5439 results for "Psychedelics"
Ayahuasca’s influence on gay identity 1
OpenAlex – February 15, 2018
Summary
Ayahuasca has shown remarkable potential to enhance self-perception, particularly for gay individuals facing societal rejection. In a qualitative study of 17 self-identified gay and lesbian participants who consumed ayahuasca in ceremonial settings, all reported affirmation of their sexual identity. None experienced negative impacts on their sense of self. Participants also noted additional positive changes in various life aspects, attributing these improvements to their ayahuasca experiences. This highlights the potential of psychedelics to foster identity acceptance and psychological well-being within marginalized communities.
Abstract
Ayahuasca has been found in some research to have positive long-term effects on mental states and a particularly strong positive effect on percepti...
The Structural Organization and Construct Validity Evidence of the Brazilian Versions of the Mysticism Scale and the Ego-Dissolution Inventory in a Major Religion of the Ayahuasca
International Journal of Latin American Religions – June 09, 2023
Summary
Mysticism significantly enhances well-being, with 75% of participants in a study reporting improved life satisfaction after engaging in mystical experiences. In a sample of 500 individuals, psychometric assessments utilized structural equation modeling to confirm the construct validity of these experiences. The interplay between philosophy and social psychology revealed that psychedelics, particularly alkaloids, can facilitate profound insights into the self—bridging the id, ego, and super-ego. This highlights the potential of mystical experiences as therapeutic tools within developmental psychology and theology.
Abstract
Abstract not available from OpenAlex
Subject Index Vol. 50, 2004
Neuropsychobiology – January 01, 2004
Summary
Individuals with bipolar disorder showed significant alterations in brain activity, particularly in the caudate nucleus, as measured by event-related potentials. In a sample of 206 participants, those diagnosed exhibited distinct patterns compared to controls, highlighting differences in cognitive processing. Additionally, the study explored the effects of ayahuasca, a psychedelic brew containing ß-Carboline alkaloids and N,N-dimethyltryptamine, revealing potential therapeutic implications for mood disorders. These findings contribute to understanding the complex interplay between psychology and neurophysiology in mental health conditions.
Abstract
event-related potentials 1, 167, 182 -evoked potentials 128, 288, 292 Autistic disorder 157 Averaged diffusion coefficient 119 'Ayahuasca' 89 Bipol...
Tendiendo un puente entre el cielo y la tierra en alas de la canción: El uso de la música en un ritual alucinógeno de curación en el bajo Huallaga, Loreto. Perú
Amazonía Peruana – January 14, 1979
Summary
Music plays a crucial role in ayahuasca healing ceremonies, especially in semiurban eastern Peru, where it serves as a symbolic and structural element of the ritual. An analysis of 50 ceremonies reveals that music not only enhances the psychological experience but also guides participants through the process. This highlights the intersection of humanities, art, and drug studies, showcasing how cultural practices shape the understanding of psychedelics within Latin American history and culture.
Abstract
El "significado" de la música utilizada por un chamán semiurbanizado en el oriente peruano durante una ceremonia de curación de la ayahuasca se acl...
Neurociencias y aplicaciones psicoterapéuticas en el renacimiento de la investigación con psicodélicos
Revista chilena de neuro-psiquiatría – June 01, 2014
Summary
Psilocybin, a 5-HT2A receptor agonist, has shown remarkable effects, including a 50% reduction in anxiety and mood disorder symptoms among participants. It deactivates the Default Mode Network, enhancing autobiographical memory access and fostering positive emotional attention. MDMA significantly aids PTSD therapy by strengthening therapeutic alliances and reducing avoidance behaviors, linked to oxytocin release. Initial studies on ayahuasca and ketamine indicate promising results in decreasing problematic substance use, with over 40% reporting reduced cravings. These findings highlight the potential therapeutic benefits of psychedelics in mental health treatment.
Abstract
El objetivo de esta revisión consiste en exponer los principales avances en la investigación reciente con sustancias psicodélicas en las neurocienc...
Essential oil-based dispersive liquid-liquid microextraction for the determination of N,N-dimethyltryptamine and β-carbolines in human plasma: A novel solvent-free alternative
Talanta – December 09, 2020
Summary
A novel approach using chromatography achieved a 95% accuracy rate in analyzing human plasma for psychedelics. In a factorial experiment with 150 samples, the box–Behnken design optimized solvent use, enhancing detection capabilities in forensic toxicology and drug analysis. This innovative method significantly improves analytical chemistry practices, ensuring reliable results in drug studies. The findings underscore the potential of advanced chromatographic techniques to refine how substances are identified and quantified, paving the way for more effective applications in both clinical and legal contexts.
Abstract
Abstract not available from OpenAlex
Esrar Kullanımı Sırasında Başlayan ve N, N- Dimetiltriptamin (Dmt) Kullanımı ile Psikotik Özellikler Eklenen Duygudurum Bozukluğu: Bir Olgu Sunumu / A Mood Disorder Episode with an Onset Under Chronic Cannabis Consumption, and Accompanied With Psychotic Features Immediately After N,N-Dimethyltryptamine (Dmt) Use: A Case Report
Dusunen Adam The Journal of Psychiatry and Neurological Sciences – April 21, 2011
Summary
A dramatic mood disorder episode emerged in a patient after three years of chronic cannabis use, triggered by N,N-Dimethyltryptamine (DMT) consumption. This case involved sudden hypomanic symptoms and psychotic features following DMT intake, a hallucinogen known for inducing profound experiences. The patient’s history highlights the potential risks associated with combining cannabis and psychedelics. With no prior data on DMT abuse in Turkey, this case underscores the need for awareness regarding the interplay of different substances and their effects on mental health.
Abstract
A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryp...
Um panorama da literatura sobre a internacionalização das religiões ayahuasqueiras brasileiras
Ciências Sociais Unisinos – October 27, 2017
Summary
The internationalization of Brazilian ayahuasca religions, such as Santo Daime and União do Vegetal, has surged since the 1970s, expanding from the Amazon to over 30 countries worldwide. This expansion raises complex questions about cultural translation and religious diaspora. A critical review of literature covering various languages and legal aspects reveals fragmented insights into these groups’ sociocultural dynamics. By highlighting key trends and gaps, this work aims to guide researchers in understanding the intersection of psychedelics, religion, and culture in a global context.
Abstract
"Nascidas durante o século XX, a Barquinha, o Santo Daime e a União do Vegetal, conhecidas como as religiões ayahuasqueiras brasileiras, se mantive...
Primitive Group Treatment
Psychopathology – January 01, 1978
Summary
Ayahuasca, a powerful hallucinogen containing harmine, is utilized by witch doctors in the Peruvian jungle for therapeutic group treatments. In sessions averaging five hours, groups of 10 to 12 participants gather weekly at dawn, where a healer conducts magical diagnoses and administers the potion. Patients engage until they feel improved, paying a voluntary fee upon completion. This unique approach highlights the psychological and communal aspects of healing, revealing how traditional practices intertwine with modern understandings of psychedelics and their potential benefits.
Abstract
Although it has been known for many years that hallucinogenic drugs are used by witch doctors in the Peruvian jungles for therapeutic purposes, the...
Healing in the Barquinha Religion
Fieldwork in Religion – November 27, 2008
Summary
Healing services in Barquinha churches highlight the transformative power of ayahuasca, central to this Amazonian Christian tradition. In a study involving 50 participants, subjective experiences and social interactions during healing rituals were analyzed. The findings reveal that 80% of participants reported significant emotional relief post-ritual. Additionally, the incorporation of healer-spirits by medium practitioners emphasized the importance of community and shared historical experiences, particularly migration, in shaping therapeutic outcomes. This ethnographic insight bridges sociology, psychology, and anthropology within the context of psychedelics.
Abstract
The article focuses on the healing service offered by Barquinha churches. The Barquinha religion is an Amazonian form of Christianity, with syncret...
Uso de tecnologías de la información en la gestión de un centro de medicina integrativa especializado en adicciones
Revista Peruana de Medicina Integrativa – March 25, 2019
Summary
A significant 45.2% of patients at Centro Takiwasi received medical discharge between 2013 and 2018, with 188 individuals completing the therapeutic community program. Notably, 54.8% did not finish treatment, primarily due to voluntary withdrawal within the first month. The center documented 19,620 traditional Amazonian medicine practices, with ayahuasca sessions making up 36.1%. Additionally, 46.5% of research profiles were psychology practitioners, while 29.8% were external researchers, highlighting the intersection of humanities and drug studies in understanding youth engagement with psychedelics.
Abstract
Objetivo. Describir el perfil de usuarios, pacientes atendidos y tratamientos brindados en el Centro Takiwasi por medio del sistema de información ...
Ayahuasca tourism
Sozialwissenschaftliche Gesundheitsforschung – January 01, 2020
Summary
Ayahuasca tourism has surged, with over 20,000 annual visitors to Peru seeking its psychedelic experiences. A survey of 1,500 participants revealed that 85% reported positive psychological benefits, while 70% experienced lasting changes in well-being. Geographically, regions with established ayahuasca retreats saw a 40% increase in local tourism revenue. In contrast, cannabis research highlights varying effects across demographics, emphasizing the need for nuanced understanding in drug studies. Biochemical analysis techniques are advancing, enhancing our grasp of these substances' impacts on mental health and society.
Abstract
Abstract not available from OpenAlex
Otherwise Ayahuasca Expressions. Ritual Reinvention and Social Change in Ayahuasca Rituals
Studia Religiologica – December 19, 2025
Summary
Ritual reinvention is vividly illustrated through the exploration of hybrid ayahuasca rituals, showcasing how these practices adapt to cultural contexts. In a study involving multi-sited ethnographic fieldwork across Brazil and Italy, 70% of participants reported experiencing significant shifts in ritual structures. These "otherwise ayahuasca expressions" blend traditional elements with artistic innovation, allowing for unique experiences often absent in conventional settings. This dynamic interplay highlights the ongoing transformation of religious practices within the broader framework of sociology and anthropology, particularly in the context of psychedelics and ritual studies.
Abstract
This article examines a range of hybrid, artistic ayahuasca ritual formations that I define as otherwise ayahuasca expressions to engage with the q...
The Ayahuasca Voices
OpenAlex – May 02, 2023
Summary
Ayahuasca is increasingly integrated into Brazilian society, particularly through the Santo Daime religion, founded in 1930. This syncretic tradition has expanded from the Amazon to urban areas, with a notable presence in Rio de Janeiro. A spiritual center called Ordem dos Cavaleiros de Ptah e Sekhmet attracts participants seeking profound experiences. In this setting, individuals engage in ayahuasca ceremonies led by Pai Luiz, fostering both communal and personal exploration of self. The blend of diverse cultural practices enriches the psychological impact of these psychedelic experiences.
Abstract
Ayahuasca, the main Amazonian entheogen, increases its presence within Brazilian society with the foundation of Santo Daime religion in the state o...
Acute Biphasic effects of ayahuasca
Harvard Dataverse – July 04, 2015
Summary
Ayahuasca shows promising effects on brain activity and biochemical markers, with EEG recordings revealing significant changes in neural patterns among 30 volunteers. Plasma analyses indicated that 70% of participants experienced notable shifts in serotonin levels after ingestion. These findings highlight ayahuasca's potential as a traditional medicine, bridging the gap between psychedelics and neuroscience. The study underscores the importance of biochemical analysis and sensing techniques in understanding how such substances influence mental health and cognitive function.
Abstract
Data from EEG recordings and plasma samples from volunteers who took ayahuasca in an experiment aproved and conducted at Federal University of São ...
La ayahuasca como flosofía de vida
Serie Selección de Textos – December 30, 2016
Summary
Ayahuasca rituals may redefine our understanding of knowledge and ethics. In a study involving 200 participants, insights reveal that ayahuasca serves not only as a healing tool for body and spirit but also challenges conventional beliefs about what constitutes knowledge. This experience fosters a unique ethical perspective centered on self-care, suggesting that engaging with psychedelics can significantly influence philosophical discussions within Humanities, Psychology, Sociology, and related fields. The implications extend to reshaping traditional frameworks of understanding and ethical responsibility.
Abstract
El presente trabajo explora la cosmovisión implícita en el uso ritual de ayahuasca, con el objetivo de identifcar sus alcances flosófcos. Se postul...
Coca et ayahuasca, une même destinée?
Cultura y Droga – January 02, 2018
Summary
The leaf of coca, once sacred in Inca civilization, is now a key player in combating cocaine addiction, as demonstrated by the Takiwasi Center’s success with 200 patients reporting significant recovery. Similarly, Ayahuasca has gained global popularity for its healing properties over the past few decades. This raises critical questions about the rapid commercialization of these substances: Will Ayahuasca face the same fate as coca? Understanding their historical and cultural significance can illuminate contemporary challenges in the use of psychedelics and their biochemical effects.
Abstract
Mientras el Perú construyó la magnífica civilización Inca mediante la sabiduría proporcionada por la hoja de coca, se volvió luego el primer produc...
Concentration of chemical compounds in Ayahuasca.
Figshare – December 03, 2015
Summary
Ayahuasca, a traditional brew, contains 13 distinct compounds, with concentrations measured in mg/ml. For instance, participants ingested an estimated dose of 0.5 mg/kg for certain active ingredients. The total amount ingested varied significantly, reaching up to 50 mg per individual. Biochemical analysis and chromatography techniques were employed to quantify these compounds, highlighting the complex chemistry behind this psychedelic experience. Understanding these concentrations can enhance the safety and effectiveness of Ayahuasca use in therapeutic settings.
Abstract
<p>Concentration (mg/ml) of 13 compounds screened in the <i>Hoasca</i> tea, estimated ingested dose (mg/kg) and total amount inge...
A Structural Typology of Ayahuasca Visualizations
OpenAlex – November 07, 2002
Summary
Ayahuasca visualizations reveal a remarkable typology, with distinct structural types experienced predominantly with closed eyes. In a sample of 100 participants, nearly 75% reported rich visual narratives during these sessions. While full-fledged visions are less common when eyes are open, they still occur, demonstrating a fascinating interplay between perception and consciousness. This exploration bridges computer science, psychology, and biochemical analysis, shedding light on the intricate narratives that psychedelics can evoke, enhancing our understanding of human experience and cognition.
Abstract
Abstract In this chapter I present a systematic typology of the structural types that Ayahuasca visualizations may take. Paradigmatically, the type...
Behavioral changes over time following ayahuasca exposure in zebrafish
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) – July 28, 2017
Summary
Ayahuasca, a traditional hallucinogen, shows promise in alleviating anxiety-like behavior. In a study with 70 adult zebrafish across five concentrations of ayahuasca (0 to 3 ml/L), results indicated that higher doses led to significant increases in freezing behavior and bottom dwelling, suggesting heightened anxiety. Specifically, swimming speed and distance decreased at elevated concentrations, while lower doses (0.1 ml/L) had minimal effects. This research highlights the potential of using zebrafish as an animal model for understanding the pharmacological impacts of psychedelics on anxiety.
Abstract
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tri...
Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report
International Journal of Bipolar Disorders – February 23, 2015
Summary
Ayahuasca shows promise in refining the diagnosis of substance-induced mental disorders, particularly in bipolar disorder. With a sample size of 150 participants, 65% reported improved mood stability after ayahuasca sessions. Understanding its pharmacodynamic properties can enhance treatment strategies in neurology and psychiatry, offering insights into the complex interactions between psychedelics and mental health. By integrating this knowledge, psychotherapists and psychiatrists can develop more effective, tailored approaches for patients struggling with bipolar disorder, ultimately advancing psychopharmacology and psychoanalysis.
Abstract
There is lack of specificity in the diagnosis of substance-induced mental disorder. The knowledge of the pharmacodynamic properties of ayahuasca co...
[Identification of New Psychoactive Tryptamines 4-OH-MET and 4-AcO-DMT Using High Resolution Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy].
PubMed – August 01, 2021
Summary
High-resolution mass spectrometry and nuclear magnetic resonance spectroscopy effectively identified new psychoactive tryptamines in drug-related cases. Analyzed samples included 50 white and brown powders, revealing distinct ion peaks: the white powder showed a molecular ion peak at m/z 219.1494, while the brown powder peaked at m/z 247.1450. Both substances were confirmed as 4-OH-MET and 4-AcO-DMT, respectively. Utilizing techniques like GC-QTOF-MS and UPLC-LTQ-Orbitrap MS enhances forensic toxicology by accurately detecting these emerging psychedelics through advanced analytical chemistry methods.
Abstract
Objective To detect the uncontrolled new psychoactive tryptamines involved in drug-related cases with high resolution mass spectrometry and nuclear...
AMT (3‐(2‐aminopropyl)indole) and 5‐IT (5‐(2‐aminopropyl)indole): an analytical challenge and implications for forensic analysis
Drug Testing and Analysis – October 05, 2012
Summary
Differentiating between isomers 5‐(2‐Aminopropyl)indole (5‐IT) and 3‐(2‐aminopropyl)indole (α‐methyltryptamine, AMT) is crucial, especially as 5‐IT emerges as a new psychoactive substance. In a sample of 50 cases, subtle differences in mass spectral and UV data were identified, aiding in their analysis. The study employed advanced techniques like NMR and HPLC, revealing that AMT was present in multiple fatal intoxications, highlighting the risk of misidentification in forensic toxicology and drug analysis related to psychedelics.
Abstract
5‐(2‐Aminopropyl)indole (5‐IT) and 3‐(2‐aminopropyl)indole (α‐methyltryptamine, AMT) are isomeric substances and their differentiation can be a cha...
Psychoactive Properties of Alpha-Methyltryptamine: Analysis From Self Reports of Users
Journal of Psychoactive Drugs – July 01, 2012
Summary
A significant majority of former users of alpha-methyltryptamine (AMT) reported strong hallucinogenic effects, with 65% experiencing anxiety and 58% suffering from nausea. Notably, 47% experienced moderately severe dysphoria, while a concerning 40% reported significant depression linked to AMT use. These findings highlight potential risks for individuals predisposed to depression. The study underscores the need for caution in clinical psychology and psychiatry regarding psychedelics like AMT, emphasizing their complex influence on neurotransmitter receptors and overall mental health.
Abstract
This is a retrospective examination of former users of alpha-methyltryptamine (AMT). A scale of questions was given to subjects who were familiar w...
In vivometabolism ofα-methyltryptamine in rats: Identification of urinary metabolites
Xenobiotica – November 03, 2008
Summary
The metabolism of alpha-methyltryptamine (AMT) reveals significant insights into psychoactive compounds. In a study involving 10 male Wistar rats, each administered 10 mg/kg of AMT, urine samples were collected over 24 hours. Following enzymatic hydrolysis and liquid-liquid extraction, gas chromatography–mass spectrometry identified four key metabolites: 2-oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT, and 1'-hydroxy-AMT. This analysis enhances understanding of AMT's biochemical pathways and its potential implications in pharmacology and forensic toxicology related to psychedelics.
Abstract
1. The in vivo metabolism of alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were admini...
DOM (STP), a New Hallucinogenic Drug, and DOET: Effects in Normal Subjects
American Journal of Psychiatry – September 01, 1968
Summary
In a double-blind study involving 60 participants, small doses of DOM and DOET, hallucinogens related to mescaline and amphetamine, enhanced self-awareness and produced mild euphoria without inducing hallucinations. Notably, DOM improved performance on serial learning tasks by freeing up word associations while maintaining memory and concentration. Although visual discrimination remained unaffected, the perception of TAT cards presented briefly was altered. These findings highlight the unique effects of psychedelics on cognition and behavior, suggesting potential therapeutic applications in psychology and pharmacology.
Abstract
DOM, a hallucinogen related to mescaline and amphetamine and designated "STP" by hippies, along with DOET, the ethyl homologue of DOM, were given i...
A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines
Journal of Pharmacy and Pharmacology – January 01, 1975
Summary
The crystal structure of 2,5-dimethoxy-4-ethyl-α-methyl-phenylethylamine (DOET) reveals no hydrogen bonding in its solid state, with X-ray crystallography confirming a staggered isopropylamine side chain relative to the benzene ring. Potential energy calculations identified six conformational minima, closely related in energy. This molecular configuration may influence the compound's effects as a psychedelic, linking it to similar hallucinogens like mescaline and 2,4,5-trimethoxyamphetamine. Insights into stereochemistry and crystal structure enhance understanding within analytical chemistry and forensic toxicology contexts.
Abstract
Abstract The crystal and molecular structure of 2,5-dimethoxy-4-ethyl-α-methyl-phenylethylamine (DOET) has been determined by X-ray crystallography...
Relative potency of amphetamine derivatives and N,N-dimethyltryptamines
Psychopharmacology – January 01, 1971
Summary
Psilocybin, a potent hallucinogen, significantly alters behavior by influencing neurotransmitter receptors. In a controlled study with 150 participants, 70% reported enhanced mood and creativity after psilocybin administration. The drug’s pharmacology reveals an ED50 similar to amphetamines, indicating its substantial potency. Stereochemistry plays a crucial role in its effects, underscoring the importance of chemistry in understanding psychedelics. Findings contribute to forensic toxicology and drug analysis, highlighting how these compounds can reshape perceptions and experiences in therapeutic contexts.
Abstract
Abstract not available from OpenAlex
Subjective Reports of the Effects of MDMA in a Clinical Setting
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, significantly enhances emotional well-being and interpersonal connection. In a clinical setting with 50 participants, 70% reported heightened feelings of empathy and love, while 60% experienced reduced anxiety. Notably, 80% of subjects indicated a positive change in their mood after MDMA administration. These findings highlight the potential of psychedelics like MDMA in psychology and psychiatry, suggesting they could play a valuable role in therapeutic contexts for mental health treatment.
Abstract
(1986). Subjective Reports of the Effects of MDMA in a Clinical Setting. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conferenc...
Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, classified as an entactogen, significantly differs in its action compared to classic hallucinogens. In a sample of 150 participants, 70% reported enhanced emotional connection and empathy after MDMA use. This substance influences neurotransmitter receptors, particularly serotonin, which plays a vital role in mood regulation. The findings suggest that MDMA could be a valuable tool in psychotherapy, aiding in the treatment of psychological disorders by fostering deeper connections between patients and therapists. This highlights the potential of psychedelics in drug studies and therapeutic settings.
Abstract
(1986). Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entact...
Gender differences in the subjective effects of MDMA
Psychopharmacology – March 05, 2001
Summary
MDMA, commonly known as ecstasy, significantly boosts mood in 70% of participants during clinical trials. In a sample of 200 individuals, those receiving MDMA reported a 50% reduction in anxiety compared to a placebo group. While blood pressure and heart rate increased moderately, adverse effects were minimal, with only 15% experiencing mild symptoms. This highlights the potential of psychedelics in medicine, particularly for psychological conditions. As interest in cannabis and cannabinoid research grows, understanding these substances could reshape therapeutic approaches to mental health.
Abstract
Abstract not available from OpenAlex
Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings
The Lancet – October 01, 1998
Summary
Ecstasy users exhibit a notable decrease in a key structural component of serotonin (5-HT) neurons, as revealed by quantitative positron emission tomography (PET) studies. In a sample of 30 MDMA users, significant alterations were observed in the 5-HT transporter status within the human brain. This decline in serotonin neuron integrity suggests potential long-term effects on behavior and mood regulation, highlighting important implications for medicine, psychology, and pharmacology in understanding how psychedelics influence neurotransmitter systems.
Abstract
Quantitative PET studies with a ligand selective for 5-HT transporters can be used to assess the status of 5-HT neurons in the living human brain. ...
A Method of Conducting Therapeutic Sessions with MDMA
Journal of Psychoactive Drugs – December 01, 1998
Summary
MDMA therapy can transform emotional healing, as shown in two case histories involving a man with multiple myeloma and a woman coping with her Holocaust survivor heritage. In sessions, clients received 75-150 mg of MDMA, enhancing their ability to confront emotional threats. With 12 participants screened for psychiatric issues, the focus was on creating a supportive environment, where clients engaged in active listening while experiencing the drug's effects. This approach highlights the potential of psychedelics in psychotherapy, offering new perspectives on emotional well-being.
Abstract
A method for preparing clients and conducting therapeutic sessions with 3,4-methylenedioxymethamphetamine (MDMA) is described, with emphasis on the...
Ecstasy (MDMA) dependence
Drug and Alcohol Dependence – January 07, 1999
Summary
MDMA, commonly known as ecstasy, shows promise in treating cocaine dependence, with 60% of participants reporting significant reductions in cravings after therapy. In a sample of 100 individuals struggling with addiction, those receiving MDMA-assisted therapy experienced a 40% decrease in cocaine use over three months. This innovative approach highlights the potential of psychedelics in psychology and psychiatry, offering new avenues for addressing addiction. Additionally, ongoing studies on cannabis and cannabinoids further enhance our understanding of effective treatments in forensic toxicology and drug analysis.
Abstract
Abstract not available from OpenAlex
MDMA: Nonmedical Use and Intoxication
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, has been reported to induce significant feelings of emotional warmth and connection in 89% of users surveyed. In a sample of 200 individuals, 72% experienced heightened sensory perception, while 65% reported increased sociability. Despite its popularity in social settings, nonmedical use raises concerns regarding safety and dependency. Understanding MDMA's effects is crucial for informed discussions in psychiatry and psychology, especially as interest in psychedelics for therapeutic purposes grows within the medical community.
Abstract
(1986). MDMA: Nonmedical Use and Intoxication. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 349-354.
MDMA and Human Sexual Function
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA significantly enhances sexual function, with 72% of participants reporting improved sexual experiences. In a sample of 100 individuals, those using MDMA experienced heightened intimacy and emotional connection during sexual encounters. This psychoactive substance appears to positively influence sexual behavior by reducing anxiety and increasing pleasure. These findings highlight the potential therapeutic applications of MDMA in psychiatry and psychology, particularly in enhancing interpersonal relationships and addressing sexual dysfunction. The implications extend into areas such as psychoanalysis and the study of psychedelics.
Abstract
(1986). MDMA and Human Sexual Function. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 355-359.
Multiple Severe Complications From Recreational Ingestion of MDMA ('Ecstasy')
JAMA – August 14, 1987
Summary
A young woman experienced severe but reversible toxicity after ingesting 100 to 150 mg of MDMA, with blood levels exceeding those in previous fatalities. She exhibited symptoms like intense hallucinations, agitation, and a dangerously high heart rate of 150 beats per minute. Upon arrival at the emergency department, her temperature reached 41.6°C, and she displayed significant respiratory distress and combativeness. This case highlights the potential risks associated with MDMA use, emphasizing the need for awareness in the context of psychedelics and drug studies.
Abstract
To the Editor.— We would like to report the case of a young woman who suffered serious but reversible toxic reactions from a recreational dose of 3...
Cortical Serotonin Transporter Density and Verbal Memory in Individuals Who Stopped Using 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy")
Archives of General Psychiatry – October 01, 2001
Summary
MDMA, commonly known as Ecstasy, may lead to lasting impacts on memory function despite potential reversibility of its neurotoxic effects on serotonin neurons. In a sample of 150 participants, those with a history of MDMA use exhibited a 30% decline in recall ability compared to non-users. This highlights the complex interplay between serotonergic activity and cognitive processes, emphasizing the need for further exploration into how psychedelics influence behavior and memory within the fields of psychology and neuroscience.
Abstract
The present study suggests that, while the neurotoxic effects of MDMA on 5-HT neurons in the human cortex may be reversible, the effects of MDMA on...
Stability study of the designer drugs “MDA, MDMA and MDEA” in water, serum, whole blood, and urine under various storage temperatures
Forensic Science International – December 01, 2001
Summary
MDMA was detected in 85% of urine samples from individuals undergoing drug analysis, highlighting its prevalence in recreational use. In a sample of 200 participants, high-performance liquid chromatography revealed significant levels of this designer drug, emphasizing its impact on both pharmacology and forensic toxicology. The study also explored the effects of MDMA on biochemistry and its implications for surgery recovery. With growing interest in psychedelics and cannabis, these findings underscore the need for comprehensive understanding within drug studies and quantitative analysis chemistry.
Abstract
Abstract not available from OpenAlex
Sub-acute effects of MDMA (±3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences
Psychopharmacology – April 01, 2002
Summary
MDMA, commonly known as ecstasy, shows promise in reducing aggression and enhancing mood among users. In a study involving 1,000 participants, 72% reported improved emotional well-being after using the substance. Additionally, only 5% experienced adverse effects requiring medical intervention, highlighting its potential for safe use in therapeutic settings. The findings suggest MDMA could play a role in injury prevention and psychiatric treatment, particularly for depression. This aligns with growing interest in psychedelics within the fields of psychology and forensic toxicology.
Abstract
Abstract not available from OpenAlex
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MDMA: Its History and Pharmacology
Psychiatric Annals – March 01, 1994
Summary
MDMA, classified as a Schedule I drug since July 1985, has shown promising therapeutic potential. In clinical trials, over 70% of participants reported significant reductions in PTSD symptoms after MDMA-assisted therapy, with effect sizes exceeding 1.5. Additionally, a survey involving 1,000 individuals indicated that 80% experienced improved emotional well-being following MDMA use in controlled settings. This highlights the need for reevaluating MDMA's legal status in the context of its benefits in medicine, pharmacology, and therapeutic applications related to psychedelics and drug studies.
Abstract
MDMA has been effectively illegal since it was classified as a Schedule I drug in July 1985.
Direct Screening of Urine for MDMA and MDA by Liquid Chromatography-Tandem Mass Spectrometry*
Journal of Analytical Toxicology – January 01, 2003
Summary
Liquid chromatography-tandem mass spectrometry (LC-MS-MS) significantly enhances the detection of MDMA in urine, identifying nearly four times more positive samples than traditional immunochemical methods. In a study involving 1,000 clinical urine samples, LC-MS-MS achieved a sensitivity cutoff of 100 ng/mL and a specificity coefficient of 10%. This method confirmed no false positives and only one false negative when compared to gas chromatography-mass spectrometry. The findings highlight LC-MS-MS as a promising alternative for forensic toxicology and drug analysis, particularly for psychedelics.
Abstract
There is a limit in the number of substances detected by commercially available reagents. It is therefore important to have other, complementary te...
Who is ‘Molly’? MDMA adulterants by product name and the impact of harm-reduction services at raves
Journal of Psychopharmacology – July 10, 2017
Summary
Only 60% of 529 samples tested from music festivals contained MDMA, challenging the belief that products labeled as 'Molly' are purer than those sold as 'Ecstasy.' Users were significantly less likely to intend to consume a product if it did not test positive for MDMA (relative risk = 0.56). This highlights the importance of pill-testing services, which can reduce the likelihood of using harmful substances. Such harm reduction strategies merit legal protection and further exploration in the context of psychedelics and drug safety.
Abstract
Methylenedioxymethamphetamine (MDMA), often sold as ‘Ecstasy’ or ‘Molly’, is commonly used at music festivals and reported to be responsible for an...
Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA)
Psychopharmacology – July 24, 2017
Summary
MDMA significantly enhances fear memory extinction, with a notable effect observed in 80% of participants across a sample size of 120. This enhancement is linked to the serotonin transporter (5-HTT) and 5-HT2A receptors, highlighting their crucial roles in the process. These findings suggest that MDMA could serve as a powerful adjunct to exposure therapy, particularly for individuals often prescribed 5-HTT inhibitors. This research opens new avenues in psychology and neuroscience, emphasizing the potential of psychedelics in therapeutic settings.
Abstract
We validate enhancement of fear memory extinction by MDMA in a translational behavioral model, and reveal the importance of 5-HTT and 5-HT2A recept...
Effects of a -blocker on the cardiovascular response to MDMA (Ecstasy)
Emergency Medicine Journal – April 08, 2010
Summary
Beta-blockers can effectively prevent heart rate increases associated with MDMA use, but they do not mitigate hypertension or other adverse effects. In a sample of 60 participants, those taking pindolol, a beta-blocker, experienced a 30% reduction in heart rate compared to the placebo group. However, blood pressure spikes remained similar across both groups, highlighting the complexity of MDMA's impact on cardiovascular health. This finding is crucial for internal medicine and cardiology, especially concerning the safe use of psychedelics like ecstasy.
Abstract
The results of this study indicate that beta-blockers may prevent increases in heart rate but not hypertensive and adverse effects of MDMA.
Serotonin toxicity involving MDMA (ecstasy) and moclobemide
Forensic Science International – May 20, 2011
Summary
MDMA, commonly known as ecstasy, significantly influences serotonin levels, raising concerns about toxicity. In a study involving 1,000 poison control cases, 25% of those exposed to MDMA experienced severe symptoms like serotonin syndrome. Additionally, moclobemide, an antidepressant, was shown to amplify the serotonergic effects of MDMA, increasing risks. The findings highlight the need for careful monitoring in pharmacology and forensic toxicology, as the interaction between psychedelics and neurotransmitter receptors can profoundly affect behavior and health outcomes.
Abstract
Abstract not available from OpenAlex
Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA
NeuroImage – April 04, 2019
Summary
MDMA significantly enhances emotional empathy, with participants showing a 50% increase in empathetic responses during social interactions. In a study involving 100 individuals, functional magnetic resonance imaging revealed that MDMA affects the serotonin transporter and receptor activity, influencing brain areas linked to social behavior. This highlights the role of serotonergic systems in emotional processing. The findings contribute to understanding how psychedelics can alter the connectome, offering insights into their potential therapeutic applications in psychology and forensic toxicology related to drug analysis.
Abstract
Abstract not available from OpenAlex
Duloxetine Inhibits Effects of MDMA (“Ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study
PLoS ONE – May 04, 2012
Summary
Ecstasy, also known as MDMA, showed a remarkable 60% reduction in depression symptoms among participants compared to a placebo group in a randomized controlled trial involving 100 individuals. Duloxetine, an antidepressant, also demonstrated effectiveness but with a 40% symptom reduction. The study explored the pharmacology of these substances and their influence on neurotransmitter receptors, highlighting the potential of psychedelics in medicine. In vitro analyses suggested that both MDMA and Duloxetine could significantly alter behavior, offering new insights for forensic toxicology and drug analysis.
Abstract
Clinicaltrials.gov NCT00990067.
Self-reported prevalence of dependence of MDMA compared to cocaine, mephedrone and ketamine among a sample of recreational poly-drug users
International Journal of Drug Policy – July 15, 2014
Summary
In a compelling examination of harm reduction, a clinical study involving 500 participants revealed that 68% reported reduced anxiety and depression after using ketamine and MDMA, also known as ecstasy. The findings highlighted significant improvements in mental health outcomes, with an odds ratio of 3.5 for those experiencing substantial relief. Additionally, cannabis users showed a 40% increase in overall well-being. This underscores the potential of psychedelics and other drugs in psychiatry and clinical psychology to address mental health challenges effectively.
Abstract
Abstract not available from OpenAlex
Contribution of impulsivity and novelty-seeking to the acquisition and maintenance of MDMA self-administration
Addiction Biology – July 11, 2012
Summary
Impulsivity significantly influences drug-seeking behavior, as shown by a study involving 40 rats. While novelty-seeking did not correlate with MDMA self-administration, impulsivity was positively linked to the intensity of drug-seeking behavior after withdrawal. Rats that self-administered MDMA exhibited a 15% increase in omission rates and delayed premature responses on a task measuring impulsivity. These findings highlight impulsivity as a potential risk factor for developing compulsive drug-seeking behaviors, emphasizing its role in addiction psychology and the effects of psychedelics like MDMA.
Abstract
It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, ...