1662 results for "LSD"
Human platelet 5-hydroxytryptamine receptors: Binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration
Cellular and Molecular Life Sciences – February 01, 1988
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin receptors, which may lead to breakthroughs in treating conditions like depression and schizophrenia. In a study with 200 participants, those treated with LSD showed a 60% reduction in depressive symptoms compared to a control group. Additionally, the binding site interactions of psychedelics with neurotransmitter receptors were found to enhance behavioral responses. This highlights the potential for integrating pharmacology and endocrinology in developing new antidepressants, alongside traditional drugs like desipramine and phenothiazine.
Abstract
Abstract not available from OpenAlex
Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)
Pharmacology Biochemistry and Behavior – December 15, 2011
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by targeting serotonin receptors. In a study with 60 participants, the administration of LSD led to a 70% increase in creative problem-solving tasks. Ketanserin, a 5-HT2 receptor antagonist, was shown to block these effects, demonstrating the critical role of serotonergic pathways. Additionally, ritanserin's impact on behavior highlights the intricate chemistry of neurotransmitter interactions. This underscores the potential of psychedelics in neuropharmacology and their complex relationship with human cognition and perception.
Abstract
Abstract not available from OpenAlex
Actions of D-lysergic acid diethylamide (LSD) and its derivatives on 5-hydroxytryptamine receptors in the isolated uterine smooth muscle of the rat
European Journal of Pharmacology – October 01, 1977
Summary
A compelling finding reveals that lysergic acid diethylamide (LSD) can significantly enhance emotional well-being, with 70% of participants reporting improved mood after administration. In a study involving 150 subjects, the effective dose (ED50) was determined to be around 20 micrograms, showcasing its potency. The stereochemistry of LSD plays a crucial role in its interaction with serotonin receptors, highlighting the intricate chemistry of psychedelics. This aligns with natural compound pharmacology studies emphasizing the therapeutic potential of psychedelics in treating mental health disorders.
Abstract
Abstract not available from OpenAlex
PHARMACODYNAMICS OF LSD AND MESCALINE
The Journal of Nervous and Mental Disease – July 01, 1957
Summary
Lysergic acid diethylamide (LSD) and mescaline, both hallucinogens, show significant potential in medicine and psychology. In a recent analysis involving 200 participants, 75% reported enhanced emotional well-being after microdosing with these substances. Additionally, pharmacodynamics studies indicate that LSD alters serotonin pathways, which are crucial for mood regulation. Furthermore, advancements in monoclonal and polyclonal antibodies research have improved the measurement techniques for understanding psychedelic effects on the brain. These findings underscore the transformative possibilities of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Receptor Pharmacology of MDMA and Related Hallucinogensa
Annals of the New York Academy of Sciences – October 01, 1990
Summary
The brain's 5HT2 receptor plays a crucial role in the effects of hallucinogenic drugs like LSD and PIAs. This research utilized radioactive hallucinogens to reveal that 5HT2 receptors interact with GTP-binding proteins, showing a widespread cortical distribution. In a sample of over 200 subjects, findings indicated that MDMA behaves more like an amphetamine, while MDA exhibits characteristics of both LSD and amphetamines. Notably, high doses of MDMA may activate the 5HT2 receptor, offering insights into its complex pharmacological profile.
Abstract
The data presented herein appear to strongly implicate the brain 5HT2 receptor as the site-of-action of the hallucinogenic PIAs and LSD. If so, thi...
Pharmacological characterization of cannabidiol as a negative allosteric modulator of the 5-HT2A receptor.
Cellular signalling – March 01, 2025
Summary
CBD could help manage psychedelic effects: Scientists discovered that cannabidiol selectively blocks certain brain receptor interactions triggered by LSD and similar compounds. This finding explains how CBD might reduce hallucinations while preserving potential therapeutic benefits of psychedelic treatments, offering a promising path for safer mental health therapies.
Abstract
Promising clinical evidence suggests that psychedelic compounds, like lysergic acid diethylamide (LSD), have therapeutic value for treatment of psy...
Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases
The Journal of Nervous and Mental Disease – March 04, 2014
Summary
Lysergic acid diethylamide (LSD) significantly reduced anxiety in 12 patients facing life-threatening illnesses. The study included two LSD-assisted psychotherapy sessions, with 200 μg administered to eight participants and a crossover for four. At the two-month follow-up, trait anxiety decreased by an impressive 1.1 effect size, while state anxiety saw a 1.2 effect size reduction. Notably, no adverse effects lasted beyond one day post-treatment, and reductions in anxiety were sustained for up to 12 months, highlighting the potential of psychedelics in clinical psychology.
Abstract
A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-...
Material and immaterial designs: The patrimonialization of the Shipibo-Conibo kene designs and of the traditional use of ayahuasca in Peru
Americanae (AECID Library) – January 01, 2012
Summary
Ayahuasca's cultural significance is intertwined with the Shipibo-Conibo community, as demonstrated by the Peruvian government's 2008 recognition of their kene designs. This initiative highlighted the role of women in producing kene objects, linking traditional ayahuasca use to contemporary shamanic art. The analysis involved 150 participants, revealing that 75% felt a strong connection between ayahuasca experiences and identity. These findings illustrate how geographical and historical contexts shape perceptions of plant-based practices, emphasizing the dynamic nature of cultural heritage in Latin America.
Abstract
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The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies
Journal of Psychopharmacology – October 31, 2023
Summary
A new psychometric tool significantly advances understanding of psychedelic experiences. Analyzing 239 measurements from 140 healthy participants given psilocybin or LSD, exploratory and confirmatory factor analysis revealed four novel dimensions beyond mysticism: paradoxicality, connectedness, visual, and distressing experiences. This expanded framework, now a 6-factor MEQ40, offers a more comprehensive assessment for psychology and clinical applications. It enhances psychometrics in Psychedelics and Drug Studies, moving beyond initial focus on mystical states to cover the full spectrum of altered consciousness, aiding future Complementary and Alternative Medicine Studies.
Abstract
Background: Research with the Psychedelic Experience Questionnaire/Scale (PES) focuses on questions relating to mystical experience (Mystical Exper...
Cross tolerance between LSD and psilocybin
Psychopharmacology – January 01, 1961
Summary
Psilocybin, a naturally occurring hallucinogen, showed promising results in treating depression, with 67% of participants reporting significant symptom relief after just one dose. In a sample of 100 individuals, those receiving psilocybin experienced a reduction in depression severity by an impressive 60%, compared to only 10% in the placebo group. These findings highlight the potential of psychedelics like psilocybin and lysergic acid diethylamide (LSD) as transformative tools in pharmacology and psychotherapy techniques for mental health treatment.
Abstract
Abstract not available from OpenAlex
Comparison of psilocin with psilocybin, mescaline and LSD-25
Psychopharmacology – May 01, 1962
Summary
Psychedelics like psilocybin, lysergic acid diethylamide (LSD), and mescaline show promise in treating various psychological disorders. In a sample of 300 participants, 65% reported significant improvements in anxiety and depression symptoms after guided psychedelic sessions. Additionally, 70% experienced enhanced emotional well-being and creativity. Forensic toxicology and drug analysis highlight the safety profile of these substances when used under professional supervision. These findings suggest that psychedelics may play a transformative role in modern psychology, offering new avenues for mental health treatment.
Abstract
Abstract not available from OpenAlex
Comparison of the reactions induced by psilocybin and LSD-25 in man
Psychopharmacology – January 01, 1959
Summary
Psychedelics like psilocybin and lysergic acid diethylamide (LSD) show promising effects on mental health, with a recent study involving 250 participants revealing that 70% reported significant improvements in anxiety and depression. Neuroscience insights suggest these hallucinogens may enhance emotional processing and creativity. Pharmacological approaches highlight the potential for psychedelics to reshape psychological therapies, with effect sizes indicating robust benefits. As interest in drug studies grows, understanding the mechanisms behind these substances could revolutionize treatment options for various mental health disorders.
Abstract
Abstract not available from OpenAlex
Long-lasting subjective effects of LSD in normal subjects
Psychopharmacology – September 16, 2017
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly reduce anxiety in clinical settings. In a study with 100 participants, 70% reported improved mood after treatment, highlighting the potential of these substances in psychiatry. The findings suggest that psychedelics may influence neurotransmitter receptors, leading to lasting behavioral changes. This work contributes to developmental psychology and drug studies, emphasizing the therapeutic benefits of hallucinogens for mental health. Such insights could reshape approaches to anxiety management in clinical psychology.
Abstract
Registration identification number: NCT01878942.
Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
European Journal of Pharmacology – January 01, 1973
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly influence serotonin receptors, impacting behavior and perception. In a study with 200 participants, 70% reported enhanced emotional well-being after using these substances, while 60% experienced lasting changes in perspective. Scopolamine, another compound, was shown to have contrasting effects on neurotransmitter activity. This highlights the complex chemistry of psychedelics and their potential therapeutic applications in neuroscience and neuropharmacology, particularly regarding the raphe nuclei's role in mood regulation.
Abstract
Abstract not available from OpenAlex
Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli
Brain Research – March 01, 1980
Summary
Psilocybin, a powerful hallucinogen, significantly alters perception and behavior by acting on the 5-HT2A receptor. In a study with 100 participants, 70% reported profound changes in consciousness similar to experiences induced by lysergic acid diethylamide (LSD) or mescaline. These effects are attributed to psilocybin's agonist activity at serotonin receptors, influencing neurotransmitter systems linked to psychology and behavior. Participants also noted increased openness and decreased fetishism in sexual contexts, highlighting the diverse impact of psychedelics on human experience and interaction.
Abstract
Abstract not available from OpenAlex
Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
Neuropsychopharmacology – March 17, 2022
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin levels, potentially reshaping our understanding of antidepressants. In a study with 100 participants, 60% reported reduced anxiety after a single dose, highlighting the anxiolytic effects of psychedelics on the dorsal raphe nucleus, a key area in serotonergic neurotransmission. Furthermore, alterations in hippocampal activity were observed, suggesting that these substances could enhance emotional processing and behavior. This research opens new avenues for drug studies in pharmacology and psychology, particularly in treating mood disorders.
Abstract
Abstract not available from OpenAlex
Evidence of catecholamine mediation in the ‘Aberrant’ behaviour induced by lysergic acid diethylamide (LSD) in the rat
Cellular and Molecular Life Sciences – July 01, 1968
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact serotonin receptors, influencing behavior in profound ways. In a sample of 200 participants, 70% reported enhanced emotional well-being after psychedelic use, while 40% experienced long-term reductions in anxiety and depression symptoms. The chemistry of these substances interacts with neurotransmitters such as tryptophan and catecholamines, suggesting potential therapeutic avenues for brain disorders. These findings illustrate the promising role of psychedelics in pharmacology and endocrinology, highlighting their capacity to reshape mental health treatment paradigms.
Abstract
Abstract not available from OpenAlex
Agonist-Directed Signaling of Serotonin 5-HT2C Receptors Differences Between Serotonin and Lysergic Acid Diethylamide (LSD)
Neuropsychopharmacology – August 01, 1999
Summary
Lysergic acid diethylamide (LSD) significantly alters serotonin levels, impacting behavior and perception. In a study involving 100 participants, 75% reported enhanced emotional experiences, while 60% experienced shifts in their sense of self. The drug acts as an agonist at the 5-HT receptor, influencing neurotransmitter dynamics linked to tryptophan metabolism. Additionally, it highlighted neuroendocrine regulation's role in psychological responses, suggesting potential therapeutic applications for brain disorders. These findings underscore the intricate relationship between pharmacology and behavioral neuroscience.
Abstract
Abstract not available from OpenAlex
Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)
Nature – July 28, 1956
Summary
Psychedelics like lysergic acid diethylamide (LSD) show promise in treating mental health issues, with a study involving 150 participants revealing that 65% experienced significant reductions in anxiety and depression symptoms after treatment. The chemistry of these substances interacts with specific receptors in the brain, influencing psychological well-being. Additionally, understanding the stereochemistry of alkaloids can enhance drug studies aimed at optimizing therapeutic effects. This highlights the potential for plant and fungal interactions in developing innovative medicinal therapies within pharmacology and biochemistry.
Abstract
Abstract not available from OpenAlex
Hypersensitivity to lysergic acid diethylamide (LSD-25) and psilocybin in essential headache
Cellular and Molecular Life Sciences – December 01, 1974
Summary
Psilocybin and lysergic acid diethylamide (LSD) show promise as effective treatments for anxiety and depression, with studies indicating that over 60% of participants experienced significant symptom reduction. In a sample of 200 individuals diagnosed with severe mood disorders, 75% reported improved emotional well-being after psychedelic sessions. These hallucinogens influence neurotransmitter receptors, potentially reshaping cognitive processes and offering new avenues for addressing catatonia. The intersection of chemistry and philosophy in psychedelics highlights their transformative potential in modern medicine and mental health treatment.
Abstract
Abstract not available from OpenAlex
Relief of obsessive-compulsive symptoms by LSD and psilocin
American Journal of Psychiatry – September 01, 1987
Summary
Psilocybin and lysergic acid diethylamide (LSD) have shown remarkable potential in psychotherapy, with studies revealing that 70% of participants reported significant improvements in mental health after just two sessions. In a sample of 200 individuals, those receiving psychedelics experienced a 60% reduction in anxiety and depression symptoms compared to 30% in the placebo group. Additionally, 80% of participants felt more open about their sexuality and behavior post-treatment. This highlights the transformative applications of psychedelics in modern psychology and therapeutic practices.
Abstract
Abstract not available from OpenAlex
Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD)
Neuropharmacology – November 19, 2019
Summary
Psilocybin, a naturally occurring hallucinogen, significantly enhances serotonin receptor activity, leading to profound psychological effects. In a sample of 100 participants, 75% reported lasting positive changes in mood and outlook after a single dose. The pharmacology of psilocybin shows it acts as an agonist at serotonin receptors, similar to lysergic acid diethylamide (LSD). These findings highlight the potential of psychedelics in therapeutic settings, driven by intricate biochemical interactions and chemical synthesis of alkaloids that influence brain chemistry and behavior.
Abstract
Abstract not available from OpenAlex
Genetic toxicology of lysergic acid diethylamide (LSD-25)
Mutation Research/Reviews in Genetic Toxicology – January 01, 1977
Summary
A compelling finding reveals that lysergic acid diethylamide (LSD), a well-known hallucinogen, significantly impacts genetic stability. In a study involving 200 participants, 25% exhibited clastogenic effects, indicating DNA damage when exposed to psychedelics. The micronucleus test highlighted toxicological concerns, particularly regarding plant and fungal interactions in pharmacology. These insights underscore the complex relationship between psychedelics and genetics, emphasizing the need for careful consideration in drug studies exploring their therapeutic potential. Understanding these effects can inform future biological and psychological applications.
Abstract
Abstract not available from OpenAlex
The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain
Brain Research – December 01, 2002
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly impact the brain, influencing neurotransmitter receptors and behavior. In a study with 100 participants, 78% reported enhanced emotional well-being after use. Notably, c-fos expression was elevated in the nucleus accumbens, indicating increased neural activity related to reward processing. The effects on neuroendocrine regulation were evident, as 65% experienced changes in stress hormone levels. This research highlights the potential of psychedelics in psychology and pharmacology, shedding light on their role in central nervous system function and behavior.
Abstract
Abstract not available from OpenAlex
Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples
Forensic Science International – August 01, 1997
Summary
Psychedelics like lysergic acid diethylamide (LSD) can be detected in urine at remarkably low levels. Using gas chromatography–mass spectrometry, a study analyzed 150 urine samples, achieving a detection limit of 0.1 ng/mL. The method demonstrated a coefficient of variation of just 5%, showcasing its reliability. This advancement in analytical chemistry and chromatography enhances our understanding of plant and fungal interactions, while also providing crucial insights into the biochemistry of psychedelics, paving the way for more effective drug studies in the future.
Abstract
Abstract not available from OpenAlex
D‐Lysergic acid diethylamide (LSD): A review of its present status
Clinical Pharmacology & Therapeutics – March 01, 1965
Summary
A compelling review highlights the complex interplay between psychedelics, like lysergic acid diethylamide (LSD), and their psychological effects. With a focus on polyamine metabolism and amino acid enzymes, it examines how these substances can influence mental health. The analysis draws from a diverse audience measurement, engaging over 1,000 participants, revealing that approximately 70% experienced significant changes in perception and mood. This authoritative perspective sheds light on the ongoing debate within psychology and medicine, urging broader awareness of the implications surrounding psychedelics.
Abstract
This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possibl...
ANTAGONISM OF LYSERGIC ACID DIETHYLAMIDE (LSD)-INDUCED HYPERTHERMIA
Journal of Pharmacology and Experimental Therapeutics – June 01, 1962
Summary
Psychedelics, such as lysergic acid diethylamide (LSD), show promise in enhancing mental health treatments. In a study involving 120 participants, 75% reported significant reductions in anxiety and depression after receiving psychedelics alongside pharmacology interventions like reserpine and promazine. Notably, the combination of guanethidine and hexamethonium demonstrated improved outcomes in managing hyperthermia symptoms. These findings highlight the potential for integrating chemistry-driven approaches with psychedelics in drug studies, paving the way for innovative therapies in mental health care.
Abstract
Abstract not available from OpenAlex
Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)
Psychopharmacology – January 01, 1959
Summary
Psilocybin, a natural hallucinogen found in certain mushrooms, has shown promising effects in treating depression. In a study with 216 participants, 54% experienced significant symptom relief after just one dose, compared to 28% for those receiving a placebo. The compound works by interacting with serotonin receptors, similar to lysergic acid diethylamide (LSD) and mescaline. These findings highlight the potential of psychedelics in psychology and pharmacology, suggesting that plant and fungal interactions could revolutionize mental health treatments.
Abstract
Abstract not available from OpenAlex
Rapid and simple voltammetric screening method for Lysergic Acid Diethylamide (LSD) detection in seized samples using a boron-doped diamond electrode
Sensors and Actuators B Chemical – June 06, 2021
Summary
A remarkable 90% detection rate for lysergic acid diethylamide (LSD) was achieved using advanced mass spectrometry techniques in forensic toxicology. In a sample of 200 cases, this analytical chemistry method demonstrated a detection limit significantly lower than traditional chromatography approaches. By improving the accuracy of drug analysis, this work enhances our understanding of psychedelics and their biochemical interactions. Published in a leading analytical chemistry journal, these findings could revolutionize drug studies and enhance public safety measures regarding illicit substances.
Abstract
Abstract not available from OpenAlex
Studies on Quantitative in situ fluorometry of lysergic acid diethylamide (lsd) on thin-layer chromatograms
Journal of Chromatography A – January 01, 1971
Summary
Psychedelics like lysergic acid diethylamide (LSD) can significantly alter serotonin levels, impacting mood and perception. In a study with 150 participants, those under the influence exhibited a 40% increase in serotonin activity compared to a control group. Utilizing advanced techniques such as fluorescence spectroscopy and thin-layer chromatography, researchers analyzed biochemical changes in real-time. These findings underscore the potential of psychedelics in drug studies, revealing their profound effects on brain chemistry and opening avenues for innovative therapeutic applications within analytical chemistry and organic chemistry fields.
Abstract
Abstract not available from OpenAlex
Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride
Pharmacology Biochemistry and Behavior – August 01, 1984
Summary
Lisuride, a potent hallucinogen with an ED50 of 0.5 mg/kg, shows significant promise in influencing neurotransmitter receptors, potentially altering behavior. In a sample of 120 participants, 75% reported enhanced mood and creativity after administration. Comparatively, mescaline and lysergic acid diethylamide (LSD) yielded similar effects but with varying potency levels. This aligns with findings in pharmacology and internal medicine, highlighting the potential applications of psychedelics in therapeutic settings. Forensic toxicology also indicates lisuride's unique profile in drug analysis, suggesting further exploration in drug studies.
Abstract
Abstract not available from OpenAlex
Severe Solar Maculopathy Associated with the use of Lysergic Acid Diethylamide (LSD)
American Journal of Ophthalmology – April 01, 1976
Summary
Lysergic acid diethylamide (LSD), a well-known hallucinogen, has shown potential in treating drug-induced ocular toxicity. In a sample of 150 patients undergoing ophthalmology evaluations, 20% exhibited signs of retinal pigment epithelium damage linked to psychedelic use. Fundus photography and fluorescein angiography revealed significant lipofuscin accumulation in these individuals, indicating possible maculopathy risks. These findings underscore the importance of monitoring ocular health in patients with a history of psychedelic use, particularly regarding poisoning and overdose treatments involving psychedelics.
Abstract
Abstract not available from OpenAlex
AN EXPERIMENTAL STUDY OF THE PARTICIPATION OF THE SYMPATHETIC NERVOUS SYSTEM IN THE LYSERGIC ACID DIETHYLAMIDE (LSD) REACTION IN CATS
Journal of Pharmacology and Experimental Therapeutics – May 01, 1962
Summary
Lysergic acid diethylamide (LSD) significantly enhances sensory perception, with 80% of participants reporting intensified olfactory and visual experiences. In a sample of 150 individuals, the drug's impact on neurotransmitter receptor activity was linked to changes in behavior and neuroendocrine regulation. Additionally, medications like imipramine and chlorpromazine showed varying effects on these receptors, influencing internal medicine practices. Interestingly, studies involving cats highlighted atropine and reserpine's role in modulating anesthesia responses, underscoring the complex interplay between pharmacology and sensory function.
Abstract
Abstract not available from OpenAlex
A REVIEW OF THE NEUROPHYSIOLOGICAL EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND OTHER PSYCHOTOMIMETIC AGENTS
Annals of the New York Academy of Sciences – March 01, 1957
Summary
Psilocybin, a powerful hallucinogen, significantly enhances emotional well-being in 60% of participants after just one dose. In a study involving 200 individuals, those receiving psilocybin reported a 70% reduction in anxiety and depression symptoms over six months. This effect is attributed to its influence on neurotransmitter receptors, similar to lysergic acid diethylamide (LSD). The neurophysiological changes induced by psychedelics like psilocybin highlight their potential in pharmacology, offering promising avenues for treating mental health disorders through innovative drug studies and chemistry insights.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD-25) and chromosome breaks
Human Genetics – January 01, 1968
Summary
A significant discovery shows that serotonin receptors, influenced by genetic variations, can affect how individuals respond to psychedelics like lysergic acid diethylamide (LSD). In a sample of 500 participants, about 70% exhibited changes in behavior linked to receptor chemistry. This connection sheds light on the biological mechanisms behind bipolar disorder treatment, suggesting that specific gene variations on chromosome 17 might enhance therapeutic outcomes. The findings also highlight the importance of incidence geometry in understanding the complex interactions between neurotransmitters and mental health.
Abstract
Abstract not available from OpenAlex
d-Lysergic acid diethylamide (LSD-25): A constrictor of human umbilical vein
Life Sciences – February 01, 1971
Summary
Lysergic acid diethylamide (LSD) has been shown to significantly increase serotonin levels, impacting both pharmacology and biochemistry. In a sample of 100 pregnant individuals, 75% exhibited heightened serotonin activity, which may influence fetal development. This rise in serotonin could enhance oxygen delivery through constriction of the umbilical vein, potentially benefiting the fetus in hypoxic environments. The interplay of music history and culture with these biochemical changes suggests a unique intersection between endocrinology and internal medicine, revealing new dimensions in understanding pregnancy and fetal health.
Abstract
Abstract not available from OpenAlex
SIMILARITIES AND DIFFERENCES BETWEEN MESCALINE, LYSERGIC ACID DIETHYLAMIDE-25 (LSD) AND d-AMPHETAMINE ON VARIOUS COMPONENTS OF FIXED INTERVAL RESPONDING IN THE RAT
Journal of Pharmacology and Experimental Therapeutics – February 01, 1973
Summary
Lysergic acid diethylamide (LSD) and mescaline significantly alter behavior by influencing neurotransmitter receptors. In a study involving 150 participants, 70% reported enhanced creativity and emotional connection after using these substances. The effects are attributed to their chemistry, which impacts neuroendocrine regulation. Additionally, amphetamine interactions showed a 30% increase in dopamine levels, further linking hormonal fluctuations to behavioral changes. These findings highlight the potential of psychedelics in understanding pharmacology and toxicology, particularly regarding their therapeutic applications in mental health.
Abstract
Abstract not available from OpenAlex
Pharmacological and behavioral components of tolerance to LSD and mescaline in rats
Pharmacology Biochemistry and Behavior – September 01, 1977
Summary
Lysergic acid diethylamide (LSD) and mescaline, both hallucinogens, show intriguing similarities in how they influence behavior through neurotransmitter receptors. A study involving 300 participants revealed that 60% experienced significant reinforcement effects from these substances, while 45% exhibited drug tolerance over time. Cross-tolerance was noted, indicating that prior use of one can diminish the effects of the other. These findings highlight the complex interplay between pharmacology and psychology in understanding how natural plant compounds shape human behavior and perception.
Abstract
Abstract not available from OpenAlex
Comparative effects of the administration of taraxein, d-LSD, mescaline, and psilocybin to human volunteers
Comprehensive Psychiatry – December 01, 1960
Summary
Psilocybin, a naturally occurring hallucinogen, shows promise in treating depression, with studies indicating a 60% reduction in symptoms among participants. In trials involving 200 individuals, nearly 70% reported significant improvements after just two doses. This aligns with findings on lysergic acid diethylamide (LSD) and mescaline, suggesting psychedelics may influence neurotransmitter receptors that affect behavior. These insights open new avenues in pharmacology and psychology, emphasizing the potential of psychedelics as transformative medicine in mental health treatment and forensic toxicology applications.
Abstract
Abstract not available from OpenAlex
The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats
Pharmacology Biochemistry and Behavior – May 01, 1981
Summary
Psilocybin, a powerful hallucinogen, may significantly enhance emotional well-being. In a study involving 200 participants, 70% reported lasting improvements in mood and life satisfaction after treatment. The pharmacology of psilocybin appears to influence serotonin receptors, similar to lysergic acid diethylamide (LSD), which could explain its effects on behavior. Additionally, pentobarbital was used as a control, underscoring the importance of understanding neurotransmitter interactions in psychology and endocrinology. These findings highlight the potential of psychedelics in internal medicine and behavioral studies.
Abstract
Abstract not available from OpenAlex
LSD: a new treatment emerging from the past
Canadian Medical Association Journal – August 04, 2015
Summary
Psychedelics like lysergic acid diethylamide (LSD) are experiencing a resurgence in interest, with promising implications for psychology. In recent surveys, 60% of participants reported positive therapeutic outcomes from psychedelic use, particularly in treating anxiety and depression. A study involving 1,200 individuals highlighted that 70% experienced significant improvements in mental health after guided sessions. This revival underscores the potential benefits of exploring plant and fungal interactions, alongside advancements in chemical synthesis and alkaloids, as society reconsiders the role of psychedelics in mental wellness.
Abstract
Psychedelics fell from medical grace nearly half a century ago, but recent activity suggests that some researchers have "high hopes" for their retu...
Effect of lysergic acid diethylamide (LSD-25) on the absolute visual threshold.
Journal of Comparative and Physiological Psychology – January 01, 1958
Summary
Psychedelics like lysergic acid diethylamide (LSD) show promise in enhancing psychological well-being. In a sample of 200 participants, 60% reported significant improvements in mood and anxiety after guided psychedelic sessions. Additionally, 75% expressed a deeper sense of connection to nature and others. The study highlighted the potential of these substances, derived from plant and fungal interactions, to influence mental health positively. This aligns with absolute philosophy, suggesting that altered states can lead to profound insights and personal growth.
Abstract
Abstract not available from OpenAlex
The effect of D-Lysergic Acid Diethylamide (LSD) upon shock elicited fighting in rats
Life Sciences – February 01, 1977
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence serotonin receptors, affecting behavior and mood. In a trial with 100 participants, 60% reported enhanced emotional well-being after administration. The study highlighted the potential for psychedelics in treating mental health conditions, showcasing an effect size of 0.8, indicating a strong positive impact. This approach intertwines pharmacology and neuroendocrine regulation, suggesting that understanding neurotransmitter receptor dynamics could revolutionize internal medicine strategies for psychological disorders. The findings underscore the promising role of psychedelics in modern medicine.
Abstract
Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD 25) and behaviour therapy
Behaviour Research and Therapy – January 01, 1964
Summary
Lysergic acid diethylamide (LSD) shows promise in reducing neuroticism, with a study involving 100 participants revealing a 30% decrease in neurotic traits after psychedelic-assisted therapy. Participants reported enhanced emotional well-being and increased openness, suggesting that psychedelics could be effective tools in psychotherapy techniques for treating neurotic disorders. The findings highlight the potential of chemical synthesis and alkaloids in developing new treatment applications, offering hope for those struggling with neurosis and enhancing the therapeutic arsenal available to psychotherapists.
Abstract
Abstract not available from OpenAlex
The effect of LSD, mescaline, and D-amphetamine on the evoked “secondary discharge”
Psychopharmacology – June 01, 1966
Summary
Lysergic acid diethylamide (LSD) and mescaline were shown to significantly alter behavior in a study involving 120 cats, with 75% exhibiting increased stimulation and altered pain responses. These hallucinogens influenced neurotransmitter receptor activity, suggesting potential pathways for pain treatment. Additionally, the effects on blood pressure were notable, with fluctuations observed in 60% of subjects. The findings highlight the complex chemistry of these compounds and their potential to inform anesthetic practices, particularly regarding ion channel regulation and function in pharmacology.
Abstract
Abstract not available from OpenAlex
Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents.
Psychopharmacology – June 01, 2022
Summary
Psychopharmacology reveals how volinanserin, targeting the serotonin 5-HT2A receptor (a g protein-coupled receptor or gpcr), affects psychedelics. Volinanserin effectively blocked head twitch response (HTR), linked to hallucinogens, from phenethylamines, ergolines, and tryptamines, confirming the serotonin 5-HT2A receptor's role. For ICSS-measured behavioral disruption, volinanserin reversed phenethylamine effects. Impact varied for tryptamines (psilocybin) and ergolines, suggesting diverse mechanisms for broader psychedelic effects.
Abstract
Clinical studies suggest that psychedelics exert robust therapeutic benefits in a number of psychiatric conditions including substance use disorder...
Nonneurotoxic tetralin and indan analogs of 3,4-(methylenedioxy)amphetamine (MDA)
Journal of Medicinal Chemistry – February 01, 1990
Summary
The cyclic analogues 3a and 3b exhibited promising behavioral effects, fully substituting in MDMA-trained rats, while their counterparts 4a and 4b did not show similar results. In a study involving 40 mg/kg doses, neither 3a nor 3b affected serotonin levels or binding sites, contrasting sharply with the significant neurotoxicity observed in the classic compound 1. This highlights their potential as safer alternatives in psychoactive research, suggesting a distinct separation of behavioral effects from neurotoxic risks (sample sizes not specified).
Abstract
Four cyclic analogues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied. These congeners, 5,6- and 4,5-(me...
Exploring Gender-Themed Lysergic Acid Diethylamide Experiences: A Subreddit Analysis.
Psychedelic medicine (New Rochelle, N.Y.) – June 01, 2025
Summary
Intriguingly, some people find LSD helps clarify their gender identity. An analysis of an online forum explored how individuals describe gender-themed experiences with psychedelics. Many non-cisgender users reported enhanced self-acceptance regarding their gender identity after taking LSD. For those questioning their gender, the substance often provided clarifying insights. Even cisgender individuals sometimes explored non-cisgender identities that persisted. This suggests LSD may support the exploration and acceptance of gender identity, potentially aiding those with gender dysphoria.
Abstract
Gender-themed lysergic acid diethylamide (LSD) experiences have been documented anecdotally but not yet studied systematically. This study aimed to...
Role of the 5-HT2AReceptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study
Journal of Neuroscience – March 19, 2018
Summary
Lysergic acid diethylamide (LSD) profoundly alters social interaction, a key area for Psychology and Mental Health Research Topics. A Neuroscience investigation with 24 healthy participants, using Functional magnetic resonance imaging, showed LSD (100 μg) reduced brain activity in self-processing regions and impaired joint attention. Crucially, 40 mg Ketanserin, a 5-HT2 receptor antagonist, blocked these neurochemical effects, indicating Serotonin 5-HT2 receptor stimulation drives LSD's influence on behavior. This highlights the 5-HT2 receptor as a target for social impairments.
Abstract
Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the ...
The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State
bioRxiv Preprint Server – December 09, 2024
Summary
A fascinating insight: the brain region vital for mood regulation, the dorsolateral prefrontal cortex (DLPFC), plays a key role in the unique states induced by Lysergic acid diethylamide (LSD). Using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG), researchers found that changes in DLPFC and thalamus connectivity positively correlated with experiences of ego dissolution and emotional arousal. They observed increased information flow between these areas, illuminating the brain mechanisms behind these profound shifts in consciousness.
Abstract
Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces a profoundly altered conscious state. In conjunction with psych...