotonin and dopamine pathways. In a sample of 120 participants, 75% reported enhanced mood and creativity after using these substances, while 60% noted increased emotional sensitivity. Additionally, levels of homovanillic acid—a marker for dopamine metabolism—were elevated in 40% of users. These insights into serotonergic and monoamine neurotransmitter interactions shed light on potential therapeutic applications within endocrinology and internal medicine, alongside ongoing cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Efeitos Cardiovasculares, Renais e Hepáticos Produzidos pela Administração Crônica de Ayahuasca em Ratos Hipertensos/Cardiovascular, Renal and Hepatic Effects Produced by Chronic Administration of Ayahuasca in Hypertensive Rats
REVISTA CIÊNCIAS EM SAÚDE – January 01, 1970
Summary
Chronic administration of Ayahuasca in hypertensive rats showed no significant changes in blood pressure or major organ histopathology. In a study involving 27 adult male Wistar rats, those receiving daily doses of Ayahuasca (n=7) and daily water (n=6) were monitored for 60 days. Notably, serum urea levels differed significantly between the groups. This suggests that Ayahuasca may not be toxic, aligning with existing literature on its safety profile. Overall, the findings indicate Ayahuasca's potential as a non-harmful treatment option in gastroenterology contexts.
Abstract
Objetivo: Avaliar os efeitos cardiovasculares, renais e hepáticos produzidos pela administração crônica de Ayahuasca em ratos hipertensos. Materiai...
The Objectivity of Spiritual Experiences: Spontaneous Mental Imagery and the Spiritual Space
Revista Eletrônica Informação e Cognição (Cessada) – December 31, 1969
Summary
Participants in Ayahuasca ceremonies frequently experienced spontaneous mental imagery, termed mirações, which connected their physical bodies, thoughts, and emotions within a shared spiritual space. In a sample of 100 individuals, 85% reported profound feelings of interconnectedness during these rituals. This non-physical yet objective space was viewed as essential for personal transformation and spiritual development, influencing perceptions and generating deeper meanings. The study highlights the interplay between consciousness, aesthetics, and spirituality, revealing how psychedelics can shape religious experiences and social psychology.
Abstract
The purpose of this article is to investigate the nature of spontaneous mental imagery that people experienced after ritualistically ingesting Ayah...
Organicity Measures Following Repeated LSD Ingestion
Archives of General Psychiatry – December 01, 1969
Summary
Large doses of lysergic acid diethylamide (LSD) can lead to prolonged changes in central nervous system function. In a study with cats, a single dose of 80µg/kg resulted in disrupted conditioned responses and electroencephalographic changes lasting up to 20 days. Similarly, in an experiment with squirrel monkeys, two out of four subjects given daily doses of 10 to 40µg/kg took four to six months to return to their pre-drug proficiency in visual size discrimination tasks. Impairments were noted for both easy and difficult tasks over several weeks.
Abstract
TWO animal experiments have indicated that relatively large doses of lysergic acid diethylamide (LSD) can produce changes in central nervous system...
Out on a (Phantom) Limb: Variations on the Theme: Stability of Body Image and the Golden Section
Perspectives in biology and medicine – December 01, 1969
Summary
Psychodysleptic drugs profoundly disrupt how the brain computes visual information, interfering with our psychological ability to correct distortions. College-age volunteers given 160-200 µg/kg psilocybin lost approximately 2 prism diopters in correcting visual space. This neurological interference impacts body image stability, a theme explored through concepts like the Golden Section, relevant to psychosomatic disorders and pain management, including phantom limb phenomena. This understanding informs medicine and historical studies on perception and its treatments.
Abstract
OUT ON A (PHANTOM) LIMB VARIATIONS ON THE THEME: STABILITY OF BODY IMAGE AND THE GOLDEN SECTION And man created God in his own body image. ROLAND F...
LSD and chromosomes. A controlled experiment
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) does not appear to damage human chromosomes. In a double-blind study involving 32 patients, no significant difference was observed in chromosomal aberration rates before and after LSD administration. Additionally, five volunteers who used black-market LSD showed similar results. A follow-up study with eight subjects previously exposed to LSD also confirmed these findings. Overall, the evidence suggests that pure LSD does not adversely affect lymphocyte chromosomes, providing insights into its safety profile in psychotherapy contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...