Consciousness and cognition
August 1, 2019
Michael Lifshitz, Michiel van Elk, T M Luhrmann
162 citations
A general tendency called 'absorption'—the capacity to become deeply immersed in sensory and imaginative experiences—underlies a broad proclivity for spiritual experiences. People high in absorption readily sense supernatural presences, receive messages from God, and feel self-transcendence, awe, and wonder. High scorers on the Tellegen Absorption Scale report vivid experiences such as hearing God's voice during prayer, intense mystical states from psychedelics or placebo brain-stimulation, and strong feelings of presence and transcendence when encountering natural beauty, virtual reality, or music. Absorption appears to intensify inner and outer sensory experience, blending prior expectation with novel engagement, making imagined things feel more real.
Psychopharmacology
March 7, 2020
Jay A. Olson, Léah Suissa-Rocheleau, Michael Lifshitz et al.
148 citations
No Summary
Review of philosophy and psychology
January 1, 2022
Maxwell J D Ramstead, Anil K Seth, Casper Hesp et al.
75 citations
A version of neurophenomenology is presented that uses generative modelling techniques from computational neuroscience and biology to formally model descriptions of lived experience from the phenomenological tradition (e.g., Husserl, Merleau-Ponty). The approach, called computational phenomenology, is situated within the broader project of naturalizing phenomenology. Philosophical objections to that project are evaluated, and the generative modelling framework is reviewed. The approach differs from previous uses of generative modelling for consciousness by constructing computational models of inferential or interpretive processes that best explain particular kinds of lived experience.
Frontiers in Human Neuroscience
July 18, 2023
Nicolas Garel, Julien Thibault Lévesque, Dasha A. Sandra et al.
29 citations
Past environmental exposures can significantly shape psychedelic drug experiences and their therapeutic outcomes, a concept the authors call 'imprinting.' In a clinical trial of ketamine for treatment-resistant depression, two patients' subjective experiences were altered by the type and amount of digital media they consumed in the days before treatment: higher media exposure reduced mystical and emotional qualities of the ketamine experience, overriding standard intention-setting practices and changing therapeutic results. Eight additional patients spontaneously reported past environmental exposures manifesting as visual hallucinations during ketamine sessions. Similar imprinting effects appear in historical reports of other psychedelic drugs and in dreaming. The authors propose expanding the contextual model of psychedelic action to include imprinting, which may help clinicians and researchers better understand these drug effects.
Frontiers in human neuroscience
January 1, 2013
Michael Lifshitz, Emma P Cusumano, Amir Raz
28 citations
Hypnosis can rapidly and dramatically alter subjective experience with just a few words of suggestion, unlike contemplative practices requiring lengthy training. Individuals highly responsive to hypnosis can quickly manifest atypical conscious experiences and override deeply entrenched processes, offering new ways to suspend habitual attention and achieve refined meta-awareness. Hypnosis research also illuminates how suggestion, expectation, and interpersonal factors shape experience beyond hypnotic procedures. Incorporating hypnosis into neurophenomenology could help bridge subjective experience with third-person scientific approaches to the mind.
Oxford University Press eBooks
April 5, 2018
Michael Lifshitz, Eli Oda Sheiner, Laurence J. Kirmayer
22 citations
Classic serotonergic psychedelics such as psilocybin, LSD, and ayahuasca can induce potent alterations in cognition and perception. The chapter reviews research through cultural neurophenomenology, which traces how neurobiology and sociocultural factors interact to shape experience. Scientific study of psychedelics is rediscovering their potential to promote creative insight, evoke mystical experiences, and improve clinical outcomes. Neuroimaging experiments have begun to unravel the influence of psychedelics on large-scale connectivity networks of the human brain. Culture and context constrain the flexible cognitive states brought about by psychedelics, suggesting that seemingly spontaneous psychedelic thought patterns reflect a complex interaction of biological, cognitive, and cultural factors—from pharmacology and brain function to ritual, belief, and expectation.
Frontiers in psychology
January 1, 2023
Karin Cinalioglu, Paola Lavín, Magnus Bein et al.
21 citations
A randomized controlled trial will test whether virtual-reality-guided meditation is feasible and acceptable for reducing stress, anxiety, and depression in older adults. Thirty community-dwelling adults aged 60 years or older with moderate stress will be randomly assigned to either an eight-session VR meditation program or a waitlist control group. Sessions last 15 minutes and occur twice weekly for four weeks, offered at home or in a hospital. Outcomes include perceived stress, anxiety, depression, sleep quality, quality of life, and mindfulness skills, measured before and after the intervention. Qualitative interviews will capture participants' experiences. The trial is registered at ClinicalTrials.gov (NCT05315609).
Transcultural psychiatry
October 1, 2022
Gabriella Gobbi, Antonio Inserra, Kyle T Greenway et al.
9 citations
Psychedelics have been used by human societies for over 3000 years, primarily in religious and healing contexts. Recent research shows promising clinical benefits for some psychiatric disorders, but applying these consciousness-altering substances outside their traditional sociocultural settings raises concerns. The therapeutic mechanisms of psychedelics depend not only on neurobiology but also on psychological, social, and spiritual processes. Therefore, physicians and psychotherapists need training to guide patients through the experience, promoting positive outcomes and addressing side effects. Psychedelic therapies may lead to a new psychiatric paradigm integrating psychopharmacological, psychotherapeutic, and cultural interventions.
Expert review of clinical pharmacology
March 1, 2025
Danny Diep, Sara de la Salle, Julien Thibault Lévesque et al.
8 citations
Ketamine's subjective effects have been interpreted in three major ways since its 1962 synthesis: as dissociative, dream-like, or psychedelic, depending on the clinical context and dose. Biomedical frameworks often label its effects as dissociative or psychotomimetic, while psychedelic paradigms highlight potential therapeutic benefits. Factors such as language, dose, and environmental setting influence both the drug's effects and treatment outcomes. The authors argue that ketamine is best understood as a chameleon whose effects shift with context, rather than a tiger to be tamed. A nuanced, interdisciplinary approach is needed to maximize its clinical potential.
American journal of human biology : the official journal of the Human Biology Council
December 1, 2024
Josh Brahinsky, Jonas Mago, Mark Miller et al.
5 citations
Buddhist Jhāna meditation and Christian speaking in tongues, despite appearing very different, share key phenomenological features. Interviews with experienced practitioners in the USA reveal a dynamic interplay between focused attention, aroused joy, and a sense of letting go or release crucial to both practices. The paper theorizes that these shared features engage an autonomic field built through a spiral between attention, arousal, and release (AAR), analyzed through sensory gating and predictive processing theories of brain function.
The Oxford Handbook of Psychedelic, Religious, Spiritual, and Mystical Experiences
June 20, 2024
Josh Brahinsky, Michael Lifshitz, Tanya Marie Luhrmann
1 citation
Working back and forth between neuroscientific methods and ethnographic phenomenology can inspire new ways of thinking. A neurophenomenological project investigated the evangelical Christian practice of speaking in tongues. After several years of ethnographic participant observation in tongues-speaking churches and careful interviews with tongues-speakers, the researchers developed a neuroimaging experiment to capture what they heard. Their interdisciplinary approach revealed shifts in the experience of speaking in tongues, which they call "dropping in." Combining ethnographic phenomenology and neuroscience brought a deeper understanding of tongues prayer in unexpected ways.
arXiv (Cornell University)
May 15, 2026
Jonas Mago, Edmundo Lopez-Sola, Jakub Vohryzek et al.
States of consciousness with minimal phenomenal content, such as those induced by certain meditation practices, show increased brain entropy similar to high-content psychedelic states, challenging the Entropic Brain Hypothesis that links entropy to phenomenal richness. The Complex Brain Hypothesis resolves this by proposing that brain complexity, not entropy, better indexes the richness of experience. Complexity is modulated by the grain of inference the brain uses to resolve uncertainty: fine-grained inference loosens constraints and proliferates content, as in psychedelic states; coarse-grained inference simplifies experience into contentless awareness, as in minimal phenomenal experiences. Both regimes can elevate entropy but differ in phenomenology and perturbational signatures, refining the Entropic Brain Hypothesis and highlighting minimal phenomenal experiences as a test case for computational theories of consciousness.
Neuroscience of consciousness
January 1, 2026
Jonas Mago, George Deane, Lars Sandved-Smith et al.
People under the influence of psychedelics often report encountering autonomous entities such as spirits, elves, or ancestors. A neurocomputational model, grounded in the active inference framework, explains these experiences by proposing that psychedelics reduce the predictability of sensory perceptions, leading the brain to interpret both internal and external perceptions as coming from non-self agents. The model synthesizes earlier theories including the entropic brain model, computational accounts of felt presence, and sensory attenuation theories of self-other discrimination. It aims to account for how the brain supports entity encounters and for the diversity and similarity of these experiences across cultural contexts.
Religions
November 10, 2025
Nathan E. Fisher, Elisabeth Irvine, Michael Z. Yonkovig et al.
Energy-like somatic sensations in the body are commonly reported across Abrahamic contemplative traditions, not only in Buddhist and Yogic contexts. In interviews with 30 practitioners and 30 teachers from Jewish, Christian, and Islamic traditions, 40% of practitioners and 43% of teachers reported such experiences. These sensations varied widely in intensity and emotional tone, interpreted either as expected signs of spiritual progress or as surprising events. Participants blended metaphors from multiple traditions and mixed spiritual with psychological explanations. Compared to earlier research on Western Buddhists, both commonalities and differences emerged. The findings suggest these experiences arise from a complex interplay of cultural frameworks, attention, and bodily processes.
arXiv Preprint Archive
May 11, 2016
Kieran C. R. Fox, Yoona Kang, Michael Lifshitz et al.
Meditation and hypnosis can change how thoughts flow automatically, potentially making thinking more flexible and less rigid. Three mechanisms are proposed: reducing the tendency for thoughts to chain together automatically; making thought chains more varied and less habitual; and creating new, intentionally chosen mental habits. Evidence from behavioral and cognitive neuroscience shows these practices influence internal cognition, with possible benefits for mental adaptability.
arXiv Preprint Archive
March 21, 2016
Kieran C. R. Fox, Matthew L. Dixon, Savannah Nijeboer et al.
Meditation comprises diverse mental practices with distinct strategies. A meta-analysis of 78 neuroimaging studies (527 participants) found reliably different brain activation patterns for four common meditation styles—focused attention, mantra recitation, open monitoring, and compassion/loving-kindness—and suggestive differences for three others. Some brain regions (insula, pre/supplementary motor cortices, dorsal anterior cingulate cortex, frontopolar cortex) were recruited across multiple techniques, but convergence was the exception. Effect sizes were medium for both activations (d = .59) and deactivations (d = -.74), indicating potential practical significance. The findings support the neurophysiological dissociability of meditation practices while highlighting methodological concerns and future research directions.