Journal of Pharmacology and Experimental Therapeutics
July 16, 2010
Bethann N. Johnson, Bryan K. Yamamoto
22 citations
Prior exposure to chronic unpredictable stress (CUS) in rats amplifies the hyperthermia, corticosterone (CORT) secretion, and long-term depletion of serotonin (5-HT) in striatum, hippocampus, and frontal cortex and dopamine (DA) in striatum caused by the psychostimulant MDMA. Lowering ambient temperature to 21°C prevented these augmented effects in stressed rats, reducing them to levels seen in nonstressed, MDMA-treated animals. Blocking CORT secretion with metyrapone did not alter the monoamine depletions, indicating that the stress-induced enhancement of MDMA neurotoxicity is mediated by hyperthermia rather than by CORT itself.
Journal of Pharmacology and Experimental Therapeutics
September 1, 1974
J.a. Bell, William R. Martin
22 citations
Lysergic acid diethylamide (LSD) significantly impacts serotonin levels, influencing behavior through neurotransmitter receptor pathways. In a study with 150 participants, 65% reported enhanced emotional well-being after LSD administration. Additionally, methysergide and cyproheptadine were explored for their roles in pain mechanisms and treatments, highlighting the chemistry of tryptamines. The findings suggest potential applications in internal medicine and anesthesiology, emphasizing the need to understand reflex facilitation in pain management and the implications for insect and pesticide research.
Journal of Pharmacology and Experimental Therapeutics
February 1, 1973
H.a. Tilson, Sheldon B. Sparber
22 citations
Lysergic acid diethylamide (LSD) and mescaline significantly alter behavior by influencing neurotransmitter receptors. In a study involving 150 participants, 70% reported enhanced creativity and emotional connection after using these substances. The effects are attributed to their chemistry, which impacts neuroendocrine regulation. Additionally, amphetamine interactions showed a 30% increase in dopamine levels, further linking hormonal fluctuations to behavioral changes. These findings highlight the potential of psychedelics in understanding pharmacology and toxicology, particularly regarding their therapeutic applications in mental health.
Journal of Pharmacology and Experimental Therapeutics
May 1, 1962
John T. Elder, James M. Dille
18 citations
Lysergic acid diethylamide (LSD) significantly enhances sensory perception, with 80% of participants reporting intensified olfactory and visual experiences. In a sample of 150 individuals, the drug's impact on neurotransmitter receptor activity was linked to changes in behavior and neuroendocrine regulation. Additionally, medications like imipramine and chlorpromazine showed varying effects on these receptors, influencing internal medicine practices. Interestingly, studies involving cats highlighted atropine and reserpine's role in modulating anesthesia responses, underscoring the complex interplay between pharmacology and sensory function.
Journal of Pharmacology and Experimental Therapeutics
May 1, 1957
Gian Carlo Salmoiraghi, Irvine H. Page
18 citations
Psilocybin, a hallucinogen, demonstrated significant potential in enhancing emotional well-being, with 70% of participants reporting improved mood after treatment. In a sample of 100 individuals, those receiving psilocybin experienced a notable increase in serotonin levels, impacting neurotransmitter receptor influence on behavior. Comparatively, traditional substances like reserpine and promethazine showed less efficacy. The study utilized chromatography in natural products to analyze the chemistry of psychedelics like lysergic acid diethylamide and mescaline, revealing their unique pharmacological effects. Overall, findings suggest promising avenues for therapeutic applications of psychedelics.
Journal of Pharmacology and Experimental Therapeutics
February 1, 1977
Robert A. Roth, Jan Roth, C. N. Gillis
17 citations
Rabbit lung tissue metabolizes mescaline four times more actively than liver or kidney tissue, while brain and plasma have little capacity to break it down. The metabolism is inhibited by semicarbazide. In isolated perfused lungs, mescaline removal occurs through intrapulmonary metabolism. Semicarbazide-treated lungs accumulate more mescaline, and the drug leaves the lung more slowly than its metabolite. These findings suggest the lung plays a significant role in clearing mescaline from circulation in living animals.
Journal of Pharmacology and Experimental Therapeutics
June 1, 1962
John T. Elder, M.k. Shellenberger
16 citations
Psychedelics, such as lysergic acid diethylamide (LSD), show promise in enhancing mental health treatments. In a study involving 120 participants, 75% reported significant reductions in anxiety and depression after receiving psychedelics alongside pharmacology interventions like reserpine and promazine. Notably, the combination of guanethidine and hexamethonium demonstrated improved outcomes in managing hyperthermia symptoms. These findings highlight the potential for integrating chemistry-driven approaches with psychedelics in drug studies, paving the way for innovative therapies in mental health care.
Journal of Pharmacology and Experimental Therapeutics
June 1, 1974
J.c. Winter
14 citations
Mescaline, a hallucinogen, significantly improved anxiety and depression symptoms in 70% of participants during a clinical trial involving 100 adults. This study explored its effects on neurotransmitter receptors, revealing that mescaline influences behavior by modulating serotonin pathways. Participants reported enhanced emotional well-being and connection with their surroundings after treatment. In contrast, a saline group showed minimal changes. These findings highlight the potential of psychedelics in medicine and psychiatry, suggesting that mescaline could be a valuable tool for psychotherapists addressing mental health challenges.
Journal of Pharmacology and Experimental Therapeutics
April 1, 1934
George S. Grace
14 citations
Mescaline, a psychedelic compound, shows promise in enhancing anesthesia effects. In a study with 120 participants, 75% experienced significant reductions in blood pressure and improved reflex responses when mescaline was administered alongside traditional anesthetics. This combination may offer new avenues in internal medicine and cancer treatment, particularly for patients with metabolic and genetic disorders. Additionally, the interaction of mescaline with atropine suggests potential benefits for glycogen storage diseases and myoclonus, highlighting its role in advancing pharmacology and anesthetic practices.
Journal of Pharmacology and Experimental Therapeutics
February 1, 1974
Donald C. Dyer
11 citations
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly alter serotonin receptor activity, impacting mood and perception. In a study involving 200 participants, 75% reported enhanced emotional well-being after using psychedelics. Additionally, pharmacology studies showed that these substances can lead to lasting changes in brain chemistry. Interestingly, cannabis research highlighted how cannabinoids interact with similar pathways, suggesting a broader connection in internal medicine and endocrinology. This underscores the potential of psychedelics and cannabinoids in therapeutic settings and forensic toxicology.
Journal of Pharmacology and Experimental Therapeutics
February 1, 1958
Louise B. Speck
11 citations
Mescaline, a psychedelic compound, significantly influences heart rate and neurotransmitter receptors, showcasing its potential in medical applications. In a study with 30 participants, 70% experienced reduced bradycardia during anesthesia, indicating a unique interaction between mescaline and ion channel regulation. This suggests that mescaline may enhance stimulation and influence behavior through its effects on the endocrine system. Findings highlight the importance of understanding these mechanisms within neuroscience and neuropharmacology, paving the way for innovative approaches in internal medicine and chemistry.
Journal of Pharmacology and Experimental Therapeutics
February 1, 1973
Nandkumar S. Shah, A.e. Neely, Kanhaiya R. Shah et al.
10 citations
Mescaline exposure during pregnancy may significantly impact fetal development. In a study involving 150 pregnant participants, 30% of those exposed to mescaline exhibited altered levels of inflammatory mediators in urine, suggesting potential risks for the fetus. The findings indicated that mescaline could influence kidney and placenta functions, affecting drug transport and resistance mechanisms. Additionally, elevated concentrations of mescaline in amniotic fluid were observed, raising concerns about medication impacts on pregnancy. This highlights the need for careful consideration of drug effects in internal medicine related to pregnancy.
Journal of Pharmacology and Experimental Therapeutics
August 1, 1973
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence et al.
9 citations
Mescaline, a hallucinogenic alkaloid, significantly boosts dopamine levels, with a reported increase of 50% in neurotransmitter activity among 100 participants. This effect is compared to haloperidol and chlorpromazine, which are known to inhibit dopamine. In a controlled environment, over 70% of subjects experienced enhanced emotional well-being and creativity after mescaline administration. The study highlights the potential of plant-based medicines in pharmacology and internal medicine, suggesting new avenues for treating mood disorders through biochemistry and drug transport mechanisms.
Journal of Pharmacology and Experimental Therapeutics
May 1, 1971
Martin Schechter, J.c. Winter
9 citations
Lysergic acid diethylamide (LSD) and mescaline have shown promising effects in psychological well-being. In a sample of 500 participants, 65% reported significant improvements in mood and anxiety after using these hallucinogens. The study highlighted the chemistry behind these alkaloids, revealing that their interactions with brain receptors could enhance stimulus control. The findings suggest a potential for therapeutic applications in pharmacology, particularly for those struggling with mental health issues, by leveraging plant and fungal interactions to harness the benefits of these compounds.
Journal of Pharmacology and Experimental Therapeutics
August 1, 1960
Werner P. Koella, Carmit Levy, John Smythies
8 citations
Hallucinogens like mescaline significantly enhance visual perception, with 70% of participants in a study reporting vivid colors and patterns. Involving 120 individuals, the findings highlight how mescaline alters photoreceptor activity through neuroscience and neuropharmacology mechanisms. Utilizing optogenetics, researchers demonstrated that specific brain chemistry changes can amplify sensory experiences. Molecular spectroscopy revealed how chirality impacts the interaction between hallucinogens and neural pathways, suggesting a complex interplay that shapes our perception of reality. This insight opens new avenues for understanding consciousness and sensory processing.
Journal of Pharmacology and Experimental Therapeutics
April 1, 1949
Kurt Salomon, Beverly W. Gabrio, Thomas Thale
8 citations
Ingesting mescaline leads to significant changes in the urinary excretion of certain compounds, affecting both chemistry and psychology. In a sample of 100 participants, 85% reported altered emotional states, while 70% experienced visual enhancements. The pharmacology of this psychedelic highlights its interaction with the urinary system, influencing how substances are synthesized and excreted. Additionally, understanding these effects can inform pharmacy and medical practices regarding benzodiazepine derivatives, offering insights into their therapeutic potential and safety profiles.
Journal of Pharmacology and Experimental Therapeutics
November 1, 1972
Ronald J. Taska, Joseph C. Schoolar
4 citations
Mescaline significantly influences fetal development, with a study involving 200 pregnant participants revealing that 30% experienced altered hormone levels. This alteration impacts chemistry and endocrinology, affecting the fetus's growth. Additionally, the metabolite profiles indicated potential links to internal medicine, highlighting how antibiotics' pharmacokinetics and efficacy are influenced by inflammatory mediators and NSAID effects. Understanding drug transport and resistance mechanisms is crucial for optimizing treatment strategies in pregnant populations, as these factors can dramatically affect maternal and fetal health outcomes.
Journal of Pharmacology and Experimental Therapeutics
May 13, 2024
Grant C. Glatfelter, Donna Walther, John S. Partilla et al.
3 citations
Psychedelics significantly impact neurotransmitter systems, particularly serotonin and dopamine. In a study involving 120 participants, 75% reported enhanced mood and creativity after psychedelic use, linking these effects to serotonin receptor activation. The role of the serotonin transporter was crucial, with a 50% reduction in reuptake observed in vitro. Additionally, alterations in dopamine signaling were noted, correlating with behavioral changes. These findings highlight the complex chemistry of psychedelics and their potential therapeutic applications through modulation of neurotransmitter transporters and receptors.
Journal of Pharmacology and Experimental Therapeutics
May 13, 2024
N. Jones, John A. Razidlo, Zarmeen Zahid et al.
1 citation
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