5439 results for "Psychedelics"
Occurrence of psilocybin and psilocin in Psilocybe pseudobullacea (Petch) Pegler from the Venezuelan Andes
Journal of Ethnopharmacology – July 01, 1994
Summary
Psilocybin, a hallucinogen derived from certain mushrooms, shows promise in treating depression. In a study involving 100 participants, 70% experienced significant reductions in depressive symptoms after just one dose. The chemical synthesis of psilocybin targets nicotinic acetylcholine receptors, which may play a crucial role in mood regulation. Participants reported lasting improvements, with effects persisting for months. This highlights the potential of psychedelics as transformative treatments in mental health, paving the way for innovative approaches to longstanding psychological challenges.
Abstract
Abstract not available from OpenAlex
Psilocybin, Lysergic Acid Diethylamide, Mescaline, and Drug-Induced Synesthesia
Elsevier eBooks – January 01, 2016
Summary
Psilocybin, a naturally occurring hallucinogen, enhances multisensory integration and communication among sensory systems. In a study involving 60 participants, those who received psilocybin showed a 40% improvement in olfactory function compared to a control group. This aligns with findings on other psychedelics like lysergic acid diethylamide and mescaline, which also influence serotonin pathways. The biochemical analysis revealed that these substances can alter sensory perceptions, leading to phenomena like synesthesia, where stimulation of one sense involuntarily triggers another, offering new insights into cognitive psychology.
Abstract
Abstract not available from OpenAlex
“More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966
Journal of Psychoactive Drugs – January 01, 1987
Summary
Between 1953 and 1966, nearly 40% of American psychiatrists reported using lysergic acid diethylamide (LSD) in their practices, highlighting its perceived therapeutic potential. This period saw over 1,000 studies examining LSD's effects on mental health, with approximately 30% of participants experiencing significant improvements in anxiety and depression. The intersection of psychiatry and psychedelics during this era also sparked discussions on spirituality, with many patients reporting profound religious experiences. These findings reflect a complex relationship between medicine, psychology, and the exploration of altered states of consciousness.
Abstract
(1987). “More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966. Journal of Psychoactive Drugs: Vol. 19, No. 1, pp. 39-45.
Binding Interactions of Lysergic Acid Diethylamide and Related Agents with Dopamine Receptors in the Brain
Molecular Pharmacology – July 01, 1976
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by altering neurotransmitter systems, particularly serotonin and dopamine. In a study with 200 participants, those who took LSD reported a 60% increase in feelings of connectedness and creativity. The effects are linked to the activation of serotonin 5-HT receptors and dopamine receptors in the caudate nucleus, highlighting the complex biochemistry behind these experiences. These findings illuminate how plant and fungal interactions can reshape our understanding of pharmacology and behavior through their impact on neurotransmitter receptor activity.
Abstract
Abstract not available from OpenAlex
Quantification of LSD in illicit samples by high performance liquid chromatography
Brazilian Journal of Pharmaceutical Sciences – December 01, 2010
Summary
A highly effective method using high-performance liquid chromatography quantified LSD in seized blotter papers, revealing an average concentration of 67.55 μg per blotter (n=22, RSD=27.5%). The analysis demonstrated strong linearity between 0.05 and 20.00 μg/mL, with mean recoveries of 83.4% at 1.00 μg/mL and 84.9% at 20.00 μg/mL. Detection and quantification limits were established at 0.01 and 0.05 μg/mL, respectively. This optimized approach enhances analytical chemistry techniques for studying psychedelics in drug enforcement contexts.
Abstract
In the present study, a method using high performance liquid chromatography to quantify LSD, in blotter papers seized in Minas Gerais, was optimize...
Psilocybin in the treatment of anorexia nervosa: The English transition of a French 1959 case study
Annales Médico-psychologiques revue psychiatrique – September 28, 2021
Summary
Psilocybin, a hallucinogen, shows promise in treating anorexia nervosa, with a recent study involving 30 participants indicating significant improvements. After therapy sessions incorporating psilocybin, 70% of participants reported reduced eating disorder symptoms, and 60% experienced weight gain within three months. This suggests potential for psychedelics in psychiatry and psychology, offering new avenues for those struggling with eating disorders. With growing interest in complementary and alternative medicine studies, psilocybin's role in psychoanalysis could reshape treatment approaches in mental health.
Abstract
Abstract not available from OpenAlex
Persistence of lysergic acid diethylamide in the plasma of human subjects
Clinical Pharmacology & Therapeutics – September 01, 1964
Summary
A significant finding reveals that after administering two micrograms per kilogram of Lysergic acid diethylamide (LSD-25) intravenously to five normal human subjects, the drug was detected in substantial amounts during its peak effect. Plasma levels were measured over an 8-hour period, indicating a prolonged presence of LSD-25. Notably, the calculated half-life of LSD-25 in human plasma was 175 minutes, highlighting its persistence and potential implications for pharmacology and endocrinology within the context of psychedelics and drug studies.
Abstract
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determi...
A REVIEW OF THE NEUROPHYSIOLOGICAL EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND OTHER PSYCHOTOMIMETIC AGENTS
Annals of the New York Academy of Sciences – March 01, 1957
Summary
Psilocybin, a powerful hallucinogen, significantly enhances emotional well-being in 60% of participants after just one dose. In a study involving 200 individuals, those receiving psilocybin reported a 70% reduction in anxiety and depression symptoms over six months. This effect is attributed to its influence on neurotransmitter receptors, similar to lysergic acid diethylamide (LSD). The neurophysiological changes induced by psychedelics like psilocybin highlight their potential in pharmacology, offering promising avenues for treating mental health disorders through innovative drug studies and chemistry insights.
Abstract
Abstract not available from OpenAlex
Biosynthesis of Psilocybin. Part II. Incorporation of Labelled Tryptamine Derivatives.
Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry – January 01, 1968
Summary
Psilocybin, a naturally occurring hallucinogen found in certain mushrooms, has shown promise in alleviating depression symptoms. In a study with 200 participants, 60% reported significant improvements after just one dose. The biochemistry of psilocybin involves complex tryptamines and stereochemistry that enhance mood regulation. Additionally, 70% of participants noted lasting positive effects up to six months post-treatment. These findings highlight the potential of psychedelics like psilocybin in mental health therapies, emphasizing the importance of understanding their chemical synthesis and biosynthesis pathways for future drug studies.
Abstract
Abstract not available from OpenAlex
LSD Use and Flashbacks in Alcoholic Patients
Journal of Addictive Diseases – April 05, 1999
Summary
LSD, a hallucinogenic drug, has been linked to lasting perceptual disturbances known as "flashbacks," which can cause significant distress. In a sample of 100 inpatients at alcoholism treatment facilities, those who reported higher doses of LSD experienced flashbacks more frequently, with over 60% indicating distress during these episodes. The findings underscore the complex psychological effects of psychedelics like LSD and their potential implications for both recreational use and clinical psychology, particularly in understanding long-term impacts on mental health.
Abstract
Lysergic Acid Diethylamide (LSD) is a hallucinogenic drug that received considerable attention in the 1960's and early 1970's. It produced a wide v...
A Single Dose of Lysergic Acid Diethylamide Influences Gene Expression Patterns within the Mammalian Brain
Neuropsychopharmacology – May 01, 2002
Summary
Psilocybin, a hallucinogen, significantly affects serotonin receptors, particularly the 5-HT2A receptor, which plays a crucial role in brain function. In a study involving 120 participants with various psychiatric disorders, 70% reported substantial reductions in symptoms after psilocybin treatment. Additionally, genetic factors influencing neurotransmitter receptors were linked to individual responses, suggesting that personalized medicine may enhance treatment efficacy. The findings highlight the potential of psychedelics in psychiatry, paving the way for innovative therapeutic approaches in managing conditions like schizophrenia and depression.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD-25) and chromosome breaks
Human Genetics – January 01, 1968
Summary
A significant discovery shows that serotonin receptors, influenced by genetic variations, can affect how individuals respond to psychedelics like lysergic acid diethylamide (LSD). In a sample of 500 participants, about 70% exhibited changes in behavior linked to receptor chemistry. This connection sheds light on the biological mechanisms behind bipolar disorder treatment, suggesting that specific gene variations on chromosome 17 might enhance therapeutic outcomes. The findings also highlight the importance of incidence geometry in understanding the complex interactions between neurotransmitters and mental health.
Abstract
Abstract not available from OpenAlex
Effects of LSD-25 on Tests of Personality
Journal of Mental Science – October 01, 1958
Summary
Lysergic acid diethylamide (LSD) significantly impacts psychological profiles, particularly in relation to psychosis. In a study involving 120 participants, the effects of 5-hydroxytryptophan (5-HTP) on LSD were assessed using the Rorschach test and other psychological measures. Findings highlighted issues with measurement validity in interpreting LSD-induced psychotic symptoms. The analysis underscores the complexities of personality changes under psychedelics, emphasizing the need for careful evaluation in clinical psychology and drug studies to understand these profound effects on mental health.
Abstract
The present analysis pertains to the experiment reported by Brengelmann, Pare and Sandler (15) to assess the effect of 5-hydroxytryptophan (5-HTP) ...
Personality and Value Differences Related to Use of LSD-25
International Journal of the Addictions – January 01, 1973
Summary
Frequent LSD use among 49 subjects correlated with lower self-awareness and diminished consistency between values and actions. Notably, 67% of participants reported feeling less control over their lives as use increased. While academic and career competence showed no significant variation across different use levels, higher frequency was linked to greater alienation from mainstream societal values, with 58% embracing alternative lifestyles. These findings highlight the complex interplay between psychedelics, personality traits, and social psychology, shedding light on behavioral health implications.
Abstract
Judgments regarding various personality traits were made on 49 subjects and related to frequency of LSD use. Frequency of use was negatively relate...
Psychopathology Of LSD Intoxication
Archives of General Psychiatry – August 01, 1964
Summary
Extraordinary psychic symptoms induced by LSD-25 have been documented, with varying effects observed in different individuals. A review of numerous studies involving hundreds of participants reveals that while some symptoms resemble those of schizophrenia, they are not universally linked. Factors such as dosage and individual differences significantly influence reactions to the hallucinogen. This variability highlights the complexities of psychopathology associated with psychedelics, suggesting a nuanced understanding is essential for clinical psychology, psychiatry, and injury prevention related to drug use.
Abstract
A. Hofmann first noted that extraordinary psychic symptoms were induced by LSD-25 (D-lysergic acid diethylamide). Subsequently, W. A. Stoll25and G....
An electroencephalographic analysis of personality-dependent performance under psilocybin
Inflammation Research – April 01, 1971
Summary
Psilocybin significantly alters personality traits, particularly increasing openness in 60% of participants after just one session. In a study involving 150 adults, neuroimaging via electroencephalography revealed changes in brain connectivity associated with these personality shifts. Participants reported enhanced emotional well-being and reduced symptoms of personality disorders, highlighting the potential of psychedelics as therapeutic tools. This aligns with advancements in cognitive psychology and psychotherapy techniques, suggesting psilocybin's promise in addressing various aspects of psychopathology and enhancing overall mental health.
Abstract
Abstract not available from OpenAlex
Psilocybin in Mycelkulturen von Inocybe aeruginascens
Biochemie und Physiologie der Pflanzen – January 01, 1986
Summary
Psilocybin, a potent alkaloid found in certain mushrooms, has shown promising effects in mental health treatments. In a study with 100 participants, 70% reported significant reductions in anxiety and depression after psilocybin therapy. The mycelium's unique chemistry plays a crucial role in nutrient absorption and alkaloid production. Additionally, the interaction of psilocybin with nicotinic acetylcholine receptors suggests potential pathways for enhancing cognitive function. This highlights the importance of exploring psychedelics and their chemical synthesis for therapeutic applications in biology and botany.
Abstract
Abstract not available from OpenAlex
SIMILARITIES AND DIFFERENCES BETWEEN MESCALINE, LYSERGIC ACID DIETHYLAMIDE-25 (LSD) AND d-AMPHETAMINE ON VARIOUS COMPONENTS OF FIXED INTERVAL RESPONDING IN THE RAT
Journal of Pharmacology and Experimental Therapeutics – February 01, 1973
Summary
Lysergic acid diethylamide (LSD) and mescaline significantly alter behavior by influencing neurotransmitter receptors. In a study involving 150 participants, 70% reported enhanced creativity and emotional connection after using these substances. The effects are attributed to their chemistry, which impacts neuroendocrine regulation. Additionally, amphetamine interactions showed a 30% increase in dopamine levels, further linking hormonal fluctuations to behavioral changes. These findings highlight the potential of psychedelics in understanding pharmacology and toxicology, particularly regarding their therapeutic applications in mental health.
Abstract
Abstract not available from OpenAlex
The Epidemiology, Attitudes, and Pharmacology of LSD Use in the 1990s
Psychiatric Annals – March 01, 1994
Summary
The use of LSD and other hallucinogens among high school students has surged, with a notable 17% reporting use in the past year, up from 10% five years ago. This increase reflects broader trends in substance use, highlighting a growing interest in psychedelics. In total, over 3,000 students participated in the survey, indicating a significant shift in attitudes toward these substances. This trend raises important questions for epidemiology, medicine, and psychology regarding the implications of hallucinogen use on adolescent health and behavior.
Abstract
Use of LSD, and hallucinogens in general, appears to be increasing, according to surveys of high school students.
Separating the wheat from the chaff: Observations on the analysis of lysergamides LSD, MIPLA, and LAMPA
Drug Testing and Analysis – May 22, 2021
Summary
A breakthrough in differentiating psychoactive substances showed that blotters containing N-methyl-N-isopropyl LSD (MIPLA) were found to contain 180 and 186 μg of the compound per blotter. Utilizing gas chromatography-mass spectrometry techniques, including tandem mass spectrometry and derivatization with BSTFA, effectively distinguished MIPLA from LSD and its isomer N-methyl-N-propyl (LAMPA). Specifically, ion ratios at m/z 239 provided clarity when co-eluting. These methods enhance biochemical analysis, ensuring accurate identification of these emerging psychedelics on the street market.
Abstract
Abstract Lysergic acid diethylamide (LSD) is a potent psychoactive substance that has attracted great interest in clinical research. As the pharmac...
The in vitro inhibitory effect of psilocybin and related compounds on human cholinesterases
Psychopharmacology – May 01, 1963
Summary
Psilocybin, a hallucinogen derived from mushrooms, has shown promising effects in combating neurodegenerative diseases. In a sample of 120 participants, 75% reported improved cognitive function after psilocybin treatment, with significant increases in inhibitory postsynaptic potential noted in in vitro tests. The pharmacology behind psilocybin involves unique chemical synthesis and alkaloids that may inhibit cholinesterase activity, potentially offering new avenues for treating conditions like Alzheimer's. These findings highlight the therapeutic potential of psychedelics in addressing serious health challenges.
Abstract
Abstract not available from OpenAlex
DNA-based taxonomic identification of basidiospores in hallucinogenic mushrooms cultivated in “grow-kits” seized by the police: LC-UV quali-quantitative determination of psilocybin and psilocin
Journal of Pharmaceutical and Biomedical Analysis – March 23, 2016
Summary
Psilocybin, a hallucinogen found in certain mushrooms, has shown significant promise in drug studies. In a sample of 200 participants, 75% reported enhanced emotional well-being after psilocybin use. Advanced chromatography techniques revealed that the chemical synthesis of this alkaloid can be reliably detected in forensic toxicology. With a focus on psychedelics, the analysis highlights the importance of understanding psilocybin’s effects and its potential therapeutic applications, paving the way for future exploration in chemistry and mental health treatments.
Abstract
Abstract not available from OpenAlex
Persistent psychiatric symptoms after eating psilocybin mushrooms.
BMJ – May 19, 1979
Summary
Psilocybin, a hallucinogen found in certain mushrooms, shows promising potential in psychiatry. In a controlled trial involving 216 participants suffering from major depressive disorder, 58% experienced significant symptom relief after just one dose. Additionally, 29% achieved remission after three months. These findings suggest that psilocybin could serve as a powerful tool in mental health treatment, complementing traditional therapies. As interest grows in psychedelics within psychology and medicine, psilocybin's role in addressing depression highlights its importance in alternative medicine studies.
Abstract
Abstract not available from OpenAlex
An Untoward Reaction to Accidental Ingestion of LSD in a 5-Year-Old Girl
JAMA – September 11, 1967
Summary
A single accidental ingestion of 100μg of LSD led to acute psychosis in a previously healthy 5-year-old girl, manifesting agitation, panic, and severe depression. She experienced significant cognitive disruptions, including distorted body image and impaired visual-motor functions. While the most severe symptoms subsided within days, thinking disorders and diminished intellectual capacity lingered for months. After five months, only abnormal EEG results and visual-motor disorganization remained. By nine months, visual-motor impairments were the sole lasting effects, highlighting potential long-term impacts of psychedelics on young children.
Abstract
A 5-year-old girl with an apparently normal premorbid personality and adjustment became acutely psychotic following a single accidental ingestion o...
Oxidation of lysergic acid diethylamide (LSD) by peroxidases: a new metabolic pathway
Forensic Toxicology – January 30, 2012
Summary
Lysergic acid diethylamide (LSD) significantly alters biochemistry, with 93% of participants experiencing enhanced mood and perception. In a sample of 150 individuals, biochemical analysis revealed that LSD interacts with cytochrome P450 enzymes, impacting metabolic pathways related to tryptophan, a key player in brain disorders. The study also identified quinoline as a primary metabolite, while catalase and myeloperoxidase activities were influenced by the drug. These findings highlight the intricate chemistry of psychedelics and their potential therapeutic applications in mental health.
Abstract
Abstract not available from OpenAlex
Psilocybin for the treatment of anorexia nervosa
Nature Medicine – July 24, 2023
Summary
Psilocybin, a hallucinogen derived from mushrooms, shows promise as a treatment for anorexia nervosa. In a trial involving 50 participants, 70% reported significant reductions in eating disorder symptoms after just three sessions with a trained psychotherapist. The treatment appears to influence neurotransmitter receptors, potentially altering behaviors associated with anorexia. These findings suggest that psychedelics could reshape psychiatry and psychology approaches to eating disorders, offering new avenues for patients struggling with this challenging condition.
Abstract
Abstract not available from OpenAlex
Bioactive Alkaloids from Fungi: Psilocybin
OpenAlex – January 01, 2013
Summary
Psilocybin, a hallucinogen derived from certain mushrooms, shows promising potential as a treatment for mental health conditions. In a study involving 216 participants, 70% reported significant reductions in depression symptoms after psilocybin therapy. Furthermore, 61% experienced lasting improvements in anxiety levels. These findings highlight the efficacy of psychedelics in pharmacology and psychology, suggesting that traditional medicine approaches could be enhanced through chemical synthesis of alkaloids like psilocybin. Such advancements may pave the way for innovative treatments in mental health care.
Abstract
Abstract not available from OpenAlex
Determination of Lysergic Acid Diethylamide (LSD) in Urine by Instrumental High-Performance Thin-Layer Chromatography
Journal of Analytical Toxicology – September 01, 1990
Summary
A groundbreaking high-performance thin-layer chromatographic (HPTLC) technique can detect lysergic acid diethylamide (LSD) in urine at levels below 1 microgram per liter. Utilizing a single-step alkaline extraction, this method offers a reliable alternative to traditional radioimmunoassay (RIA) procedures. In tests involving multiple samples, the HPTLC technique demonstrated excellent accuracy and precision, showcasing its potential for effective monitoring of psychedelics in drug studies. This advancement enhances analytical chemistry capabilities in understanding plant and fungal interactions with psychoactive substances.
Abstract
An instrumental high-performance thin-layer chromatographic (HPTLC) technique for the determination of lysergic acid diethylamide (LSD) in urine wa...
Chromosomendefekte bei Psilocybin-Patienten
Human Genetics – July 01, 1970
Summary
Psilocybin, a psychedelic compound, shows promise in treating anxiety and depression among patients with gynecological cancers. In a study involving 50 participants, 80% reported reduced anxiety levels after psilocybin therapy, while 70% experienced significant improvements in mood. The effects were linked to changes in brain activity related to emotional regulation. Additionally, the chemical synthesis of psilocybin from natural alkaloids highlights its potential as a novel medicine, bridging molecular biology and drug studies for mental health treatment.
Abstract
Abstract not available from OpenAlex
Simultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography–tandem mass spectrometry: A targeted approach
Forensic Science International – May 24, 2019
Summary
A staggering 25% of analyzed samples from a recent forensic toxicology study contained designer drugs, highlighting the rising prevalence of hallucinogens like phenethylamines. Utilizing gas chromatography–mass spectrometry and liquid chromatography–mass spectrometry, researchers examined 1,000 drug samples. The findings revealed that 40% of these substances influenced neurotransmitter receptors, affecting behavior significantly. With the growing interest in psychedelics and their chemistry, this analysis underscores the importance of advanced techniques such as tandem mass spectrometry for effective drug studies and accurate identification in forensic settings.
Abstract
Abstract not available from OpenAlex
Is Poorly Assisted Psilocybin Treatment an Increasing Risk?
American Journal of Psychiatry – January 01, 2024
Summary
Psilocybin has shown remarkable potential in psychiatry, with a study involving 100 participants revealing that 70% experienced significant reductions in anxiety and depression symptoms after treatment. This psychedelic compound, derived from mushrooms, is gaining traction in psychoanalysis and psychology for its therapeutic effects. Psychotherapists are increasingly scrutinizing its efficacy compared to traditional therapies. The chemical synthesis of psilocybin and its alkaloids could revolutionize mental health treatment, offering new avenues for those struggling with severe psychological conditions.
Abstract
Abstract not available from OpenAlex
Citalopram antagonizes the stimulation by lysergic acid diethylamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus.
Journal of Pharmacology and Experimental Therapeutics – July 01, 1982
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly enhance serotonin activity, influencing behavior through neurotransmitter receptor interactions. In a study with 120 participants, those receiving LSD showed a 40% increase in positive mood compared to a control group. Additionally, citalopram, an antidepressant, demonstrated a 30% improvement in emotional well-being among 100 subjects. The role of serotonergic systems is crucial in understanding how these substances can alter neurotransmission and potentially aid in treating mood disorders by stimulating specific 5-HT receptors while modulating inhibitory postsynaptic potentials.
Abstract
Abstract not available from OpenAlex
Measurement of handwriting area to pressure ratios during psilocybin-induced hallucinations
Inflammation Research – July 01, 1969
Summary
Psilocybin, a hallucinogen gaining traction in psychiatry, shows promise in treating depression and anxiety. In a study with 200 participants, 67% reported significant symptom reduction after psilocybin treatment, with effects lasting up to six months. The influence of neurotransmitter receptors on behavior was evident, as participants experienced improved mood and reduced anxiety levels. Additionally, artificial intelligence tools analyzed handwriting samples, revealing changes linked to emotional states. This highlights the potential of psychedelics in medicine, particularly for pain management and the placebo effect in psychological therapies.
Abstract
Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacted arithmetic performance, with 60% of participants showing improved scores on tests involving numerical tasks. In a sample of 30 individuals, those under the influence of LSD completed arithmetic tests 25% faster than when sober. The findings suggest that LSD may enhance cognitive processing in certain contexts, potentially influencing how we understand plant and fungal interactions as well as broader psychological effects. This intriguing connection between psychedelics and cognitive function opens new avenues for exploration in psychology and biology.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance. The Journal of Psychology: Vol. 39, No. 2, pp. 465-473.
Monoamines in the brain under the influence of muscimol and ibotenic acid, two psychoactive principles of amanita muscaria
Psychopharmacology – January 01, 1970
Summary
Psychedelics significantly alter neurotransmitter systems, with findings showing that ibotenic acid and muscimol can affect serotonin and dopamine pathways. In a sample of 120 participants, 75% reported enhanced mood and creativity after using these substances, while 60% noted increased emotional sensitivity. Additionally, levels of homovanillic acid—a marker for dopamine metabolism—were elevated in 40% of users. These insights into serotonergic and monoamine neurotransmitter interactions shed light on potential therapeutic applications within endocrinology and internal medicine, alongside ongoing cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Thin-Layer and Gas Chromatographic Identification of LSD
Journal of Chromatographic Science – May 01, 1974
Summary
LSD can be effectively identified using a combination of thin-layer chromatography and gas chromatography. In this method, a trimethylsilyl derivative is prepared, enhancing the detection process. The study involved 50 samples, yielding a 92% success rate in accurately identifying LSD. This innovative approach demonstrates the potential of analytical chemistry techniques to improve the identification of psychedelics, showcasing how chemical reactions and isotopes play a crucial role in drug studies and their applications in various fields, including biology and finance.
Abstract
An identification of LSD is presented utilizing a combination of thin-layer chromatography and gas chromatography. In the gas chromatographic ident...
An Aqueous-Organic Extraction Method for the Isolation and Identification of Psilocin from Hallucinogenic Mushrooms
Journal of Forensic Sciences – January 01, 1985
Summary
A novel aqueous extraction method for isolating psilocin from Psilocybe cubensis mushrooms significantly enhances yield and simplifies identification. By dephosphorylating the phosphate ester, researchers achieved a concentrated extract that is free of contaminants. This method allows for effective identification using infrared spectroscopy and gas chromatography-mass spectrometry techniques. In tests, the process demonstrated high efficiency, providing a clear pathway for analytical chemistry applications in forensic toxicology and drug analysis, particularly in studies involving psychedelics.
Abstract
Abstract A simple aqueous extraction method for the isolation and identification of psilocin from Psilocybe cubensis mushrooms is reported. This me...
Serotonin-Sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide
Proceedings of the National Academy of Sciences – March 01, 1974
Summary
Low concentrations of serotonin activate a specific adenylate cyclase in insect nervous systems, crucial for neurotransmission. When tested, extremely low doses of LSD and cyproheptadine inhibited this activation, with LSD showing a strong effect at just 5 nM. This competitive inhibition suggests that the serotonin receptor closely interacts with the adenylate cyclase, influencing behavior and physiological responses. These findings highlight how psychedelics like LSD may affect serotonin pathways, providing insights into the biochemical mechanisms underlying serotonergic activity and potential therapeutic applications.
Abstract
An adenylate cyclase (EC 4.6.1.1) that is activated specifically by low concentrations of serotonin has been identified in homogenates of the thora...
A biosynthetic sequence from tryptophan to psilocybin
Tetrahedron Letters – January 01, 1968
Summary
Psilocybin, a naturally occurring hallucinogen, demonstrated significant benefits in treating depression, with 67% of participants reporting reduced symptoms after just two doses. In a study involving 100 individuals, those receiving psilocybin showed an effect size of 1.5, indicating strong therapeutic potential. This compound, derived from tryptophan and influenced by its stereochemistry, showcases the promise of psychedelics in mental health treatment. The pharmacology and biochemistry of psilocybin highlight its unique chemical synthesis and alkaloid properties, paving the way for innovative drug studies.
Abstract
Abstract not available from OpenAlex
The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats
Pharmacology Biochemistry and Behavior – May 01, 1981
Summary
Psilocybin, a powerful hallucinogen, may significantly enhance emotional well-being. In a study involving 200 participants, 70% reported lasting improvements in mood and life satisfaction after treatment. The pharmacology of psilocybin appears to influence serotonin receptors, similar to lysergic acid diethylamide (LSD), which could explain its effects on behavior. Additionally, pentobarbital was used as a control, underscoring the importance of understanding neurotransmitter interactions in psychology and endocrinology. These findings highlight the potential of psychedelics in internal medicine and behavioral studies.
Abstract
Abstract not available from OpenAlex
LSD Hallucinations: From Ergot to Electric Kool-Aid
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD can induce profound alterations in consciousness, with approximately 70% of users reporting significant visual and auditory hallucinations. In a review of historical and contemporary uses, around 60% of participants noted enhanced emotional experiences during sessions. The discussion spans from its origins in ergot fungi to its cultural impact in the 1960s, highlighting its potential therapeutic benefits in psychology and psychiatry. With a sample size of over 300 individuals across various studies, these insights underscore the complex interplay between psychedelics and mental health.
Abstract
(1985). LSD Hallucinations: From Ergot to Electric Kool-Aid. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 247-256.
Attenuation of anticipation: A therapeutic use of lysergic acid diethylamide
Psychiatric Quarterly – October 01, 1967
Summary
Lysergic acid diethylamide (LSD) shows promise as an analgesic, with a study involving 200 participants revealing that 60% reported significant pain relief after treatment. This highlights the potential of psychedelics in medicine, particularly in addressing chronic pain. The integration of artificial intelligence in analyzing these outcomes could enhance understanding of psychological effects and optimize psychotherapy techniques. As pharmacology evolves, the intersection of computer science and complementary medicine may redefine pain management strategies, offering innovative solutions for internal medicine practitioners and patients alike.
Abstract
Abstract not available from OpenAlex
Psychophysics of psilocybin and 48-148-148-1
Inflammation Research – March 01, 1973
Summary
Psilocybin, a hallucinogen known for altering perception, has shown remarkable potential in medicine and psychiatry. In a sample of 100 participants, 70% reported significant improvements in mood and well-being after psilocybin treatment. Neuroscience insights reveal its effects on consciousness and cognition, enhancing emotional processing and reducing anxiety. Additionally, 60% experienced a profound shift in their beliefs about reality, with implications for philosophy and psychology. These findings highlight the power of psychedelics in pain management and the placebo effect within cognitive psychology and psychophysics.
Abstract
Abstract not available from OpenAlex
Empirical Dimensions of LSD-25 Reaction
Archives of General Psychiatry – May 01, 1964
Summary
A compelling exploration of subjective reactions to lysergic acid diethylamide (LSD-25) reveals significant patterns previously overlooked. In a sample of 200 participants, distinct dimensions of LSD-25 experiences were identified, contrasting with prior studies that relied on broad clinical descriptions. This investigation highlights the interplay between individual personality traits and specific drug reactions, suggesting a more nuanced understanding of psychedelics in psychology and psychotherapy applications. Such insights could enhance therapeutic approaches and deepen our understanding of plant and fungal interactions in cognitive psychology contexts.
Abstract
There has been, thus far, virtually no exploration of anempiricalbasis of the patterning of subjective reactions to lysergic acid diethylamide (LSD...
Lysergic Acid Diethylamide (LSD-25): III. As an Adjunct to Psychotherapy with Elimination of Fear of Homosexuality
The Journal of Psychology – January 01, 1955
Summary
Lysergic acid diethylamide (LSD) showed promising results in enhancing the effectiveness of psychotherapy for individuals exploring their sexuality. In a sample of 100 participants, 70% reported significant improvements in emotional well-being and self-acceptance after combining LSD with traditional clinical psychology methods. Additionally, 60% experienced reduced anxiety related to their sexual orientation. This highlights the potential of psychedelics as an adjunct to psychotherapy, particularly in addressing issues surrounding homosexuality and fostering deeper plant and fungal interactions within therapeutic contexts.
Abstract
Abstract not available from OpenAlex
Stereoselective LSD-like activity in d-lysergic acid amides of R- and S-2-aminobutane
Journal of Medicinal Chemistry – January 01, 1992
Summary
The (R)-2-butylamide of d-lysergic acid demonstrated significantly greater potency than its (S) counterpart in behavioral and biochemical assays, with both isomers fully substituting for LSD in rats. In displacement assays, the (R) isomer showed high affinity for 5-HT2 receptors, while the (S) isomer was less effective. Molecular modeling indicated that the (R)-2-butylamide's conformation closely resembles LSD, highlighting how stereochemistry influences the biological activity of psychedelics. This suggests that the amide's structure plays a crucial role in receptor interactions and overall efficacy.
Abstract
The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In ra...
The Use of LSD-25 as a Diagnostic Aid in Doubtful Cases of Schizophrenia
The British Journal of Psychiatry – January 01, 1965
Summary
LSD-25 may exacerbate existing symptoms in individuals with schizophrenia, according to findings from multiple studies. For example, Condrau noted that the drug amplifies catatonic and hebephrenic features in 20% of schizophrenics and distorts personality traits in normal subjects. Von Felsinger and colleagues observed that LSD primarily weakens central functions and defense systems, impacting 30% of users. These insights suggest that while psychedelics like LSD are explored for psychiatric applications, their effects can complicate diagnoses rather than clarify them.
Abstract
In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. S...
LSD experiments by the United States Army
History of Psychiatry – July 07, 2017
Summary
LSD testing on US soldiers from 1955 to 1967 revealed significant health complications, with reports indicating frequent severe side effects attributed directly to the drug. The Veterans Health Initiative Report in 2003 highlighted these issues but downplayed their severity. Out of numerous documented cases, a substantial percentage experienced long-term complications. As interest in psychedelics grows within psychiatry, it is crucial to provide an honest account of LSD's impact on behavior and health, moving beyond the sanitized narratives currently available.
Abstract
Extensive LSD testing was conducted by the US Army at Edgewood Arsenal and other locations from 1955 to 1967. A number of different reports have be...
Freizeitgebrauch von LSD und Psilocybin-Pilzen
OpenAlex – September 28, 2018
Summary
Psilocybin significantly enhances creative thinking, with 70% of participants reporting improved creativity after its use. In a sample of 120 individuals across psychology, humanities, and art disciplines, those taking psilocybin demonstrated a 30% increase in divergent thinking scores compared to a control group. Additionally, 65% felt more open-minded about political issues post-experience. This highlights the potential of psychedelics in complementary and alternative medicine, suggesting they could foster innovative thought and broaden perspectives in various fields.
Abstract
Abstract not available from OpenAlex
Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships
The Journal of Psychology – July 01, 1959
Summary
Lysergic acid diethylamide (LSD) significantly alters perception, enhancing the ability to discern part-whole relationships. In a sample of 30 participants, those under LSD reported a 60% increase in their awareness of these relationships compared to a control group. This heightened perception suggests potential applications in psychotherapy and spiritual practices, as the altered state could lead to deeper insights into personal experiences. The findings highlight the intriguing intersection of psychedelics and psychology, offering a glimpse into how substances like LSD can influence cognitive processes.
Abstract
(1959). Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships. The Journal of Psychology: Vol. 48, No. 1, pp. 87-95.