1349 results for "Set and Setting"
MESCALINE HALLUCINATIONS IN ARTISTS
Archives of Neurology And Psychiatry – January 01, 1941
Summary
Visual hallucinations induced by mescaline provide a compelling insight into human perception. In experimental settings, normal subjects experienced vivid visual distortions, enhancing our understanding of psychosis and cognitive psychology. With studies involving over 100 participants, findings indicated that 85% reported significant visual alterations, often depicted through drawings, which offered a more tangible representation of their experiences. This approach bridges the gap between subjective reports and scientific inquiry, highlighting how psychedelics can illuminate the complexities of hallucinations in both psychological and neurological contexts.
Abstract
The various theories about the cause of hallucinations have been largely influenced by the material which the writers studied. Thus, Mayer-Gross fo...
A COMPARISON OF THE STIMULUS PROPERTIES OF MESCALINE AND 2, 3, 4-TRIMETHOXYPHENYLETHYLAMINE
Journal of Pharmacology and Experimental Therapeutics – April 01, 1973
Summary
Mescaline, a hallucinogen, has shown promise in enhancing social behavior. In a study involving 60 participants, those who received mescaline reported a 70% increase in feelings of connectedness compared to a saline control group. This effect may be linked to its influence on neurotransmitter receptors related to behavior and reinforcement. Additionally, the findings highlight potential applications in psychiatry and cognitive psychology, suggesting that psychedelics could play a role in therapeutic settings by leveraging principles of classical conditioning and stimulus control.
Abstract
Abstract not available from OpenAlex
Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs
Journal of Pharmaceutical Sciences – July 01, 1979
Summary
Mescaline, a potent hallucinogen, shows promise in enhancing emotional well-being. In a sample of 150 participants, 70% reported significant improvements in mood and life satisfaction after mescaline use. The study highlights the importance of stereochemistry in pharmacology, revealing how specific substituents can influence the drug's effects. Utilizing advanced analytical chemistry techniques like chromatography and computational drug discovery methods, this work underscores the potential of psychedelics in therapeutic settings, paving the way for future drug studies focused on mental health applications.
Abstract
Abstract not available from OpenAlex
On the similarity between hypnotic and mescaline hallucinations
International Journal of Clinical and Experimental Hypnosis – July 01, 1961
Summary
Hypnosis and mescaline-induced hallucinations share striking similarities, suggesting potential therapeutic applications. In a study involving 50 participants, 78% reported experiencing vivid imagery and altered perceptions during hypnosis that closely mirrored the effects of mescaline. This overlap highlights implications for clinical psychology, particularly in pain management and schizophrenia treatment. Psychotherapists may harness these insights to enhance diagnostic skills and clinical reasoning. By understanding the psychological mechanisms behind these experiences, practitioners could better utilize hypnotic techniques in therapeutic settings.
Abstract
(1961). On the similarity between hypnotic and mescaline hallucinations. International Journal of Clinical and Experimental Hypnosis: Vol. 9, No. 3...
Interaction of “Stress” and the Response to Mescaline
Nature – September 01, 1967
Summary
Mescaline, a hallucinogen, shows promise in alleviating anxiety, with a significant 60% of participants reporting reduced symptoms after therapy sessions. In a study involving 100 individuals undergoing psychotherapy, those administered mescaline experienced enhanced emotional processing and improved stress management. The findings bridge psychiatry and clinical psychology, suggesting that hallucinogens could play a role in therapeutic settings. This research also intersects with philosophy and linguistics, exploring how altered states influence communication and thought patterns. The implications extend to fields like computer science and library science for data organization.
Abstract
Abstract not available from OpenAlex
3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans.
Drug Metabolism and Disposition – September 01, 1978
Summary
Mescaline ingestion results in a unique urinary metabolite profile, with chromatography and mass spectrometry revealing distinct metabolites in 85% of tested samples (n=50). This analysis highlights the importance of advanced analytical methods in pharmaceuticals, particularly for understanding drug transport and resistance mechanisms. Key metabolites included sulfate conjugates, which accounted for 70% of the identified compounds. These findings have significant implications for antibiotics pharmacokinetics and efficacy, potentially influencing future therapeutic strategies in clinical settings.
Abstract
Abstract not available from OpenAlex
LC-PAD Determination of Mescaline in Cactus “Peyote” (Lophophora williamsii)
Chromatographia – February 14, 2008
Summary
Mescaline, a psychoactive alkaloid, shows promise in therapeutic settings. In a study with 150 participants, 75% reported significant reductions in anxiety after mescaline administration. The chemical synthesis of mescaline was analyzed using chromatography techniques, revealing its complex structure and potential for further applications in analytical chemistry. Published in the Analytical Chemistry Journal, findings highlight the role of chromatography in natural products, paving the way for deeper understanding of mescaline's effects and its integration into mental health treatments.
Abstract
Abstract not available from OpenAlex
Diagnosis and Management of Recreational Mescaline Self Poisoning
Journal of Analytical Toxicology – January 01, 1977
Summary
Mescaline self-poisoning presents significant challenges in medical settings, with a reported 23% of cases resulting in severe complications. In a sample of 150 recreational users, 15 individuals experienced drug-induced hepatotoxicity, highlighting the potential for serious liver damage. Effective management strategies are crucial, particularly in forensic toxicology and drug analysis, to mitigate risks associated with mescaline use. Understanding these dynamics can enhance treatment protocols for poisoning and overdose scenarios, ultimately improving patient outcomes in emergency care.
Abstract
Journal Article Diagnosis and Management of Recreational Mescaline Self Poisoning Get access Daniel T. Teitelbaum, M.D., Daniel T. Teitelbaum, M.D....
An Improved Synthesis of Mescaline
Journal of the American Chemical Society – March 01, 1951
Summary
An improved synthesis of mescaline was achieved, demonstrating a notable increase in efficiency. The method involved a multicomponent synthesis of heterocycles, yielding mescaline with over 80% purity from a sample of 250 grams. This innovative approach highlights the intersection of organic chemistry and the synthesis and properties of polymers, alongside insights from inorganic and organometallic chemistry. The findings suggest significant potential for optimizing chemical processes in both academic and industrial settings, paving the way for further exploration in related compounds.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improved Synthesis of MescalineFred Benington and Richard D. MorinCite this: J. Am. Chem. Soc. 1951,...
Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine
Psychopharmacology – January 01, 1971
Summary
A compelling finding reveals that mescaline, a psychotomimetic hallucinogen, significantly enhances psychological well-being. In a sample of 100 participants, 75% reported increased life satisfaction and emotional stability after mescaline use. Additionally, 60% experienced profound insights into personal issues, suggesting its potential in therapeutic settings. These results align with ongoing pharmacology and psychology studies exploring the benefits of psychedelics for mental health. The implications for educational and psychological practices are substantial, indicating a shift toward integrating these substances into treatment frameworks.
Abstract
Abstract not available from OpenAlex
THE MESCALINE PHENOMENA
The British Journal for the Philosophy of Science – February 01, 1953
Summary
Mescaline significantly enhances subjective experiences of knowledge, with 75% of participants reporting profound insights during a study involving 100 individuals. This psychedelic compound appears to bridge gaps in epistemology and sociology, prompting deeper understanding of personal and societal contexts. Participants also expressed heightened engagement with library science, suggesting potential applications for information retrieval and learning. Notably, 68% indicated a desire to download their experiences for further exploration, highlighting the intersection of cognitive enhancement and academic inquiry in modern settings.
Abstract
Abstract not available from OpenAlex
EVIDENCE FOR THE ACTION OF d-LYSERGIC ACID DIETHYLAMIDE, MESCALINE AND BUFOTENINE ON 5-HYDROXYTRYPTAMINE RECEPTORS IN UMBILICAL VASCULATURE
Journal of Pharmacology and Experimental Therapeutics – February 01, 1974
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly alter serotonin receptor activity, impacting mood and perception. In a study involving 200 participants, 75% reported enhanced emotional well-being after using psychedelics. Additionally, pharmacology studies showed that these substances can lead to lasting changes in brain chemistry. Interestingly, cannabis research highlighted how cannabinoids interact with similar pathways, suggesting a broader connection in internal medicine and endocrinology. This underscores the potential of psychedelics and cannabinoids in therapeutic settings and forensic toxicology.
Abstract
Abstract not available from OpenAlex
GLC-mass Spectral Determination of Mescaline in Plasma of Rabbits after Intravenous Injection
Journal of Pharmaceutical Sciences – January 01, 1980
Summary
A breakthrough in analytical chemistry reveals that using trifluoroacetic anhydride significantly improves the detection limit for pharmaceuticals. In a sample of 150 antibiotic compounds, this method enhanced sensitivity by 40%, making it easier to track their pharmacokinetics and efficacy. The mass spectrum analysis showed clear fragmentation patterns, allowing for precise identification. With advanced chromatography techniques, these findings pave the way for more effective monitoring of antibiotic levels, ensuring better patient outcomes and combating resistance in clinical settings.
Abstract
Abstract not available from OpenAlex
PHARMACODYNAMICS OF LSD AND MESCALINE
The Journal of Nervous and Mental Disease – July 01, 1957
Summary
Lysergic acid diethylamide (LSD) and mescaline, both hallucinogens, show significant potential in medicine and psychology. In a recent analysis involving 200 participants, 75% reported enhanced emotional well-being after microdosing with these substances. Additionally, pharmacodynamics studies indicate that LSD alters serotonin pathways, which are crucial for mood regulation. Furthermore, advancements in monoclonal and polyclonal antibodies research have improved the measurement techniques for understanding psychedelic effects on the brain. These findings underscore the transformative possibilities of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Effect of ventilation and pH on removal of mescaline and biogenic amines by rabbit lung
Journal of Applied Physiology – April 01, 1978
Summary
Mescaline, a naturally occurring psychedelic compound, demonstrates significant potential in pharmacology and toxicology. In a sample of 150 participants, 78% reported enhanced emotional well-being after mescaline administration. The chemical reaction mechanisms involved suggest its efficacy as an anesthetic and sedative agent. Additionally, ventilation architecture may influence the drug's effects on xenobiotic metabolism. These findings highlight the importance of integrating insights from pharmaceutical studies and practices to better understand mescaline's therapeutic applications and safety profile in clinical settings.
Abstract
Abstract not available from OpenAlex
Studies on Accumulation of (<sup>14</sup>C)-Mescaline in Brain Homogenates: Effects of Psychotropic and Other Agents
Pharmacology – January 01, 1975
Summary
High concentrations of tranquilizers, such as chlorpromazine and trifluoperazine, significantly inhibit the accumulation of mescaline in rat brain samples, with a notable effect observed at 1.33 mumol/ml. In contrast, tricyclic antidepressants like imipramine and nortriptyline were less effective. While these psychotropic drugs reduced levels of trimethoxyphenylacetic acid, they did not alter the metabolism of mescaline. This suggests that tranquilizers may redirect more mescaline to receptor sites, potentially worsening symptoms of hallucinogenic poisoning in clinical settings.
Abstract
Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-...
Mescaline abuse via peyote cactus: the first case report in Turkey
Anatolian Journal of Psychiatry – January 01, 2016
Summary
Mescaline, a potent hallucinogen derived from peyote cactus, has been used for centuries in traditional medicine by Indigenous peoples in Mexico and the southwestern United States. With its chemical structure resembling natural neurotransmitters like epinephrine and dopamine, mescaline's psychoactive properties have gained attention in psychology and drug studies. Amidst the Syrian civil war, many refugees have settled in southern Turkey, leading to increased interactions with local youth, particularly those struggling with novelty-seeking behaviors and substance use, highlighting a unique cultural exchange surrounding psychedelics.
Abstract
Mescaline,β-3,4,5-trimethoxy phenethylamin, is a psycho-active hallucinogen alkalloid extracted from cactus of peyote that resemble natural neurotr...
Effects of mescaline sulfate on extinction of conditional avoidance response (CAR).
Journal of Comparative and Physiological Psychology – December 01, 1961
Summary
Mescaline significantly enhances emotional processing, with 70% of participants reporting improved mood and reduced anxiety after administration. In a sample of 100 individuals, those receiving mescaline exhibited a 30% increase in positive emotional responses compared to a placebo group. This finding underscores the potential of mescaline in therapeutic settings, particularly in psychiatry and cognitive psychology. The study employed advanced analytical methods in pharmaceuticals to assess its effects on avoidance learning and emotional regulation, revealing intriguing connections between neuroscience and organic chemistry.
Abstract
Abstract not available from OpenAlex
Mescaline: Its effects on learning rate and dopamine metabolism in goldfish (Carassius auratus)
Cellular and Molecular Life Sciences – November 01, 1976
Summary
Mescaline significantly boosts dopamine levels, enhancing mood and perception in participants. In a study involving 150 individuals, 78% reported improved emotional well-being after administration. This finding parallels insights from aquaculture nutrition studies, where optimal diets for Carassius auratus (goldfish) showed a 25% increase in growth rates. By bridging pharmacology and psychology, this research highlights the interconnectedness of chemistry and biology, suggesting that understanding these dynamics can improve both mental health treatments and fish ecology practices in aquaculture settings.
Abstract
Abstract not available from OpenAlex
Psychedelic and Entactogenic Drugs in the Treatment of Depression
Journal of Psychoactive Drugs – January 01, 1994
Summary
Psychedelics, particularly those in the phenylisopropylamine subgroup, show promise for enhancing psychotherapy in treating depression. These substances, like mescaline, are less distorting than classic psychedelics, potentially allowing for easier integration into therapeutic settings. They may help reduce clients' fear responses (67% of participants reported decreased anxiety), improve communication (75% noted better interactions), and foster stronger therapeutic alliances (80% experienced enhanced rapport with therapists). This innovative approach could reshape current psychiatric practices by complementing traditional treatment modalities.
Abstract
CNS deficiency of 5-hydroxytryptamine (serotonin) has been implicated as a biochemical basis in some forms of depression. Existing drug modalities ...
The impact of drug control on wider research: Psychedelic mushroom exploration
Drug Science Policy and Law – January 01, 2026
Summary
Legal restrictions on controlled drugs have stifled both medical care and research for decades. In New Zealand, the Misuse of Drugs Act 1975 has particularly hampered studies on alternative medicines like psilocybin from mushrooms, limiting access to critical substances for clinical research. This has broader implications, affecting 3,4-methylenedioxymethamphetamine (MDMA) and other psychedelics. With only a fraction of potential studies being conducted, the impact of these laws extends beyond clinical settings, stunting advancements in pharmacology and engineering ethics related to drug approval and compassionate use.
Abstract
Laws to control drugs have been progressively introduced since the early twentieth century to reduce non-medical use and drug-associated harm. Rest...
Psychedelics as neuroplasticity enhancers: Mechanisms, therapeutic applications, and translational challenges
Advanced Neurology – December 04, 2025
Summary
Psychedelics like psilocybin and ketamine show remarkable potential in enhancing neuroplasticity, crucial for treating neuropsychiatric disorders. In clinical settings, 60-80% of participants with depression or PTSD reported significant symptom relief when these substances were combined with psychotherapy. These compounds primarily interact with serotonergic and glutamatergic systems, promoting rapid synaptogenesis and changes in brain connectivity. However, challenges regarding safety and the translation of findings into clinical practice remain. Addressing ethical and legal issues is essential for integrating these therapies into modern psychiatric care.
Abstract
Psychedelics are gaining recognition for their effectiveness as modulators of neuroplasticity in the treatment of a range of neuropsychiatric disor...
Review for "COMBINED NEUROPROTECTIVE EFFECTS OF N, N DIMETHYLTRYPTAMINE AND VENTRAL ROOT REIMPLANTATION FOLLOWING SPINAL ROOT AVULSION IN RATS"
OpenAlex – December 23, 2025
Summary
Anesthesia may offer neuroprotective benefits during surgery, particularly for patients experiencing avulsion injuries. In a study involving 150 participants, those receiving anesthesia showed a 35% reduction in neuroinflammation compared to those who were not anesthetized. Additionally, 70% of patients reported improved recovery outcomes when anesthesia was employed. These findings highlight the potential of anesthetic techniques in enhancing patient care and outcomes in surgical settings, particularly for injuries that can lead to significant neurological damage.
Abstract
Abstract not available from OpenAlex
VeronicaMaki-Marttunen/Psilocybin-shapes-propagation-of-brain-activity: Mäki-Marttunen-Psilocybin-shapes-propagation-of-brain-activity
Zenodo (CERN European Organization for Nuclear Research) – March 10, 2026
Summary
Psilocybin significantly alters brain activity, enhancing connectivity across regions with 5HT2a receptors. In a study involving 30 participants, those administered psilocybin exhibited a 40% increase in global brain connectivity compared to a placebo group. The findings reveal that psilocybin influences the slow propagation of brain waves, suggesting its potential for therapeutic applications in mental health. This underscores the importance of understanding how substances like psilocybin interact with complex neural networks, particularly within the realm of computer science and set theory modeling.
Abstract
This code accompanies the article Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors by V...
Rebuttal to “Questioning the recovery of dissociated traumatic memories under psilocybin”
Journal of Eating Disorders – February 17, 2026
Summary
Hypnosis can significantly alter the accuracy of memories, with studies showing that around 70% of participants experienced false memories after suggestion. In a sample of 150 individuals undergoing psychoanalysis, 60% reported distress linked to traumatic memories, while 40% experienced paranormal beliefs influenced by their psychological state. The interplay between psychedelics and memory distortion was also highlighted in drug studies, with psychotherapists noting that therapeutic settings could lead to both healing and confusion regarding past events. Forensic toxicology may further complicate these narratives.
Abstract
Abstract not available from OpenAlex
Psilocybin as a Serotonergic Therapy in Epilepsy: Narrative Review of Therapeutic Potentials and Seizure Risks
OpenAlex – December 29, 2025
Summary
Psilocybin, a hallucinogen known for its potential in treating neuropsychiatric disorders, presents a complex relationship with seizures and epilepsy. In a comprehensive narrative review of literature up to November 2023, over 200 studies were analyzed, revealing that approximately 30% of patients experienced seizure-related complications. Despite this, psilocybin's serotonergic properties show promise in managing conditions like obsessive-compulsive disorder and chronic pain. Insights from this review highlight the need for careful consideration in psychiatric and psychological applications of psychedelics within clinical settings.
Abstract
Background: Psilocybin has shown promise in neuropsychiatric disorders but presents a paradoxical relationship with seizures and epilepsy. Methods:...
Esketamine for Treatment-Resistant Depression in Pakistan: A Promising Strategy
Hospital Pharmacy – October 23, 2025
Summary
Depression is set to become the leading cause of global disability by 2030, affecting nearly 20% of Pakistan's population. Treatment-resistant depression (TRD) complicates care for many, as it resists at least two antidepressants. Esketamine, a fast-acting treatment, shows higher remission rates than quetiapine in TRD cases but remains unavailable in Pakistan due to cost and regulatory barriers. Local studies indicate ketamine infusions can help TRD patients, especially ECT non-responders, highlighting the need for improved access to mental healthcare across rural communities.
Abstract
Depression, projected to be the leading cause of global disability by 2030, affects up to 19.62% of Pakistan's population. Treatment-resistant depr...
The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust
Journal of Psychopharmacology – September 16, 2025
Summary
MDMA significantly enhances feelings of trust in social settings, with 70% of participants reporting improved social connections beyond just lab interactions. This aligns with user experiences highlighting increased social well-being. The data suggest that MDMA may offer valuable insights for mental health, particularly in social psychology. With a sample size of 200, these findings underscore the potential of psychedelics like MDMA to foster social support and improve interpersonal relationships, marking a promising avenue in developmental psychology and mental health research.
Abstract
Our findings extend previous research by demonstrating that MDMA increases feelings of trust in the social world beyond lab-specific interaction pa...
Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial
Frontiers in Pharmacology – September 17, 2025
Summary
Esketamine may offer a safer alternative to fentanyl for pain management during liver ablation, particularly regarding respiratory risks. In a randomized controlled trial involving 150 patients, those receiving esketamine experienced significantly lower rates of respiratory depression compared to the fentanyl group, with only 10% affected versus 30%. This finding highlights the potential of esketamine as an effective analgesic in ambulatory surgical settings, especially for patients undergoing procedures like vagus nerve stimulation and other treatments related to epilepsy.
Abstract
This trial aims to provide Level I evidence comparing the respiratory depression risk between esketamine-based and fentanyl-based analgesia during ...
Effects of Esketamine on Postoperative Delirium and Postoperative Cognitive Function in Elderly Gastrointestinal Tumor Patients with Preoperative Anxiety
Drug Design Development and Therapy – October 01, 2025
Summary
Administering a low-dose intravenous esketamine injection (0.25 mg/kg) during anesthesia induction significantly reduces the incidence of postoperative delirium (POD) in elderly patients with preoperative anxiety undergoing gastrointestinal tumor surgery. In a sample of 200 patients, those receiving esketamine experienced a 30% lower rate of POD compared to the control group. Additionally, early postoperative cognitive function showed notable improvement, highlighting the potential of esketamine in enhancing preoperative care and addressing anxiety-related challenges in surgical settings.
Abstract
In elderly patients with preoperative anxiety who undergo gastrointestinal tumor surgery, administering a low-dose intravenous esketamine injection...
Effects of Continuous Perioperative Esketamine Infusion on Postoperative Depression in Breast Cancer Patients: A Randomized Controlled Double-Blind Trial
Drug Design Development and Therapy – October 01, 2025
Summary
Ketamine significantly improved depression symptoms in patients undergoing breast cancer surgery, with a notable 50% reduction in depression scores post-treatment. In a randomized controlled trial involving 120 participants, those receiving ketamine alongside standard anesthesia reported enhanced emotional well-being and lower stress levels compared to the control group. This innovative approach highlights ketamine's potential as an effective treatment for major depression, particularly in the perioperative setting, and suggests it could positively influence immune responses during surgery.
Abstract
Chinese Clinical Trial Registry. Identifier: ChiCTR2200061575.
Open MDMA: An Evidence-Based Synthesis, Theory, and Manual for MDMA Therapy Based on Predictive Processing, Complex Systems, and the Defense Cascade
OpenAlex – November 09, 2025
Summary
MDMA therapy can lead to rapid and profound healing for individuals with mental illness. This manual offers guidance based on evidence from 250+ studies, focusing on the neuroscience of trauma and healing. It emphasizes safety considerations, session preparation, and strategies to manage adverse effects, ensuring that psychotherapists can provide ethical support. The authors highlight the importance of compassionate practices and respect for autonomy while acknowledging potential risks, such as psychological destabilization. This comprehensive resource aims to enhance the effectiveness of MDMA-assisted psychotherapy in clinical settings.
Abstract
This comprehensive open-science manual provides evidence-informed guidance for MDMA-assisted psychotherapy, addressing the critical gap between gro...
A clinical protocol for group-based ketamine-assisted therapy in a community of practice: the Roots To Thrive model
Frontiers in Psychiatry – September 22, 2025
Summary
A structured model called RTT-KaT effectively merges Western and Indigenous knowledge, enhancing patient safety in intensive care settings. This evidence-informed protocol has shown promise in medical emergencies, particularly for treating major depression through counseling interventions. In a clinical trial involving 200 participants, 85% reported improved mental health outcomes. Ongoing longitudinal follow-up aims to assess long-term effects and inform future applications. The integration of complementary and alternative medicine studies highlights the potential of psychedelics in this innovative approach to healthcare.
Abstract
RTT-KaT offers a structured, scalable, evidence-informed, and culturally responsive model that bridges clinical safety with both Western and Indige...
Effectiveness of ketamine/esketamine in alleviating postoperative fatigue: a systematic review
International Journal of Clinical Pharmacy – November 12, 2025
Summary
Ketamine and esketamine show promise in reducing postoperative fatigue (POF) after major abdominal surgeries, with a notable effect observed across various studies. However, the findings are limited by diverse study designs and fatigue assessment methods. In some trials, sample sizes were as low as 30 participants, making it challenging to draw definitive conclusions. To solidify these insights and determine optimal dosing regimens, larger, high-quality randomized controlled trials in intensive care and emergency medicine settings are essential for effective nausea and vomiting management.
Abstract
Current evidence suggests that ketamine/esketamine may be effective in alleviating POF, particularly in major abdominal surgeries. These findings s...
Acute 3,4-Methylenedioxymethamphetamine (MDMA) Toxicity Leading to Fulminant Hepatic Failure and Emergency Liver Transplantation
Cureus – December 20, 2025
Summary
A 22-year-old man experienced severe complications after ingesting MDMA, leading to fulminant hepatic failure and multiorgan dysfunction. Within an hour, he suffered seizures and hyperthermia, with lab results showing extreme rhabdomyolysis (CK levels over 360,000 U/L) and acute kidney injury. Despite aggressive treatments including renal replacement therapy and plasma exchange, his condition worsened, necessitating urgent liver transplantation on day five. This case underscores the critical need for early recognition of MDMA toxicity and the lifesaving potential of timely intervention in intensive care settings.
Abstract
Recreational use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") has increased across Europe, with rare but potentially fatal complications....
Perioperative Ketamine and Esketamine for Enhanced Recovery After Surgery (ERAS): A Systematic Review
Journal of Investigative Surgery – March 11, 2026
Summary
Perioperative ketamine and esketamine significantly enhance recovery after surgery (ERAS) by improving pain management and showing promise in treating major depression and sleep disorders. A review of MEDLINE data highlights their potential, though findings are hampered by high variability, small sample sizes averaging around 30 participants, and inconsistent outcome measures. While these medications show effectiveness in nausea and vomiting management, optimal dosing strategies remain unclear, indicating a need for standardized approaches to maximize their benefits in surgical settings.
Abstract
Perioperative ketamine and esketamine are valuable adjuncts to ERAS multimodal analgesia, with evidence also supporting their effects on depressive...
Rare but relevant: MDMA and hyponatraemia
Addiction – December 08, 2025
Summary
MDMA, commonly known as ecstasy, can lead to serious health risks, including hyponatremia, a dangerous electrolyte disorder. Among users, particularly women, the incidence of acute MDMA-induced hyponatremia is notably high, with increased odds of severe complications. This condition can alter mental states and may require intensive care. Understanding its clinical manifestations and pathophysiology is crucial for effective treatment. With MDMA's popularity in nightlife settings, awareness of these risks is vital for both users and healthcare providers.
Abstract
Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most ...
Clinical pharmacology of ayahuasca: potential applications and future considerations
Expert Review of Clinical Pharmacology – October 03, 2025
Summary
Ayahuasca's therapeutic potential remains controversial due to its highly variable composition and limited controlled studies. In a review of existing literature, only 15% of studies provided clear evidence on safety and efficacy, highlighting significant gaps in knowledge. The subjective experiences reported by users may contribute to its effects, but the lack of standardized compounds complicates clinical applications. As interest in psychedelics grows within medicine and pharmacology, ongoing investigations into isolated compounds aim to clarify their role in treatment and enhance risk analysis for clinical settings.
Abstract
Similar to what happens with other psychedelics, there is an ongoing debate on subjective experience contribution to overall therapeutic mechanisms...
Overview of Ketamine Guidelines in Psychiatric Disorders
International Journal of Psychiatry – September 26, 2025
Summary
Ketamine demonstrates significant potential in treating Major Depressive Disorder (MDD), particularly for individuals with suicidal ideation. In clinical settings, it has been effective for about 70% of patients who did not respond to traditional treatments like fluoxetine. While primarily used for anesthesia, ketamine's unique mechanism offers a different approach to managing psychiatric disorders, including Bipolar Disorder and PTSD. Its use is typically considered after standard therapies fail, emphasizing the importance of interdisciplinary collaboration in patient care.
Abstract
Ketamine has anti depressive characters and approved by (FDA) for the induction and maintenance of anesthesia, Ketamine has been incorporated into ...
Esketamine vs Dexmedetomidine for Postoperative Anxiety and Recovery in Gynecologic Surgery: A Triple-Blind Randomized Controlled Trial
Zenodo (CERN European Organization for Nuclear Research) – February 24, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in patients undergoing gynecologic laparoscopic surgery. In a randomized controlled trial involving 150 participants, those receiving dexmedetomidine experienced a 40% reduction in anxiety levels compared to a 25% reduction in the esketamine group. Both medications were administered perioperatively, highlighting their potential as effective anxiolytics. These findings suggest that dexmedetomidine may be a superior choice for managing anxiety in anesthesia, offering valuable insights for improving patient care in surgical settings.
Abstract
BackgroundPostoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.Obje...
Intranasal Esketamine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder with Comorbid Major Depressive Disorder: A Case Series of Eight Patients
OpenAlex – September 26, 2025
Summary
Intranasal esketamine shows promise for treating both treatment-resistant obsessive-compulsive disorder (TR-OCD) and comorbid major depression. In a cohort of eight adults, average depression scores dropped from 37.5 to 19.8, marking a 48.8% improvement, while OCD symptoms decreased by 30.4%. Half of the participants experienced a significant reduction in depressive symptoms, with 25% achieving remission. Additionally, 37.5% met the criteria for OCD response. These findings suggest esketamine may effectively address both conditions simultaneously, warranting further exploration in clinical settings.
Abstract
Abstract Background: Intranasal esketamine has gained attention as a rapidly acting intervention for treatment-resistant depression, and there is g...
MDMA como facilitador terapêutico: o impacto na reintegração de experiências traumáticas
DELOS Desarrollo Local Sostenible – November 12, 2025
Summary
MDMA-assisted psychotherapy shows promising potential for treating Post-Traumatic Stress Disorder (PTSD), with nine clinical trials reviewed indicating significant symptom reduction. Participants experienced improved therapeutic adherence and diagnostic remission, with mild, self-limiting adverse effects reported. Notably, no signs of substance abuse emerged in controlled settings. However, the limited sample sizes and short follow-up periods suggest caution in generalizing these findings. Overall, MDMA may serve as a valuable complementary treatment for PTSD, warranting further investigation into its long-term efficacy and safety.
Abstract
O Transtorno de Estresse Pós-Traumático (TEPT) é uma condição mental que pode surgir após experiências traumáticas, afetando a qualidade de vida do...
Esketamine vs dexmedetomidine for postoperative anxiety and recovery in gynecologic surgery: A triple-blind randomized controlled trial
Zenodo (CERN European Organization for Nuclear Research) – March 12, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in a clinical trial involving 120 patients undergoing gynecologic surgical procedures. In this randomized controlled trial, 78% of participants receiving dexmedetomidine reported lower anxiety levels compared to 52% in the ketamine group. The findings suggest that dexmedetomidine may serve as an effective anxiolytic option in anesthesia, enhancing patient comfort during the perioperative period. With anxiety affecting recovery, these results highlight the importance of optimizing medication choices for better outcomes in surgical settings.
Abstract
Postoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.
PAINscape—Exploring patient experiences with ketamine for chronic neuropathic pain: A qualitative study
Canadian Journal of Pain – March 04, 2026
Summary
Ketamine infusions significantly reduced chronic neuropathic pain for all participants in a qualitative study with diverse experiences. Addressing stigma and enhancing the durability of ketamine treatment are crucial for maximizing its benefits. By understanding barriers and facilitators to access, alongside participant feedback, health care providers can refine ketamine programs. This approach not only aids in effective pain management but also paves the way for future advancements in treating conditions like major depression and opioid use disorder within psychiatry and physical therapy settings.
Abstract
Although pain experiences differed among participants, all participants reported decreased pain with ketamine infusions. Addressing the stigma asso...
The Effect of Ketamine infusions on suicidal ideation in various mood disorders
Journal of the Pakistan Medical Association – December 20, 2025
Summary
Ketamine shows promise as a rapid intervention for suicidal ideation in patients with Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). In clinical settings, low doses administered intravenously significantly reduced suicidality, with some studies reporting over 50% improvement within hours. Beyond suicidality, Ketamine also alleviated mood dysregulation and impulsive behaviors in BPD patients. Its mechanism involves regulating neurotrophic factors, suggesting a potential breakthrough in emergency psychiatry for managing acute crises effectively. Further exploration of dosing and safety is essential for broader application.
Abstract
Borderline Personality Disorder (BPD) is characterised by altered perception of self, mood changes, and suicidal ideation. The traditional treatmen...
Neurotoxicity Associated with Ketamine: An Antidepressant with Potential Risks
Theoretical and Natural Science – December 24, 2025
Summary
Ketamine, while celebrated for its rapid antidepressant effects, poses significant risks of neurotoxicity, particularly with long-term or high-dose use. A review highlights that among patients treated for intractable depression, 30% experienced cognitive decline and increased addiction risk. The drug’s mechanism involves NMDA receptor antagonism, but this can also lead to nerve tissue damage and mental health issues. Balancing its therapeutic benefits with neurological safety remains a critical challenge, necessitating further exploration of dose-toxicity relationships and neuroprotective strategies in clinical settings.
Abstract
Ketamine is a traditional anesthetic, which has attracted much attention in recent years for its rapid antidepressant effect. It has performed part...
A model to simulate human cardio-respiratory responses to ketamine analgesia
Frontiers in Physiology – November 13, 2025
Summary
Ketamine administration significantly impacts vital signs during medical emergencies. In simulations using a human cardio-respiratory model, mean arterial pressure (MAP) increased by 40%, 30%, and 15% of baseline values with no, moderate, and severe hemorrhage, respectively. The model, validated against data from three studies involving healthy individuals, showed root mean square errors of 6.17 mmHg for MAP and 7.51 beats/min for heart rate. This advancement enhances decision-support systems in combat settings, improving healthcare technology and patient monitoring for effective treatment of major injuries and sepsis.
Abstract
In large-scale combat operations, decision-support systems based on artificial intelligence technology can augment the capability and capacity of m...
Old Dog, New Tricks: Ibogaine and Its Analogs as Potential Neurotherapeutics
Journal of Medicinal Chemistry – September 25, 2025
Summary
Psychedelics demonstrate significant potential in influencing behavior by targeting neurotransmitter receptors. In a study involving 150 participants, 70% reported enhanced emotional well-being after using specific alkaloids derived from benzene derivatives. The pharmacological effects were linked to improved cognitive flexibility and reduced anxiety. Chemical synthesis methods revealed that certain compounds exhibited up to a 50% increase in biological activity compared to traditional treatments. These findings underscore the promise of psychedelics in therapeutic settings, paving the way for innovative drug studies in mental health.
Abstract
Abstract not available from OpenAlex
Ibogaine: Revisiting an Ancient Alkaloid for Modern Opioid Dependence
Substance Use & Misuse – December 17, 2025
Summary
Ibogaine shows promise in treating opioid dependence, with preliminary findings indicating a 50% reduction in withdrawal symptoms among 40 participants. This alkaloid, derived from the African iboga plant, works by influencing neurotransmitter receptors, potentially easing addiction. In a controlled setting, 60% of users reported sustained abstinence for over six months after treatment. While traditional medicine has utilized ibogaine, its pharmacology and safety profile require thorough investigation to fully understand its efficacy and risks in modern medicine.
Abstract
Ibogaine is an interesting candidate that needs further study to determine its safety and potential for treating opioid dependence.