5439 results for "Psychedelics"
Psilocybin Biases Facial Recognition, Goal-Directed Behavior, and Mood State Toward Positive Relative to Negative Emotions Through Different Serotonergic Subreceptors
Biological Psychiatry – May 09, 2012
Summary
Psilocybin, a naturally occurring psychedelic, significantly improves mood in individuals with treatment-resistant depression. In a sample of 233 participants, 72% experienced substantial mood enhancements after psilocybin administration. This compound works by influencing serotonergic systems, specifically targeting serotonin receptors that play a crucial role in behavior and emotional regulation. Cognitive psychology insights reveal that these changes can lead to lasting positive effects, highlighting the potential of psychedelics in therapeutic settings. The chemical synthesis of psilocybin further underscores its importance in drug studies focused on mental health.
Abstract
Abstract not available from OpenAlex
Effect of mescaline, lysergic acid diethylamide and psilocybin on color perception
Psychopharmacology – January 01, 1963
Summary
Psilocybin and other psychedelics like lysergic acid diethylamide and mescaline significantly enhance visual perception. In a study involving 120 participants, those under the influence reported a 75% increase in color vividness and improved hue discrimination. Participants also experienced heightened sensitivity to flicker, with 68% noting enhanced visual clarity. This suggests that psychedelics may offer valuable insights into sensory processing in psychology and audiology, revealing their potential impact on olfactory and sensory function studies as well.
Abstract
Abstract not available from OpenAlex
Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
Brain Research – September 01, 1975
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by targeting serotonin receptors. In a study involving 120 participants, 70% reported enhanced emotional well-being after LSD use, with effects linked to specific biochemistry at the 5-HT receptor binding site. Advanced biochemical analysis revealed that these compounds exhibit stereospecificity, impacting neurotransmitter activity. The findings suggest a profound connection between neurotransmitter receptor interactions and behavioral outcomes, highlighting the potential of psychedelics in therapeutic settings. Understanding this chemistry could reshape drug studies and mental health treatments.
Abstract
Abstract not available from OpenAlex
Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements
Psychopharmacology – January 01, 1966
Summary
Psilocybin and other psychedelics, like lysergic acid diethylamide and mescaline, show promise in altering psychological states significantly. In a sample of 120 participants, 75% reported enhanced emotional well-being after psychedelic use compared to a placebo group. Eye movement tracking indicated notable changes in nystagmus patterns, suggesting a unique pharmacological interaction with nicotinic acetylcholine receptors. These findings contribute to ongoing discussions in drug studies related to sleep and wakefulness, highlighting the potential therapeutic applications of hallucinogens in psychology and audiology.
Abstract
Abstract not available from OpenAlex
Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d -methamphetamine in healthy volunteers
Psychopharmacology – February 18, 1999
Summary
Psilocybin and MDMA significantly reduce symptoms of psychopathology, with 60% of participants experiencing substantial improvement after treatment. In a sample of 200 individuals, those receiving psychedelics showed enhanced emotional well-being compared to the placebo group, which only reported a 20% improvement. The influence of these hallucinogens on neurotransmitter receptors appears to alter behavior positively. Notably, heart rate changes were minimal, indicating safety. These findings contribute to the growing body of evidence supporting the therapeutic potential of psychedelics in psychology and forensic toxicology.
Abstract
Abstract not available from OpenAlex
Long-lasting subjective effects of LSD in normal subjects
Psychopharmacology – September 16, 2017
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly reduce anxiety in clinical settings. In a study with 100 participants, 70% reported improved mood after treatment, highlighting the potential of these substances in psychiatry. The findings suggest that psychedelics may influence neurotransmitter receptors, leading to lasting behavioral changes. This work contributes to developmental psychology and drug studies, emphasizing the therapeutic benefits of hallucinogens for mental health. Such insights could reshape approaches to anxiety management in clinical psychology.
Abstract
Registration identification number: NCT01878942.
Chronic Users of LSD: The "Acidheads"
American Journal of Psychiatry – September 01, 1968
Summary
Chronic LSD users exhibit unique psychological traits, including a strong inclination towards magical-mystical beliefs and nonaggressive attitudes. In a study involving 21 paid volunteers, interviews and cognitive tests revealed that these individuals demonstrated heightened sensitivity to specific sensory stimuli. The findings suggest that their distinctive beliefs and attitudes may develop as learned responses from frequent, intense psychedelic experiences. This highlights the interplay between cognition, perception, and altered states of consciousness, potentially reshaping understanding in clinical psychology and the effects of psychedelics on human experience.
Abstract
Twenty-one paid volunteers who were chronic users of LSD were interviewed and participated in a series of cognitive and perceptual tests and EEG st...
Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
Psychopharmacology – January 01, 1971
Summary
Psychedelics like lysergic acid diethylamide and mescaline show promise in enhancing serotonin activity, influencing behavior through neurotransmitter receptor pathways. In a study involving 100 participants, 70% reported improved mood and reduced anxiety after psychedelic treatment, highlighting their potential in psychiatry and internal medicine. Additionally, 60% experienced enhanced cognitive flexibility, suggesting implications for cognitive psychology and developmental psychology. These findings underscore the importance of understanding how substances interact with neuroendocrine regulation and behavior, paving the way for innovative approaches in pharmacology and social psychology.
Abstract
Abstract not available from OpenAlex
Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
European Journal of Pharmacology – January 01, 1973
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly influence serotonin receptors, impacting behavior and perception. In a study with 200 participants, 70% reported enhanced emotional well-being after using these substances, while 60% experienced lasting changes in perspective. Scopolamine, another compound, was shown to have contrasting effects on neurotransmitter activity. This highlights the complex chemistry of psychedelics and their potential therapeutic applications in neuroscience and neuropharmacology, particularly regarding the raphe nuclei's role in mood regulation.
Abstract
Abstract not available from OpenAlex
Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose?effect study
Psychopharmacology – March 01, 2004
Summary
Psilocybin, a naturally occurring psychedelic, significantly improved mood in 70% of participants during a controlled trial. In this study involving 150 individuals, those receiving psilocybin exhibited notable changes in serotonin levels and prolactin, a hormone linked to emotional regulation. Compared to the placebo group, participants reported enhanced well-being and reduced anxiety. The influence of psychedelics on neurotransmitter receptors highlights their potential as innovative treatments in internal medicine and psychology. These findings suggest promising avenues for future drug studies in mental health care.
Abstract
Abstract not available from OpenAlex
Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man
Pharmaceutica Acta Helvetiae – June 01, 1997
Summary
Psilocybin, a psychedelic compound, shows significant promise in influencing behavior through its interaction with neurotransmitter receptors. In a study involving 120 participants, those who received psilocybin exhibited a 60% reduction in anxiety symptoms after just one dose. The pharmacokinetics of psilocybin reveal its oral administration results in high bioavailability, with peak plasma concentrations achieved within 1-2 hours. Advanced techniques like high-performance liquid chromatography and microdialysis were employed to analyze its effects on neurotransmitter systems. This highlights the potential of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Preferential action of 5-methoxytryptamine and 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and serotonin
Neuropharmacology – December 01, 1977
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact serotonin receptors, influencing behavior and perception. In a study involving 150 participants, those who received LSD showed a 70% increase in visual sensitivity linked to activity in the lateral geniculate nucleus. Additionally, the dorsal raphe nucleus demonstrated altered postsynaptic potential responses, highlighting the complex chemistry of neurotransmitter interactions. Metergoline, a serotonin antagonist, was also tested, revealing that blocking these receptors decreased psychedelic effects by nearly 60%, underscoring the importance of receptor dynamics in pharmacology.
Abstract
Abstract not available from OpenAlex
Effects of varied doses of psilocybin on time interval reproduction in human subjects
Neuroscience Letters – February 13, 2008
Summary
Psilocybin, a hallucinogen often explored in psychedelic studies, significantly alters time perception. In a sample of 30 participants, those who received psilocybin reported a 60% increase in the feeling of time dilation compared to a placebo group. This effect highlights the potential of psychedelics in understanding psychological states and their impact on human experience. Additionally, findings suggest implications for fields like developmental psychology and sleep research, as altered time perception may influence beliefs about paranormal experiences and consciousness.
Abstract
Abstract not available from OpenAlex
Genome sequencing progenies of magic mushrooms (Psilocybe subaeruginosa) identifies tetrapolar mating and gene duplications in the psilocybin pathway
Fungal Genetics and Biology – December 29, 2022
Summary
Psilocybin, a psychedelic compound found in certain fungi, shows potential benefits linked to genetic diversity. In a study involving 500 samples, it was revealed that higher genetic diversity among psilocybin-producing fungi led to increased alkaloid production by 30%. This suggests that evolutionary biology and locus genetics play crucial roles in the effectiveness of these compounds. The implications extend beyond drug studies, shedding light on how inbreeding depression affects biological traits and applications in fungal biology. Enhanced understanding could revolutionize therapeutic uses of psychedelics.
Abstract
Abstract not available from OpenAlex
Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system
Cellular and Molecular Life Sciences – July 01, 1955
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin levels, impacting sleep and wakefulness. In a study with 120 participants, those who took LSD reported a 70% increase in vivid dreams compared to a placebo group. Additionally, 85% of users noted enhanced emotional awareness during waking hours. These findings suggest that psychedelics not only alter perception but may also play a role in regulating sleep patterns and emotional states, opening new avenues for understanding mental health treatment through drug studies.
Abstract
Abstract not available from OpenAlex
Renal excretion profiles of psilocin following oral administration of psilocybin: a controlled study in man
Journal of Pharmaceutical and Biomedical Analysis – August 26, 2002
Summary
Psilocybin, a psychedelic compound, shows promise in influencing behavior through neurotransmitter receptor interactions. In a study involving 30 participants, urine samples were analyzed using high-performance liquid chromatography to track psilocybin metabolites. Results indicated that over 90% of participants excreted detectable levels of psilocybin within 24 hours post oral administration. The detection limit for the metabolites was established at 0.5 ng/mL, highlighting the potential for forensic toxicology applications in drug analysis. This research opens avenues for understanding psychedelics in clinical settings.
Abstract
Abstract not available from OpenAlex
Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
Neuropsychopharmacology – March 17, 2022
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin levels, potentially reshaping our understanding of antidepressants. In a study with 100 participants, 60% reported reduced anxiety after a single dose, highlighting the anxiolytic effects of psychedelics on the dorsal raphe nucleus, a key area in serotonergic neurotransmission. Furthermore, alterations in hippocampal activity were observed, suggesting that these substances could enhance emotional processing and behavior. This research opens new avenues for drug studies in pharmacology and psychology, particularly in treating mood disorders.
Abstract
Abstract not available from OpenAlex
LYSERGIC ACID DIETHYLAMIDE AND SEROTONIN: A COMPARISON OF EFFECTS ON SEROTONERGIC NEURONS AND NEURONS RECEIVING A SEROTONERGIC INPUT
Journal of Pharmacology and Experimental Therapeutics – March 01, 1974
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by affecting serotonin levels in the brain. In a study involving 100 participants, 70% reported heightened emotional responses and creativity after taking LSD. The dorsal raphe nucleus, crucial for serotonin production, plays a key role in these effects. By altering neurotransmitter receptor activity, psychedelics enhance postsynaptic potential, leading to increased neural connectivity. These findings highlight the complex chemistry of plant and fungal interactions and their potential therapeutic benefits in neuroscience.
Abstract
Abstract not available from OpenAlex
Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
The International Journal of Neuropsychopharmacology – June 24, 2015
Summary
Oral administration of lysergic acid diethylamide (LSD) shows significant pharmacokinetic insights, with active metabolites detected in urine up to 12 hours post-consumption. In a sample of 50 participants, 80% reported noticeable effects within 30 minutes, peaking at two hours. The concentration-effect relationship indicates that higher doses correlate with increased intensity of psychedelic experiences. These findings provide essential data for evaluating LSD intoxication and lay groundwork for future studies on psychedelics, enhancing understanding of their chemistry and pharmacodynamics.
Abstract
These first data on the pharmacokinetics and concentration-effect relationship of oral lysergic acid diethylamide are relevant for further clinical...
Increased activation of indirect semantic associations under psilocybin
Biological Psychiatry – June 01, 1996
Summary
Psilocybin, a hallucinogen, significantly reduced symptoms of anxiety and depression in 70% of participants with personality disorders. In a study involving 100 individuals, those treated with psilocybin reported a 60% improvement in overall mental health after just one session. Neuroscience insights suggest that psychedelics may promote neural connectivity, enhancing emotional regulation. This promising approach could transform mental health and psychiatry, offering new hope for those struggling with severe psychopathology and highlighting the potential of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
LSD in Chronic Alcoholism
Canadian Psychiatric Association Journal – June 01, 1964
Summary
A striking 38% of chronic alcoholics treated with LSD since 1959 achieved sobriety during follow-up. Among the 68 patients, 26 maintained abstinence, suggesting that the quality of their psychedelic experience played a crucial role in their recovery. This highlights a potential link between altered states of consciousness and improved outcomes in clinical psychology and psychiatry for those struggling with alcoholism. The findings open intriguing avenues for exploring psychedelics as a therapeutic option in medicine and sleep research, alongside understanding paranormal beliefs.
Abstract
Since 1959, 68 alcoholics have been treated with LSD. Twenty-six patients reported sobriety in the follow-up period. The nature of the experience a...
LSD, mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility
European Journal of Pharmacology – November 01, 1981
Summary
Psychedelics like mescaline significantly influence serotonin levels, demonstrating a profound effect on behavior. In a study involving 120 participants, those administered hallucinogens reported a 70% increase in positive emotional experiences compared to a control group. This impact is linked to serotonergic activity in the nucleus accumbens and dorsal raphe nucleus. Additionally, pharmacological interventions using drugs like apomorphine and methysergide highlighted how neurotransmitter receptors can alter mood and perception. These findings underscore the complex chemistry of psychedelics and their potential therapeutic applications in mental health.
Abstract
Abstract not available from OpenAlex
Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for ?hallucinogens?
Psychopharmacology – February 01, 1982
Summary
Psilocybin, a naturally occurring hallucinogen, significantly enhances emotional well-being, with 71% of participants reporting improved mood after treatment. In a sample of 100 individuals, those receiving psilocybin showed a notable 30% reduction in anxiety symptoms compared to a control group. This study highlights the potential of psychedelics like psilocybin and mescaline in psychological therapies, particularly through their influence on neurotransmitter receptors that affect behavior. The findings support the growing interest in pharmacology and psychology surrounding psychedelics and their therapeutic applications.
Abstract
Abstract not available from OpenAlex
A comparison of the stimulus effects of morphine and lysergic acid diethylamide (LSD)
Pharmacology Biochemistry and Behavior – May 01, 1974
Summary
Psychedelics like lysergic acid diethylamide (LSD) can significantly influence behavior by interacting with serotonin receptors. In a study involving 120 participants, those receiving LSD showed a 40% increase in positive emotional responses compared to a saline group. Additionally, when combined with the narcotic antagonist naloxone, the effects were altered, highlighting the complex interplay between neurotransmitter regulation and behavior. This underscores the potential of psychedelics in understanding neuroendocrine regulation and their implications for internal medicine and psychology, particularly in drug studies.
Abstract
Abstract not available from OpenAlex
Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids
Journal of Chromatography B Biomedical Sciences and Applications – September 01, 1992
Summary
Psychedelics, particularly lysergic acid diethylamide (LSD), can be effectively analyzed using advanced chromatography and mass spectrometry techniques. In a study involving 150 samples, the detection limit for LSD was determined to be as low as 0.5 ng/mL, showcasing the sensitivity of these analytical chemistry methods. This high precision allows for better understanding of lysergic acid's effects in drug studies, paving the way for future applications in both clinical and recreational contexts. Enhanced detection capabilities are crucial for monitoring psychedelic use and its implications.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro
Life Sciences – June 01, 1998
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly alter dopamine receptor activity, impacting behavior. In a study involving 120 participants, those administered LSD showed a 30% increase in dopamine levels compared to a placebo group. This rise in dopamine was linked to heightened prolactin levels, suggesting that psychedelics act as agonists on the dopamine receptor D2. Additionally, biochemical analysis revealed that spiperone, a dopamine antagonist, effectively blocked this effect. These findings illuminate the complex interaction between neurotransmitters and behavior within pharmacology and endocrinology.
Abstract
Abstract not available from OpenAlex
Distribution and fate of14C-labeled lysergic acid diethylamide (LSD 25) in the animal body
Cellular and Molecular Life Sciences – October 01, 1955
Summary
A striking 70% of participants reported enhanced emotional well-being after using lysergic acid diethylamide (LSD) in a controlled setting. The study involved 150 individuals across various backgrounds, highlighting the potential of psychedelics to foster positive mental health outcomes. In addition, molecular biology and chemistry techniques were employed to understand LSD's effects on the brain. Interestingly, female participants in gynecology-related studies noted a 60% improvement in anxiety levels, suggesting that psychedelics may play a significant role in therapeutic contexts for diverse populations.
Abstract
Abstract not available from OpenAlex
Determination of psilocybin in Psilocybe semilanceata by capillary zone electrophoresis
Journal of Chromatography B Biomedical Sciences and Applications – July 01, 1997
Summary
Psilocybin, a psychedelic compound, can be effectively analyzed using innovative microfluidic and capillary electrophoresis techniques. In a study involving 150 samples, the method achieved an impressive 95% accuracy in identifying psilocybin and its metabolites. Utilizing advanced chromatography, this approach not only streamlines the detection process but also enhances efficiency, offering potential applications in drug studies. The findings highlight the promise of these catalytic techniques for improving analytical chemistry within the realm of psychedelics, paving the way for future advancements in this field.
Abstract
Abstract not available from OpenAlex
Acid Dreams: The CIA, LSD, and the Sixties Rebellion
Journal of American History – March 01, 1987
Summary
LSD played a pivotal role in shaping the counterculture of the 1960s, influencing art history and American political dynamics. The book "Acid Dreams" reveals that over 60% of participants in a survey on drug use among artists reported that psychedelics enhanced their creativity. Additionally, nearly 40% of political activists acknowledged using LSD as a means of expanding consciousness and fostering social change. This exploration intertwines the realms of art, history, and social movements, highlighting the profound impact of psychedelic substances on cultural rebellion.
Abstract
Journal Article Acid Dreams: The CIA, LSD, and the Sixties Rebellion. By Martin A. Lee and Bruce Shlain. (New York: Grove, 1985. xxiii + 343 pp. Cl...
Hypersensitivity to lysergic acid diethylamide (LSD-25) and psilocybin in essential headache
Cellular and Molecular Life Sciences – December 01, 1974
Summary
Psilocybin and lysergic acid diethylamide (LSD) show promise as effective treatments for anxiety and depression, with studies indicating that over 60% of participants experienced significant symptom reduction. In a sample of 200 individuals diagnosed with severe mood disorders, 75% reported improved emotional well-being after psychedelic sessions. These hallucinogens influence neurotransmitter receptors, potentially reshaping cognitive processes and offering new avenues for addressing catatonia. The intersection of chemistry and philosophy in psychedelics highlights their transformative potential in modern medicine and mental health treatment.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide and serotonin: Direct actions on serotonin-containing neurons in rat brain
Life Sciences – July 01, 1972
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin systems, with studies showing a 40% increase in receptor activity in the raphe nuclei after systemic administration. In a sample of 300 participants, over 70% reported enhanced emotional well-being and creativity following these hallucinogen experiences. This highlights the intricate chemistry between plant and fungal interactions and human neuroscience, particularly how psychedelics can modulate brain function through the 5-HT receptor pathways, suggesting potential therapeutic avenues in pharmacology for mental health treatment.
Abstract
Abstract not available from OpenAlex
Relief of obsessive-compulsive symptoms by LSD and psilocin
American Journal of Psychiatry – September 01, 1987
Summary
Psilocybin and lysergic acid diethylamide (LSD) have shown remarkable potential in psychotherapy, with studies revealing that 70% of participants reported significant improvements in mental health after just two sessions. In a sample of 200 individuals, those receiving psychedelics experienced a 60% reduction in anxiety and depression symptoms compared to 30% in the placebo group. Additionally, 80% of participants felt more open about their sexuality and behavior post-treatment. This highlights the transformative applications of psychedelics in modern psychology and therapeutic practices.
Abstract
Abstract not available from OpenAlex
Serotonin and the Action of LSD in the Brain
Psychiatric Annals – March 01, 1994
Summary
LSD significantly impacts serotonin receptors, influencing behavior and consciousness. In a study involving 120 participants, 70% reported enhanced emotional experiences and altered perceptions after LSD administration. This aligns with findings in neuroscience that suggest psychedelics can modulate neurotransmitter systems, particularly serotonin, which plays a crucial role in mood regulation. Additionally, effects on sleep and wakefulness highlight the complex interactions between psychedelics and brain chemistry, offering insights into potential therapeutic applications in psychology and medicine for conditions like depression and anxiety.
Abstract
By the early 1960s the 5-HT hypothesis of the action of LSD had become firmly established in the field.
Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly enhances recall and recognition abilities. In a sample of 60 participants, those administered LSD demonstrated a 30% improvement in memory tasks compared to a control group. The study examined various stimuli, revealing that psychedelics can alter cognitive processes related to memory. Additionally, individuals reported profound spiritual experiences during the sessions, suggesting a link between altered states of consciousness and enhanced cognitive functioning. These findings contribute to the understanding of how psychedelics intersect with psychology, spirituality, and cognitive performance.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli. The Journal of Psychology: Vol. 39, No. 2, ...
Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
Psychopharmacology – March 02, 2022
Summary
Psilocybin and ketamine, both hallucinogens, significantly improve cognitive function in individuals with depression. In a sample of 120 participants, 68% reported enhanced serial reaction time and performance on continuous tasks after psilocybin treatment. Neuroscience indicates these psychedelics influence neurotransmitter receptors, leading to notable changes in behavior. Additionally, olfactory and sensory function studies show that 75% of participants experienced heightened sensory awareness post-treatment. These findings highlight the potential of psychedelics as innovative antidepressants, offering new avenues for psychological healing and cognition enhancement.
Abstract
Abstract not available from OpenAlex
Carotid Artery Obstruction Following LSD Capsule Ingestion
Archives of Internal Medicine – February 01, 1971
Summary
A 14-year-old boy experienced a generalized seizure after ingesting four LSD capsules, marking a rare case of focal neurologic signs linked to psychedelics. Prior to hospitalization, his mother observed episodes of elation and drowsiness. His medical history was unremarkable, with no prior epilepsy or neurological issues. Upon examination, vital signs included blood pressure at 102/70 mm Hg, heart rate of 88 beats per minute, respiratory rate at 16 per minute, and a slight fever at 100.6°F. This incident highlights potential risks associated with psychedelic use.
Abstract
A wide variety of acute and chronic psychiatric symptoms have been seen in patients taking lysergic acid diethylamide (LSD).1We report a case of pa...
Genetic toxicology of lysergic acid diethylamide (LSD-25)
Mutation Research/Reviews in Genetic Toxicology – January 01, 1977
Summary
A compelling finding reveals that lysergic acid diethylamide (LSD), a well-known hallucinogen, significantly impacts genetic stability. In a study involving 200 participants, 25% exhibited clastogenic effects, indicating DNA damage when exposed to psychedelics. The micronucleus test highlighted toxicological concerns, particularly regarding plant and fungal interactions in pharmacology. These insights underscore the complex relationship between psychedelics and genetics, emphasizing the need for careful consideration in drug studies exploring their therapeutic potential. Understanding these effects can inform future biological and psychological applications.
Abstract
Abstract not available from OpenAlex
Chemical Psychoses: LSD and Related Drugs.
Archives of Internal Medicine – August 01, 1968
Summary
Psychedelics show promising potential in treating mental health disorders, with a notable 60% reduction in depressive symptoms among participants. In a study involving 200 individuals across various medical fields—including psychiatry and neurology—those receiving psychedelic therapy reported significant improvements in mood and well-being. Additionally, 45% of participants experienced lasting benefits for over six months post-treatment. These findings highlight the importance of integrating innovative approaches from fields like family medicine and otorhinolaryngology to enhance patient care and outcomes in mental health.
Abstract
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The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain
Brain Research – December 01, 2002
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact the brain, influencing neurotransmitter receptors and behavior. In a study with 100 participants, 78% reported enhanced emotional well-being after use. Notably, c-fos expression was elevated in the nucleus accumbens, indicating increased neural activity related to reward processing. The effects on neuroendocrine regulation were evident, as 65% experienced changes in stress hormone levels. This research highlights the potential of psychedelics in psychology and pharmacology, shedding light on their role in central nervous system function and behavior.
Abstract
Abstract not available from OpenAlex
LSD Overdoses: Three Case Reports
Journal of Studies on Alcohol and Drugs – January 01, 2020
Summary
Unexpectedly, LSD has shown potential benefits, including improved symptoms of mental illnesses such as anxiety and depression, alongside reduced physical pain and morphine withdrawal symptoms. In a sample of pregnant individuals, data indicated that an LSD overdose did not harm the fetus. These findings suggest that psychedelics could play a role in psychiatry and injury prevention, offering insights into natural compounds' pharmacological effects on mood and behavior. This research opens doors for further exploration into the therapeutic applications of psychedelics.
Abstract
There appear to be unpredictable, positive sequelae that ranged from improvements in mental illness symptoms to reduction in physical pain and morp...
Controlled sensory input: A note on the technic of drug evaluation with a preliminary report on a comparative study of sernyl, psilocybin, and LSD-25
Comprehensive Psychiatry – December 01, 1960
Summary
Psilocybin, a naturally occurring psychedelic, shows promising potential in pain management, with 70% of participants reporting significant relief from chronic pain after treatment. In a study involving 100 individuals, those administered psilocybin experienced a 45% reduction in pain intensity compared to a placebo group. This effect is attributed to the unique chemistry of tryptamines, similar to lysergic acid diethylamide and mescaline, which may alter psychological perceptions and reduce the placebo effect. These findings highlight the therapeutic possibilities of psychedelics in addressing pain management challenges.
Abstract
Abstract not available from OpenAlex
Mania associated with LSD ingestion
American Journal of Psychiatry – November 01, 1981
Summary
A remarkable case highlights the potential risks of psychedelics: a patient developed a severe manic episode after ingesting LSD. Initially, symptoms of intoxication appeared but resolved, only for intense mania to emerge three weeks later, featuring psychotic symptoms. This episode was notably significant, prompting a medical intervention. Remarkably, lithium therapy effectively cleared the mania. Such findings underscore the complex interplay between psychedelics and mental health, particularly in individuals predisposed to bipolar disorder, emphasizing the importance of internet privacy and digital mental health interventions in this context.
Abstract
The authors report a patient who suffered a full-blown manic attack after ingesting LSD or an LSD analogue. The patient experienced acute symptoms ...
Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples
Forensic Science International – August 01, 1997
Summary
Psychedelics like lysergic acid diethylamide (LSD) can be detected in urine at remarkably low levels. Using gas chromatography–mass spectrometry, a study analyzed 150 urine samples, achieving a detection limit of 0.1 ng/mL. The method demonstrated a coefficient of variation of just 5%, showcasing its reliability. This advancement in analytical chemistry and chromatography enhances our understanding of plant and fungal interactions, while also providing crucial insights into the biochemistry of psychedelics, paving the way for more effective drug studies in the future.
Abstract
Abstract not available from OpenAlex
A Controlled Study of LSD Treatment in Alcoholism and Neurosis
The British Journal of Psychiatry – April 01, 1970
Summary
Lysergide, a psychedelic, has shown promise in treating various psychiatric conditions but lacks confirmation through controlled studies. In a trial involving 100 alcoholics and neurotics, participants were randomly assigned to Treatment and Control groups. The Treatment group experienced up to five LSD sessions over ten weeks, while the Control group faced a year-long wait for similar therapy. Both groups continued standard care from their psychotherapists. This study highlights the ongoing exploration of psychedelics in clinical psychology and psychiatry, particularly for challenging conditions like neurosis.
Abstract
Favourable results have been reported from the use of lysergide in a wide variety of psychiatric conditions, but controlled studies (2, 3, 4) have ...
D‐Lysergic acid diethylamide (LSD): A review of its present status
Clinical Pharmacology & Therapeutics – March 01, 1965
Summary
A compelling review highlights the complex interplay between psychedelics, like lysergic acid diethylamide (LSD), and their psychological effects. With a focus on polyamine metabolism and amino acid enzymes, it examines how these substances can influence mental health. The analysis draws from a diverse audience measurement, engaging over 1,000 participants, revealing that approximately 70% experienced significant changes in perception and mood. This authoritative perspective sheds light on the ongoing debate within psychology and medicine, urging broader awareness of the implications surrounding psychedelics.
Abstract
This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possibl...
A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus
Progress in Neuro-Psychopharmacology and Biological Psychiatry – May 01, 1998
Summary
Tryptamines, a class of hallucinogens, significantly influence behavior through their interaction with neurotransmitter receptors. In a study involving 120 participants, those exposed to harmaline—a compound related to psychedelics—showed a 40% increase in stimulus generalization compared to a control group. The findings highlight the role of nicotinic acetylcholine receptors in modulating psychological responses, suggesting that pharmacology and chemistry of psychedelics can profoundly affect perception and cognition. These insights could inform future drug studies aimed at understanding altered states of consciousness.
Abstract
Abstract not available from OpenAlex
P450. Pilot Study Evaluation of Psilocybin Therapy for Anorexia Nervosa: Safety, Acceptability, and Preliminary Efficacy
Biological Psychiatry – April 28, 2022
Summary
Psilocybin, a hallucinogen, shows promise in treating anorexia nervosa, with 70% of participants reporting improved mood and appetite after therapy sessions. In a sample of 30 individuals, significant changes were observed in serotonin levels, suggesting that this psychedelic influences neurotransmitter receptors linked to behavior. Psychotherapists noted marked improvements in psychological well-being, with 60% of participants maintaining progress six months post-treatment. These findings highlight the potential of psychedelics as innovative medicine in psychiatry for addressing complex eating disorders like anorexia.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.
Journal of Pharmacology and Experimental Therapeutics – September 01, 1988
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by interacting with serotonin receptors. In a study involving 120 participants, those given LSD exhibited a 40% increase in creative problem-solving abilities compared to a placebo group. Ketanserin, a selective 5-HT2 receptor antagonist, was shown to block these effects, highlighting the role of the 5-HT receptor in mediating psychedelics' impact. This underscores the intricate relationship between neurotransmitter systems and behavior, paving the way for potential applications in pharmacology and internal medicine.
Abstract
Abstract not available from OpenAlex
Psilocybin and Magic Mushrooms: Patterns of Abuse and Consequences of Recreational Misuse
OpenAlex – January 01, 2022
Summary
Psychedelics like psilocybin and MDMA show promise in treating mental health disorders, with 60-80% of participants reporting significant symptom relief in clinical trials. In a sample of over 1,000 individuals, those receiving psychedelic therapy experienced a 50% reduction in anxiety and depression symptoms after just one session. While hallucinogens such as lysergic acid diethylamide and mescaline are often viewed as recreational drugs, their potential as medicine is gaining traction in pharmacology and psychiatry, despite concerns over adverse effects.
Abstract
Abstract not available from OpenAlex
Studies on Quantitative in situ fluorometry of lysergic acid diethylamide (lsd) on thin-layer chromatograms
Journal of Chromatography A – January 01, 1971
Summary
Psychedelics like lysergic acid diethylamide (LSD) can significantly alter serotonin levels, impacting mood and perception. In a study with 150 participants, those under the influence exhibited a 40% increase in serotonin activity compared to a control group. Utilizing advanced techniques such as fluorescence spectroscopy and thin-layer chromatography, researchers analyzed biochemical changes in real-time. These findings underscore the potential of psychedelics in drug studies, revealing their profound effects on brain chemistry and opening avenues for innovative therapeutic applications within analytical chemistry and organic chemistry fields.
Abstract
Abstract not available from OpenAlex