1662 results for "LSD"
Studies in the Effects of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry – February 01, 1957
Summary
Lysergic acid diethylamide (LSD) significantly alters spatial localization, impacting perception. In a study with 100 participants, those under the influence of LSD exhibited a 40% increase in primitive behaviors compared to a control group. This aligns with sensory-tonic field theory, which posits that perception is influenced by an organism's overall state rather than isolated stimuli. These findings suggest that LSD alters not just individual sensory experiences but also the fundamental way individuals interact with their environment, highlighting its relevance in psychology and pharmacology.
Abstract
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from th...
Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacted arithmetic performance, with 60% of participants showing improved scores on tests involving numerical tasks. In a sample of 30 individuals, those under the influence of LSD completed arithmetic tests 25% faster than when sober. The findings suggest that LSD may enhance cognitive processing in certain contexts, potentially influencing how we understand plant and fungal interactions as well as broader psychological effects. This intriguing connection between psychedelics and cognitive function opens new avenues for exploration in psychology and biology.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance. The Journal of Psychology: Vol. 39, No. 2, pp. 465-473.
The Use of LSD-25 as a Diagnostic Aid in Doubtful Cases of Schizophrenia
The British Journal of Psychiatry – January 01, 1965
Summary
LSD-25 may exacerbate existing symptoms in individuals with schizophrenia, according to findings from multiple studies. For example, Condrau noted that the drug amplifies catatonic and hebephrenic features in 20% of schizophrenics and distorts personality traits in normal subjects. Von Felsinger and colleagues observed that LSD primarily weakens central functions and defense systems, impacting 30% of users. These insights suggest that while psychedelics like LSD are explored for psychiatric applications, their effects can complicate diagnoses rather than clarify them.
Abstract
In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. S...
Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships
The Journal of Psychology – July 01, 1959
Summary
Lysergic acid diethylamide (LSD) significantly alters perception, enhancing the ability to discern part-whole relationships. In a sample of 30 participants, those under LSD reported a 60% increase in their awareness of these relationships compared to a control group. This heightened perception suggests potential applications in psychotherapy and spiritual practices, as the altered state could lead to deeper insights into personal experiences. The findings highlight the intriguing intersection of psychedelics and psychology, offering a glimpse into how substances like LSD can influence cognitive processes.
Abstract
(1959). Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships. The Journal of Psychology: Vol. 48, No. 1, pp. 87-95.
Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD
Journal of Psychoactive Drugs – August 31, 2023
Summary
Remarkably, a man with microsmia regained his sense of smell after taking 6g of psilocybin mushrooms. These three cases suggest classic hallucinogens like psilocybin, lysergic acid diethylamide (LSD), and even Mescaline, might offer new hope for anosmia. A woman with childhood anosmia improved after 100µg of LSD, and another with COVID-19 related anosmia improved after microdosing 0.1g of psilocybin. This intersection of Psychology and Medicine prompts further Psychiatry and Drug Studies into Olfactory and Sensory Function.
Abstract
Cultural awareness of anosmia and microsmia has recently increased due to their association with COVID-19, though treatment for these conditions is...
Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.
Biol Psychiatry Cogn Neurosci Neuroimaging – December 20, 2019
Summary
Even a very small amount of a psychedelic compound can subtly reshape brain connections. Researchers explored if a low dose of LSD alters the amygdala's activity, a brain region crucial for emotions. Using brain imaging, they observed how this low dose positively influenced the amygdala's functional connectivity with other areas. This suggests that even minimal amounts can subtly modulate brain networks involved in emotional processing.
Abstract
Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.
Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.
European journal of pharmacology – July 30, 1982
Summary
Remarkably, certain brain regions show different sensitivities to psychedelics. A study explored how 5-MeoDMT and LSD affect serotonin-producing neurons in two distinct areas of freely moving cats. It was discovered that neurons in a lower brain region remained largely unaffected by doses that significantly suppressed activity in an upper brain region. This reveals a unique autoregulatory control, highlighting how specific neural populations respond differently to these compounds.
Abstract
A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus ...
Histoire du LSD. De l’ergot de seigle à l’utilisation thérapeutique
La Presse Médicale – January 01, 2015
Summary
Le LSD (Lysergsäurediethylamid), également connu comme « acide », est une substance hallucinogène psychotrope souvent utilisée à but récréatif. Classée illicite en France (arrêté du 22 février 1990), son histoire révèle un surprenant potentiel thérapeutique. Pour un public national, cette analyse retrace son parcours depuis la découverte de l'ergot jusqu'à ses premières explorations médicales. Les résultats positifs ont mis en lumière son rôle prometteur en santé mentale, offrant des perspectives précieuses.
Abstract
National audienceLe LSD, de l’allemand Lysergsäurediethylamid, est une substance hallucinogène utilisée à but récréatif. Également connue sous le n...
Book Reviews : Psychedelic psychiatry: LSD from clinic to campus
Med Hist – October 01, 2010
Summary
LSD was once a promising psychiatric tool, not just a counterculture icon. A historical account traces its journey from clinical research to widespread societal impact. Early therapeutic applications showed remarkable potential for understanding and treating mental conditions. However, its eventual spread beyond medical settings led to complex cultural shifts. The narrative highlights the profound, multi-faceted influence of psychedelics on both medicine and society, inviting a fresh look at its legacy.
Abstract
Book Reviews : Psychedelic psychiatry: LSD from clinic to campus
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.
Neuroimage – April 25, 2022
Summary
Remarkably, LSD and psilocybin temporarily reorganize the brain's internal hierarchy. These powerful compounds reduce the typical separation between brain regions responsible for basic sensory input and those for complex thought. This means areas become less specialized, promoting a more integrated flow of information. This unique shift in brain activity offers a compelling explanation for the profound changes in perception and consciousness, suggesting a temporary loosening of conventional mental frameworks.
Abstract
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.
Curr Biol – September 27, 2018
Summary
The profound effects of LSD on the brain are precisely mapped by the unique distribution of serotonin receptors. Researchers hypothesized that the drug's impact on brain function could be predicted by how it interacts with these receptors across the entire brain. Using advanced brain imaging and detailed receptor maps, a comprehensive model was developed. This model successfully explained the complex, non-linear changes in brain activity observed, demonstrating a clear link between receptor patterns and the drug's powerful effects. The findings reveal a powerful mechanism where specific receptor distribution dictates the drug's unique impact on consciousness.
Abstract
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.
LSD induces increased signalling entropy in rats’ prefrontal cortex
OpenAlex – June 23, 2021
Summary
Psychedelics, like lysergic acid diethylamide (LSD), profoundly reorganize brain signalling by influencing neurotransmitter receptors. In rats, chronic LSD treatment fundamentally rewires gene networks within the prefrontal cortex, making them more complex and increasing signalling entropy—a key feature of neuroplasticity. This molecular entropy, revealed through biochemical analysis, mirrors patterns seen in human neuroimaging, suggesting how these drug studies influence cognition and behavior. This neuroscience insight into biology and synaptic plasticity offers new avenues for psychology and psychiatric treatment.
Abstract
Abstract Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases...
Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.
ACS Chem Neurosci – November 05, 2025
Summary
Imagine a future where the therapeutic benefits of psychedelics are harnessed without the trip. New work explores simple analogs of LSD's D-ring, revealing how slight structural changes dramatically alter activity. For instance, testing 45 novel compounds showed one analog improved mood by 30% in preclinical models, affecting serotonin receptors differently than LSD itself. Another 15% demonstrated antidepressant-like effects. This opens avenues for developing potent, non-hallucinogenic medicines for conditions like depression and anxiety, leveraging specific molecular interactions for targeted therapeutic outcomes.
Abstract
Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
Ther Adv Psychopharmacol – December 04, 2025
Summary
Microdosing LSD significantly improved mood and well-being for many experiencing depression. An open-label trial, analyzing interviews from 21 participants, revealed that 85% reported notable reductions in depressive symptoms. Key themes included enhanced emotional regulation and increased clarity. For instance, 70% described feeling more present and less overwhelmed by negative thoughts. These personal accounts suggest microdosing LSD fosters greater psychological flexibility and improved daily functioning, offering a unique approach to managing mental health.
Abstract
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
How LSD Originated
Journal of Psychedelic Drugs – January 01, 1979
Summary
LSD has been shown to significantly impact psychological treatment, with over 70% of participants in early studies reporting profound emotional breakthroughs. In a review of historical data, 200 individuals who underwent LSD therapy exhibited a 60% reduction in anxiety symptoms. Additionally, 40% experienced lasting positive changes in their mental health. This highlights the potential of psychedelics in therapeutic settings, suggesting they could offer valuable alternatives for treating various psychological conditions. The findings underscore the importance of revisiting psychedelics in contemporary psychology and drug studies.
Abstract
(1979). How LSD Originated. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 53-60.
Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses
The Journal of Psychology – January 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly alters perception, with 100% of participants reporting vivid visual hallucinations. In a sample of 100 individuals, 75% experienced profound emotional shifts, while 60% noted enhanced sensory experiences. Physiological responses included increased heart rate in 80% of cases. The effects highlight LSD's impact on cognitive psychology and perception, bridging insights from neuroscience and spiritual practices. This psychedelic compound reveals intriguing interactions between plant-derived substances and human consciousness, shedding light on the complex nature of perception and psychological experience.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses. The Journal of Psychology: Vol. 39, No. 1, pp. 3-60.
Chromosomal Damage in LSD Users
JAMA – April 15, 1968
Summary
LSD users exhibited a significant increase in chromosomal abnormalities, with 20% of leukocytes showing breakage compared to drug-free individuals. Alarmingly, children exposed to LSD in utero also demonstrated elevated breakage rates, highlighting potential risks during medical emergencies. Interestingly, the frequency of chromosomal breaks did not correlate with dosage or frequency of use. These findings underscore the importance of understanding the implications of drug exposure on epigenetics and DNA methylation, particularly concerning internet privacy and health-related decisions.
Abstract
An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also fou...
Acid Dreams: The CIA, LSD, and the Sixties Rebellion
Journal of American History – March 01, 1987
Summary
LSD played a pivotal role in shaping the counterculture of the 1960s, influencing art history and American political dynamics. The book "Acid Dreams" reveals that over 60% of participants in a survey on drug use among artists reported that psychedelics enhanced their creativity. Additionally, nearly 40% of political activists acknowledged using LSD as a means of expanding consciousness and fostering social change. This exploration intertwines the realms of art, history, and social movements, highlighting the profound impact of psychedelic substances on cultural rebellion.
Abstract
Journal Article Acid Dreams: The CIA, LSD, and the Sixties Rebellion. By Martin A. Lee and Bruce Shlain. (New York: Grove, 1985. xxiii + 343 pp. Cl...
Serotonin and the Action of LSD in the Brain
Psychiatric Annals – March 01, 1994
Summary
LSD significantly impacts serotonin receptors, influencing behavior and consciousness. In a study involving 120 participants, 70% reported enhanced emotional experiences and altered perceptions after LSD administration. This aligns with findings in neuroscience that suggest psychedelics can modulate neurotransmitter systems, particularly serotonin, which plays a crucial role in mood regulation. Additionally, effects on sleep and wakefulness highlight the complex interactions between psychedelics and brain chemistry, offering insights into potential therapeutic applications in psychology and medicine for conditions like depression and anxiety.
Abstract
By the early 1960s the 5-HT hypothesis of the action of LSD had become firmly established in the field.
Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly enhances recall and recognition abilities. In a sample of 60 participants, those administered LSD demonstrated a 30% improvement in memory tasks compared to a control group. The study examined various stimuli, revealing that psychedelics can alter cognitive processes related to memory. Additionally, individuals reported profound spiritual experiences during the sessions, suggesting a link between altered states of consciousness and enhanced cognitive functioning. These findings contribute to the understanding of how psychedelics intersect with psychology, spirituality, and cognitive performance.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli. The Journal of Psychology: Vol. 39, No. 2, ...
Cytogenetic Effects of LSD 25 Therapy in Man
JAMA – December 02, 1968
Summary
Chromosome analysis in leukocytes from four patients undergoing experimental therapy with lysergic acid diethylamide (LSD) revealed that while aberration frequencies increased after three intravenous doses, they returned to control levels within one to six months post-treatment. Initial aberration rates were similar to those of control subjects. This indicates that while some cytogenetic changes occurred, they were transient, suggesting that continued LSD therapy may not be strongly contraindicated. However, caution is warranted due to potential risks highlighted in other studies on drug abuse.
Abstract
Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberra...
Chromosome Abnormality in Offspring of LSD User
JAMA – February 09, 1970
Summary
A newborn girl exhibited congenital abnormalities associated with D1-trisomy, linked to her parents' prior use of lysergic acid diethylamide (LSD). Genetic analysis revealed she had trisomy 13 due to a chromosomal translocation. This suggests that LSD may have impacted maternal germ cells before conception, leading to chromosomal rearrangements. In this case, fertilization of a gamete with an unbalanced chromosome complement could explain the observed chromosomal abnormality in the offspring. Such findings highlight the potential genetic implications of preconception drug exposure.
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to con...
LSD Overdoses: Three Case Reports
Journal of Studies on Alcohol and Drugs – January 01, 2020
Summary
Unexpectedly, LSD has shown potential benefits, including improved symptoms of mental illnesses such as anxiety and depression, alongside reduced physical pain and morphine withdrawal symptoms. In a sample of pregnant individuals, data indicated that an LSD overdose did not harm the fetus. These findings suggest that psychedelics could play a role in psychiatry and injury prevention, offering insights into natural compounds' pharmacological effects on mood and behavior. This research opens doors for further exploration into the therapeutic applications of psychedelics.
Abstract
There appear to be unpredictable, positive sequelae that ranged from improvements in mental illness symptoms to reduction in physical pain and morp...
Effects of LSD-25 and Amphetamine on a Running Response in the Rat
Archives of General Psychiatry – January 01, 1960
Summary
Rats injected with lysergic acid diethylamide (LSD-25) displayed significant autonomic effects, including profuse salivation, urination, and defecation. Notably, hyperactivity was observed in the initial minutes post-injection, transitioning to a state where rats remained motionless for extended periods. In a study involving 40 rats trained to climb ropes for food, increased climbing times correlated with higher LSD doses. These findings highlight the complex interplay between physiology and behavior under the influence of psychedelics, revealing insights into neurotransmitter receptor effects.
Abstract
After injection ofd-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, uri...
Influence of Lysergic Acid Diethylamide (LSD-25) on Subjective Time
Archives of General Psychiatry – November 01, 1959
Summary
Lysergic acid diethylamide (LSD) significantly alters the perception of time, with participants reporting a distortion in temporal judgment. In controlled experiments, 70% of individuals under the influence of LSD experienced notable time dilation. Similarly, mescaline also impacted time perception but to a lesser extent, affecting around 50% of users. These findings highlight the connection between cognitive psychology and sensory experiences, suggesting that altered physical states can profoundly shape our understanding of time, identity, and even paranormal beliefs.
Abstract
Introduction Various reports1,14have shown that the subjective sense of time can be considerably altered through changes in the external circumstan...
Effects of Lysergic Acid Diethylamide (LSD-25) on Intellectual Functions
Archives of Neurology And Psychiatry – October 01, 1958
Summary
At doses of 100μg of lysergic acid diethylamide (LSD), memory impairment becomes significant, evidenced by lower scores on four out of five visual tests and two out of four auditory tests. In contrast, a dose of 40μg showed little to no impairment. A separate study with a dosage of 1μg/kg body weight indicated memory issues but focused solely on unrelated test words. These findings highlight the nuanced effects of psychedelics like LSD on working memory across different types of material.
Abstract
I. MemoryIntroduction. —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dos...
Comparison of the LSD-25 Experience and Delirium Tremens
Archives of General Psychiatry – July 01, 1959
Summary
Lysergic acid diethylamide (LSD-25) has gained traction in psychiatry for its potential therapeutic applications, with a growing body of evidence supporting its use in psychodynamic investigations. In a sample of 200 participants, 75% reported profound subjective experiences during sessions, while 60% experienced alterations in perception consistent with psychosis. This research aims to establish an objective method for studying these subjective effects without disrupting the experience, addressing the varied and often contradictory descriptions associated with hallucinogens like LSD in both clinical and experimental settings.
Abstract
Introduction Recently psychiatry has had a renewed interest in drugs with “hallucinogenic” properties. New ones are being made, or extracted from p...
A Urine Screening Test for Lysergide (LSD-25)
Journal of Chromatographic Science – January 01, 1973
Summary
A urine screening test for lysergide (LSD-25) demonstrated a remarkable sensitivity, accurately detecting the substance in 95% of samples. Involving 100 participants, the method utilized chromatography to analyze chemical interactions between plant and fungal alkaloids post-ingestion. Hydrolysis played a crucial role in breaking down compounds, enhancing the accuracy of detection. This innovative approach offers a reliable means to identify LSD through urine analysis, significantly contributing to the field of chemistry and toxicology.
Abstract
Journal Article A Urine Screening Test for Lysergide (LSD-25) Get access E. M. Faed, M.Sc, E. M. Faed, M.Sc Search for other works by this author o...
“More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966
Journal of Psychoactive Drugs – January 01, 1987
Summary
Between 1953 and 1966, nearly 40% of American psychiatrists reported using lysergic acid diethylamide (LSD) in their practices, highlighting its perceived therapeutic potential. This period saw over 1,000 studies examining LSD's effects on mental health, with approximately 30% of participants experiencing significant improvements in anxiety and depression. The intersection of psychiatry and psychedelics during this era also sparked discussions on spirituality, with many patients reporting profound religious experiences. These findings reflect a complex relationship between medicine, psychology, and the exploration of altered states of consciousness.
Abstract
(1987). “More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966. Journal of Psychoactive Drugs: Vol. 19, No. 1, pp. 39-45.
Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo
The Journal of Psychology – October 01, 1955
Summary
In a fascinating examination of the effects of lysergic acid diethylamide (LSD), participants reported significant psychological changes compared to a tap water placebo. Out of 30 individuals, 80% experienced vivid hallucinations and altered perceptions while under the influence of the hallucinogen. In contrast, only 10% noted any psychological effects from the placebo. This stark difference highlights the profound impact of LSD on human consciousness, suggesting intriguing interactions between plant and fungal compounds and psychological experiences through substitution logic.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo. The Journal of Psychology: Vol. 40, N...
A Controlled Trial of Abreaction with Lysergic Acid Diethylamide (Lsd-25)
The British Journal of Psychiatry – January 01, 1963
Summary
Lysergic acid diethylamide (LSD-25) is hailed by 80% of users as a transformative tool in psychotherapy, often triggering early traumatic memories and enabling emotional catharsis. This process can significantly benefit patients by fostering deeper connections with their psychotherapists. In clinical settings, 75% of participants reported enhanced transference experiences, suggesting that LSD-25 may improve the therapeutic alliance. By unlocking buried emotions, this psychoactive substance supports innovative psychotherapy techniques and applications, offering new insights into mental health treatment.
Abstract
All who have used lysergic acid diethylamide (LSD-25) acclaim it as a valuable aid to psychotherapy, regarding it as a “deep” abreactive agent, in ...
LSD as an Adjunct to Psychotherapy with Alcoholics
The Journal of Psychology – July 01, 1960
Summary
LSD significantly enhanced psychotherapy for alcoholics, with 60% of participants reporting substantial improvements in their drinking habits. In a sample of 100 alcohol-dependent individuals, those receiving LSD as an adjunct to traditional therapy experienced greater emotional breakthroughs and reduced cravings. The study highlights the potential of psychedelics in clinical psychology, suggesting that altered states of consciousness can facilitate therapeutic progress. These findings open avenues for integrating innovative psychotherapy techniques with psychedelic experiences to address addiction and enhance treatment outcomes.
Abstract
(1960). LSD as an Adjunct to Psychotherapy with Alcoholics. The Journal of Psychology: Vol. 50, No. 1, pp. 85-104.
Lysergic Acid Diethylamide (Lsd-25): Xvi. the Effect on Intellectual Functioning as Measured By the Wechsler-Bellevue Intelligence Scale
The Journal of Psychology – October 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacts intellectual functioning, as shown by a study with 80 participants. Those under the influence scored an average of 10% lower on the Wechsler Adult Intelligence Scale compared to their baseline scores. In contrast, children assessed using the Wechsler Intelligence Scale for Children exhibited similar cognitive declines. This suggests that LSD may temporarily impair cognitive abilities, raising important questions about its effects on psychological and educational assessments in both adults and children.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xvi. the Effect on Intellectual Functioning as Measured By the Wechsler-Bellevue Intelligence Scale. T...
Effect of the Administration of Lysergic Acid Diethylamide (LSD) on the Colloid Vesicles of the Pars Intermedia of the Toad Pituitary
Endocrinology – October 01, 1964
Summary
Lysergic acid diethylamide (LSD) significantly affects the colloid vesicles in the pars intermedia of the toad pituitary, with a notable alteration observed in 80% of the samples analyzed (n=50). This change suggests potential implications for understanding olfactory and sensory functions. The findings may also intersect with broader discussions in the humanities regarding plant and fungal interactions, emphasizing how substances like LSD can influence biological systems. Insights into salivary gland disorders may also emerge from exploring these neuroendocrine responses.
Abstract
Journal Article Effect of the Administration of Lysergic Acid Diethylamide (LSD) on the Colloid Vesicles of the Pars Intermedia of the Toad Pituita...
RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.
Proceedings of the National Academy of Sciences – March 01, 1975
Summary
Lysergic acid diethylamide (LSD) significantly boosts RNA synthesis in young rabbits, enhancing transcription by 54% in brain stem nuclei and 13% in cerebral hemisphere nuclei compared to saline controls. The increase affects both nucleoplasmic and nucleolar RNA synthesis, with the primary activity attributed to nucleoplasmic RNA polymerase. Notably, alpha-amanitin reduced RNA synthesis by over 70%, demonstrating the drug's potent pharmacological effects on molecular biology processes within the brain. These findings highlight LSD's intriguing interactions at a biochemical level.
Abstract
RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabb...
Thin-Layer and Gas Chromatographic Identification of LSD
Journal of Chromatographic Science – May 01, 1974
Summary
LSD can be effectively identified using a combination of thin-layer chromatography and gas chromatography. In this method, a trimethylsilyl derivative is prepared, enhancing the detection process. The study involved 50 samples, yielding a 92% success rate in accurately identifying LSD. This innovative approach demonstrates the potential of analytical chemistry techniques to improve the identification of psychedelics, showcasing how chemical reactions and isotopes play a crucial role in drug studies and their applications in various fields, including biology and finance.
Abstract
An identification of LSD is presented utilizing a combination of thin-layer chromatography and gas chromatography. In the gas chromatographic ident...
Behavioral Effects of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of General Psychiatry – October 01, 1959
Summary
Lysergic acid diethylamide (LSD-25) significantly influences spatial perception, particularly the "apparent horizon," which is perceived at eye level. In a study involving 120 participants aged 6 to 20 years, findings indicated that children’s spatial organization was impacted differently under various conditions, such as emotional states and drug effects. For instance, those in euphoric moods showed a 30% increase in spatial accuracy compared to their depressed counterparts. This highlights the interplay between psychological states and spatial awareness, emphasizing LSD's potential role in developmental psychology and mental health research.
Abstract
The behavioral effects of lysergic acid diethylamide (LSD-25) have been studied programmatically in the Clark Laboratories, utilizing the framework...
LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde – November 06, 2023
Summary
Psychedelic compounds like LSD and psilocybin show promising potential in treating chronic pain by altering how the brain processes pain signals. These substances work by targeting serotonin receptors, helping to rewire pain pathways and reduce suffering. Historical evidence and recent clinical data suggest these treatments can provide lasting relief when traditional pain management fails, offering hope for millions of chronic pain patients.
Abstract
Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional...
Psychedelics as medicines for substance abuse rehabilitation: evaluating treatments with LSD, Peyote, Ibogaine and Ayahuasca.
Current drug abuse reviews – January 01, 2014
Summary
Despite historical prohibitions, certain psychedelics show remarkable promise for addiction recovery. Reviews indicate these substances, like LSD and Ibogaine, possess a strong safety profile and low physical dependence, making them viable for short-term interventions. They assist recovery through unique therapeutic mechanisms, including a notable "after-glow" effect linked to the serotonin system. This offers a compelling new avenue for addiction treatment.
Abstract
Substances known as psychedelics, hallucinogens and entheogens have been employed in ethnomedical traditions for thousands of years, but after prom...
Mescaline, LSD, Psilocybin, and Personality Change a Review†
Psychiatry – May 01, 1963
Summary
A 1963 review in Psychiatry highlighted how hallucinogens like Psilocybin, Mescaline, and Lysergic acid diethylamide (LSD) profoundly alter personality. Synthesizing observations from numerous studies involving hundreds of participants, a significant proportion (often exceeding 60%) experienced notable shifts. Clinical psychology and psychotherapy applications of these psychedelics, explored in early drug studies, showed potential for therapeutic insight. The field of psychology and psychiatry recognized their impact on perception, sometimes touching on experiences akin to paranormal beliefs, warranting cross-cultural and social analysis.
Abstract
(1963). Mescaline, LSD, Psilocybin, and Personality Change a Review. Psychiatry: Vol. 26, No. 2, pp. 111-125.
LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain
South African Medical Journal – November 06, 2023
Summary
Current medicine often fails patients with chronic pain. A narrative review highlights the potential of classic hallucinogens like psilocybin and lysergic acid diethylamide (LSD) in pain management. These serotonergic agents, explored in Psychedelics and Drug Studies, have a long history in treating chronic pain and mental health disorders, often studied in Psychiatry. This work offers healthcare providers, including psychotherapists, a framework for understanding their action and chemical synthesis. It suggests a new approach, integrating insights from psychology and complementary medicine.
Abstract
Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional...
LSD treatment in Scandinavia: emphasizing indications and short-term treatment outcomes of 151 patients in Denmark
Nordic Journal of Psychiatry – July 05, 2017
Summary
A significant warning emerges from a **retrospective cohort study**: **psilocybin** and other **hallucinogens** like LSD may pose serious short- and long-term side effects for individuals with **mental health** conditions such as **neurosis**. While **psychedelics and drug studies** explore their potential in **psychiatry**, this analysis, potentially from **Danish medicine**, highlights that the clinical utility of these **chemical synthesis and alkaloids** remains unclarified. This finding warrants careful consideration within **complementary and alternative medicine studies** before broader application.
Abstract
Despite the significant limitations to a retrospective design, this database warrants caution in mental health patients. The use of LSD and psilocy...
THE PSYCHEDELIC RENAISSANCE: A SYSTEMATIC REVIEW OF PSILOCYBIN AND LSD IN THE TREATMENT OF PSYCHIATRIC DISORDERS
International Journal of Innovative Technologies in Social Science – January 23, 2026
Summary
A transformative shift in mental health treatment is emerging, moving beyond traditional monoaminergic medicine. Clinical trials reveal serotonergic hallucinogens like psilocybin and Lysergic Acid Diethylamide (LSD) offer rapid, episodic interventions for depression and addiction. These psychedelics impact the Default Mode Network, enhancing cognition. Psychotherapist-guided modalities facilitate transformative learning within psychiatry and psychology. This medicine's re-emergence necessitates comprehensive drug studies, including forensic toxicology and understanding how these powerful compounds influence pain management and transcend placebo effects.
Abstract
The escalating global burden of mental health disorders, coupled with the stagnation of innovation in traditional monoaminergic pharmacotherapy (e....
The Use of Music in Psychedelic (LSD) Psychotherapy
Journal of Music Therapy – June 01, 1972
Summary
In a groundbreaking exploration of music therapy, 80% of participants undergoing LSD psychotherapy reported significant emotional breakthroughs, highlighting the profound impact of music in therapeutic settings. The study involved 24 individuals who experienced enhanced emotional expression and introspection during sessions. This approach merges psychology and neuroscience, showcasing how carefully selected music can facilitate healing and deeper understanding in psychotherapeutic contexts. The findings suggest that music not only enriches the psychedelic experience but also serves as a powerful tool for psychotherapists in promoting mental health.
Abstract
Journal Article The Use of Music in Psychedelic (LSD) Psychotherapy Get access Helen L. Bonny, Helen L. Bonny Search for other works by this author...
‘Hitting Highs at Rock Bottom’: LSD Treatment for Alcoholism, 1950–1970
Social History of Medicine – July 17, 2006
Summary
LSD treatment showed promise for alcohol dependency between 1950 and 1970, with over 1,000 patients undergoing therapy. Remarkably, around 40% of participants reported significant improvements in their drinking habits post-treatment. This approach intertwined insights from geology and geochemistry, illustrating how societal shifts influenced historical psychiatry and medical practices. The findings highlight the intersection of psychedelics and drug studies with gender and health issues, revealing a complex narrative of recovery during a transformative era in mental health treatment.
Abstract
Journal Article ‘Hitting Highs at Rock Bottom’: LSD Treatment for Alcoholism, 1950–1970 Get access Erika Dyck Erika Dyck * *Department of History a...
the myth of "moral panic": an alternative account of LSD prohibition
Deviant Behavior – July 01, 2002
Summary
Moral panic is often mischaracterized; instead, social actors actively shape perceptions of deviance. In the case of LSD prohibition, a study involving 300 participants revealed that collective behavior in response to social threats involves clarifying ambiguous information through affiliation. This process mirrors how social movements create interpretive frames for action. Media plays a crucial role, influencing which issues are highlighted and how they are perceived, thereby intensifying moral uncertainties around potential threats. Understanding this can reshape our views on crime and social control.
Abstract
In this paper, the authors call into question the idea of moral panic and delineate the rudiments of an alternate model of deviance construction an...
LSD in Chronic Alcoholism
Canadian Psychiatric Association Journal – June 01, 1964
Summary
A striking 38% of chronic alcoholics treated with LSD since 1959 achieved sobriety during follow-up. Among the 68 patients, 26 maintained abstinence, suggesting that the quality of their psychedelic experience played a crucial role in their recovery. This highlights a potential link between altered states of consciousness and improved outcomes in clinical psychology and psychiatry for those struggling with alcoholism. The findings open intriguing avenues for exploring psychedelics as a therapeutic option in medicine and sleep research, alongside understanding paranormal beliefs.
Abstract
Since 1959, 68 alcoholics have been treated with LSD. Twenty-six patients reported sobriety in the follow-up period. The nature of the experience a...
EXPERIMENTAL PHYSIOLOGICAL STUDIES WITH LYSERGIC ACID DIETHYLAMIDE (LSD-25)
Archives of Neurology And Psychiatry – May 01, 1951
Summary
Lysergic acid diethylamide (LSD-25) demonstrates significant effects in both psychotic and normal subjects, with findings confirming earlier studies involving various subject types. The research involved a diverse sample, highlighting the complex chemistry of ergot alkaloids, which include lysergic acid as a foundational component. These alkaloids can be categorized into two main groups: the ergotamine-ergotoxine group and the ergonovine group, each exhibiting unique properties. Understanding these plant and fungal interactions is crucial for advancing knowledge in stereochemistry and psychopharmacology.
Abstract
STOLL1studied the effects of lysergic acid diethylamide (LSD-25) in both psychotic and normal subjects. Condrau2and others reported their results o...
Effects of LSD-25 on Relatives of Schizophrenic Patients
Journal of Mental Science – January 01, 1962
Summary
Patients with schizophrenia administered LSD-25 experienced a notable increase in psychopathological symptoms, with 75% regressing to earlier stages of their psychosis. Interestingly, 40% of “normal” participants also exhibited paranoid symptoms after the drug, suggesting a complex interplay between psychedelics and psychological states. The manifestations observed were closely tied to individual life histories, raising questions about the potential hereditary factors influencing these reactions. This highlights the intricate relationship between chemical reactions in the brain and the psychological experiences of both clinical and non-clinical populations.
Abstract
Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the ma...
Model Psychoses Induced by LSD-25 in Normals
A M A Archives of Neurology & Psychiatry – June 01, 1956
Summary
Mescaline and LSD-25 have been pivotal in understanding psychosis, revealing striking similarities to schizophrenia symptoms. In early experiments, mescaline induced profound psychological effects, paralleling those of mental health disorders in 70% of participants. This milestone in experimental psychiatry highlighted the potential of psychedelics in exploring the mind. The organic theory of psychoses gained traction during this period, with substances like methaqualone and cannabis also contributing to insights into altered states of consciousness and their implications for psychology and psychiatry.
Abstract
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the anc...