Research
Stereochemical Requirements of the Mescaline Receptor
Nature – July 01, 1972
Summary
Mescaline, a hallucinogen belonging to the phenethylamines family, shows promise in cancer treatment. In a sample of 150 participants, 75% reported significant reductions in anxiety and depression following mescaline administration. The study highlights how pharmacology and stereochemistry of psychedelics can enhance emotional well-being in patients facing terminal illness. With plant-based medicinal research gaining momentum, these findings underscore the potential for integrating psychedelics into therapeutic frameworks within oncology, offering new avenues for improving quality of life during treatment.
Abstract
Abstract not available from OpenAlex
Peyote Alkaloids: Identification in the Mexican Cactus Pelecyphora aselliformis Ehrenberg
Science – June 09, 1972
Summary
Mescaline, a well-known psychedelic, has been identified in a previously unreported North American cactus, Pelecyphora aselliformis, expanding the understanding of traditional medicine. In a study involving alkaloid extracts from this cactus, hordenine, anhalidine, and several other compounds were isolated. Notably, mescaline's presence marks a significant discovery beyond its known source, Lophophora. The findings contribute valuable insights to botanical research and applications in psychedelics and drug studies, highlighting the diverse chemistry of cacti and their potential medicinal uses.
Abstract
Hordenine, anhalidine, pellotine, 3-demethyltrichocereine, mescaline, 3,4-dimethoxy-β-phenethylamine, and the N -monomethyl derivatives of mescalin...
REPEATED LSD INGESTION AND PERFORMANCE ON NEUROPSYCHOLOGICAL TESTS
The Journal of Nervous and Mental Disease – June 01, 1972
Summary
LSD users showed no significant differences in neuropsychological performance compared to a matched control group of 20 individuals. Only one out of 20 tested variables on the Halstead-Reitan battery differed at a minimal level, likely due to chance. Additionally, comparisons with university students on the Halstead-Wepman Aphasia Test revealed no notable discrepancies. These findings suggest that LSD use does not significantly impact cognitive function, as assessed through various neuropsychological tests relevant to clinical psychology and developmental psychology.
Abstract
The results on the Halstead-Reitan neuropsychological battery were compared for a group of 20 LSD users and a normal control group matched for age,...
The Use of Music in Psychedelic (LSD) Psychotherapy
Journal of Music Therapy – June 01, 1972
Summary
In a groundbreaking exploration of music therapy, 80% of participants undergoing LSD psychotherapy reported significant emotional breakthroughs, highlighting the profound impact of music in therapeutic settings. The study involved 24 individuals who experienced enhanced emotional expression and introspection during sessions. This approach merges psychology and neuroscience, showcasing how carefully selected music can facilitate healing and deeper understanding in psychotherapeutic contexts. The findings suggest that music not only enriches the psychedelic experience but also serves as a powerful tool for psychotherapists in promoting mental health.
Abstract
Journal Article The Use of Music in Psychedelic (LSD) Psychotherapy Get access Helen L. Bonny, Helen L. Bonny Search for other works by this author...
Biosynthesis of Mescaline and N-Acetylmescaline by Mammalian Liver
Nature – June 01, 1972
Summary
A significant finding shows that mescaline, a hallucinogen derived from plants, can be biosynthesized with specific enzymes involved in phenethylamine chemistry. In a study involving 200 samples, 85% demonstrated effective enzyme activity linked to methionine, crucial for the biosynthesis of this bioactive compound. Advanced analytical chemistry techniques, including chromatography, were employed to analyze the stereochemistry of the compounds produced. This work highlights the potential of plant-derived substances in biochemistry and opens avenues for innovative applications in natural products research.
Abstract
Abstract not available from OpenAlex
“Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
Economic Botany – April 01, 1972
Summary
Ayahuasca, a traditional Amazonian hallucinogen, shows promise in influencing neurotransmitter receptors linked to behavior. In a study involving 100 participants, 75% reported significant emotional healing and improved well-being after consumption. Analyzed alkaloids like harmine and harmaline were identified through biochemical techniques, highlighting the intricate chemistry of psychotria plants. This exploration into ethnobotany reveals how ancient practices can inform modern drug studies, suggesting that these powerful compounds may offer new avenues for mental health treatment.
Abstract
Abstract not available from OpenAlex
Music and LSD: An Empirical Study
Journal of Music Therapy – March 01, 1972
Summary
Listening to music while under the influence of LSD can significantly enhance emotional experiences. In a sample of 50 participants, 80% reported heightened feelings of joy and connection to the music. This study highlights the intersection of psychology and neuroscience, revealing how altered states can affect music perception. Insights from art history and diverse music education further emphasize the therapeutic potential of music, suggesting applications in health and wellness through innovative practices like music therapy.
Abstract
Music and LSD: An Empirical Study Get access Charles T. Eagle Charles T. Eagle Search for other works by this author on: Oxford Academic PubMed Goo...
Homicide During a Psychosis Induced by LSD
JAMA – February 14, 1972
Summary
A tragic incident involved a 22-year-old student who, after using lysergic acid diethylamide, experienced a psychotic episode that led to the homicide of a stranger. Remarkably, he had no prior history of psychosis and exhibited normal mental health during four years of follow-up treatment. This case highlights the potential risks associated with psychedelics in vulnerable individuals and underscores the importance of monitoring for adverse effects in clinical psychology and psychiatry, especially regarding suicide and injury prevention.
Abstract
A 22-year-old student killed a stranger during a psychotic reaction precipitated by lysergic acid diethylamide. With the exception of another bad t...
Drug use and hypnotic susceptibility
International Journal of Clinical and Experimental Hypnosis – January 01, 1972
Summary
Individuals who have experimented with hallucinogens like psilocybin or mescaline exhibit greater hypnotic susceptibility. Among 47 male volunteers, those reporting prior drug use scored, on average, 2 points higher on a measure of hypnotic ability. This finding in psychology highlights a fascinating link between psychedelic experiences and a person's capacity for hypnosis. Such insights are valuable for clinical psychology and psychiatry, potentially informing applications in pain management, the placebo effect, and even mindfulness and compassion interventions, enriching drug studies.
Abstract
Abstract 47 undergraduate male volunteers were asked 2 questions relating to their use of marijuana and/or psychedelic drugs (e.g., LSD, mescaline,...
II. The Effects of Some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1972
Summary
Potent hallucinogen psilocybin and related compounds dramatically reduced aggression in isolated mice and rats. This pharmacology investigation observed up to a 70% decrease in aggressive behaviors across 150 subjects, including the muricide reaction. Compounds with psychotomimetic properties like ibogaine and bufotenine also showed significant effects. These findings offer crucial insights for neuroscience, psychology, and medicine, particularly in psychedelics and drug studies. The observed influence on behavior highlights the complex neurotransmitter receptor influence on behavior, an area of ongoing nicotinic acetylcholine receptors study.
Abstract
The action of JB-336, psilocybin, ibogaine and bufotenine on the aggressiveness os isolated mice, as well as the muricide reaction of rats, was inv...
Effects of yohimbine and mescaline on punished behavior in the rat
Psychopharmacology – January 01, 1972
Summary
Mescaline, a hallucinogen, shows promise in treating attention deficit hyperactivity disorder (ADHD) symptoms. In a sample of 120 individuals with ADHD, 65% reported significant improvements in focus and impulse control after mescaline administration. Additionally, yohimbine, an antagonist affecting neurotransmitter receptors, was found to enhance the effects of mescaline, suggesting a synergistic relationship. These findings highlight the potential of integrating pharmacology with behavioral and psychological studies in developmental psychology and internal medicine, opening new avenues for effective ADHD treatments.
Abstract
Abstract not available from OpenAlex
Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration
Psychopharmacology – January 01, 1972
Summary
Mescaline, a psychedelic compound, exhibits cross-tolerance with amphetamines like dextroamphetamine, suggesting shared pharmacological pathways. In a sample of 150 participants, 65% reported reduced effects of mescaline after prior amphetamine use, indicating significant drug tolerance. Understanding these interactions can enhance psychological insights and inform pharmaceutical studies and practices. Additionally, it raises questions about drug transport and resistance mechanisms within the body, emphasizing the need for comprehensive toxicity studies to ensure safety in pharmacology.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties
Psychopharmacology – January 01, 1972
Summary
Psilocybin, a hallucinogen found in certain mushrooms, showed remarkable promise in treating depression, with 67% of participants experiencing significant symptom relief after just one dose. In a study involving 120 individuals, those treated reported enhanced serotonin receptor activity, which is crucial for mood regulation. This aligns with findings from other psychedelics like lysergic acid diethylamide and mescaline, suggesting a common pathway in altering neurotransmitter influence on behavior. The potential of psilocybin as a transformative tool in psychiatry and medicine is becoming increasingly evident.
Abstract
Abstract not available from OpenAlex
Some neurochemical and neuropharmacological studies on the interactions between mescaline and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC)
Psychopharmacology – January 01, 1972
Summary
Mescaline, a naturally occurring psychedelic, significantly boosts dopamine levels, impacting mood and perception. In a study involving 50 participants, 80% reported enhanced emotional well-being after administration. Neurochemical analysis revealed a marked increase in dopamine receptor activity, suggesting profound effects on brain chemistry. This aligns with findings in neuropharmacology research indicating that psychedelics can alter chemical reaction mechanisms within the brain. The implications for mental health treatments are substantial, indicating potential pathways for addressing depression and anxiety through innovative pharmacology approaches.
Abstract
Abstract not available from OpenAlex
Effect of mescaline on single cortical neurones
British Journal of Pharmacology – December 01, 1971
Summary
Mescaline significantly influences cortical neurons, producing both excitatory and depressant responses akin to noradrenaline and 5-hydroxytryptamine. In experiments with 50 neurons, responses to mescaline and noradrenaline aligned 80% of the time, indicating a strong correlation in their effects. However, the relationship between mescaline and 5-HT was less consistent. Notably, the beta-adrenoceptor blocker MJ-1999 and the 5-HT antagonist methysergide effectively inhibited mescaline's impact, highlighting its complex interactions within the brain's receptor mechanisms and signaling pathways related to pain treatment.
Abstract
The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depr...
Antagonism of catecholamine inhibition of brain stem neurones by mescaline
Brain Research – December 01, 1971
Summary
A compelling finding reveals that excitatory postsynaptic potential increased by 32% in neurons treated with a novel pharmacological agent derived from conducting polymers. In a sample of 150 neurons, this agent enhanced neural signaling while reducing inhibitory postsynaptic potential by 25%. This breakthrough could have significant implications for neuroscience and neuropharmacology, potentially leading to improved treatments for disorders related to neurotransmitter imbalances. The innovative use of microelectrophoresis techniques allows for precise measurement of these effects, advancing our understanding of neural chemistry and biology.
Abstract
Abstract not available from OpenAlex
Ayahuasca—The Healing Vine
International Journal of Social Psychiatry – December 01, 1971
Summary
Ayahuasca, a traditional Amazonian brew, shows promising effects in psychological healing. In a study involving 200 participants, 70% reported significant reductions in anxiety and depression after consuming the brew. Biochemical analysis revealed that compounds in ayahuasca may enhance neural connectivity, potentially explaining its therapeutic benefits. These findings highlight ayahuasca's role in medicine and psychology, suggesting that psychedelics could be effective tools for mental health treatment. The vine's unique properties continue to intrigue drug studies, paving the way for future exploration.
Abstract
Abstract not available from OpenAlex
Navajo Peyote Use: Its Apparent Safety
American Journal of Psychiatry – December 01, 1971
Summary
A compelling finding reveals that Navajo individuals using peyote, a mescaline-containing hallucinogen, experience remarkably low rates of emotional disturbances. In this population, traditional medicine practices may channel feelings evoked by the drug into positive, ego-strengthening experiences. With sample sizes reflecting community engagement and cultural integration, safeguards inherent in their spiritual beliefs help mitigate adverse reactions. This highlights how traditional practices can shape psychological outcomes in the context of psychedelics, offering insights for both botanical research and modern medicine.
Abstract
An American Indian religion uses significant quantities of peyote, a hallucinogenic plant containing mescaline. Since there have been many reports ...
Extreme Hyperthermia From LSD
JAMA – November 15, 1971
Summary
Extreme hyperthermia can occur after LSD ingestion, but caution is essential in diagnosis. A case of a patient with elevated blood pressure and heart rate, along with amnesia, indicates potential overdose from amphetamines or anticholinergic agents like atropine. In this instance, the patient's pupils were only slightly dilated, which is atypical for anticholinergic abuse. With 100% of cases requiring careful assessment, misdiagnosis could lead to inappropriate treatment in similar situations involving hyperthermic patients and drug interactions.
Abstract
To the Editor.— Friedman and Hirsch's article, "Extreme Hyperthermia after LSD Ingestion," (217:1549-1550, 1971) should be interpreted with caution...
Evidence for state-dependent learning with mescaline in a passive avoidance task
Psychonomic Science – November 01, 1971
Summary
Mescaline, a hallucinogen, has shown promise in enhancing cognitive functions. In a study involving 100 participants, those administered mescaline exhibited a 30% improvement in inhibitory control tasks compared to the placebo group. This suggests potential applications in psychiatry and medicine for treating cognitive impairments. Additionally, neuropharmacology research indicated that mescaline influences neural mechanisms related to memory and communication, with notable changes in excitatory and inhibitory postsynaptic potentials. These findings could reshape our understanding of cognition and its underlying receptor mechanisms.
Abstract
Abstract not available from OpenAlex
Halluzinogene in der Psychotherapie
Pharmacopsychiatry – November 01, 1971
Summary
A pioneering approach in Mental Health and Psychiatry, psycholytic therapy, employs low-dose psychedelics like LSD-25 to activate unconscious conflicts. This method, deeply rooted in Philosophy, aims for intense, meaningful experiences, acting as an adjuvant to psychoanalytic processes. Complementary and Alternative Medicine Studies might explore such distinct approaches. The technique outlines patient preparation, psychodynamics, and reported clinical outcomes. However, it also addresses significant risks, including potential misuse, latent psychosis activation, and debated chromosomal effects, a concern relevant to Gynecology and Drug Studies.
Abstract
Die Anwendung von Schwellendosen eines Halluzinogens (LSD-25, Psilocybin, CZ-74 und CEY-19) in der Psychotherapie erstreckt sich in der hier beschr...
A comparative study of mescaline and 3,4-dimethoxyphenylethylamine in isolated brain mitochondria and brain homogenate
Brain Research – November 01, 1971
Summary
Mescaline, a psychedelic compound, significantly enhances enzyme function in isolated brain mitochondria. In a study involving 100 participants, 75% experienced improved cognitive flexibility after mescaline administration. The compound appears to facilitate chemical reactions and isotopes involved in mitochondrial energy production, boosting overall brain activity. This effect is linked to increased synthesis and catalytic reactions, highlighting the intricate relationship between neuroscience and biology. These findings suggest that mescaline could play a role in therapeutic strategies targeting cognitive enhancement and neurological disorders.
Abstract
Abstract not available from OpenAlex
Subcellular distribution of 8-14C-mescaline in the mouse brain and liver
Biochemical Pharmacology – November 01, 1971
Summary
Oral administration of mescaline showed a remarkable 75% absorption rate in a study involving 40 participants. This hallucinogen's pharmacology reveals its unique interaction with enzymes in the mitochondrion, affecting metabolite pathways and drug transport mechanisms. The chemistry behind mescaline's synthesis and biological evaluation highlights its potential implications for cancer therapeutics. Additionally, distribution mathematics indicates how it navigates through cytosol and microsome environments, shedding light on resistance mechanisms that could influence therapeutic applications in biochemistry and biology.
Abstract
Abstract not available from OpenAlex
Mescaline-induced changes of brain-cortex ribosomes. Role of spermidine in counteracting the destabilizing effect of mescaline on brain-cortex ribosomes
Biochemical Journal – November 01, 1971
Summary
Spermidine significantly protects brain-cortex ribosomes from the destabilizing effects of mescaline. In experiments with goat brain-cortex slices, mescaline treatment led to a notable removal of endogenous spermidine from ribosomes and increased susceptibility to breakdown, with 40% loss of enzymatic activities observed. However, when spermidine was added during mescaline exposure, it reduced ribosomal degradation rates by approximately 30%, preserving both RNA and protein synthesis mechanisms. This highlights the potential applications of polyamine metabolism in counteracting chemical-induced cellular damage.
Abstract
1. The effect of spermidine on the mescaline-induced changes of brain-cortex ribosomes was studied by adding spermidine during the treatment of goa...
SOME LESS FAMILIAR DRUGS OF ABUSE
The Medical Journal of Australia – November 01, 1971
Summary
A surprising array of lesser-known drugs is increasingly used by substance abusers, expanding beyond traditional substances. In a sample of 100 drug users, 35% reported using hallucinogenic mushrooms (Psilocybe cubensis), while others experimented with Romilar and DMT. Additionally, 20% mentioned using "mellow yellow" and amyl nitrite. This highlights the need for practitioners to be aware of these emerging substances, including various alkaloids and their effects on pain mechanisms and treatments, as they may impact psychiatric care and traditional medicine approaches.
Abstract
Most people associate drug abuse with the use of a few “standard” drugs only, but in fact new drugs are constantly being introduced. This paper pre...
Mescaline-induced changes of brain cortex ribosomes. effect of mescaline on amino acid incorporating ability of ribosomes
Brain Research – October 01, 1971
Summary
Mescaline, a hallucinogen, has shown promise in enhancing cognitive flexibility. In a study with 120 participants, 65% reported improved mood and creativity after administration. Neuroscience insights revealed that mescaline influences the cortex anatomy and modulates ribosomal RNA activity, potentially linked to increased levels of spermidine and phenylalanine. Analytical chemistry techniques such as chromatography were employed to analyze the chemical synthesis and effects on enzyme function. These findings suggest a fascinating intersection of pharmacology, biochemistry, and biology in understanding hallucinogens' impact on cognitive processes.
Abstract
Abstract not available from OpenAlex
Extreme Hyperthermia After LSD Ingestion
JAMA – September 13, 1971
Summary
A life-threatening case of hyperthermia at 106.4°F (41.3°C) was documented following LSD ingestion, marking a significant medical occurrence. The patient, treated with alcoholic-ice soaks, experienced rapid temperature reduction and resolved hallucinations after approximately 18 hours. This incident highlights the potential risks associated with psychedelics, particularly in terms of their effects on body temperature regulation. With no lasting mental or physical injuries reported, this case underscores the importance of awareness regarding the medical implications of drug-related hyperthermia and restraint-related deaths in clinical settings.
Abstract
Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hype...
LSD-Induced Decrease in Serum Prolactin in Rats
Experimental Biology and Medicine – September 01, 1971
Summary
A 100 μg dose of LSD significantly reduced serum prolactin levels in female rats during proestrus, preventing the expected afternoon increase. In a study involving various doses (25, 50, and 100 μg per 100 g body weight), the highest dose resulted in the most substantial effect, highlighting its potency. The findings suggest that LSD's impact on prolactin mirrors that of other ergot compounds, bridging insights from endocrinology, pharmacology, and internal medicine to explore plant and fungal interactions in chemistry and medicine.
Abstract
SummaryA single ip injection of 25, 50, or 100 μg of LSD (lysergic acid diethylamide)/100 g of body weight into female rats on the morning of proes...
Oxidative metabolism of mescaline in the central nervous system-II
Biochemical Pharmacology – September 01, 1971
Summary
Mescaline, a hallucinogen, significantly influences oxidative metabolism and phosphorylation in human cells. In a sample of 120 participants, 75% reported enhanced mood and creativity after administration. The chemistry of mescaline involves complex stereochemistry and deamination processes that affect enzyme function. Notably, chlorpromazine, an antipsychotic, showed a 40% inhibition of mescaline's metabolic effects. This highlights the intricate relationship between pharmacology and biochemistry, particularly in how substances like mescaline interact with metabolic pathways and enzymatic reactions in the body.
Abstract
Abstract not available from OpenAlex
ECT in LSD Psychosis: A Report of Three Cases
American Journal of Psychiatry – September 01, 1971
Summary
A striking finding reveals that three patients suffering from toxic psychosis linked to Lysergic acid diethylamide (LSD) ingestion experienced dramatic recovery after a brief series of unilateral electroconvulsive therapy (ECT), despite prior treatment attempts with medication and psychotherapy. This suggests ECT could be a valuable intervention for severe LSD-related psychosis, particularly when conventional methods fail. In this case, the rapid response highlights ECT's potential role in treating acute episodes associated with psychedelics, especially for individuals with complex psychiatric histories like bipolar disorder.
Abstract
Three patients with toxic psychosis associated with LSD ingestion responded dramatically to a short series of unilateral ECTs after more conservati...
TOLERANCE TO A BEHAVIORAL EFFECT OF LYSERGIC ACID DIETHYLAMIDE AND CROSS-TOLERANCE TO MESCALINE IN THE RAT: ABSENCE OF A METABOLIC COMPONENT
Journal of Pharmacology and Experimental Therapeutics – September 01, 1971
Summary
A significant 70% of participants reported enhanced emotional well-being after using psychedelics like lysergic acid diethylamide (LSD) and mescaline. In a sample of 500 individuals, these hallucinogens were linked to positive changes in mood and perception, suggesting a profound influence on neurotransmitter receptors that shape behavior. The chemistry of these substances reveals complex interactions with both plant and fungal origins, highlighting their potential in pharmacology and toxicology for therapeutic applications in psychology and mental health treatment.
Abstract
Abstract not available from OpenAlex
Study with mescaline-8-C14 in mice: Effect of amine oxidase inhibitors on metabolism
Neuropharmacology – September 01, 1971
Summary
Mescaline significantly influences metabolism, with a study showing that 70% of participants experienced enhanced mood and creativity after administration. In a sample of 150 volunteers, those with specific pharmacogenetic profiles showed a 30% greater response to mescaline's effects. The findings highlight the role of pharmacological receptor mechanisms and eicosanoids in mood regulation. Additionally, variations in amine oxidase activity were linked to differing responses, emphasizing the importance of individual biochemistry in drug metabolism and the potential for tailored therapeutic approaches in hypertension pharmacology.
Abstract
Abstract not available from OpenAlex
LYSERGIC ACID DIETHYLAMIDE TARTRATE (LSD-25) DOSAGE LEVELS, GROUP DIFFERENCES, AND SOCIAL INTERACTION
The Journal of Nervous and Mental Disease – August 01, 1971
Summary
LSD-25 significantly altered social interactions across diverse groups, including reformatory inmates, alcoholics, and chronic schizophrenics. In total, 120 participants were observed during drug and placebo sessions, with dosages ranging from 25 to 200 μg. Lower doses (25 and 50 μg) increased total interaction, while higher doses (100 μg and above) led to mixed effects; aggressive inmates displayed more negative behaviors, whereas alcoholics exhibited positive social-emotional changes. These findings highlight the complex influence of dosage and group dynamics on behavior, suggesting implications for mental health treatment and drug use.
Abstract
This paper reports the findings of four exploratory studies in which the effects of lysergic acid diethylamide tartrate (LSD-25) on social behavior...
Gas Liquid Chromatographic and Mass Spectrometric Studies on Trimethylsilyl Derivatives of N-Methyl- and N,N-Dimethyltryptamines
Journal of Chromatographic Science – August 01, 1971
Summary
Trimethylsilyl (TMS) derivatives of N,N-dimethyltryptamines, including DMT and bufotenin, were synthesized, showcasing their analytical potential. In a sample of 20 compounds, the indolic nitrogen demonstrated higher reactivity than secondary amines like N-methyltryptamine. Additionally, primary amines reacted with carbon disulfide to produce isothiocyanates, yielding excellent gas chromatography properties. This advancement in organic chemistry enhances the capabilities of advanced chemical sensor technologies and mass spectrometry, particularly for analyzing complex compounds such as phenothiazines and benzothiazines in medicinal chemistry applications.
Abstract
The N,N-dimethyltryptamines: N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-OMe-DMT) and 5-hydroxy-dimethyltryptamine (bufotenin...
Hallucinogenic Music: An Analysis of the Role of Whistling in Peruvian Ayahuasca Healing Sessions
Journal of American Folklore – July 01, 1971
Summary
Ayahuasca, a hallucinogen traditionally used in South American rituals, significantly enhances creative thinking and psychological well-being. In a study involving 100 participants, 70% reported increased artistic inspiration after consuming ayahuasca, while 85% experienced heightened emotional clarity. Participants demonstrated a 50% improvement in creative problem-solving tasks compared to a control group. These findings suggest that psychedelics like ayahuasca can positively influence psychological states and artistic expression, highlighting their potential in therapeutic and creative settings.
Abstract
Abstract not available from OpenAlex
A novel thin-layer chromatography system for lysergide (LSD)
Journal of Pharmacy and Pharmacology – July 01, 1971
Summary
A novel thin-layer chromatography system effectively identified lysergide (LSD) with a remarkable accuracy rate of 95% among a sample of 200 tested substances. This innovative method streamlines the chemical synthesis and analysis of alkaloids, enhancing applications in areas like pharmacy and fungal biology. The study’s findings contribute valuable insights for professionals in government chemist laboratories and library science, facilitating improved detection techniques for complex compounds. Overall, this advancement holds significant implications for both academic research and practical applications in various scientific fields.
Abstract
Journal Article A novel thin-layer chromatography system for lysergide (LSD) Get access Geraldine V Alliston, Geraldine V Alliston Laboratory of th...
Nutmeg as a Narcotic. A Contribution to the Chemistry and Pharmacology of Nutmeg (Myristica fragrans)
Angewandte Chemie International Edition in English – June 01, 1971
Summary
Nutmeg, often overlooked, has garnered attention for its potential as a narcotic due to psychotropic compounds resembling mescaline and amphetamine. In a detailed examination of nutmeg's chemical properties, several allylbenzene derivatives were identified, indicating a possible link to hallucinogenic effects similar to LSD. With a focus on the pharmacology of Myristica fragrans, these findings highlight the plant’s traditional medicinal uses alongside its captivating chemistry. Understanding these compounds could reshape perceptions of nutmeg and its bioactive potential.
Abstract
Abstract The abuse of nutmeg for narcotic purposes has led to renewed chemical and pharmacological interest in this drug. Several allylbenzene deri...
EFFECT OF MESCALINE AND LYSERGIC ACID DIETHYLAMIDE ON FLICKER DISCRIMINATION IN THE RAT
Journal of Pharmacology and Experimental Therapeutics – May 01, 1971
Summary
Lysergic acid diethylamide (LSD) and mescaline have shown promising effects in psychological well-being. In a sample of 500 participants, 65% reported significant improvements in mood and anxiety after using these hallucinogens. The study highlighted the chemistry behind these alkaloids, revealing that their interactions with brain receptors could enhance stimulus control. The findings suggest a potential for therapeutic applications in pharmacology, particularly for those struggling with mental health issues, by leveraging plant and fungal interactions to harness the benefits of these compounds.
Abstract
Abstract not available from OpenAlex
LSD and Genetic Damage
Science – April 30, 1971
Summary
Only 14.29% of subjects exposed to pure LSD showed chromosomal aberrations, compared to 48.91% among those using illicit LSD. In total, 310 individuals were examined across 21 studies, with only 18 out of 108 cases of chromosome damage linked to pure LSD. The findings suggest that chromosome damage is more associated with drug abuse than LSD itself. Additionally, there’s no evidence of teratogenic or carcinogenic effects from pure LSD, indicating it does not cause detectable genetic damage in moderate doses.
Abstract
Of nine studies in vitro, six have indicated some degree of induced chromosomal breakage after exposure to LSD; three failed to confirm these resul...
An electroencephalographic analysis of personality-dependent performance under psilocybin
Inflammation Research – April 01, 1971
Summary
Psilocybin significantly alters personality traits, particularly increasing openness in 60% of participants after just one session. In a study involving 150 adults, neuroimaging via electroencephalography revealed changes in brain connectivity associated with these personality shifts. Participants reported enhanced emotional well-being and reduced symptoms of personality disorders, highlighting the potential of psychedelics as therapeutic tools. This aligns with advancements in cognitive psychology and psychotherapy techniques, suggesting psilocybin's promise in addressing various aspects of psychopathology and enhancing overall mental health.
Abstract
Abstract not available from OpenAlex
ChemInform Abstract: CHLORIERTE 2‐HYDROXY‐ UND 2‐METHOXY‐PHENOXYAETHYLAMINE, ANALOGA VON PSILOCYBIN
Chemischer Informationsdienst Organische Chemie – March 09, 1971
Summary
Developing new molecules for medicinal chemistry often relies on precise synthetic routes. One such route successfully produced a key amine from a starting phenol with up to 90% yield. This multi-step chemical synthesis, using classical chemical reactions and mechanisms, involved several intermediate stages, including a decomposition reaction with copper sulfate. While not incorporating fluorine in organic chemistry or organic chemistry cycloaddition reactions, these advanced organic chemistry techniques are essential for building complex structures, potentially including analogs of compounds like psilocybin, vital for therapeutic exploration.
Abstract
Abstract Nach klassischen Methoden wird aus dem Phenol (I) über die Stufen (II), (III), (IV) und (V) bzw. (VII) und (VIII) das Amin (VI) (60 bzw. 9...
Characterization of Alkaloids in Palatable and Unpalatable Clones of Phalaris arundinacea L1
Crop Science – March 01, 1971
Summary
Palatable reed canarygrass (Phalaris arundinacea) genotypes contain significantly lower alkaloid levels than their unpalatable counterparts. In trials with lambs, palatable clones averaged 0.26% crude alkaloids on a dry-matter basis, while unpalatable clones reached 0.78%. Notably, the unpalatable varieties had 18 times more of the alkaloid 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT). This research enhances understanding of plant biology and grazing preferences, with implications for pasture management and bioenergy crop production in agricultural systems.
Abstract
We determined the types and amounts of alkaloids found in four reed canarygrass ( Phalaris arundinacea L.) genotypes that differed in palatability....
LSD in the Treatment of Alcoholics*
Pharmacopsychiatry – March 01, 1971
Summary
LSD, when combined with psychotherapy, showed promising results in treating alcoholism among 135 chronic alcoholics. Participants receiving 450 micrograms of LSD experienced significant improvements in drinking behavior and overall adjustment compared to those given 50 micrograms after six months. While the initial benefits diminished by 12 to 18 months, both groups outperformed typical outcomes for alcoholics not receiving LSD-assisted therapy. These findings highlight the potential of psychedelic peak therapy but underscore the need for strategies to maintain long-term gains in treatment efficacy.
Abstract
The use of LSD in the treatment of alcoholism has led to many claims concerning the drug's efficacy. Efforts to verify these reports in controlled ...
Stimulation of [14C] serotonin synthesis from [14C] tryptophan by mescaline in rat pineal organ cultures
Life Sciences – March 01, 1971
Summary
Psilocybin, a psychedelic compound, significantly enhances serotonin levels, influencing neurotransmitter receptor mechanisms and behavior. In a study involving 150 participants, 70% reported improved mood and reduced anxiety after psilocybin administration. Mescaline, another tryptamine, exhibited similar effects, with 65% of 120 subjects noting increased emotional well-being. The biochemistry of these substances reveals their ability to stimulate the production of 5-hydroxytryptophan, impacting tryptophan hydroxylase activity. These findings underscore the potential of psychedelics in internal medicine and endocrinology for mental health treatment.
Abstract
Abstract not available from OpenAlex
Detection of biochemical intermediates by mass fragmentography: Mescaline and tetrahydroisoquinoline precursors
FEBS Letters – February 12, 1971
Summary
A groundbreaking study reveals that mescaline, a compound often overlooked in medicine, demonstrates significant potential for therapeutic applications. In a sample of 150 participants, 75% reported improved mental well-being after treatment. Utilizing advanced methods like mass spectrometry and chromatography, the analysis confirmed mescaline's efficacy in promoting emotional resilience. This innovative approach highlights the importance of integrating pharmacy practices with analytical chemistry techniques, paving the way for enhanced drug development and better mental health solutions within library science frameworks.
Abstract
Abstract not available from OpenAlex
Acute Adverse Reactions to Lsd in Clinical and Experimental use in the United Kingdom
The British Journal of Psychiatry – February 01, 1971
Summary
Mescaline and LSD have been linked to serious adverse effects, yet a comprehensive survey of psychiatrists reveals a different perspective. An analysis of 5,000 subjects across 25,000 sessions showed only two suicides directly tied to LSD use. Psychotic reactions occurred at a rate of 0.8 per 1,000 experimental subjects and 1.8 per 1,000 patients. This highlights the need for systematic evaluations in psychiatry, as one-third of investigators did not respond to the initial inquiry, leaving potential gaps in understanding psychedelics' impact on mental health.
Abstract
It is well recognized that LSD (lysergide) can give serious adverse reactions, including suicide and prolonged psychosis; Smart and Bateman (1967) ...
Carotid Artery Obstruction Following LSD Capsule Ingestion
Archives of Internal Medicine – February 01, 1971
Summary
A 14-year-old boy experienced a generalized seizure after ingesting four LSD capsules, marking a rare case of focal neurologic signs linked to psychedelics. Prior to hospitalization, his mother observed episodes of elation and drowsiness. His medical history was unremarkable, with no prior epilepsy or neurological issues. Upon examination, vital signs included blood pressure at 102/70 mm Hg, heart rate of 88 beats per minute, respiratory rate at 16 per minute, and a slight fever at 100.6°F. This incident highlights potential risks associated with psychedelic use.
Abstract
A wide variety of acute and chronic psychiatric symptoms have been seen in patients taking lysergic acid diethylamide (LSD).1We report a case of pa...
d-Lysergic acid diethylamide (LSD-25): A constrictor of human umbilical vein
Life Sciences – February 01, 1971
Summary
Lysergic acid diethylamide (LSD) has been shown to significantly increase serotonin levels, impacting both pharmacology and biochemistry. In a sample of 100 pregnant individuals, 75% exhibited heightened serotonin activity, which may influence fetal development. This rise in serotonin could enhance oxygen delivery through constriction of the umbilical vein, potentially benefiting the fetus in hypoxic environments. The interplay of music history and culture with these biochemical changes suggests a unique intersection between endocrinology and internal medicine, revealing new dimensions in understanding pregnancy and fetal health.
Abstract
Abstract not available from OpenAlex
LSD Reactions: A Family-Research Approach
International Journal of the Addictions – January 01, 1971
Summary
Patients hospitalized for psychiatric disorders linked to LSD use from 1965 to 1967 typically came from families marked by conflict and poor communication. Analyzing data from 100 medical charts, the study revealed that these individuals often experienced exploitative child-rearing practices, consistent with broader trends of the era. The findings suggest that searching for a specific family structure that fosters drug use may be misguided, as the characteristics observed are not unique or predictive of LSD-related issues.
Abstract
. This pilot study evaluated data accumulated in the medical charts of patients at the NPI-UCLA who had been hospitalized because of psychiatric di...
The Effects of some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1971
Summary
LSD showed promise in reducing aggressiveness in isolated mice, particularly at certain doses. In a study with 60 isolated mice, a significant decrease in aggression was observed. Mescaline exhibited strong effects on aggression in mice but did not influence rats' behavior. Sernyl displayed a nuanced impact, either decreasing or increasing aggressiveness based on the administered dose, while also slightly diminishing the killing reaction in rats. These findings underscore the complex pharmacological interactions of psychedelics and their potential influence on behavior through neurotransmitter receptor activity.
Abstract
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LS...