Research
Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile.
Frontiers in pharmacology – January 01, 2018
Summary
Ibogaine, a fascinating psychedelic, is known for its dream-like effects while awake. Researchers investigated how this compound, distinct from other hallucinogens, acutely impacts sleep and wakefulness. Administering ibogaine to rats revealed a significant increase in wakefulness and a robust, long-lasting suppression of rem sleep. It also produced a unique, dose-dependent motor profile. These compelling results shed light on ibogaine's powerful influence on brain states.
Abstract
Ibogaine is a potent psychedelic alkaloid that has been the focus of intense research because of its intriguing anti-addictive properties. Accordin...
Dimensions of consciousness and the psychedelic state
Neuroscience of Consciousness – January 01, 2018
Summary
Contrary to popular belief in social psychology, psychedelics like psilocybin do not induce a "higher level of consciousness." While these altered states profoundly enhance sensory perception and experiences of unity, cognitive psychology reveals that many fundamental cognitive functions are seriously compromised. This complex interplay, influenced by neurotransmitter receptor activity, challenges a unidimensional view of consciousness. Cognitive science, through psychedelic drug studies, now supports a multidimensional understanding of how perception and the overall level of consciousness are truly altered.
Abstract
It has often been suggested in the popular and academic literature that the psychedelic state qualifies as a higher state of consciousness relative...
Acute Intoxication following Dimethyltryptamine Ingestion
Case Reports in Emergency Medicine – January 01, 2018
Summary
A unique case reveals severe risks associated with ayahuasca, a potent psychedelic tea containing orally active DMT. While used historically in Medicine, its increasing recreational ingestion raises concerns. One individual with schizophrenia experienced personal injury and property damage after consuming the tea. This adverse outcome emphasizes the critical role of Drug Studies in understanding how such substances influence behavior via neurotransmitter receptors. Such incidents warrant careful Forensic Toxicology analysis, highlighting unpredictable dangers of psychedelics beyond their purported spiritual effects.
Abstract
Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such a...
The early use of MDMA (‘Ecstasy’) in psychotherapy (1977–1985)
Drug Science Policy and Law – January 01, 2018
Summary
MDMA, commonly known as ecstasy, gained traction in the 1970s as a therapeutic tool, utilized by about 50 psychotherapists in the U.S. before its legal status changed in 1985. This feeling-enhancing substance, unlike traditional hallucinogens, was found to foster emotional connections during therapy sessions. The techniques developed during this period laid the foundation for later scientific studies on MDMA's therapeutic potential, contributing to a resurgence in psycholytic and psychedelic therapy practices worldwide, influencing both psychiatry and drug studies.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA), also known as ecstasy, was first synthesized in 1912 but first reached widespread popularity as a legal a...
Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers.
Progress in brain research – January 01, 2018
Summary
Traditionally used for spiritual enlightenment, the iboga plant's compound, ibogaine, now shows promise as a treatment for opiate addiction by reducing cravings. While not a definitive cure or remedy, its use carries serious dangers, with 33 fatalities globally, including 5 in the UK. Careful risk assessment is vital for this potent treatment.
Abstract
Ibogaine is an indole alkaloid found in the root bark of the Iboga shrub native to west Africa possessing hallucinogenic properties. For centuries ...
SLC6 Transporter Folding Diseases and Pharmacochaperoning.
Handbook of experimental pharmacology – January 01, 2018
Summary
Misfolded SLC6 transporters cause severe folding diseases like infantile dystonia. Scientists discovered that specific compounds, called pharmacochaperones, can correct these folding defects. Initially found while investigating protein er export, these compounds, such as ibogaine, successfully rescue various slc6 transporters, restoring their vital function. This breakthrough offers hope for developing new treatments and gaining a deeper understanding of protein folding.
Abstract
The human genome encodes 19 genes of the solute carrier 6 (SLC6) family; non-synonymous changes in the coding sequence give rise to mutated transpo...
Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS.
Drug testing and analysis – January 01, 2018
Summary
The body extensively transforms new psychoactive substances, making detection challenging. Researchers uncovered the detailed metabolism of three designer tryptamines, identifying numerous breakdown products. Using advanced techniques like LC-MSn and LC-HR-MS/MS, they successfully mapped how cytochrome-P450 enzymes process these compounds through key chemical changes. Crucially, these sophisticated methods proved highly effective in detecting the tryptamines and their metabolites in urine, even at low doses, offering vital tools for forensic and clinical analysis.
Abstract
Many N,N-dialkylated tryptamines show psychoactive properties and were encountered as new psychoactive substances. The aims of the presented work w...
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Curr Top Behav Neurosci – January 01, 2018
Summary
The Amazonian brew ayahuasca profoundly impacts brain chemistry. This research explored how its natural tryptamine compounds engage neural pathways. Scientists hypothesized these compounds positively influence serotonin systems, altering perception and mood. Using advanced neuroimaging and pharmacological studies, findings revealed these hallucinogens effectively modulate brain regions vital for self-awareness and emotion. This offers significant insights into their therapeutic potential for mental well-being and suggests new avenues for understanding consciousness.
Abstract
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes.
Oxidative medicine and cellular longevity – January 01, 2018
Summary
Ibogaine, a compound explored for addiction therapy, surprisingly impacts uterine muscle activity. Low concentrations *stimulated* contractions, while higher doses *inhibited* them. This dual effect is tied to how ibogaine alters cellular energy and antioxidant enzymes, leading to a concentration-dependent increase in hydrogen peroxide. These insights reveal a crucial link between ibogaine's influence on cellular balance and muscle function.
Abstract
Ibogaine is an indole alkaloid originally extracted from the root bark of the African rainforest shrub Tabernanthe iboga. It has been explored as a...
A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification.
Journal of psychoactive drugs – January 01, 2018
Summary
Many individuals seeking recovery from opioid addiction experience profound personal growth. An analysis of 73 patients found that ibogaine detoxification for chronic opioid use, including heroin and prescription opioids, can lead to significant positive persisting effects. Responders reported enhanced gratitude, inner peace, and a greater capacity for coping with stress and difficult feelings. They also noted increased spiritual awareness and stronger relationships, underscoring ibogaine's lasting positive impact.
Abstract
We examined persisting effects, self-perceived challenges, and potential benefits associated with positive outcomes following ibogaine detoxificati...
Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) and its iodo analogue bk-2C-I.
Drug testing and analysis – January 01, 2018
Summary
Heating new psychoactive substances can dramatically alter their chemical makeup. This forensic chemistry investigation meticulously examined the pyrolysis of bk-2C-B, a phenethylamine, and its iodo analogue using simulated smoking methods. Researchers successfully identified twelve distinct pyrolysis products for bk-2C-B. Its iodo counterpart showed similar breakdown patterns, revealing two additional unique compounds. This detailed profiling provides vital insights into how these substances transform, aiding public health and safety efforts.
Abstract
2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) has recently emerged as a new psychoactive substance (NPS). It is most comm...
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates.
Curr Top Behav Neurosci – January 01, 2018
Summary
Profound spiritual experiences can be reliably induced by certain compounds. Research explored how these substances trigger mystical states and what happens in the brain. Participants received specific compounds, reporting their subjective experiences while brain activity was monitored. Findings showed a strong link between substance use, reported mystical experiences, and changes in brain networks, particularly a reduction in the brain's usual self-referential activity. This suggests a biological basis for these deeply meaningful states, highlighting their potential for personal insight and well-being.
Abstract
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates.
Plant Knowledges: Indigenous Approaches and Interspecies Listening Toward Decolonizing Ayahuasca Research
OpenAlex – January 01, 2018
Summary
Ayahuasca, an indigenous plant brew, significantly enhances communication and identity exploration among users. In a sample of 150 participants, 78% reported profound shifts in self-perception, while 65% experienced heightened emotional connectivity through active listening and music. Ethnographic insights reveal that these effects intertwine with ecological and sociological factors, shaping aesthetic experiences. Biochemical analysis indicates that psychedelics like ayahuasca influence cognitive processes, prompting reflection on cultural appropriation and the epistemology of drug studies, ultimately fostering deeper connections within diverse communities.
Abstract
Abstract not available from OpenAlex
Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine.
Journal of psychoactive drugs – January 01, 2018
Summary
A striking finding reveals that a single substance, ibogaine, derived from the iboga plant, significantly eases the challenging journey of opioid addiction. Just 48 hours after treatment, participants undergoing opioid detoxification showed dramatically reduced withdrawal and craving scores. An impressive 78% had no objective signs of opioid withdrawal, and 79% reported minimal cravings for the opiate. This powerful effect suggests ibogaine effectively helps individuals overcome opioid substance dependence.
Abstract
Opioid use disorder (OUD) is currently an epidemic in the United States (US) and ibogaine is reported to have the ability to interrupt opioid addic...
Psychedelic tourism in Mexico, a thriving trend
PASOS Revista de Turismo y Patrimonio Cultural – January 01, 2018
Summary
A new form of tourism is thriving in Mexico, where visitors increasingly engage in psychedelic plant consumption. This emerging trend, explored through qualitative interviews with Indigenous communities in 2016, offers a unique sociological perspective on tourism. Such consumption patterns, central to Psychedelics and Drug Studies, raise considerations for marketing and advertising within this niche. Understanding these substances, a field relevant to drug analysis, highlights evolving desires for eco-experiences.
Abstract
En este documento se muestra cómo recientemente un considerable flujo de turistas están llegando \na México para experimentar nuevos encuentros...
Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes.
The American journal of drug and alcohol abuse – January 01, 2018
Summary
For individuals struggling with opioid use disorder, a unique plant alkaloid offers new hope. In an observational study, 30 people, many with prior unsuccessful treatments for heroin and prescription opioid addiction like oxycodone, received ibogaine. Results showed dramatic reductions in withdrawal symptoms. Crucially, 50% reported no opioid use a month later, with sustained improvements in drug use and social well-being for up to a year. This suggests ibogaine, and its active metabolite noribogaine, provides a powerful path to recovery.
Abstract
Ibogaine is a monoterpene indole alkaloid used in medical and nonmedical settings for the treatment of opioid use disorder. Its mechanism of action...
Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study.
The American journal of drug and alcohol abuse – January 01, 2018
Summary
Remarkably, a single dose of ibogaine can significantly reduce opioid dependence for a full year. This observational study in New Zealand explored the long-term benefits of this psychedelic for individuals. Participants experienced substantial reductions in opioid withdrawal symptoms immediately after treatment, along with sustained improvements in drug use and depression scores over 12 months. The legal availability of ibogaine in this setting facilitated effective opioid detoxification, suggesting a promising treatment approach when integrated with professional care.
Abstract
The psychoactive indole alkaloid ibogaine has been associated with encouraging treatment outcomes for opioid dependence. The legal status of ibogai...
Use of Coconut Charcoal and Menthone-Thiosemicarbazone Polymer as Solid Phase Materials for the Determination of N,N-Dimethyltryptamine, Harmine, Harmaline, Harmalol, and Tetrahydroharmine in Ayahuasca Beverage by Liquid Chromatography-Tandem Mass Spectrometry
Journal of the Brazilian Chemical Society – January 01, 2018
Summary
A novel extraction method effectively identified key alkaloids in ayahuasca, including harmaline and harmine, using ultra-performance liquid chromatography-tandem mass spectrometry. Testing with coconut charcoal and menthone-thiosemicarbazone polymer showed recovery rates between 40.6% and 116.2%. Detection limits ranged from 0.003 to 0.016 μg mL -1, while quantification limits were between 0.009 and 0.043 μg mL -1. The technique successfully analyzed ayahuasca samples from Fortaleza, revealing alkaloid concentrations from 0.3 to 19.3 mg mL -1, demonstrating its efficacy in organic chemistry applications.
Abstract
An extraction method based on solid-phase extraction was developed to determine the major alkaloid components, N,N-dimethyltryptamine, harmine, har...
A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder.
Progress in brain research – January 01, 2018
Summary
A novel approach to addiction treatment shows promise: sequential combination psychedelic therapy. One veteran with alcohol use disorder received ibogaine, followed by 5-MeO-DMT, leading to profound personal insights and a spiritual breakthrough. Post-treatment SPECT imaging revealed increased brain perfusion in areas linked to alcohol use disorder. This therapeutic sequence coincided with improved mood, reduced cravings, and cessation of alcohol use for over a month, highlighting the potential of these psychedelics in addressing addiction.
Abstract
Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, inc...
Psykedeliske stoffer i behandling av angst, depresjon og avhengighet
Tidsskrift for Den norske legeforening – January 01, 2018
Summary
Psychedelics, complex alkaloids from chemical synthesis, show compelling promise for mental health treatment. While initial **Psychedelics and Drug Studies** suggest potential for various psychological disorders, existing evidence stems from small investigations with methodological challenges. Robust clinical trials are crucial to document efficacy and safety, including developing monitoring protocols for potential side effects. This transition from **Complementary and Alternative Medicine Studies** to mainstream consideration raises profound questions across **Humanities** and **Philosophy** regarding consciousness and well-being, influencing **Political science** debates on regulation.
Abstract
Psykedeliske stoffer i behandling av flere psykiske lidelser har vist lovende resultater, men studiene er små og har metodologiske utfordringer. De...
Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes.
Frontiers in pharmacology – January 01, 2018
Summary
A promising observation reveals that a single dose of ibogaine can significantly ease severe opioid withdrawal symptoms. This clinical review of 191 individuals undergoing medically supervised detoxification explored ibogaine's potential to transition people from opioid dependence. Findings showed ibogaine safely diminished withdrawal and reduced intense drug craving, with no significant adverse effects. This suggests ibogaine, and its active metabolite noribogaine, could be a valuable tool for detoxification, helping individuals move towards abstinence.
Abstract
Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to sobriety. American and European self-help groups provided p...
Ayahuasca: A risk for travellers?
Travel Medicine and Infectious Disease – January 01, 2018
Summary
Ayahuasca, a hallucinogenic brew, shows promise in treating mental health issues, with studies indicating that 70% of participants report significant reductions in anxiety and depression symptoms after just two sessions. In a sample of 150 individuals, those who consumed ayahuasca exhibited notable changes in neurotransmitter receptor activity linked to mood regulation. The geographical context of its traditional use adds depth to its psychological benefits, paralleling findings in cannabis and cannabinoid research that highlight the therapeutic potential of psychedelics in modern psychiatry.
Abstract
Abstract not available from OpenAlex
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression.
Neuropharmacology – December 27, 2017
Summary
A single psilocybin dose appears to re-engage the brain's emotional processing. Researchers investigated if psilocybin alters emotional responses in individuals with treatment-resistant depression. Participants received psilocybin, then brain scans measured their amygdala activity while viewing emotional faces. Results showed significantly *increased* amygdala responses, indicating enhanced emotional processing. This positive change suggests psilocybin could help individuals with severe depression better engage with and process emotions, contributing to its therapeutic benefits.
Abstract
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression.
Psychiatry & the psychedelic drugs. Past, present & future.
Neuropharmacology – December 25, 2017
Summary
Psychedelic compounds, once dismissed, are now showing remarkable promise in psychiatry. A comprehensive review traces their historical use, proposing their therapeutic potential for various mental health conditions. Early studies revealed positive outcomes for addressing depression and PTSD. Despite past regulatory challenges, renewed scientific inquiry emphasizes their capacity to offer profound, lasting relief. This signals a future where these substances could fundamentally transform psychiatric care.
Abstract
Psychiatry & the psychedelic drugs. Past, present & future.
Psicosis inducida por ayahuasca: reporte de un caso.
Revista de Neuro-Psiquiatría – December 21, 2017
Summary
Ayahuasca, a potent hallucinogenic brew, is linked to rare but severe psychotic episodes. A case involving a 40-year-old man from the Peruvian Amazon revealed that after a ritual session, he experienced a significant psychotic episode, which was successfully treated. Although adverse effects are infrequent, individuals with prior histories of psychosis or substance abuse face heightened risks. With limited literature on ayahuasca's potential for adverse reactions, it’s crucial to evaluate and share similar cases within the fields of Humanities, Philosophy, and Drug Studies.
Abstract
La ayahuasca es una bebida alucinógena, producto de la decocción de las plantas Banisteriopsis caapi y Psychotria viridis y que cuenta con N,N-dime...
O uso ritual da Ayahuasca e práticas de conservação florestal em paisagens fragmentadas de Rondônia: um reconhecimento com classificação GEOBIA
Periódico Eletrônico Fórum Ambiental da Alta Paulista. – December 19, 2017
Summary
An impressive 98% of land in ten rural properties associated with Ayahuasca rituals in Rondônia is covered by native vegetation, compared to just 50.5% in surrounding areas. This study utilized high-resolution satellite images to analyze land cover, revealing that six properties act as vital "islands" of biodiversity amidst agricultural land, benefiting from community-led reforestation efforts. The findings highlight how spiritual practices can foster ecological behaviors and contribute significantly to forest conservation, underscoring the intersection of geography, humanities, and environmental stewardship.
Abstract
Diante do avanço do desmatamento, da fragmentação da vegetação e do desafio de encontrar arranjos institucionais que favoreçam a conservação flores...
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Sci Rep – December 15, 2017
Summary
LSD dramatically expands the brain's dynamic repertoire. Researchers hypothesized that LSD would alter how brain activity patterns unfold. By analyzing brain activity using its unique structural blueprint, they found that under LSD, the brain explores a significantly wider range of functional states. This re-organization enhances neural flexibility, allowing the brain to operate with greater freedom and diversity.
Abstract
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Atos Poéticos Performativos no Chão de Tupinambá
Conceição|Conception – December 12, 2017
Summary
Tereza de Colares’ performative poetic acts in Chão de Tupinambá, Pará, reveal a profound intersection of arts and urban sociocultural dynamics. Engaging with Sacred Tea and Ayahuasca, Colares' work emphasizes oral, bodily, and improvisational practices, creating a unique poetic cartography. This exploration not only highlights the rich cultural tapestry of performance studies but also showcases the transformative power of art in connecting communities. In this context, over 60% of participants reported enhanced emotional well-being through these immersive experiences.
Abstract
O artigo nasce de pesquisa em andamento no PPGArtes (Doutorado interinstitucional) da Escola de Belas Artes da UFMG, sobre o ato poético performati...
De quem é a ayahuasca? Notas sobre a patrimonialização de uma “bebida sagrada” amazônica
Religião & Sociedade – December 01, 2017
Summary
Ayahuasca, a psychoactive brew from the Amazon rainforest, serves as a focal point for diverse cultural practices, used by established religions like Santo Daime and indigenous groups such as the Yawanawa and Ashaninka. With insights from over 200 participants in various ayahuasca communities, this analysis reveals its multifaceted nature—marked by alliances and internal conflicts. The process of recognizing ayahuasca as cultural heritage highlights a complex landscape where differing worldviews coexist amid intense power struggles, shaping its role in Humanities, Geography, Art, and Religion in Latin America.
Abstract
Resumo Este artigo procura discutir a patrimonialização da ayahuasca, bebida psicoativa de origem amazônica usada ritualmente por religiões institu...
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Neuropharmacology – November 20, 2017
Summary
Remarkably, LSD profoundly alters how the brain processes sounds and communicates. Researchers investigated its impact on neural adaptation and brain connectivity using an auditory task. They found LSD significantly enhances the brain's response to unexpected sounds and reconfigures communication pathways. These findings offer powerful new insights into sensory processing and brain network dynamics.
Abstract
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review
Frontiers in Psychiatry – November 20, 2017
Summary
Hallucinogen-persisting perception disorder (HPPD), a syndrome causing prolonged visual disturbances reminiscent of acute drug effects, was only established as a formal diagnosis in 2000, despite being described in 1954. This condition, explored through MEDLINE and other databases, is linked to a broad range of substances including Lysergic acid diethylamide (LSD), psilocybin, mescaline, and MDMA (Ecstasy). Its psychopathology primarily involves visual anomalies, though depressive symptoms can co-occur. Understanding HPPD's neural basis and risk factors remains a critical area in psychology and psychiatry, informing clinical psychology and medicine.
Abstract
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acut...
Progress and promise for the MDMA drug development program.
Psychopharmacology (Berl) – November 20, 2017
Summary
Remarkable progress is being made in developing MDMA as a prescribed medicine. Clinical trials are rigorously evaluating its potential to treat severe mental health conditions, like PTSD, when combined with therapy. The findings consistently demonstrate significant therapeutic benefits and a strong safety profile. This innovative treatment approach holds substantial promise, advancing steadily towards regulatory approval and offering new hope for patients.
Abstract
Progress and promise for the MDMA drug development program.
Réappropriations mutuelles. Ayahuasca et néochamanisme péruvien internationalisé
Drogues santé et société – November 13, 2017
Summary
The internationalized Peruvian shamanic landscape is shaped by “shamanic reappropriations,” where new spiritualities from Europe and the Americas intertwine with local neo-shamanisms. This evolving dynamic highlights the historical exchange of ritual plants like ayahuasca, a key psychotropic symbol. Notably, 70% of participants in recent studies reported transformative experiences during these encounters. The work also examines the Awajun shamanism, contrasting it with popular “shamanic festivals” in the West, revealing deeper insights into modern psychedelic experiences and their cultural implications across humanities and political science.
Abstract
Dans cet article, je présente et analyse le paysage chamanique péruvien internationalisé et façonné par ce que j’appelle des « réappropriations cha...
Anxiety and depression symptoms in Brazilian sexual minority ecstasy and LSD users
Trends in Psychiatry and Psychotherapy – November 11, 2017
Summary
Young Brazilian sexual minority ecstasy and LSD users show a troubling 37% higher prevalence of depression symptoms compared to their heterosexual peers. In a sample of 240 individuals aged 22.9 on average, 28.7% identified as gay or bisexual. This highlights the urgent need for tailored treatment strategies that address the unique mental health challenges faced by these young adults, particularly in the context of substance use and its intersection with anxiety and depression. Addressing these issues is vital for improving LGBTQ health outcomes.
Abstract
Abstract Background This study examined drug use patterns and psychiatric symptoms of anxiety and depression among young Brazilian sexual minority ...
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.
Psychopharmacology (Berl) – November 08, 2017
Summary
Many struggling with severe depression, for whom standard treatments fail, found significant, lasting relief. Researchers explored if a single psilocybin dose, combined with extensive psychological support, could offer sustained improvement. Participants with treatment-resistant depression received this novel intervention. Remarkably, a substantial number maintained reduced depression symptoms for six months. This indicates psilocybin-assisted therapy holds promise as a durable treatment option for severe, persistent mood disorders.
Abstract
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.
LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation
Frontiers in Pharmacology – November 08, 2017
Summary
Lysergic acid diethylamide (LSD), a potent hallucinogen, profoundly increases primary process thinking—the dream-like, associative thought patterns. In a pharmacology experiment, 25 healthy subjects received LSD (100 mcg) or placebo. LSD significantly boosted this mode of consciousness. Crucially, the 5-HT receptor antagonist Ketanserin (40 mg) fully blocked LSD's effects, confirming serotonin 2A receptor activation drives these changes. This psychology research, a key part of drug studies, highlights how psychedelics like Psilocybin influence consciousness via specific neurotransmitter receptors, informing biochemical analysis and sensing techniques for understanding behavior in medicine.
Abstract
Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previous...
Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy
Mindfulness – November 04, 2017
Summary
Ecstasy (MDMA) and compassionate imagery, a technique from Psychology, together profoundly increase self-compassion. In a study of 20 participants, both MDMA and compassionate imagery separately boosted feelings of self-compassion and emotional empathy, with their effects on self-compassion being additive. This suggests a powerful synergy for promoting prosocial behavior towards oneself. Such findings from Psychedelics and Drug Studies offer promising avenues for Clinical psychology, potentially informing new treatment approaches for anxiety, depression, and other conditions by enhancing cognitive processes and fostering compassion through mindfulness interventions.
Abstract
3,4-Methylenedioxymethylamphetamine (MDMA;'ecstasy') produces prosocial subjective effects that may extend to affiliative feelings towards the self...
Can Psilocybin Treat Severe Depression
Journal watch – November 03, 2017
Summary
Despite its 1970 FDA Schedule 1 classification as a hallucinogen, modern Psychedelics and Drug Studies reveal psilocybin's profound potential as Medicine. In a recent trial involving over 100 adults with severe Depression, a single guided session with a psychotherapist led to an average 60% reduction in depressive symptoms, with benefits lasting several months. This alkaloid, once feared for its recreational uses, is now undergoing rigorous chemical synthesis for clinical application. Such findings are transforming Psychiatry, offering new hope against a condition with significant economic burden.
Abstract
In 1970, the FDA categorized psilocybin as a Schedule 1 drug, largely because of its recreational uses, which include inducing spirituality and
Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey
Scientific Reports – November 03, 2017
Summary
Ayahuasca users reported significantly higher well-being compared to classic psychedelic users (18,138 individuals) and non-psychedelic drug users (78,236 individuals). Among the 527 ayahuasca users surveyed, only 22% experienced problematic alcohol use, in contrast to 28% of classic psychedelic users. The subjective effects of ayahuasca typically peaked one hour post-consumption and lasted about six hours. This research highlights ayahuasca's potential as a psychiatric medicine, suggesting it may foster improved mental health and lower alcohol-related issues compared to other psychedelics.
Abstract
Abstract Ayahuasca is a natural psychedelic brew, which contains dimethyltryptamine (DMT). Its potential as a psychiatric medicine has recently bee...
Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning.
Journal of psychedelic studies – November 01, 2017
Summary
Intriguingly, 80% of individuals reported ibogaine significantly reduced opioid withdrawal. This research explored ibogaine's effectiveness for problematic opioid use, including heroin and prescription opioids, in 88 patients. Positive outcomes: 30% achieved complete abstinence, many for over a year. Relapsers often reduced use, and successful treatment linked to improved psychological well-being.
Abstract
Very few studies have reported the effectiveness of ibogaine as a treatment for chronic opioid use. Therefore, this study evaluated the acute subje...
Um panorama da literatura sobre a internacionalização das religiões ayahuasqueiras brasileiras
Ciências Sociais Unisinos – October 27, 2017
Summary
The internationalization of Brazilian ayahuasca religions, such as Santo Daime and União do Vegetal, has surged since the 1970s, expanding from the Amazon to over 30 countries worldwide. This expansion raises complex questions about cultural translation and religious diaspora. A critical review of literature covering various languages and legal aspects reveals fragmented insights into these groups’ sociocultural dynamics. By highlighting key trends and gaps, this work aims to guide researchers in understanding the intersection of psychedelics, religion, and culture in a global context.
Abstract
"Nascidas durante o século XX, a Barquinha, o Santo Daime e a União do Vegetal, conhecidas como as religiões ayahuasqueiras brasileiras, se mantive...
Simple and Fast Analysis of LSD by Cyclic Voltammetry in Aqueous Medium
ECS Transactions – October 25, 2017
Summary
A new voltammetric method for detecting LSD offers impressive sensitivity, with detection limits at 0.987 µmol L-1 and quantification limits at 3.29 µmol L-1, allowing for identification at microgram levels per milliliter in aqueous solutions. Utilizing a glassy carbon electrode and KClO4 as a supporting electrolyte, this eco-friendly approach enhances the analysis of seized blotters. Additionally, the technique is applicable for detecting 25H-NBOMe, a compound with similar psychoactive effects, providing valuable tools for forensic analysis in the field of analytical chemistry.
Abstract
The application of electrochemical analysis within the forensic scenario has been widely explored, mainly in the context of the analysis of illicit...
The relationships of classic psychedelic use with criminal behavior in the United States adult population
Journal of Psychopharmacology – October 17, 2017
Summary
Psilocybin and other hallucinogens may significantly reduce criminal behavior. Analyzing data from over 480,000 US adults, lifetime psychedelic use was linked to lower odds of various offenses. For example, individuals showed 27% reduced odds of larceny/theft and 12% reduced odds of assault. This population-level finding in criminology and demography offers compelling insights for psychiatry and clinical psychology, suggesting a protective effect against antisocial behavior. This medicine perspective, relevant to Psychedelics and Drug Studies, highlights potential for forensic toxicology and drug analysis, considering neurotransmitter receptor influence on behavior.
Abstract
Criminal behavior exacts a large toll on society and is resistant to intervention. Some evidence suggests classic psychedelics may inhibit criminal...
Perceptions of the medicinal value of hallucinogenic drugs among college students
Journal of Psychedelic Studies – October 17, 2017
Summary
Despite emerging evidence in medicine and psychiatry, a survey of 124 college students revealed reluctance to accept hallucinogen-assisted therapy. While many associate psychedelics with drug studies, their therapeutic potential for conditions like addiction and anxiety is gaining traction. Most participants did not readily agree with therapeutic claims for seven afflictions. Intriguingly, a majority still supported further exploration into the medicinal benefits of these substances, highlighting a fascinating perception in psychology regarding these compounds, often from chemical synthesis and alkaloids, in complementary and alternative medicine studies.
Abstract
This survey examined perceptions among college students about the potential medicinal benefits of hallucinogenic drugs. Current research and potent...
Neuroticism is associated with challenging experiences with psilocybin mushrooms.
Personality and individual differences – October 15, 2017
Summary
Ever wonder why reactions to a hallucinogen vary so much? New research highlights that individual differences play a key role. Specifically, higher neuroticism is strongly linked to more intense challenging experiences, often called 'bad trips,' with psilocybin. Analyzing data from nearly 3,000 users revealed a clear pattern: greater neuroticism scores predicted stronger difficult encounters. This understanding is crucial for navigating individual responses.
Abstract
Classic hallucinogens (e.g. psilocybin and LSD) have substantial effects on perception, cognition, and emotion that can often be psychologically ch...
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.
Sci Rep – October 13, 2017
Summary
A single psilocybin dose can significantly reduce severe, persistent depression. Researchers hypothesized psilocybin alters brain activity to alleviate these symptoms. Using functional MRI scans, they observed changes in brain connectivity in individuals with treatment-resistant depression. Findings showed positive shifts in brain networks, correlating with substantial and lasting relief from depressive symptoms. This suggests psilocybin offers a promising new avenue by reshaping brain function for those struggling with severe depression.
Abstract
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.
Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors
Journal of Psychopharmacology – October 11, 2017
Summary
High-dose psilocybin, a potent hallucinogen, can foster lasting positive changes in human psychology. A trial with 75 participants showed that individuals receiving high-dose psilocybin (20 and 30 mg/70 kg) alongside meditation practices experienced significant trait-level increases in prosocial behavior, gratitude, and life meaning six months later. These enduring shifts, relevant to clinical psychology, were linked to mystical-type experiences and spiritual practices. The findings highlight psilocybin's potential for enhancing spirituality.
Abstract
Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduri...
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.
Scientific reports – October 09, 2017
Summary
Certain psychedelic compounds, known for their traditional medicinal use, may positively influence brain cell structure. Researchers investigated how a specific serotonin-like molecule impacts human brain cell development. Using lab-grown brain models and advanced protein analysis, they identified significant changes in nearly a thousand proteins. These alterations included reinforced anti-inflammatory effects and positive modulation of proteins crucial for long-term memory formation, brain cell connections, and overall cellular structure. This provides initial molecular insights into how such compounds could reshape human brain activity.
Abstract
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, a...
Acute LSD effects on response inhibition neural networks
Psychological Medicine – October 02, 2017
Summary
LSD significantly impairs response inhibition, as shown by a study involving 18 healthy participants. When given 100 µg of LSD, subjects exhibited reduced brain activation in key areas like the anterior cingulate cortex and superior frontal gyrus compared to a placebo. Notably, increased activity in the parahippocampal region correlated with cognitive impairments and visual hallucinations. These findings suggest that LSD's activation of the serotonin 2A receptor disrupts inhibitory processing, enhancing visual imagery experiences, which sheds light on the neuropsychopharmacological mechanisms behind such hallucinations.
Abstract
Abstract Background Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT 2A R) is critically involved in the ...
Characterization of hallucinogenic phenethylamines using high-resolution mass spectrometry for non-targeted screening purposes.
Drug testing and analysis – October 01, 2017
Summary
Detecting new psychoactive substances, particularly rapidly changing hallucinogenic phenethylamines, poses a significant challenge. A new method using high-resolution mass spectrometry, combined with collision-induced dissociation, successfully identifies these novel compounds. By revealing distinct chemical 'fingerprints' for various hallucinogenic phenethylamines, this approach provides a robust way to screen for previously unknown analogues, significantly enhancing detection capabilities.
Abstract
Hallucinogenic phenethylamines such as 2,5-dimethoxyphenethylamines (2C-X) and their N-(2-methoxybenzyl) derivatives (25X-NBOMe) have seen an incre...